ATE246516T1 - Neue enzyme und prodrugs für adept - Google Patents
Neue enzyme und prodrugs für adeptInfo
- Publication number
- ATE246516T1 ATE246516T1 AT95900827T AT95900827T ATE246516T1 AT E246516 T1 ATE246516 T1 AT E246516T1 AT 95900827 T AT95900827 T AT 95900827T AT 95900827 T AT95900827 T AT 95900827T AT E246516 T1 ATE246516 T1 AT E246516T1
- Authority
- AT
- Austria
- Prior art keywords
- adept
- prodrugs
- enzymes
- new enzymes
- nucleic acid
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 238000010913 antigen-directed enzyme pro-drug therapy Methods 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 102000000496 Carboxypeptidases A Human genes 0.000 abstract 2
- 108010080937 Carboxypeptidases A Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
- A61K47/67—Enzyme prodrug therapy, e.g. gene directed enzyme drug therapy [GDEPT] or VDEPT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939323429A GB9323429D0 (en) | 1993-11-12 | 1993-11-12 | Therapy |
| PCT/GB1994/002483 WO1995013095A2 (en) | 1993-11-12 | 1994-11-11 | Therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246516T1 true ATE246516T1 (de) | 2003-08-15 |
Family
ID=10745113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95900827T ATE246516T1 (de) | 1993-11-12 | 1994-11-11 | Neue enzyme und prodrugs für adept |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6140100A (de) |
| EP (1) | EP0728018B1 (de) |
| JP (1) | JPH09507834A (de) |
| AT (1) | ATE246516T1 (de) |
| AU (1) | AU688412B2 (de) |
| CA (1) | CA2176024A1 (de) |
| DE (1) | DE69433015T2 (de) |
| DK (1) | DK0728018T3 (de) |
| ES (1) | ES2204935T3 (de) |
| GB (1) | GB9323429D0 (de) |
| IL (1) | IL111601A0 (de) |
| MY (1) | MY114140A (de) |
| NZ (1) | NZ276137A (de) |
| WO (1) | WO1995013095A2 (de) |
| ZA (1) | ZA948987B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9323429D0 (en) * | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
| GB2309033B (en) * | 1994-12-23 | 1999-06-02 | Zeneca Ltd | Chemical compounds |
| ES2181805T3 (es) * | 1994-12-23 | 2003-03-01 | Astrazeneca Ab | Compuestos quimicos. |
| EP0844885A2 (de) * | 1995-08-16 | 1998-06-03 | Zeneca Limited | Chemische verbindungen |
| GB9703201D0 (en) * | 1997-02-15 | 1997-04-02 | Zeneca Ltd | Chemical compounds |
| JP2001526914A (ja) * | 1997-12-31 | 2001-12-25 | インサイト・ファーマスーティカルズ・インコーポレイテッド | ヒト・調節タンパク質 |
| CA2390650A1 (en) * | 1999-11-12 | 2001-05-17 | Lexicon Genetics Incorporated | Novel human proteases and polynucleotides encoding the same |
| EP1343531A2 (de) * | 2000-12-21 | 2003-09-17 | McGILL UNIVERSITY | Konjugate von antikörpern und antikrebsmitteln |
| RU2312854C2 (ru) | 2001-09-14 | 2007-12-20 | Глаксо Груп Лимитед | Производные фенэтаноламина для лечения респираторных заболеваний |
| EP2283868B1 (de) | 2002-07-15 | 2016-03-30 | Board of Regents, The University of Texas System | Peptide mit Bindung an Phosphatidylethanolamine und ihre Verwendung bei der Behandlung von Virusinfektionen und Krebs |
| US20110002978A1 (en) * | 2003-06-17 | 2011-01-06 | Harrison Roger G | Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof |
| WO2005076744A2 (en) * | 2004-02-18 | 2005-08-25 | Frutarom Ltd. | Method for the preparation of peptide-oligonucleotide conjugates |
| EP1794294B1 (de) * | 2004-09-27 | 2011-07-20 | Sanofi-Aventis Deutschland GmbH | Rekombinante carboxypeptidase b |
| WO2006059245A2 (en) * | 2004-11-16 | 2006-06-08 | Neurochem (International) Limited | Compounds for the treatment of cns and amyloid associated diseases |
| MX2010005104A (es) | 2007-11-09 | 2010-08-04 | Peregrine Pharmaceuticals Inc | Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos. |
| PL2491788T3 (pl) | 2011-02-25 | 2016-07-29 | Kraft Foods R & D Inc | Wyrób spożywczy z formowanym korpusem |
| US9340504B2 (en) * | 2013-11-21 | 2016-05-17 | Purdue Pharma L.P. | Pyridine and piperidine derivatives as novel sodium channel blockers |
| RU2668166C1 (ru) * | 2013-12-17 | 2018-09-27 | Стелла Фарма Корпорейшн | Способ получения 2-фтор-4-бороно-l-фенилаланина и вещества-предшественника 2-фтор-4-бороно-l-фенилаланина |
| US9987241B2 (en) | 2014-09-25 | 2018-06-05 | The Board Of Regents Of The University Of Oklahoma | Enzyme conjugate and prodrug cancer therapy |
| WO2020032951A1 (en) | 2018-08-09 | 2020-02-13 | The Board Of Regents Of The University Of Oklahoma | Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same |
| EP4359414A4 (de) * | 2021-06-24 | 2026-01-21 | Lycia Therapeutics Inc | Bifunktionelle folatrezeptorbindende verbindungen |
| JP2024524614A (ja) | 2021-07-14 | 2024-07-05 | ライシア セラピューティクス， インコーポレイテッド | Ａｓｇｐｒ細胞表面受容体結合化合物及びコンジュゲート |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| GB8809616D0 (en) * | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
| US5433955A (en) | 1989-01-23 | 1995-07-18 | Akzo N.V. | Site specific in vivo activation of therapeutic drugs |
| ES2075893T3 (es) * | 1989-01-23 | 1995-10-16 | Akzo Nobel Nv | Activacion in vivo especifica de sede de farmacos terapeuticos. |
| AU633867B2 (en) * | 1989-02-02 | 1993-02-11 | Eli Lilly And Company | Delivery of cytotoxic agents |
| FI94362C (fi) * | 1989-10-20 | 1995-08-25 | Squibb Bristol Myers Co | Oleellisesti puhdistettu sulfataasi, menetelmä sen valmistamiseksi ja sitä tuottava Streptomyces-kanta |
| GB9200415D0 (en) * | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Inactivation of cytotoxic drugs |
| US6187579B1 (en) * | 1993-10-28 | 2001-02-13 | Carlsberg A/S | Customized proteases |
| GB9323429D0 (en) * | 1993-11-12 | 1994-01-05 | Wellcome Found | Therapy |
| US5985627A (en) * | 1997-02-28 | 1999-11-16 | Carlsberg Laboratory | Modified carboxypeptidase |
-
1993
- 1993-11-12 GB GB939323429A patent/GB9323429D0/en active Pending
-
1994
- 1994-11-11 CA CA002176024A patent/CA2176024A1/en not_active Abandoned
- 1994-11-11 DK DK95900827T patent/DK0728018T3/da active
- 1994-11-11 MY MYPI94003012A patent/MY114140A/en unknown
- 1994-11-11 US US08/640,906 patent/US6140100A/en not_active Expired - Fee Related
- 1994-11-11 IL IL11160194A patent/IL111601A0/xx unknown
- 1994-11-11 WO PCT/GB1994/002483 patent/WO1995013095A2/en not_active Ceased
- 1994-11-11 DE DE69433015T patent/DE69433015T2/de not_active Expired - Fee Related
- 1994-11-11 AU AU81488/94A patent/AU688412B2/en not_active Ceased
- 1994-11-11 ZA ZA948987A patent/ZA948987B/xx unknown
- 1994-11-11 ES ES95900827T patent/ES2204935T3/es not_active Expired - Lifetime
- 1994-11-11 NZ NZ276137A patent/NZ276137A/en unknown
- 1994-11-11 JP JP7513695A patent/JPH09507834A/ja not_active Withdrawn
- 1994-11-11 EP EP95900827A patent/EP0728018B1/de not_active Expired - Lifetime
- 1994-11-11 AT AT95900827T patent/ATE246516T1/de not_active IP Right Cessation
-
1999
- 1999-09-14 US US09/395,936 patent/US6319702B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ276137A (en) | 1998-04-27 |
| AU8148894A (en) | 1995-05-29 |
| ZA948987B (en) | 1996-05-13 |
| JPH09507834A (ja) | 1997-08-12 |
| DK0728018T3 (da) | 2003-11-24 |
| ES2204935T3 (es) | 2004-05-01 |
| DE69433015T2 (de) | 2004-06-09 |
| AU688412B2 (en) | 1998-03-12 |
| WO1995013095A3 (en) | 1995-07-13 |
| DE69433015D1 (de) | 2003-09-11 |
| CA2176024A1 (en) | 1995-05-18 |
| EP0728018A1 (de) | 1996-08-28 |
| IL111601A0 (en) | 1995-01-24 |
| US6140100A (en) | 2000-10-31 |
| GB9323429D0 (en) | 1994-01-05 |
| US6319702B1 (en) | 2001-11-20 |
| WO1995013095A2 (en) | 1995-05-18 |
| EP0728018B1 (de) | 2003-08-06 |
| MY114140A (en) | 2002-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0728018 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |