DE69433015D1 - Neue Enzyme und Prodrugs für ADEPT - Google Patents

Neue Enzyme und Prodrugs für ADEPT

Info

Publication number
DE69433015D1
DE69433015D1 DE69433015T DE69433015T DE69433015D1 DE 69433015 D1 DE69433015 D1 DE 69433015D1 DE 69433015 T DE69433015 T DE 69433015T DE 69433015 T DE69433015 T DE 69433015T DE 69433015 D1 DE69433015 D1 DE 69433015D1
Authority
DE
Germany
Prior art keywords
adept
prodrugs
enzymes
new enzymes
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69433015T
Other languages
English (en)
Other versions
DE69433015T2 (de
Inventor
Keith Smith
Andrew Blumenkopf
Michael Cory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE69433015D1 publication Critical patent/DE69433015D1/de
Publication of DE69433015T2 publication Critical patent/DE69433015T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/67—Enzyme prodrug therapy, e.g. gene directed enzyme drug therapy [GDEPT] or VDEPT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69433015T 1993-11-12 1994-11-11 Neue Enzyme und Prodrugs für ADEPT Expired - Fee Related DE69433015T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9323429 1993-11-12
GB939323429A GB9323429D0 (en) 1993-11-12 1993-11-12 Therapy
PCT/GB1994/002483 WO1995013095A2 (en) 1993-11-12 1994-11-11 Therapy

Publications (2)

Publication Number Publication Date
DE69433015D1 true DE69433015D1 (de) 2003-09-11
DE69433015T2 DE69433015T2 (de) 2004-06-09

Family

ID=10745113

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69433015T Expired - Fee Related DE69433015T2 (de) 1993-11-12 1994-11-11 Neue Enzyme und Prodrugs für ADEPT

Country Status (15)

Country Link
US (2) US6140100A (de)
EP (1) EP0728018B1 (de)
JP (1) JPH09507834A (de)
AT (1) ATE246516T1 (de)
AU (1) AU688412B2 (de)
CA (1) CA2176024A1 (de)
DE (1) DE69433015T2 (de)
DK (1) DK0728018T3 (de)
ES (1) ES2204935T3 (de)
GB (1) GB9323429D0 (de)
IL (1) IL111601A0 (de)
MY (1) MY114140A (de)
NZ (1) NZ276137A (de)
WO (1) WO1995013095A2 (de)
ZA (1) ZA948987B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9323429D0 (en) * 1993-11-12 1994-01-05 Wellcome Found Therapy
US5985281A (en) * 1994-12-23 1999-11-16 Zeneca Limited Chemical compounds
GB2309033B (en) * 1994-12-23 1999-06-02 Zeneca Ltd Chemical compounds
CZ43098A3 (cs) 1995-08-16 1998-05-13 Zeneca Limited Konjugáty obsahující mutovanou formu enzymu karboxypeptidázy B, způsob jejich přípravy a jejich použití
GB9703201D0 (en) * 1997-02-15 1997-04-02 Zeneca Ltd Chemical compounds
AU2205499A (en) * 1997-12-31 1999-07-19 Incyte Pharmaceuticals, Inc. Human regulatory proteins
CA2390650A1 (en) * 1999-11-12 2001-05-17 Lexicon Genetics Incorporated Novel human proteases and polynucleotides encoding the same
AU2002216864A1 (en) * 2000-12-21 2002-07-01 Mcgill University Conjugates of antibodies and anticancer drugs
EP2042168B1 (de) 2001-09-14 2013-10-23 Glaxo Group Limited Inhalationszubereitung enthaltend Phenethanolamine Derivate zur Behandlung von Atemwegserkrankungen
KR101257584B1 (ko) 2002-07-15 2013-04-23 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
US20110002978A1 (en) 2003-06-17 2011-01-06 Harrison Roger G Enzyme prodrug cancer therapy selectively targeted to tumor cells or tumor vasculature and methods of production and use thereof
US20080221303A1 (en) * 2004-02-18 2008-09-11 Jehoshua Katzhendler Method for the Preparation of Peptide-Oligonucleotide Conjugates
DK1794294T3 (da) * 2004-09-27 2011-10-31 Sanofi Aventis Deutschland Rekombinant carboxypeptidase B
CN101103018A (zh) * 2004-11-16 2008-01-09 神经化学（国际）有限公司 治疗cns和淀粉样蛋白-相关疾病的化合物
US8034905B2 (en) 2007-11-09 2011-10-11 Affitech Research, AS Anti-VEGF antibody compositions and methods
EP2491788B1 (de) 2011-02-25 2015-12-23 Kraft Foods R & D, Inc. Lebensmittelprodukt mit einem formkörper
US9340504B2 (en) * 2013-11-21 2016-05-17 Purdue Pharma L.P. Pyridine and piperidine derivatives as novel sodium channel blockers
WO2015093469A1 (ja) * 2013-12-17 2015-06-25 ステラファーマ株式会社 ２－フルオロ－４－ボロノ－ｌ－フェニルアラニンの製造方法および２－フルオロ－４－ボロノ－ｌ－フェニルアラニンの前駆体
US9987241B2 (en) 2014-09-25 2018-06-05 The Board Of Regents Of The University Of Oklahoma Enzyme conjugate and prodrug cancer therapy
US11446365B2 (en) 2017-08-09 2022-09-20 The Board Of Regents Of The University Of Oklahoma Antimalarial enzyme conjugates, kits containing same, and methods of producing and using same
EP4359414A1 (de) * 2021-06-24 2024-05-01 Lycia Therapeutics, Inc. Bifunktionelle folatrezeptorbindende verbindungen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
GB8809616D0 (en) * 1988-04-22 1988-05-25 Cancer Res Campaign Tech Further improvements relating to drug delivery systems
AU648015B2 (en) * 1989-01-23 1994-04-14 Akzo N.V. Site specific in-vivo activation of therapeutic drugs
US5433955A (en) 1989-01-23 1995-07-18 Akzo N.V. Site specific in vivo activation of therapeutic drugs
AU633867B2 (en) * 1989-02-02 1993-02-11 Eli Lilly And Company Delivery of cytotoxic agents
FI94362C (fi) * 1989-10-20 1995-08-25 Squibb Bristol Myers Co Oleellisesti puhdistettu sulfataasi, menetelmä sen valmistamiseksi ja sitä tuottava Streptomyces-kanta
GB9200415D0 (en) * 1992-01-09 1992-02-26 Bagshawe Kenneth D Inactivation of cytotoxic drugs
US6187579B1 (en) * 1993-10-28 2001-02-13 Carlsberg A/S Customized proteases
GB9323429D0 (en) * 1993-11-12 1994-01-05 Wellcome Found Therapy
US5985627A (en) * 1997-02-28 1999-11-16 Carlsberg Laboratory Modified carboxypeptidase

Also Published As

Publication number Publication date
CA2176024A1 (en) 1995-05-18
ES2204935T3 (es) 2004-05-01
AU8148894A (en) 1995-05-29
ZA948987B (en) 1996-05-13
ATE246516T1 (de) 2003-08-15
IL111601A0 (en) 1995-01-24
AU688412B2 (en) 1998-03-12
MY114140A (en) 2002-08-30
WO1995013095A3 (en) 1995-07-13
DE69433015T2 (de) 2004-06-09
DK0728018T3 (da) 2003-11-24
EP0728018B1 (de) 2003-08-06
NZ276137A (en) 1998-04-27
EP0728018A1 (de) 1996-08-28
US6140100A (en) 2000-10-31
JPH09507834A (ja) 1997-08-12
GB9323429D0 (en) 1994-01-05
WO1995013095A2 (en) 1995-05-18
US6319702B1 (en) 2001-11-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee