DK0533433T3 - Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af immunoinflammatoriske sygdomme - Google Patents

Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af immunoinflammatoriske sygdomme

Info

Publication number
DK0533433T3
DK0533433T3 DK92308384.4T DK92308384T DK0533433T3 DK 0533433 T3 DK0533433 T3 DK 0533433T3 DK 92308384 T DK92308384 T DK 92308384T DK 0533433 T3 DK0533433 T3 DK 0533433T3
Authority
DK
Denmark
Prior art keywords
medicament
rapamycin
manufacture
treatment
immunoinflammatory diseases
Prior art date
Application number
DK92308384.4T
Other languages
English (en)
Inventor
Craig Eugene Caufield
John Henry Musser
Surendra Nath Sehgal
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of DK0533433T3 publication Critical patent/DK0533433T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DK92308384.4T 1991-09-17 1992-09-15 Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af immunoinflammatoriske sygdomme DK0533433T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76112091A 1991-09-17 1991-09-17

Publications (1)

Publication Number Publication Date
DK0533433T3 true DK0533433T3 (da) 1997-05-12

Family

ID=25061205

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92308384.4T DK0533433T3 (da) 1991-09-17 1992-09-15 Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af immunoinflammatoriske sygdomme

Country Status (23)

Country Link
US (1) US5286730A (da)
EP (1) EP0533433B1 (da)
JP (1) JP2810599B2 (da)
KR (1) KR100299394B1 (da)
AT (1) ATE151289T1 (da)
AU (1) AU659868B2 (da)
CA (1) CA2078379C (da)
CZ (1) CZ281900B6 (da)
DE (1) DE69218864T2 (da)
DK (1) DK0533433T3 (da)
ES (1) ES2100297T3 (da)
GR (1) GR3023680T3 (da)
HK (1) HK108697A (da)
HU (1) HU211112B (da)
IL (3) IL103189A (da)
MX (1) MX9205202A (da)
NZ (2) NZ328124A (da)
PH (1) PH30270A (da)
SG (1) SG43126A1 (da)
SK (1) SK279521B6 (da)
TW (1) TW212759B (da)
UA (1) UA27742C2 (da)
ZA (1) ZA927010B (da)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5286731A (en) * 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory bowel disease
JP2741285B2 (ja) * 1992-05-22 1998-04-15 千寿製薬株式会社 緑内障治療剤
US5489680A (en) * 1992-10-13 1996-02-06 American Home Products Corporation Carbamates of rapamycin
US5434260A (en) * 1992-10-13 1995-07-18 American Home Products Corporation Carbamates of rapamycin
US5480989A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5480988A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
DE4329503A1 (de) * 1993-09-01 1995-03-02 Galenik Labor Freiburg Gmbh Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
US5389639A (en) * 1993-12-29 1995-02-14 American Home Products Company Amino alkanoic esters of rapamycin
US5525610A (en) * 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5463048A (en) * 1994-06-14 1995-10-31 American Home Products Corporation Rapamycin amidino carbamates
US5849730A (en) * 1994-08-31 1998-12-15 Pfizer Inc. Process for preparing demethylrapamycins
US5561138A (en) * 1994-12-13 1996-10-01 American Home Products Corporation Method of treating anemia
US5496832A (en) * 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
US5912224A (en) * 1996-02-22 1999-06-15 The General Hospital Corporation Methods and compositions for enhancing cellular response to TGF-β ligands
EP1208847B8 (en) * 1996-07-30 2007-02-14 Novartis AG Pharmaceutical compositions for the treatment of transplant rejection, as well as autoimmune or inflammatory conditions
AU4919597A (en) * 1996-10-31 1998-05-22 American Home Products Corporation Synergistic composition comprising rapamycin and calcitriol
DE19844397A1 (de) * 1998-09-28 2000-03-30 Hilti Ag Abrasive Schneidkörper enthaltend Diamantpartikel und Verfahren zur Herstellung der Schneidkörper
US6670355B2 (en) 2000-06-16 2003-12-30 Wyeth Method of treating cardiovascular disease
EP1319008B1 (en) 2000-09-19 2008-10-15 Wyeth Water soluble rapamycin esters
US6399625B1 (en) 2000-09-27 2002-06-04 Wyeth 1-oxorapamycins
US6440991B1 (en) 2000-10-02 2002-08-27 Wyeth Ethers of 7-desmethlrapamycin
US6399626B1 (en) 2000-10-02 2002-06-04 Wyeth Hydroxyesters of 7-desmethylrapamycin
