IL103189A - Pharmaceuticals for the treatment of immuno-inflammatory diseases containing an amount of effective rapamycin against immune inflammation - Google Patents
Pharmaceuticals for the treatment of immuno-inflammatory diseases containing an amount of effective rapamycin against immune inflammationInfo
- Publication number
- IL103189A IL103189A IL10318992A IL10318992A IL103189A IL 103189 A IL103189 A IL 103189A IL 10318992 A IL10318992 A IL 10318992A IL 10318992 A IL10318992 A IL 10318992A IL 103189 A IL103189 A IL 103189A
- Authority
- IL
- Israel
- Prior art keywords
- rapamycin
- skin
- dermatitis
- immunoinflammatory
- antiimmunoinflammatory
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11764092A IL117640A (en) | 1991-09-17 | 1992-09-16 | Pharmaceutical compositions for treating immunoinflammatory diseases |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76112091A | 1991-09-17 | 1991-09-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL103189A0 IL103189A0 (en) | 1993-02-21 |
IL103189A true IL103189A (en) | 1996-08-04 |
Family
ID=25061205
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10318992A IL103189A (en) | 1991-09-17 | 1992-09-16 | Pharmaceuticals for the treatment of immuno-inflammatory diseases containing an amount of effective rapamycin against immune inflammation |
IL11764092A IL117640A (en) | 1991-09-17 | 1992-09-16 | Pharmaceutical compositions for treating immunoinflammatory diseases |
IL11764096A IL117640A0 (en) | 1991-09-17 | 1996-03-25 | Pharmaceutical compositions for treating immunoinflammatory diseases |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11764092A IL117640A (en) | 1991-09-17 | 1992-09-16 | Pharmaceutical compositions for treating immunoinflammatory diseases |
IL11764096A IL117640A0 (en) | 1991-09-17 | 1996-03-25 | Pharmaceutical compositions for treating immunoinflammatory diseases |
Country Status (23)
Country | Link |
---|---|
US (1) | US5286730A (ja) |
EP (1) | EP0533433B1 (ja) |
JP (1) | JP2810599B2 (ja) |
KR (1) | KR100299394B1 (ja) |
AT (1) | ATE151289T1 (ja) |
AU (1) | AU659868B2 (ja) |
CA (1) | CA2078379C (ja) |
CZ (1) | CZ281900B6 (ja) |
DE (1) | DE69218864T2 (ja) |
DK (1) | DK0533433T3 (ja) |
ES (1) | ES2100297T3 (ja) |
GR (1) | GR3023680T3 (ja) |
HK (1) | HK108697A (ja) |
HU (1) | HU211112B (ja) |
IL (3) | IL103189A (ja) |
MX (1) | MX9205202A (ja) |
NZ (2) | NZ244340A (ja) |
PH (1) | PH30270A (ja) |
SG (1) | SG43126A1 (ja) |
SK (1) | SK279521B6 (ja) |
TW (1) | TW212759B (ja) |
UA (1) | UA27742C2 (ja) |
ZA (1) | ZA927010B (ja) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5286731A (en) * | 1991-09-17 | 1994-02-15 | American Home Products Corporation | Method of treating immunoinflammatory bowel disease |
JP2741285B2 (ja) * | 1992-05-22 | 1998-04-15 | 千寿製薬株式会社 | 緑内障治療剤 |
US5434260A (en) * | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
US5489680A (en) * | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
US5480988A (en) * | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5480989A (en) * | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
DE4329503A1 (de) * | 1993-09-01 | 1995-03-02 | Galenik Labor Freiburg Gmbh | Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa |
US6204243B1 (en) | 1993-09-01 | 2001-03-20 | Novatis Ag | Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis |
WO1995014023A1 (en) * | 1993-11-19 | 1995-05-26 | Abbott Laboratories | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
US5389639A (en) * | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
US5525610A (en) * | 1994-03-31 | 1996-06-11 | American Home Products Corporation | 42-Epi-rapamycin and pharmaceutical compositions thereof |
US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5463048A (en) * | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
WO1996006847A1 (en) * | 1994-08-31 | 1996-03-07 | Pfizer Inc. | Process for preparing demethylrapamycins |
US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US5496832A (en) * | 1995-03-09 | 1996-03-05 | American Home Products Corporation | Method of treating cardiac inflammatory disease |
BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
WO1997031020A1 (en) * | 1996-02-22 | 1997-08-28 | The General Hospital Corporation | METHODS AND COMPOSITIONS FOR ENHANCING CELLULAR RESPONSE TO TGF-β LIGANDS |
CA2261666C (en) * | 1996-07-30 | 2010-09-14 | Novartis Ag | Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin |
WO1998018468A1 (en) * | 1996-10-31 | 1998-05-07 | American Home Products Corporation | Synergistic composition comprising rapamycin and calcitriol |
DE19844397A1 (de) * | 1998-09-28 | 2000-03-30 | Hilti Ag | Abrasive Schneidkörper enthaltend Diamantpartikel und Verfahren zur Herstellung der Schneidkörper |
US6670355B2 (en) * | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
ATE411321T1 (de) | 2000-09-19 | 2008-10-15 | Wyeth Corp | Wasserlösliche rapamycin-ester |
US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
KR20020050135A (ko) * | 2000-12-20 | 2002-06-26 | 조명재 | 피부 주름 예방 및 완화를 목적으로 하는 피부 외용 조성물 |
TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
TWI296196B (en) * | 2001-04-06 | 2008-05-01 | Wyeth Corp | Antineoplastic combinations |
US20020198137A1 (en) * | 2001-06-01 | 2002-12-26 | Wyeth | Antineoplastic combinations |
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
EP1419154B1 (en) | 2001-08-22 | 2005-10-05 | Wyeth | Rapamycin 29-enols |
MXPA04001523A (es) | 2001-08-22 | 2004-05-31 | Wyeth Corp | Dialdehidos de rapamicina. |
US6641611B2 (en) * | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
CN100522967C (zh) | 2002-02-01 | 2009-08-05 | 阿里亚德基因治疗公司 | 含磷化合物及其应用 |
KR101131794B1 (ko) | 2002-07-30 | 2012-03-30 | 와이어쓰 엘엘씨 | Cci-779 공용매 농축액, 비경구 cci-779 제형 및 비경구 cci-779 제형의 제조방법 |
EP1389480A1 (en) * | 2002-08-14 | 2004-02-18 | Mondobiotech Interferon SA | Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation |
MXPA05002828A (es) * | 2002-09-17 | 2005-05-27 | Wyeth Corp | Formulaciones orales. |
AR042938A1 (es) * | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
EP1615640B1 (en) * | 2003-04-22 | 2007-01-24 | Wyeth | Antineoplastic combinations |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
BRPI0416591A (pt) * | 2003-11-13 | 2007-01-30 | Combinatorx Inc | métodos e reagentes para o tratamento de distúrbios inflamatórios |
EP2583678A3 (en) | 2004-06-24 | 2013-11-13 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
US7135455B2 (en) * | 2004-11-15 | 2006-11-14 | Allergan, Inc | Methods for the therapeutic use of cyclosporine components |
US7151085B2 (en) * | 2004-11-15 | 2006-12-19 | Allergan, Inc. | Therapeutic methods using cyclosporine components |
WO2007059106A2 (en) | 2005-11-14 | 2007-05-24 | Ariad Gene Therapeutics, Inc. | Administration of mntor inhibitor to treat patients with cancer |
WO2008022256A2 (en) * | 2006-08-16 | 2008-02-21 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
CN101557814B (zh) | 2006-09-13 | 2015-05-20 | 万能医药公司 | 大环内酯化合物及它们的使用方法 |
JP2010509240A (ja) * | 2006-11-07 | 2010-03-25 | アルコン リサーチ, リミテッド | 喘息、アレルギー性鼻炎および皮膚障害の治療方法 |
WO2008063563A2 (en) * | 2006-11-16 | 2008-05-29 | Transderm, Inc. | Methods of treating keratin hyperproliferation disorders using mtor inhibitors |
JP2012504654A (ja) * | 2008-10-03 | 2012-02-23 | エリクシアー メディカル コーポレイション | 多環状ラクトン化合物およびその使用方法 |
CN102612564B (zh) | 2009-04-10 | 2015-08-26 | 齐海燕 | 新的抗衰老试剂及其鉴别方法 |
CA2899206C (en) | 2013-01-24 | 2019-07-09 | Transderm, Inc. | Compositions for transdermal delivery of mtor inhibitors |
US10293010B2 (en) * | 2013-10-14 | 2019-05-21 | Izun Pharmaceuticals Corporation | Methods for treatment of m-TOR inhibitor-associated stomatitis |
HUP1400075A2 (hu) | 2014-02-14 | 2015-08-28 | Druggability Technologies Ip Holdco Jersey Ltd | Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói |
US20160184279A1 (en) * | 2014-12-10 | 2016-06-30 | Transderm, Inc. | METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY |
KR20180081501A (ko) | 2015-09-24 | 2018-07-16 | 드렉셀유니버시티 | 진피 장애를 치료하거나 예방하는 신규한 조성물 및 방법 |
CA3049402A1 (en) | 2017-01-06 | 2018-07-12 | Palvella Therapeutics Llc | Anhydrous compositions of mtor inhibitors and methods of use |
US10456383B2 (en) * | 2017-06-01 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted approach in the management of Epidermolysis bullosa |
WO2020010073A1 (en) | 2018-07-02 | 2020-01-09 | Palvella Therapeutics, Inc. | ANHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE |
JP2022511270A (ja) * | 2018-08-30 | 2022-01-31 | ケミストリーアールエックス. | シロリムス含有組成物 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4023264A (en) * | 1976-06-21 | 1977-05-17 | Littelfuse, Inc. | Method of making miniature plug-in fuses of different fuse ratings |
DK175235B1 (da) * | 1987-11-09 | 2004-07-19 | Novartis Ag | Ny anvendelse af azatricycloderivater og farmaceutiske præparater med indhold deraf |
US4996193A (en) * | 1989-03-03 | 1991-02-26 | The Regents Of The University Of California | Combined topical and systemic method of administration of cyclosporine |
US5023263A (en) * | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
KR100215167B1 (ko) * | 1990-08-10 | 1999-08-16 | 위샤르트 아이 시 | 면역 억제 조성물 |
US5023262A (en) * | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
US5078999A (en) * | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5080899A (en) * | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
-
1992
- 1992-08-17 US US07/931,242 patent/US5286730A/en not_active Expired - Lifetime
- 1992-09-09 SK SK2785-92A patent/SK279521B6/sk unknown
- 1992-09-09 CZ CS922785A patent/CZ281900B6/cs not_active IP Right Cessation
- 1992-09-11 MX MX9205202A patent/MX9205202A/es not_active IP Right Cessation
- 1992-09-14 JP JP4244549A patent/JP2810599B2/ja not_active Expired - Fee Related
- 1992-09-14 ZA ZA927010A patent/ZA927010B/xx unknown
- 1992-09-15 DE DE69218864T patent/DE69218864T2/de not_active Expired - Fee Related
- 1992-09-15 NZ NZ244340A patent/NZ244340A/xx unknown
- 1992-09-15 AT AT92308384T patent/ATE151289T1/de not_active IP Right Cessation
- 1992-09-15 SG SG1996004061A patent/SG43126A1/en unknown
- 1992-09-15 DK DK92308384.4T patent/DK0533433T3/da active
- 1992-09-15 NZ NZ328124A patent/NZ328124A/xx unknown
- 1992-09-15 ES ES92308384T patent/ES2100297T3/es not_active Expired - Lifetime
- 1992-09-15 EP EP92308384A patent/EP0533433B1/en not_active Expired - Lifetime
- 1992-09-16 PH PH44946A patent/PH30270A/en unknown
- 1992-09-16 AU AU24507/92A patent/AU659868B2/en not_active Ceased
- 1992-09-16 CA CA002078379A patent/CA2078379C/en not_active Expired - Fee Related
- 1992-09-16 IL IL10318992A patent/IL103189A/en not_active IP Right Cessation
- 1992-09-16 HU HU9202955A patent/HU211112B/hu not_active IP Right Cessation
- 1992-09-16 KR KR1019920016795A patent/KR100299394B1/ko not_active IP Right Cessation
- 1992-09-16 IL IL11764092A patent/IL117640A/xx not_active IP Right Cessation
- 1992-10-02 TW TW081107842A patent/TW212759B/zh active
-
1993
- 1993-06-15 UA UA93002912A patent/UA27742C2/uk unknown
-
1996
- 1996-03-25 IL IL11764096A patent/IL117640A0/xx unknown
-
1997
- 1997-06-04 GR GR970401324T patent/GR3023680T3/el unknown
- 1997-06-26 HK HK108697A patent/HK108697A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE151289T1 (de) | 1997-04-15 |
TW212759B (ja) | 1993-09-11 |
CA2078379A1 (en) | 1993-03-18 |
IL103189A0 (en) | 1993-02-21 |
DE69218864D1 (de) | 1997-05-15 |
HU9202955D0 (en) | 1992-12-28 |
US5286730A (en) | 1994-02-15 |
DE69218864T2 (de) | 1997-07-17 |
HK108697A (en) | 1997-08-22 |
SK279521B6 (sk) | 1998-12-02 |
HUT64846A (en) | 1994-03-28 |
ZA927010B (en) | 1994-03-14 |
DK0533433T3 (da) | 1997-05-12 |
AU659868B2 (en) | 1995-06-01 |
PH30270A (en) | 1997-02-20 |
CZ281900B6 (cs) | 1997-03-12 |
EP0533433B1 (en) | 1997-04-09 |
AU2450792A (en) | 1993-03-18 |
JP2810599B2 (ja) | 1998-10-15 |
JPH05194529A (ja) | 1993-08-03 |
IL117640A (en) | 1999-08-17 |
SK278592A3 (en) | 1995-03-08 |
CA2078379C (en) | 2003-07-29 |
ES2100297T3 (es) | 1997-06-16 |
NZ244340A (en) | 1999-06-29 |
KR100299394B1 (ko) | 2001-10-22 |
SG43126A1 (en) | 1997-10-17 |
MX9205202A (es) | 1993-03-01 |
UA27742C2 (uk) | 2000-10-16 |
GR3023680T3 (en) | 1997-09-30 |
CZ278592A3 (en) | 1993-04-14 |
HU211112B (en) | 1995-10-30 |
EP0533433A1 (en) | 1993-03-24 |
NZ328124A (en) | 2000-01-28 |
IL117640A0 (en) | 1996-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed | ||
HCA | Change of name of proprietor(s) after amalgamation | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |