ES2196019T3 - Proteasa fungica. - Google Patents

Proteasa fungica.

Info

Publication number
ES2196019T3
ES2196019T3 ES94810616T ES94810616T ES2196019T3 ES 2196019 T3 ES2196019 T3 ES 2196019T3 ES 94810616 T ES94810616 T ES 94810616T ES 94810616 T ES94810616 T ES 94810616T ES 2196019 T3 ES2196019 T3 ES 2196019T3
Authority
ES
Spain
Prior art keywords
proteasa
aspartic
protein
fungica
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94810616T
Other languages
English (en)
Inventor
Frank Buxton
Gabor Jarai
Jacob Visser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2196019T3 publication Critical patent/ES2196019T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/62—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from Aspergillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION CONCIERNE A UNA NUEVA CODIFICACION DE SECUENCIA DE ADN PARA UNA PROTEASA ASPARTICA DE ASPERGILLUS, LA PROPIA PROTEASA ASPARTICA DE ASPERGILLUS Y UN METODO PARA SU PREPARACION CONSIGUIENTE. LA INVENCION ADEMAS CONCIERNE A UN NUEVO EFECTIVO DEL GRUPO MUTANTE ASPERGILLUS EN UNA PROTEASA DEL TIPO PROTEINAS ASPARTICA QUE ES UTIL PARA LA EXPRESION DE PROTEINA HETEROLOGA Y A UN METODO PARA LA PREPARACION DE TAL GRUPO MUTANTE.
ES94810616T 1993-11-03 1994-10-25 Proteasa fungica. Expired - Lifetime ES2196019T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93810764 1993-11-03

Publications (1)

Publication Number Publication Date
ES2196019T3 true ES2196019T3 (es) 2003-12-16

Family

ID=8215057

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94810616T Expired - Lifetime ES2196019T3 (es) 1993-11-03 1994-10-25 Proteasa fungica.

Country Status (18)

Country Link
US (2) US5674728A (es)
EP (1) EP0655497B1 (es)
JP (1) JP3727678B2 (es)
KR (1) KR100378507B1 (es)
AT (1) ATE235556T1 (es)
AU (1) AU688379B2 (es)
CA (1) CA2134863C (es)
CY (1) CY2471B1 (es)
DE (1) DE69432336T2 (es)
DK (1) DK0655497T3 (es)
ES (1) ES2196019T3 (es)
FI (1) FI119060B (es)
HU (1) HU220360B (es)
IL (2) IL168245A (es)
NO (1) NO315330B1 (es)
NZ (1) NZ264839A (es)
PT (1) PT655497E (es)
ZA (1) ZA948619B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1203627A (zh) * 1995-12-07 1998-12-30 诺沃挪第克公司 酶活性的选择性灭活
CN1160465C (zh) * 1995-12-15 2004-08-04 诺沃奇梅兹有限公司 其中areA、pepC和/或pepE基因已被灭活的真菌
JP2000511429A (ja) * 1996-06-05 2000-09-05 ギスト ブロカデス ベスローテン フェンノートシャップ 真菌メタロプロテアーゼ遺伝子
AU4200897A (en) * 1996-09-19 1998-04-14 Novo Nordisk A/S Novel host cells and methods of producing proteins
KR100880087B1 (ko) * 2001-02-23 2009-01-23 디에스엠 아이피 어셋츠 비.브이. 신규 단백질 분해효소를 암호화하는 신규 유전자
AU2006202723B2 (en) * 2001-02-23 2008-06-26 Dsm Ip Assets B.V. Novel genes encoding novel proteolytic enzymes
US7323327B2 (en) * 2001-02-23 2008-01-29 Dsm Ip Assets B.V. Genes encoding novel proteolytic enzymes
US20090253173A1 (en) * 2008-04-08 2009-10-08 Danisco Us Inc., Genencor Division Filamentous fungi with inactivated protease genes for altered protein production
FI121712B (fi) * 2009-04-30 2011-03-15 Ab Enzymes Oy Uusi sieniperäinen proteaasi ja sen käyttö
EP2800809B1 (en) 2012-01-05 2018-03-07 Glykos Finland Oy Protease deficient filamentous fungal cells and methods of use thereof
DK2852610T3 (en) 2012-05-23 2018-09-03 Glykos Finland Oy PRODUCTION OF FUCOSYLED GLYCOPROTEIN
DK3019602T3 (en) 2013-07-10 2018-11-12 Glykos Finland Oy MULTIPLE PROTEASE-DEFECTED FILAMENTARY FUNGAL CELLS AND PROCEDURES FOR USE THEREOF
AU2015293949B2 (en) 2014-07-21 2019-07-25 Teknologian Tutkimuskeskus Vtt Oy Production of glycoproteins with mammalian-like N-glycans in filamentous fungi
CN106222096B (zh) * 2016-08-18 2018-02-23 滨州学院 一株塔宾曲霉菌ct1及其在盐碱地解磷方面的应用
CN121022803B (zh) * 2025-10-29 2026-01-09 内蒙古科为博生物科技有限公司 一种耐热性提高的酸性蛋白酶突变体PepA4及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8415186D0 (en) * 1984-06-14 1984-07-18 Ciba Geigy Ag Polypeptides
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
GB8521496D0 (en) * 1985-08-29 1985-10-02 Ciba Geigy Ag Repressible yeast promoters
GB8702475D0 (en) * 1987-02-04 1987-03-11 Ciba Geigy Ag Expression system
WO1988007076A1 (en) * 1987-03-12 1988-09-22 Genex Corporation Production of bioadhesive precursor protein analogs by genetically-engineered organisms
US4871824A (en) * 1987-03-13 1989-10-03 Minnesota Mining And Manufacturing Company Variably crosslinked polymeric supports
US5252726A (en) * 1987-09-04 1993-10-12 Novo Nordisk A/S Promoters for use in aspergillus
CA1333777C (en) * 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
EP0353188B2 (en) * 1988-07-28 2002-03-06 Novartis AG Novel expression system
EP0421919A3 (en) * 1989-09-02 1992-04-15 Ciba-Geigy Ag Polygalacturonase encoding fungal expression system
FI103206B (fi) * 1990-01-29 1999-05-14 Novartis Ag Uusi ilmentämisjärjestelmä sieniä varten
JPH06506117A (ja) * 1991-04-01 1994-07-14 メルク　エンド　カンパニー　インコーポレーテッド ピキア（Ｐｉｃｈｉａ）蛋白質分解活性に影響する遺伝子およびその使用
DK47493D0 (da) * 1993-04-27 1993-04-27 Novo Nordisk As Fremgangsmaade til fremstilling af ost

Also Published As

Publication number Publication date
EP0655497B1 (en) 2003-03-26
NO315330B1 (no) 2003-08-18
FI945163L (fi) 1995-05-04
ZA948619B (en) 1995-06-27
HU9403136D0 (en) 1994-12-28
IL168245A (en) 2009-12-24
IL111482A (en) 2005-08-31
HU220360B (hu) 2001-12-28
EP0655497A2 (en) 1995-05-31
KR100378507B1 (ko) 2003-09-19
EP0655497A3 (en) 1997-05-07
US5756338A (en) 1998-05-26
FI119060B (fi) 2008-07-15
CY2471B1 (en) 2005-06-03
FI945163A0 (fi) 1994-11-02
DE69432336D1 (de) 2003-04-30
CA2134863C (en) 2008-12-30
JPH07213286A (ja) 1995-08-15
AU688379B2 (en) 1998-03-12
US5674728A (en) 1997-10-07
DE69432336T2 (de) 2003-12-04
JP3727678B2 (ja) 2005-12-14
CA2134863A1 (en) 1995-05-04
KR950014309A (ko) 1995-06-15
DK0655497T3 (da) 2003-07-21
PT655497E (pt) 2003-07-31
ATE235556T1 (de) 2003-04-15
NZ264839A (en) 1996-03-26
NO944181D0 (no) 1994-11-02
HUT69954A (en) 1995-09-28
IL111482A0 (en) 1995-01-24
NO944181L (no) 1995-05-04
AU7751494A (en) 1995-05-18

Similar Documents

Publication Publication Date Title
ES2525677T3 (es) Celulasas, genes que las codifican y usos de las mismas
AR243234A1 (es) Un gen quimerico modificado que codifica una proteina insecticida de bacillus thuringiensis,un vector que lo contiene, y un metodo para mejorar la expresion de un gen heterologo.
ES2123008T3 (es) Secuencias de adn que codifican polipeptido de gelonina.
PL329109A1 (en) Method of modulating the synthesis of melanin
ES2188920T3 (es) Composicion cosmetica que comprende un polimero anionico o no ionico y una silicona carboxilica.
ATE329028T1 (de) Nl3 tie rezeptortyrosinekinase ligandhomologe
ATE402717T1 (de) Für die termini des beta-amyloids spezifische, rekombinante antikörper, dafür kodierende dna und verfahren zu ihrer verwendung
BR9713294A (pt) "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano"
ES2121432T3 (es) Mando a distancia destinado a un aparato receptor.
ES2181674T3 (es) Dominios de union en las proteinas notch y delta.
DE69839444D1 (de) Smad 6 und dessen anwendungen
AR248044A1 (es) Una secuencia de adn que codifica anticuerpos monoclonales humanizados contra interleuquinas humanas, metodo de obtencion y de seleccion de dichos anticuerpos, vector recombinante y celula huesped.
NO20100324L (no) Fremgangsmate for trinnvis festing av polyetylenglykol (PEG) andeler i serie til et polypeptid
GT199900175A (es) Champus mejorados con estabilizadores.
EP0631623A4 (en) DNA CODING FOR TAURINE AND GABA TRANSPORTERS AND THEIR USE.
ES2332916T3 (es) Composiciones y metodo para el tratamiento de tumores.
ATE293690T1 (de) Verwendung vom krebs-assoziierten antigen 5t4 zur immuntherapie
GB9209993D0 (en) Vaccines
HUT73962A (en) New bacillus thuringiensis strains and their insecticidal proteins
ES2104596T3 (es) Nuevos polipeptidos, secuencias de adn que permiten su expresion, metodo de preparacion, y utilizacion.
ATE397062T1 (de) Chimäre polypeptide, die das fragment b des shigatoxins sowie peptide von therapeutischem interesse enthalten
ES2152313T3 (es) Gen grb-3-3, sus variantes y sus utilizaciones.
DE69432336D1 (de) Schimmel-Protease
NO972313L (no) Peptider som er i stand til å binde til GAP-protein-SH3-området, nukleotid-sekvenser som koder for dette samt fremstilling og bruk derav
HUP9802069A2 (hu) Kevésbé adszorbeálódó és jobban hidrolizáló termitáz variánsok