NO972911L - Stabiliserte ribozym-analoger - Google Patents
Stabiliserte ribozym-analogerInfo
- Publication number
- NO972911L NO972911L NO972911A NO972911A NO972911L NO 972911 L NO972911 L NO 972911L NO 972911 A NO972911 A NO 972911A NO 972911 A NO972911 A NO 972911A NO 972911 L NO972911 L NO 972911L
- Authority
- NO
- Norway
- Prior art keywords
- analogues
- ribozyme
- making
- stabilized
- stabilized ribozyme
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/312—Phosphonates
- C12N2310/3125—Methylphosphonates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Amplifiers (AREA)
Abstract
Det beskrives stabiliserte ribozym-analoger som har evne til endonukleolytisk å spalte en sekvens av 3' til 5' koblede ribonukleotider. Disse ribozym-analogene innbefatter modifikasjoner i bestemte sløyfe-, katalytisk kjerne- og flankerende region-nukleotider, hvilket gjør dem mer resistente overfor nukleaser.Det beskrives også fremgangsmåter for fremstilling og utnyttelse av ribozym-analogen ifølge oppfinnelsen, samt farmasøytiske formuleringer og sett som inneholder slike rjbozym-analoger.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/361,687 US5545729A (en) | 1994-12-22 | 1994-12-22 | Stabilized ribozyme analogs |
PCT/US1995/015871 WO1996019568A2 (en) | 1994-12-22 | 1995-12-05 | Stabilized ribozyme analogs |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972911D0 NO972911D0 (no) | 1997-06-20 |
NO972911L true NO972911L (no) | 1997-08-19 |
Family
ID=23423065
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972911A NO972911L (no) | 1994-12-22 | 1997-06-20 | Stabiliserte ribozym-analoger |
Country Status (7)
Country | Link |
---|---|
US (1) | US5545729A (no) |
EP (1) | EP0795010A2 (no) |
JP (1) | JPH10510992A (no) |
AU (1) | AU4417296A (no) |
CA (1) | CA2208427A1 (no) |
NO (1) | NO972911L (no) |
WO (1) | WO1996019568A2 (no) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846717A (en) * | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US5994069A (en) * | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
US6872816B1 (en) * | 1996-01-24 | 2005-03-29 | Third Wave Technologies, Inc. | Nucleic acid detection kits |
US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
US8153602B1 (en) | 1991-11-19 | 2012-04-10 | Isis Pharmaceuticals, Inc. | Composition and methods for the pulmonary delivery of nucleic acids |
EP0728139B1 (en) | 1993-09-03 | 2003-08-13 | Isis Pharmaceuticals, Inc. | Amine-derivatized nucleosides and oligonucleosides |
WO1997006252A1 (en) * | 1995-08-08 | 1997-02-20 | Hybridon, Inc. | Synthetic oligonucleotides with enhanced ribonuclease activity |
US7122364B1 (en) | 1998-03-24 | 2006-10-17 | Third Wave Technologies, Inc. | FEN endonucleases |
US20080160524A1 (en) * | 1996-01-24 | 2008-07-03 | Third Wave Technologies, Inc. | Methods and Compositions for Detecting Target Sequences |
US7195871B2 (en) * | 1996-01-24 | 2007-03-27 | Third Wave Technologies, Inc | Methods and compositions for detecting target sequences |
US6706471B1 (en) | 1996-01-24 | 2004-03-16 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
US5985557A (en) * | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
US6875572B2 (en) | 1996-01-24 | 2005-04-05 | Third Wave Technologies, Inc. | Nucleic acid detection assays |
US6274369B1 (en) * | 1996-02-02 | 2001-08-14 | Invitrogen Corporation | Method capable of increasing competency of bacterial cell transformation |
EP2055781B1 (en) | 1996-11-29 | 2011-10-26 | Third Wave Technologies, Inc. | FEN-1 endonucleases, mixtures and cleavage methods |
US6300483B1 (en) * | 1997-06-19 | 2001-10-09 | Ribozyme Pharmaceuticals, Inc. | Compositions inducing cleavage of RNA motifs |
EP0887405A1 (en) * | 1997-06-25 | 1998-12-30 | Gene Shears Pty Limited | Process for producing stabilised RNA molecules within cells, RNA molecules thus produced and nucleic acid precursors of such molecules |
AU731909B2 (en) | 1997-07-01 | 2001-04-05 | Isis Pharmaceuticals, Inc. | Compositions and methods for the delivery of oligonucleotides via the alimentary canal |
US8182991B1 (en) | 1997-11-26 | 2012-05-22 | Third Wave Technologies, Inc. | FEN-1 endonucleases, mixtures and cleavage methods |
US6841539B1 (en) | 1998-05-21 | 2005-01-11 | Isis Pharmaceuticals, Inc. | Compositions and methods for topical delivery of oligonucleotides |
EP1469009A2 (en) | 1998-05-21 | 2004-10-20 | Isis Parmaceuticals, Inc. | Compositions and methods for non-parenteral delivery of oligonucleotides |
US6656730B1 (en) | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
JP2005500821A (ja) * | 2000-11-15 | 2005-01-13 | サード・ウェーブ・テクノロジーズ・インク | Fenエンドヌクレアーゼ |
US20030124196A1 (en) | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
US20070021361A1 (en) * | 2002-12-04 | 2007-01-25 | Shuster Samuel J | Methods and materials for modulating trpm2 |
US8084432B2 (en) * | 2003-02-13 | 2011-12-27 | Isis Pharmaceuticals, Inc. | Compositions and methods for treatment of pouchitis |
CA2561741C (en) | 2004-04-05 | 2016-09-27 | Alnylam Pharmaceuticals, Inc. | Processes and reagents for oligonucleotide synthesis and purification |
EP1750776A2 (en) | 2004-04-30 | 2007-02-14 | Alnylam Pharmaceuticals Inc. | Oligonucleotides comprising a c5-modified pyrimidine |
JP2008504840A (ja) | 2004-06-30 | 2008-02-21 | アルニラム ファーマスーティカルズ インコーポレイテッド | 非リン酸骨格結合を含むオリゴヌクレオチド |
DK1948822T3 (da) | 2005-10-07 | 2011-10-17 | Johnson & Johnson Res Pty Ltd | Multikomponent-nukleinsyreenzymer og fremgangsmåder til deres anvendelse |
EP1934348B1 (en) * | 2005-10-11 | 2018-05-02 | Ben-Gurion University Of The Negev Research And Development Authority | Compositions for silencing the expression of vdac1 and uses thereof |
KR100652903B1 (ko) * | 2005-12-21 | 2006-12-04 | 한국과학기술연구원 | 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치 |
JP5688507B2 (ja) * | 2006-10-06 | 2015-03-25 | スピーデクス ピーティーワイ リミテッド | 分子スイッチおよびそれらの使用のための方法 |
ATE508191T1 (de) | 2006-11-01 | 2011-05-15 | Medical Res And Infrastructure Fund Of The Tel Aviv Sourasky Medical Ct | Adipozytenspezifische konstrukte und verfahren zur hemmung der expression von blutplättchen-typ- 12-lipoxygenase |
ES2425066T3 (es) * | 2007-04-05 | 2013-10-11 | Speedx Pty Ltd | Enzimas y complejos de ácidos nucleicos y métodos para su uso |
CA2718011C (en) * | 2008-03-15 | 2015-05-19 | Hologic, Inc. | Compositions and methods for analysis of nucleic acid molecules during amplification reaction using footprint probes |
EP2376633A1 (en) | 2008-12-17 | 2011-10-19 | AVI BioPharma, Inc. | Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis |
US8697858B2 (en) | 2009-11-13 | 2014-04-15 | Sarepta Therapeutics, Inc. | Antisense antiviral compound and method for treating influenza viral infection |
US9068185B2 (en) | 2010-03-12 | 2015-06-30 | Sarepta Therapeutics, Inc. | Antisense modulation of nuclear hormone receptors |
WO2011139714A2 (en) | 2010-04-26 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-trna synthetase |
EP2563381B1 (en) | 2010-04-27 | 2017-08-09 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
EP2563911B1 (en) | 2010-04-28 | 2021-07-21 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
AU2011248490B2 (en) | 2010-04-29 | 2016-11-10 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
US9034320B2 (en) | 2010-04-29 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Valyl-tRNA synthetases |
EP2566496B1 (en) | 2010-05-03 | 2018-02-28 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
CA2797277C (en) | 2010-05-03 | 2021-02-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
EP2566495B1 (en) | 2010-05-03 | 2017-03-01 | aTyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases |
AU2011248101B2 (en) | 2010-05-04 | 2016-10-20 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-tRNA synthetase complex |
EP3023496B1 (en) | 2010-05-13 | 2020-07-29 | Sarepta Therapeutics, Inc. | Compounds which modulate interleukins 17 and 23 signaling activity |
AU2011252990B2 (en) | 2010-05-14 | 2017-04-20 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
JP6046607B2 (ja) | 2010-05-27 | 2016-12-21 | エータイアー ファーマ, インコーポレイテッド | グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
JP6116479B2 (ja) | 2010-07-12 | 2017-04-19 | エータイアー ファーマ, インコーポレイテッド | グリシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US9029506B2 (en) | 2010-08-25 | 2015-05-12 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases |
WO2014170892A1 (en) | 2013-04-15 | 2014-10-23 | Yeda Research And Development Co. Ltd. | Inhibition of rip kinases for treating lysosomal storage diseases |
US11767520B2 (en) | 2017-04-20 | 2023-09-26 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6365730B1 (en) * | 1990-06-19 | 2002-04-02 | Gene Shears Pty. Limited | DNA-Armed ribozymes and minizymes |
JP3257675B2 (ja) * | 1990-10-12 | 2002-02-18 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー.ファウ. | 修飾リボザイム |
US5652094A (en) * | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
EP0625194B1 (en) * | 1992-02-04 | 1996-04-24 | The Worcester Foundation For Biomedical Research | Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide |
WO1993023569A1 (en) * | 1992-05-11 | 1993-11-25 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for inhibiting viral replication |
AU680843B2 (en) * | 1992-11-03 | 1997-08-14 | Gene Shears Pty. Limited | TNF-alpha ribozymes and degradation resistant mRNA derivatives linked to TNF-alpha ribozymes |
GB2273932A (en) * | 1992-11-24 | 1994-07-06 | Stiefel Laboratories | Stable oligonucleotides |
-
1994
- 1994-12-22 US US08/361,687 patent/US5545729A/en not_active Expired - Fee Related
-
1995
- 1995-12-05 AU AU44172/96A patent/AU4417296A/en not_active Abandoned
- 1995-12-05 CA CA002208427A patent/CA2208427A1/en not_active Abandoned
- 1995-12-05 JP JP8519838A patent/JPH10510992A/ja active Pending
- 1995-12-05 EP EP95943013A patent/EP0795010A2/en not_active Withdrawn
- 1995-12-05 WO PCT/US1995/015871 patent/WO1996019568A2/en not_active Application Discontinuation
-
1997
- 1997-06-20 NO NO972911A patent/NO972911L/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2208427A1 (en) | 1996-06-27 |
JPH10510992A (ja) | 1998-10-27 |
WO1996019568A2 (en) | 1996-06-27 |
US5545729A (en) | 1996-08-13 |
EP0795010A2 (en) | 1997-09-17 |
AU4417296A (en) | 1996-07-10 |
NO972911D0 (no) | 1997-06-20 |
WO1996019568A3 (en) | 1996-09-06 |
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