ATE264688T1 - Cd28/ctla-4 inhibierende peptidomimetika und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Cd28/ctla-4 inhibierende peptidomimetika und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE264688T1
ATE264688T1 AT98929048T AT98929048T ATE264688T1 AT E264688 T1 ATE264688 T1 AT E264688T1 AT 98929048 T AT98929048 T AT 98929048T AT 98929048 T AT98929048 T AT 98929048T AT E264688 T1 ATE264688 T1 AT E264688T1
Authority
AT
Austria
Prior art keywords
ctla
inhibiting
pharmaceutical compositions
peptidomimetics
compositions containing
Prior art date
Application number
AT98929048T
Other languages
English (en)
Inventor
Tayar Nabil El
Steven Blechner
Brad Jameson
Mark Tepper
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Application granted granted Critical
Publication of ATE264688T1 publication Critical patent/ATE264688T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98929048T 1997-06-12 1998-06-11 Cd28/ctla-4 inhibierende peptidomimetika und diese enthaltende pharmazeutische zusammensetzungen ATE264688T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4947097P 1997-06-12 1997-06-12
PCT/US1998/012312 WO1998056401A1 (en) 1997-06-12 1998-06-11 Cd28/ctla-4 inhibiting peptidomimetics, pharmaceutical compositions thereof, and method of using same

Publications (1)

Publication Number Publication Date
ATE264688T1 true ATE264688T1 (de) 2004-05-15

Family

ID=21959997

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98929048T ATE264688T1 (de) 1997-06-12 1998-06-11 Cd28/ctla-4 inhibierende peptidomimetika und diese enthaltende pharmazeutische zusammensetzungen

Country Status (12)

Country Link
US (1) US6337316B1 (de)
EP (1) EP0989858B1 (de)
JP (2) JP2002505673A (de)
AT (1) ATE264688T1 (de)
AU (1) AU743939B2 (de)
CA (1) CA2293666A1 (de)
DE (1) DE69823352T2 (de)
DK (1) DK0989858T3 (de)
ES (1) ES2215306T3 (de)
IL (2) IL133467A0 (de)
PT (1) PT989858E (de)
WO (1) WO1998056401A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3107699A (en) * 1998-03-19 1999-10-11 Heska Corporation Novel forms of t cell costimulatory proteins, nucleic acid molecules, and uses thereof
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
US7531168B2 (en) 2001-02-16 2009-05-12 Genetics Institute Llc Method for downmodulating immune response in type I diabetes
IL148993A0 (en) * 2002-04-04 2002-11-10 Yissum Res Dev Co Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof
WO2004087754A1 (en) * 2003-04-03 2004-10-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between cd28 and the superantigen and uses thereof
US8535672B2 (en) * 2002-04-04 2013-09-17 Yissum Research Development Of The Hebrew University Of Jerusalem Broad-spectrum in-vivo effective superantigen toxin antagonists based on the interaction between CD28 and the superantigen and uses thereof
WO2004081021A2 (en) * 2003-03-12 2004-09-23 Duke University Oligonucleotide mimetics
US20060075968A1 (en) * 2004-10-12 2006-04-13 Applied Materials, Inc. Leak detector and process gas monitor
US7892827B2 (en) 2004-11-26 2011-02-22 Pieris Ag Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4)
WO2008083169A2 (en) 2006-12-26 2008-07-10 The Johns Hopkins University Compositions and methods for the treatment of immunologic disorders
US20090007853A1 (en) * 2007-07-03 2009-01-08 Tyson Foods, Inc. Stackable tray system and method to load, transport, stun and singulate poultry
EP2646552B1 (de) 2010-12-02 2017-07-05 Pieris Pharmaceuticals GmbH Muteine von menschlichem lipocalin 2 mit affinität für ctla-4
EP2997373A1 (de) 2013-05-17 2016-03-23 MedImmune, LLC Rezeptoren für b7-h4
CA2936611A1 (en) 2014-01-13 2015-07-16 Pieris Pharmaceuticals Gmbh Multi-specific polypeptide useful for localized tumor immunomodulation
US20170355755A1 (en) 2014-11-21 2017-12-14 Yale University Compositions and methods for modulating salm5 and hvem
WO2018083080A2 (en) 2016-11-04 2018-05-11 Innate Pharma Nkp46 ligand
IT201800004853A1 (it) 2018-04-24 2019-10-24 Metodi per trattare il cancro
JP7498889B2 (ja) 2020-01-30 2024-06-13 東亞合成株式会社 Ｃｔｌａ４とｂ７タンパク質との結合を抑制するペプチドおよびその利用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
CA2580812A1 (en) * 1991-06-27 1993-01-07 Bristol-Myers Squibb Company Ctla4 receptor, fusion proteins containing it and uses thereof
US5773253A (en) * 1993-01-22 1998-06-30 Bristol-Myers Squibb Company MYPPPY variants of CTL A4 and uses thereof
US5888763A (en) * 1994-12-30 1999-03-30 The Rockefeller University Peptides specific for the first Crk-SH3 domain
WO1996031229A1 (en) * 1995-04-05 1996-10-10 Beth Israel Hospital Association Inhibiting rejection of a graft

Also Published As

Publication number Publication date
AU743939B2 (en) 2002-02-07
JP2009029833A (ja) 2009-02-12
ES2215306T3 (es) 2004-10-01
DE69823352D1 (de) 2004-05-27
EP0989858A4 (de) 2001-03-21
DE69823352T2 (de) 2004-09-02
IL133467A0 (en) 2001-04-30
PT989858E (pt) 2004-07-30
IL133467A (en) 2006-12-31
JP2002505673A (ja) 2002-02-19
EP0989858A1 (de) 2000-04-05
WO1998056401A1 (en) 1998-12-17
CA2293666A1 (en) 1998-12-17
US6337316B1 (en) 2002-01-08
EP0989858B1 (de) 2004-04-21
DK0989858T3 (da) 2004-08-09
AU8070698A (en) 1998-12-30

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