IL103020A - תולדות חומצה 3 )1,'1 ביפניל 4 איל מתיל( 4,5,6,7 טטראהידרו h3 אימידאזו]c 4,5[ פירידין 4 קרסבוקסילית, הכנתן ותכשירי רוקחות המכילים אותן - Google Patents

תולדות חומצה 3 )1,'1 ביפניל 4 איל מתיל( 4,5,6,7 טטראהידרו h3 אימידאזו]c 4,5[ פירידין 4 קרסבוקסילית, הכנתן ותכשירי רוקחות המכילים אותן

Info

Publication number
IL103020A
IL103020A IL10302092A IL10302092A IL103020A IL 103020 A IL103020 A IL 103020A IL 10302092 A IL10302092 A IL 10302092A IL 10302092 A IL10302092 A IL 10302092A IL 103020 A IL103020 A IL 103020A
Authority
IL
Israel
Prior art keywords
group
substituted
mixture
compound
formula
Prior art date
Application number
IL10302092A
Other languages
English (en)
Other versions
IL103020A0 (en
Original Assignee
Tanabe Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co
Publication of IL103020A0 publication Critical patent/IL103020A0/xx
Publication of IL103020A publication Critical patent/IL103020A/he

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL10302092A 1991-09-10 1992-09-02 תולדות חומצה 3 )1,'1 ביפניל 4 איל מתיל( 4,5,6,7 טטראהידרו h3 אימידאזו]c 4,5[ פירידין 4 קרסבוקסילית, הכנתן ותכשירי רוקחות המכילים אותן IL103020A (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP30856191 1991-09-10
JP5304392 1992-01-27

Publications (2)

Publication Number Publication Date
IL103020A0 IL103020A0 (en) 1993-02-21
IL103020A true IL103020A (he) 1998-10-30

Family

ID=26393752

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10302092A IL103020A (he) 1991-09-10 1992-09-02 תולדות חומצה 3 )1,'1 ביפניל 4 איל מתיל( 4,5,6,7 טטראהידרו h3 אימידאזו]c 4,5[ פירידין 4 קרסבוקסילית, הכנתן ותכשירי רוקחות המכילים אותן

Country Status (10)

Country Link
US (3) US5409936A (he)
EP (1) EP0531874A1 (he)
KR (1) KR0159538B1 (he)
CN (1) CN1039323C (he)
AU (1) AU644540B2 (he)
CA (1) CA2077419C (he)
FI (1) FI98368C (he)
IL (1) IL103020A (he)
SG (1) SG42942A1 (he)
TW (1) TW210340B (he)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9101768A (nl) * 1991-10-23 1993-05-17 Meyn Maschf Inrichting voor het verwijderen van de ingewanden uit de buikholte van gevogelte.
DE4141788A1 (de) * 1991-12-18 1993-06-24 Merck Patent Gmbh Imidazopyridine
DE4305602A1 (de) * 1992-06-17 1993-12-23 Merck Patent Gmbh Imidazopyridine
PT668272E (pt) * 1994-01-28 2000-10-31 Takeda Chemical Industries Ltd Processo para a producao de compostos de tetrazolilo
US5753672A (en) * 1994-04-19 1998-05-19 Tanabe Seiyaku Co., Ltd. Imidazopyridine derivatives and process for preparing the same
AU679616B2 (en) * 1994-04-19 1997-07-03 Tanabe Seiyaku Co., Ltd. Imidazopyridine derivatives and process for preparing the same
US6156510A (en) * 1997-12-02 2000-12-05 Gemini International Holdings Limited Polymorphisms in a microsatellite region of a glucocorticoid receptor gene
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
PT3004138T (pt) 2013-06-05 2024-06-18 Bausch Health Ireland Ltd Agonistas ultrapuros de guanilato ciclase c, método de produção e utilização dos mesmos
GB201321749D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
EP3478672B1 (en) 2016-06-29 2024-04-10 Université de Montréal Biarylmethyl heterocycles

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816463A (en) * 1986-04-01 1989-03-28 Warner-Lambert Company Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
EP0400835A1 (en) * 1989-05-15 1990-12-05 Merck & Co. Inc. Substituted benzimidazoles as angiotensin II antagonists
IE64514B1 (en) * 1989-05-23 1995-08-09 Zeneca Ltd Azaindenes
IL94390A (he) * 1989-05-30 1996-03-31 Merck & Co Inc הטרוציקלים בעלי 6 אברים מכילי-חנקן דו-מותמרים דחוסים עם אימידאזו ותכשירי רוקחות המכילים אותם
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
EP0434038A1 (en) * 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Fused imidazole derivatives, their production and use
JPH05504969A (ja) * 1990-02-13 1993-07-29 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル要素を含有するアンギオテンシン２アンタゴニスト類
EP0461040A1 (fr) * 1990-06-08 1991-12-11 Roussel Uclaf Dérivés de l'imidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
ATE171177T1 (de) * 1990-06-08 1998-10-15 Hoechst Marion Roussel Inc Benzimidazol-derivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende pharmazeutische zusammensetzungen
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
US5091390A (en) * 1990-09-20 1992-02-25 E. I. Du Pont De Nemours And Company Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs

Also Published As

Publication number Publication date
FI924044A0 (fi) 1992-09-10
IL103020A0 (en) 1993-02-21
TW210340B (he) 1993-08-01
FI98368C (fi) 1997-06-10
KR0159538B1 (ko) 1998-12-01
US5424316A (en) 1995-06-13
CA2077419C (en) 1998-08-25
US5409936A (en) 1995-04-25
US5510354A (en) 1996-04-23
SG42942A1 (en) 1997-10-17
CN1039323C (zh) 1998-07-29
EP0531874A1 (en) 1993-03-17
CA2077419A1 (en) 1993-03-11
AU644540B2 (en) 1993-12-09
KR930006018A (ko) 1993-04-20
FI98368B (fi) 1997-02-28
FI924044A (fi) 1993-03-11
CN1070912A (zh) 1993-04-14
AU2205792A (en) 1993-03-11

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