IL103078A - Quinoclidine derivatives, their preparations and pharmaceutical preparations containing them, and certain intermediates for them - Google Patents

Quinoclidine derivatives, their preparations and pharmaceutical preparations containing them, and certain intermediates for them

Info

Publication number
IL103078A
IL103078A IL10307892A IL10307892A IL103078A IL 103078 A IL103078 A IL 103078A IL 10307892 A IL10307892 A IL 10307892A IL 10307892 A IL10307892 A IL 10307892A IL 103078 A IL103078 A IL 103078A
Authority
IL
Israel
Prior art keywords
formula
compound
group
independently
alkyl
Prior art date
Application number
IL10307892A
Other languages
English (en)
Hebrew (he)
Other versions
IL103078A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL103078A0 publication Critical patent/IL103078A0/xx
Publication of IL103078A publication Critical patent/IL103078A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
IL10307892A 1991-09-14 1992-09-07 Quinoclidine derivatives, their preparations and pharmaceutical preparations containing them, and certain intermediates for them IL103078A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919119705A GB9119705D0 (en) 1991-09-14 1991-09-14 Therapeutic compounds

Publications (2)

Publication Number Publication Date
IL103078A0 IL103078A0 (en) 1993-02-21
IL103078A true IL103078A (en) 1996-07-23

Family

ID=10701448

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10307892A IL103078A (en) 1991-09-14 1992-09-07 Quinoclidine derivatives, their preparations and pharmaceutical preparations containing them, and certain intermediates for them

Country Status (31)

Country Link
US (1) US5543419A (fr)
EP (1) EP0603229B1 (fr)
JP (2) JP2672030B2 (fr)
KR (1) KR0135784B1 (fr)
CN (1) CN1037269C (fr)
AT (1) ATE167187T1 (fr)
AU (1) AU659487B2 (fr)
BR (1) BR9206499A (fr)
CA (1) CA2116356C (fr)
CZ (1) CZ281752B6 (fr)
DE (1) DE69225897T2 (fr)
DK (1) DK0603229T3 (fr)
EG (1) EG20072A (fr)
ES (1) ES2116343T3 (fr)
FI (1) FI114707B (fr)
GB (1) GB9119705D0 (fr)
GR (1) GR3027667T3 (fr)
HU (1) HU220594B1 (fr)
IL (1) IL103078A (fr)
MX (1) MX9205221A (fr)
MY (1) MY108602A (fr)
NO (1) NO305397B1 (fr)
NZ (1) NZ244324A (fr)
PL (1) PL170627B1 (fr)
PT (1) PT100863B (fr)
RU (1) RU2117669C1 (fr)
SG (1) SG50414A1 (fr)
TW (1) TW251285B (fr)
UA (1) UA42686C2 (fr)
WO (1) WO1993006098A1 (fr)
ZA (1) ZA926939B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2147889T3 (es) * 1996-01-19 2000-10-01 Lonza Ag Metodo para preparar 3-hidroxiquinuclidinol opticamente activo.
CZ54498A3 (cs) * 1997-03-07 1998-11-11 Lonza Ag Katalyzátorová směs na bázi amorfního částečně dehydratovaného hydroxidu zirkoničitého a způsob její výroby a použití
AU758370B2 (en) * 1997-08-08 2003-03-20 Duke University Compositions, apparatus and methods for facilitating surgical procedures
US6711436B1 (en) 1997-08-08 2004-03-23 Duke University Compositions, apparatus and methods for facilitating surgical procedures
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
PE20020719A1 (es) 2000-12-22 2002-10-11 Almirall Prodesfarma Ag Derivados de carbamato de quinuclidina como agentes antimuscarinicos m3
AU2002238471B2 (en) 2000-12-28 2007-06-28 Almirall, S.A. Quinuclidine derivatives and their use as M3 antagonists
DE102004057995A1 (de) * 2004-12-01 2006-06-08 Wacker Chemie Ag Verfahren zur Herstellung von α,α-Dialkyl-α-Hydroxymethyl-Carbonsäurederivaten
US20100112061A1 (en) * 2006-12-13 2010-05-06 William Baker Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis
EP2100598A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
EP2100599A1 (fr) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Composition à inhaler comprenant aclidinium pour le traitement de l'asthme et de maladies respiratoires obstructives chroniques
EP2510928A1 (fr) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium pour l'amélioration du sommeil des patients avec des maldadies respiratoires

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
GB8923590D0 (en) * 1989-10-19 1989-12-06 Pfizer Ltd Antimuscarinic bronchodilators

Also Published As

Publication number Publication date
IL103078A0 (en) 1993-02-21
ZA926939B (en) 1994-03-11
AU2482392A (en) 1993-04-27
CA2116356A1 (fr) 1993-04-01
NO305397B1 (no) 1999-05-25
SG50414A1 (en) 1998-07-20
US5543419A (en) 1996-08-06
RU2117669C1 (ru) 1998-08-20
JPH06510991A (ja) 1994-12-08
PL170627B1 (en) 1997-01-31
CZ281752B6 (cs) 1997-01-15
JP2955533B2 (ja) 1999-10-04
JP2672030B2 (ja) 1997-11-05
WO1993006098A1 (fr) 1993-04-01
CZ395392A3 (en) 1994-07-13
JPH09315970A (ja) 1997-12-09
MY108602A (en) 1996-10-31
KR0135784B1 (ko) 1998-04-23
FI114707B (fi) 2004-12-15
DE69225897D1 (de) 1998-07-16
ES2116343T3 (es) 1998-07-16
BR9206499A (pt) 1995-11-21
CN1070911A (zh) 1993-04-14
GR3027667T3 (en) 1998-11-30
MX9205221A (es) 1993-03-01
DE69225897T2 (de) 1998-10-15
HU220594B1 (hu) 2002-03-28
TW251285B (fr) 1995-07-11
EP0603229A1 (fr) 1994-06-29
AU659487B2 (en) 1995-05-18
DK0603229T3 (da) 1998-10-12
EP0603229B1 (fr) 1998-06-10
FI941170A (fi) 1994-03-11
CN1037269C (zh) 1998-02-04
PT100863B (pt) 1999-07-30
ATE167187T1 (de) 1998-06-15
FI941170A0 (fi) 1994-03-11
NO940905L (no) 1994-03-14
UA42686C2 (uk) 2001-11-15
CA2116356C (fr) 1998-03-31
PT100863A (pt) 1993-10-29
HU9400729D0 (en) 1994-06-28
HUT66772A (en) 1994-12-28
NZ244324A (en) 1993-12-23
GB9119705D0 (en) 1991-10-30
NO940905D0 (no) 1994-03-14
EG20072A (en) 1999-06-30

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees