IL102490A0 - Production of antibodies - Google Patents

Production of antibodies

Info

Publication number
IL102490A0
IL102490A0 IL102490A IL10249092A IL102490A0 IL 102490 A0 IL102490 A0 IL 102490A0 IL 102490 A IL102490 A IL 102490A IL 10249092 A IL10249092 A IL 10249092A IL 102490 A0 IL102490 A0 IL 102490A0
Authority
IL
Israel
Prior art keywords
antibodies
production
same
recombinant
prophylaxis
Prior art date
Application number
IL102490A
Other languages
English (en)
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27265765&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL102490(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919115284A external-priority patent/GB9115284D0/en
Priority claimed from GB919116594A external-priority patent/GB9116594D0/en
Priority claimed from GB929206284A external-priority patent/GB9206284D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of IL102490A0 publication Critical patent/IL102490A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1009—Picornaviridae, e.g. hepatitis A virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL102490A 1991-07-15 1992-07-14 Production of antibodies IL102490A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919115284A GB9115284D0 (en) 1991-07-15 1991-07-15 Production of antibodies
GB919116594A GB9116594D0 (en) 1991-08-01 1991-08-01 Production of antibodies
GB929206284A GB9206284D0 (en) 1992-03-23 1992-03-23 Production of antibodies

Publications (1)

Publication Number Publication Date
IL102490A0 true IL102490A0 (en) 1993-01-14

Family

ID=27265765

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102490A IL102490A0 (en) 1991-07-15 1992-07-14 Production of antibodies

Country Status (16)

Country Link
US (1) US5876961A (ko)
EP (1) EP0523949B1 (ko)
JP (1) JP3502093B2 (ko)
KR (1) KR100255717B1 (ko)
AT (1) ATE243747T1 (ko)
AU (1) AU662752B2 (ko)
CA (1) CA2111858A1 (ko)
DE (1) DE69233104T2 (ko)
ES (1) ES2199216T3 (ko)
FI (1) FI940144A (ko)
HU (1) HU220355B (ko)
IE (1) IE922287A1 (ko)
IL (1) IL102490A0 (ko)
NZ (1) NZ243558A (ko)
TW (1) TW373023B (ko)
WO (1) WO1993002190A1 (ko)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022543D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Antibody production
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
IE922437A1 (en) * 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
US5756096A (en) * 1991-07-25 1998-05-26 Idec Pharmaceuticals Corporation Recombinant antibodies for human therapy
AU673499B2 (en) * 1991-07-25 1996-11-14 Biogen Idec Inc. Recombinant antibodies for human therapy
US6136310A (en) 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
US20020122807A1 (en) * 1998-07-07 2002-09-05 Dan Michael D. Antigen binding fragments, designated 4B5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
EP1259615B1 (en) 2000-03-03 2008-11-12 Cambridge Antibody Technology Limited Antibodies against eotaxin and their use
US6946546B2 (en) 2000-03-06 2005-09-20 Cambridge Antibody Technology Limited Human antibodies against eotaxin
US20040253242A1 (en) * 2000-12-05 2004-12-16 Bowdish Katherine S. Rationally designed antibodies
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
DK1642910T3 (da) 2000-12-05 2012-05-07 Alexion Pharma Inc Rationelt designede atistoffer
US20160279239A1 (en) 2011-05-02 2016-09-29 Immunomedics, Inc. Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease
SI1523496T1 (sl) 2002-07-18 2011-11-30 Merus B V Rekombinantno proizvajanje zmesi protiteles
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
AU2004242614B2 (en) 2003-05-30 2011-09-22 Merus N.V. Fab library for the preparation of anti vegf and anti rabies virus fabs
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
EP1737971B1 (en) 2004-01-20 2017-08-16 Merus N.V. Mixtures of binding proteins
WO2006014498A2 (en) * 2004-07-06 2006-02-09 Bioren, Inc. Universal antibody libraries
US20160355591A1 (en) 2011-05-02 2016-12-08 Immunomedics, Inc. Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
ITRM20050297A1 (it) * 2005-06-08 2006-12-09 Univ Siena Anticorpi diretti contro la proteina basica della mielina che riconoscono un epitopo del cd64 e uso di essi come immunodepressivi.
SG10201510384UA (en) 2006-09-13 2016-01-28 Abbvie Inc Cell culture improvements
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
WO2008094316A2 (en) 2006-09-22 2008-08-07 Stowers Institute Of Medical Research Novel branchiostoma derived fluorescent proteins
EP2098536A1 (en) 2008-03-05 2009-09-09 4-Antibody AG Isolation and identification of antigen- or ligand-specific binding proteins
EP4176888A1 (en) 2008-11-14 2023-05-10 ViaCyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US9079942B2 (en) 2009-02-09 2015-07-14 Epitomics, Inc. CDR-anchored amplification method
US20100317539A1 (en) * 2009-06-12 2010-12-16 Guo-Liang Yu Library of Engineered-Antibody Producing Cells
US8293483B2 (en) 2009-09-11 2012-10-23 Epitomics, Inc. Method for identifying lineage-related antibodies
WO2011063395A2 (en) * 2009-11-23 2011-05-26 The Johns Hopkins University Lateral flow device for diagnosing microbial infections
US10585098B2 (en) 2009-11-23 2020-03-10 The Johns Hopkins University Optimizing diagnostics for galactofuranose containing antigens
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CA2831572C (en) 2011-05-02 2019-11-26 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
EA035344B1 (ru) 2012-04-20 2020-05-29 Мерюс Н.В. Способ получения двух антител из одной клетки-хозяина
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
US9249182B2 (en) 2012-05-24 2016-02-02 Abbvie, Inc. Purification of antibodies using hydrophobic interaction chromatography
US11180572B2 (en) 2012-07-06 2021-11-23 Genmab B.V. Dimeric protein with triple mutations
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
BR112015004467A2 (pt) 2012-09-02 2017-03-21 Abbvie Inc método para controlar a heterogeneidade de proteínas
BR112015006824A2 (pt) 2012-09-27 2017-07-04 Merus B V anticorpo igg biespecífico, método para produzir um anticorpo igg biespecífico, anticorpo, composição farmacêutica e uso de um anticorpo igg biespecífico
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
WO2014151878A2 (en) 2013-03-14 2014-09-25 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
WO2014159579A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE
JP6205175B2 (ja) 2013-05-16 2017-10-04 株式会社Ｒｅｓｖｏ 精神・神経疾患バイオマーカー
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US8946395B1 (en) 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
US10107822B2 (en) 2013-12-16 2018-10-23 The Johns Hopkins University Interferon-gamma release assays for diagnosis of invasive fungal infections
SI3110849T1 (sl) 2014-02-28 2021-01-29 Merus N.V. Protitelo, ki veže ERBB-2 in ERBB-3
SG11201607109QA (en) 2014-02-28 2016-09-29 Merus Nv Antibodies that bind egfr and erbb3
AU2016293942B2 (en) 2015-07-10 2022-06-16 Merus N.V. Human CD3 binding antibody
PL3365373T3 (pl) 2015-10-23 2021-08-23 Merus N.V. Molekuły wiążące, które hamują wzrost nowotworu
CN110650752A (zh) 2017-03-31 2020-01-03 美勒斯公司 用于治疗具有NRG1融合基因的细胞的ErbB-2和ErbB3结合双特异性抗体
WO2018187074A1 (en) 2017-04-03 2018-10-11 Immunomedics, Inc. Subcutaneous administration of antibody-drug conjugates for cancer therapy
BR112020002695A2 (pt) 2017-08-09 2020-08-25 Merus N.V. anticorpos que se ligam à egfr e cmet
JP7230819B2 (ja) 2017-10-06 2023-03-01 小野薬品工業株式会社 二重特異性抗体
TWI804572B (zh) 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
TW202102544A (zh) 2019-04-04 2021-01-16 日商小野藥品工業股份有限公司 雙特異性抗體
EP3998081A4 (en) 2019-07-05 2023-07-12 Ono Pharmaceutical Co., Ltd. TREATMENT OF BLOOD CANCER WITH PD-1/CD3 DUAL SPECIFICITY PROTEIN
KR20220039720A (ko) 2019-07-30 2022-03-29 오노 야꾸힝 고교 가부시키가이샤 이중 특이성 항체
WO2021025140A1 (ja) 2019-08-08 2021-02-11 小野薬品工業株式会社 二重特異性タンパク質

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296024A (en) * 1974-12-09 1981-10-20 Merck & Co., Inc. Human immune serum globulin with high hepatitis A antibody titer
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
CH652145A5 (de) * 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
EP0131878A3 (en) * 1983-07-19 1987-08-05 Sloan-Kettering Institute For Cancer Research Process for producing human monoclonal antibodies
US4777245A (en) * 1984-01-06 1988-10-11 Genelabs Incorporated Non-human primate monoclonal antibodies and methods
US4997764A (en) * 1987-04-23 1991-03-05 New York University Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors
WO1989000607A1 (en) * 1987-07-09 1989-01-26 The United States Of America, As Represented By Th Preparation of human monoclonal antibodies of selected specificity and isotypes
NZ226694A (en) * 1987-10-28 1994-04-27 Oncogen Human immunoglobulin produced by recombinant dna techniques
HU218093B (hu) * 1988-10-19 2000-05-28 Dow Chemical Co. Rák kezelésére alkalmazható, nagy affinitású, módosított antitestek új csoportja, eljárás előállítására, valamint az antitesteket tartalmazó konjugátumok és készítmények
DE3921211C1 (ko) * 1989-06-28 1990-11-29 Idt Ag Fuer In Vivo Diagnostik Und Therapie, Zuerich, Ch
DE69024814T2 (de) * 1989-09-19 1996-07-18 Centocor Inc Verfahren zur verbesserten herstellung von menschlichen antikörpern sowie hierzu benutzte zellen
GB8925590D0 (en) * 1989-11-13 1990-01-04 Central Blood Lab Authority Monoclonal antibodies
EP0440147B2 (de) * 1990-02-01 2014-05-14 Siemens Healthcare Diagnostics Products GmbH Herstellung und Verwendung von Genbanken menschlicher Antikörper ("Human-Antikörper-Bibliotheken")
DE4002897A1 (de) * 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
AU673499B2 (en) * 1991-07-25 1996-11-14 Biogen Idec Inc. Recombinant antibodies for human therapy

Also Published As

Publication number Publication date
AU2279892A (en) 1993-02-23
IE922287A1 (en) 1993-01-27
HU9400110D0 (en) 1994-05-30
CA2111858A1 (en) 1993-02-04
DE69233104T2 (de) 2004-05-13
US5876961A (en) 1999-03-02
NZ243558A (en) 1994-06-27
JP3502093B2 (ja) 2004-03-02
KR100255717B1 (ko) 2000-05-01
EP0523949A1 (en) 1993-01-20
TW373023B (en) 1999-11-01
WO1993002190A1 (en) 1993-02-04
DE69233104D1 (de) 2003-07-31
HU220355B (hu) 2001-12-28
AU662752B2 (en) 1995-09-14
ATE243747T1 (de) 2003-07-15
FI940144A0 (fi) 1994-01-12
FI940144A (fi) 1994-01-12
ES2199216T3 (es) 2004-02-16
HUT69798A (en) 1995-09-28
JPH07502882A (ja) 1995-03-30
EP0523949B1 (en) 2003-06-25

Similar Documents

Publication Publication Date Title
IL102490A0 (en) Production of antibodies
IL64885A (en) 3,20-dioxo-1,4-pregnadiene-17alpha-ol-17-aromatic heterocyclic esters,their preparation and pharmaceutical compositions containing them
CZ44195A3 (en) Pharmaceutical preparation containing il-4 and/or il-10 or antibodies against il-4 and il-10, process of its preparation and use
AU2118488A (en) Improvements in or relating to methods of treating damaged skin
IL87698A (en) Pharmaceutical compositions containing azithromycin and derivatives as antiprotozoal agents
EP0275005A3 (en) Complex compounds of bioflavonoids with phospholipids, their preparation and use, and pharmaceutical and cosmetic compositions containing them
CA2119562A1 (en) Method and compositions for the treatment of cerebral palsy
DE69133397D1 (de) Benzoylderivate
ZA928162B (en) Antibodies in immunosuppression.
PL308356A1 (en) Ranithidine containing compositions
GR79989B (ko)
EP0293751A3 (en) Taurohyodeoxycholic acid for the therapy of calculosis of the biliary tract and of biliary dyspepsia
CA2120153A1 (en) Recombinant immunotoxins
FI931826A (fi) Foerfarande foer framstaellning av en virussaeker, hoegt renad faktor viii
EP0054330A3 (en) Dna sequences encoding the various allelic forms of mature thaumatin, and cloning vehicles comprising said dna's and their use in transforming microorganisms
ATE103779T1 (de) Brausekomponente und verfahren zu ihrer herstellung.
IL72640A (en) 2,6-bis-fluoromethyl or 2-or-6-fluoromethyl-dihydropyridine-3,5-dicarboxylic acid esters,herbicidal compositions containing them and the preparation of some such compounds
EP0588177A3 (en) An interferon-alpha/beta binding protein, its preparation and pharmaceutical compositions containing it
PT87563A (pt) Process for the preparation of vinylcephalosporins useful as medicaments
ZA917369B (en) Calcium uptake inhibitors
NO961353L (no) Resulfurisert austenittisk rustfritt stål med forbedret bearbeidbarhet
EP0117621A3 (en) Cosmetic
AU8452791A (en) 1-phenyl-3-aryl-2-propyne-1-ones
IL103856A0 (en) Aminoalkyl-substituted 5,6-dihydro-dibenz(b,e)azepin-6,11-dione-11-oximes,their preparation and pharmaceutical compositions containing them
Suzuki Biologically active substances produced by the flour beetles, tribolium, castaneum and T. confusum