IL104061A - Bicyclopolyazamicocyclicophosphonic acid complexes, their preparation and conjugates, for use as radioactive drugs - Google Patents
Bicyclopolyazamicocyclicophosphonic acid complexes, their preparation and conjugates, for use as radioactive drugsInfo
- Publication number
- IL104061A IL104061A IL10406192A IL10406192A IL104061A IL 104061 A IL104061 A IL 104061A IL 10406192 A IL10406192 A IL 10406192A IL 10406192 A IL10406192 A IL 10406192A IL 104061 A IL104061 A IL 104061A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- complex
- terms
- term
- conjugate
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims abstract description 31
- 238000000034 method Methods 0.000 title claims description 44
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- 238000002360 preparation method Methods 0.000 title description 14
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- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 claims abstract description 17
- GYHNNYVSQQEPJS-OIOBTWANSA-N Gallium-67 Chemical compound [67Ga] GYHNNYVSQQEPJS-OIOBTWANSA-N 0.000 claims abstract description 13
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims abstract description 13
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims abstract description 13
- KZUNJOHGWZRPMI-AKLPVKDBSA-N samarium-153 Chemical compound [153Sm] KZUNJOHGWZRPMI-AKLPVKDBSA-N 0.000 claims abstract description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 77
- 102220254284 rs755928199 Human genes 0.000 claims description 38
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- 239000000203 mixture Substances 0.000 claims description 23
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- 241001465754 Metazoa Species 0.000 claims description 19
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 19
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 17
- 238000009472 formulation Methods 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 16
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 9
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- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims description 6
- 229910052738 indium Inorganic materials 0.000 claims description 5
- 101100516568 Caenorhabditis elegans nhr-7 gene Proteins 0.000 claims description 4
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- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
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- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 4
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- 238000002560 therapeutic procedure Methods 0.000 abstract description 13
- 239000003446 ligand Substances 0.000 description 24
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 21
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- UEXCJVNBTNXOEH-UHFFFAOYSA-N Ethynylbenzene Chemical group C#CC1=CC=CC=C1 UEXCJVNBTNXOEH-UHFFFAOYSA-N 0.000 description 4
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- IWQNFYRJSVJWQA-UHFFFAOYSA-N 2,6-bis(chloromethyl)pyridine Chemical compound ClCC1=CC=CC(CCl)=N1 IWQNFYRJSVJWQA-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/806,069 US5428139A (en) | 1991-12-10 | 1991-12-10 | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL104061A0 IL104061A0 (en) | 1993-05-13 |
| IL104061A true IL104061A (en) | 1999-11-30 |
Family
ID=25193240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL10406192A IL104061A (en) | 1991-12-10 | 1992-12-10 | Bicyclopolyazamicocyclicophosphonic acid complexes, their preparation and conjugates, for use as radioactive drugs |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5428139A (fr) |
| EP (1) | EP0570574B1 (fr) |
| KR (1) | KR930703025A (fr) |
| AT (1) | ATE174224T1 (fr) |
| AU (1) | AU663753B2 (fr) |
| CA (1) | CA2103555A1 (fr) |
| DE (1) | DE69227828T2 (fr) |
| DK (1) | DK0570574T3 (fr) |
| ES (1) | ES2124780T3 (fr) |
| FI (1) | FI933509A (fr) |
| GR (1) | GR3029318T3 (fr) |
| HU (1) | HUT66002A (fr) |
| IL (1) | IL104061A (fr) |
| MX (1) | MX9207167A (fr) |
| PH (1) | PH31049A (fr) |
| RU (1) | RU2118325C1 (fr) |
| WO (1) | WO1993011801A1 (fr) |
| ZA (1) | ZA929577B (fr) |
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| FR2645343A1 (fr) * | 1989-03-31 | 1990-10-05 | Jaeger Regulation | Systeme de fixation d'un raccord-bulbe de thermostat pour une enceinte telle que notamment fours |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| JP3131219B2 (ja) * | 1990-01-19 | 2001-01-31 | ニユコメド・イメージング・アクシエセルカペト | キレート化合物 |
| GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
-
1991
- 1991-12-10 US US07/806,069 patent/US5428139A/en not_active Expired - Lifetime
-
1992
- 1992-12-10 DK DK93900998T patent/DK0570574T3/da active
- 1992-12-10 MX MX9207167A patent/MX9207167A/es not_active IP Right Cessation
- 1992-12-10 ZA ZA929577A patent/ZA929577B/xx unknown
- 1992-12-10 PH PH45407A patent/PH31049A/en unknown
- 1992-12-10 DE DE69227828T patent/DE69227828T2/de not_active Expired - Fee Related
- 1992-12-10 IL IL10406192A patent/IL104061A/en not_active IP Right Cessation
- 1992-12-10 WO PCT/US1992/010664 patent/WO1993011801A1/fr active IP Right Grant
- 1992-12-10 EP EP93900998A patent/EP0570574B1/fr not_active Expired - Lifetime
- 1992-12-10 ES ES93900998T patent/ES2124780T3/es not_active Expired - Lifetime
- 1992-12-10 AT AT93900998T patent/ATE174224T1/de not_active IP Right Cessation
- 1992-12-10 RU RU93052883A patent/RU2118325C1/ru active
- 1992-12-10 KR KR1019930702372A patent/KR930703025A/ko not_active Application Discontinuation
- 1992-12-10 CA CA002103555A patent/CA2103555A1/fr not_active Abandoned
- 1992-12-10 HU HU9302310A patent/HUT66002A/hu unknown
- 1992-12-10 AU AU32466/93A patent/AU663753B2/en not_active Ceased
-
1993
- 1993-08-09 FI FI933509A patent/FI933509A/fi unknown
-
1999
- 1999-02-10 GR GR990400404T patent/GR3029318T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU663753B2 (en) | 1995-10-19 |
| HUT66002A (en) | 1994-08-29 |
| KR930703025A (ko) | 1993-11-29 |
| AU3246693A (en) | 1993-07-19 |
| US5428139A (en) | 1995-06-27 |
| CA2103555A1 (fr) | 1993-06-11 |
| EP0570574A1 (fr) | 1993-11-24 |
| EP0570574B1 (fr) | 1998-12-09 |
| FI933509A (fi) | 1993-08-31 |
| DK0570574T3 (da) | 1999-08-16 |
| MX9207167A (es) | 1993-07-01 |
| DE69227828D1 (de) | 1999-01-21 |
| DE69227828T2 (de) | 1999-04-29 |
| WO1993011801A1 (fr) | 1993-06-24 |
| ZA929577B (en) | 1994-06-10 |
| ES2124780T3 (es) | 1999-02-16 |
| HU9302310D0 (en) | 1993-12-28 |
| FI933509A0 (fi) | 1993-08-09 |
| IL104061A0 (en) | 1993-05-13 |
| GR3029318T3 (en) | 1999-05-28 |
| PH31049A (en) | 1998-02-03 |
| RU2118325C1 (ru) | 1998-08-27 |
| ATE174224T1 (de) | 1998-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| RH | Patent void |