US20040018228A1 (en) * 2000-11-06 2004-01-29 Afmedica, Inc. Compositions and methods for reducing scar tissue formation
TWI286074B (en) 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
KR20020050135A (ko) * 2000-12-20 2002-06-26 조명재 피부 주름 예방 및 완화를 목적으로 하는 피부 외용 조성물
TWI233359B (en) * 2001-04-06 2005-06-01 Wyeth Corp Pharmaceutical composition for treating neoplasm
TWI296196B (en) * 2001-04-06 2008-05-01 Wyeth Corp Antineoplastic combinations
US20020198137A1 (en) * 2001-06-01 2002-12-26 Wyeth Antineoplastic combinations
UA77200C2 (en) 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
EP1419154B1 (en) 2001-08-22 2005-10-05 Wyeth Rapamycin 29-enols
EP1419153A1 (en) 2001-08-22 2004-05-19 Wyeth Rapamycin dialdehydes
US6641611B2 (en) * 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
KR100956195B1 (ko) 2002-02-01 2010-05-06 어리어드 파마슈티칼스, 인코포레이티드 인 함유 화합물 및 이의 용도
BR0313024A (pt) 2002-07-30 2005-07-12 Wyeth Corp Formulações parenterais contendo um hidroxiéster de rapamicina
EP1389480A1 (en) * 2002-08-14 2004-02-18 Mondobiotech Interferon SA Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation
RU2326654C2 (ru) * 2002-09-17 2008-06-20 Уайт Пероральные композиции
AR042938A1 (es) * 2003-02-06 2005-07-06 Wyeth Corp Uso del cci-779 en el tratamiento de la fibrosis hepatica
UA83484C2 (uk) * 2003-03-05 2008-07-25 Уайт Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
AU2004231720A1 (en) * 2003-04-22 2004-11-04 Wyeth Antineoplastic combinations
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
EP1691744A4 (en) * 2003-11-13 2007-12-26 Combinatorx Inc METHOD AND REAGENTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
EP1962839A4 (en) 2005-11-14 2010-08-25 Ariad Pharma Inc ADMINISTRATION OF A MNTOR INHIBITOR FOR THE TREATMENT OF PATIENTS WITH CANCER
US20100081681A1 (en) * 2006-08-16 2010-04-01 Blagosklonny Mikhail V Methods and compositions for preventing or treating age-related diseases
WO2008033956A2 (en) 2006-09-13 2008-03-20 Elixir Medical Corporation Macrocyclic lactone compounds and methods for their use
CA2668645A1 (en) * 2006-11-07 2008-05-15 Alcon Research, Ltd. Method of treating asthma, allergic rhinitis, and skin disorders
WO2008063563A2 (en) * 2006-11-16 2008-05-29 Transderm, Inc. Methods of treating keratin hyperproliferation disorders using mtor inhibitors
BRPI0919794A2 (pt) * 2008-10-03 2015-12-15 Elixir Medical Corp dispositivo para uso intracorpóreo, e, composto
AU2010233073B2 (en) * 2009-04-10 2014-07-31 Haiyan Qi Novel anti-aging agents and methods to identify them
DK2948134T3 (da) 2013-01-24 2020-06-02 Palvella Therapeutics Inc Sammensætninger til transdermal indgivelse af mtor-inhibitorer
WO2015056160A1 (en) * 2013-10-14 2015-04-23 Izun Pharmaceuticals Ltd. Methods for treatment of m-tor inhibitor-associated stomatitis
HUP1400075A2 (hu) 2014-02-14 2015-08-28 Druggability Technologies Ip Holdco Jersey Ltd Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói
WO2016094732A1 (en) * 2014-12-10 2016-06-16 Transderm, Inc. METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY
CA3037469C (en) 2015-09-24 2024-04-16 Drexel University Treatment of dermal disorders comprising a mtorc1 inhibitor
JP7108631B2 (ja) 2017-01-06 2022-07-28 パルヴェラ セラピューティクス、インク. mTOR阻害剤の無水組成物およびその使用方法
US10456383B2 (en) * 2017-06-01 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Targeted approach in the management of Epidermolysis bullosa
JP2021530463A (ja) 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク. mTOR阻害剤の無水組成物および使用方法
KR20210087929A (ko) * 2018-08-30 2021-07-13 케미스트리알엑스. 시롤리무스 함유 조성물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4023264A (en) * 1976-06-21 1977-05-17 Littelfuse, Inc. Method of making miniature plug-in fuses of different fuse ratings
PH26083A (en) * 1987-11-09 1992-02-06 Sandoz Ltd 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin
KR100215167B1 (ko) * 1990-08-10 1999-08-16 위샤르트 아이 시 면역 억제 조성물
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
US5078999A (en) * 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5080899A (en) * 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation

Also Published As

Publication number Publication date
HU9202955D0 (en) 1992-12-28
SG43126A1 (en) 1997-10-17
IL117640A (en) 1999-08-17
HUT64846A (en) 1994-03-28
JPH05194529A (ja) 1993-08-03
IL117640A0 (en) 1996-07-23
EP0533433B1 (en) 1997-04-09
US5286730A (en) 1994-02-15
GR3023680T3 (en) 1997-09-30
HU211112B (en) 1995-10-30
SK279521B6 (sk) 1998-12-02
ATE151289T1 (de) 1997-04-15
JP2810599B2 (ja) 1998-10-15
CZ281900B6 (cs) 1997-03-12
ZA927010B (en) 1994-03-14
HK108697A (en) 1997-08-22
AU2450792A (en) 1993-03-18
UA27742C2 (uk) 2000-10-16
AU659868B2 (en) 1995-06-01
SK278592A3 (en) 1995-03-08
DE69218864D1 (de) 1997-05-15
MX9205202A (es) 1993-03-01
IL103189A (en) 1996-08-04
TW212759B (da) 1993-09-11
IL103189A0 (en) 1993-02-21
DE69218864T2 (de) 1997-07-17
CZ278592A3 (en) 1993-04-14
NZ328124A (en) 2000-01-28
NZ244340A (en) 1999-06-29
CA2078379A1 (en) 1993-03-18
ES2100297T3 (es) 1997-06-16
CA2078379C (en) 2003-07-29
EP0533433A1 (en) 1993-03-24
KR100299394B1 (ko) 2001-10-22
PH30270A (en) 1997-02-20

Similar Documents

Publication Publication Date Title
DK0533433T3 (da) Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af immunoinflammatoriske sygdomme
ES2177780T3 (es) Medicamentos para el tratamiento de enfermedades autoinmunes usando interferon tau.
NO20101190L (no) Anvendelse av buprenorfin i fremstillingen av et medikament
DK0668763T3 (da) Anvendelse af phenserin til fremstillingen af lægemidler til behandlingen af kognitive sygdomme
CY1107465T1 (el) Μελαγατρανη για τη θepαπευτικη αντιμετωπιση φλεγμονων
ES2159279T3 (es) Secuencias de dna relacionadas con el sindrome del cromosoma x fragil aislado.
DE69424777D1 (de) 3,4-diarylchromane zur behandlung von dermatitis
LV11728A (lv) Farmaceitiska kompozicija
LV11940A (lv) Melatonina pielietojums personu arstesanai kuras cies no zalu atkaribas
NO990450L (no) Behandling av sinnslidelser
DK0866699T3 (da) Anvendelse af cholinesteraseinhibitorer til fremstilling af et medikament til behandling af xerostomi
NO990949D0 (no) Anvendelse av PKC-inhibitorer til fremstilling av et medikament for behandling av AIDS
ATE233570T1 (de) Verwendung des leukämie-inhibitor-faktor und endothelin antagonisten
CA2142862A1 (en) Method for Inhibiting HIV Replication Using IL-4
AR015537A1 (es) Uso de brinzolamida para la manufactura de un medicamento para tratar o prevenir edema de retina.
ES2183977T3 (es) Combinacion de temozolomida y alfa-interferon para el tratamiento de cancer avanzado.
HUP0004647A2 (hu) Glükóz-amino-glükánok alkalmazása diabétesszel társult szembetegségek kezelésére szolgáló gyógyszerkészítmények előállítására
IL128494A0 (en) Use of inhibitors of pkc for the manufacture of a medicament for the treatment of central nervous system diseases associated with hiv infection
AU4250697A (en) Use of inhibitors of pkc for the manufacture of a medicament for the treatment of central nervous system diseases associated with hiv infection
CY1108922T1 (el) Θεραπεια μελανωματος
MX9800365A (es) Tratamiento de leucemia aguda con interleucina-10.
ZA897549B (en) Medicament for the treatment of diseases caused by retroviruses
ECSP003413A (es) Terapia para la leucemia mielocitica cronica