IL102473A - 2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor - Google Patents

2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor

Info

Publication number
IL102473A
IL102473A IL102473A IL10247392A IL102473A IL 102473 A IL102473 A IL 102473A IL 102473 A IL102473 A IL 102473A IL 10247392 A IL10247392 A IL 10247392A IL 102473 A IL102473 A IL 102473A
Authority
IL
Israel
Prior art keywords
carbons
alkyl
group
alkoxy
hydroxy
Prior art date
Application number
IL102473A
Other languages
English (en)
Other versions
IL102473A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL102473A0 publication Critical patent/IL102473A0/xx
Publication of IL102473A publication Critical patent/IL102473A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL102473A 1991-07-17 1992-07-12 2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor IL102473A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17

Publications (2)

Publication Number Publication Date
IL102473A0 IL102473A0 (en) 1993-01-14
IL102473A true IL102473A (en) 1997-07-13

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
IL102473A IL102473A (en) 1991-07-17 1992-07-12 2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor

Country Status (22)

Country Link
EP (1) EP0594729A1 (Direct)
JP (1) JP2571904B2 (Direct)
KR (1) KR0165003B1 (Direct)
CN (1) CN1043759C (Direct)
AU (1) AU655840B2 (Direct)
BR (1) BR9206272A (Direct)
CA (1) CA2113568A1 (Direct)
CZ (1) CZ284133B6 (Direct)
EG (1) EG20048A (Direct)
FI (2) FI940192A0 (Direct)
HU (1) HUT70528A (Direct)
IE (1) IE922311A1 (Direct)
IL (1) IL102473A (Direct)
MX (1) MX9204190A (Direct)
NO (1) NO180445C (Direct)
NZ (1) NZ243580A (Direct)
PL (1) PL169884B1 (Direct)
PT (1) PT100689B (Direct)
RU (1) RU2065859C1 (Direct)
TW (1) TW201732B (Direct)
WO (1) WO1993002052A1 (Direct)
ZA (1) ZA925306B (Direct)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
DE69309297T2 (de) * 1992-10-30 1997-07-03 Pfizer Neuroprotektive 3,4-dihydro-2(1h)-chinolone
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
US6978166B2 (en) 1994-10-07 2005-12-20 Saint Louis University System for use in displaying images of a body part
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
CA2220649C (en) * 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
EP1182193A4 (en) * 1999-04-09 2002-09-11 Mochida Pharm Co Ltd REMEDIES FOR NEUROGENIC PAIN
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
AU1153601A (en) 1999-10-29 2001-05-08 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole NMDA NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US7217716B2 (en) 2001-02-23 2007-05-15 Merck & Co., Inc. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
JP2005511478A (ja) 2001-04-03 2005-04-28 メルク　エンド　カムパニー　インコーポレーテッド Ｎ−置換非アリール複素環アミジル系ｎｍｄａ／ｎｒ２ｂ拮抗薬
JP4544999B2 (ja) 2002-11-25 2010-09-15 持田製薬株式会社 ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤
MXPA06003748A (es) * 2003-10-08 2006-06-14 Pfizer Compuestos de lactama condensada.
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途
AU2021297823A1 (en) * 2020-06-23 2023-02-16 Biohaven Therapeutics Ltd. Topical formulations of (1S)-1-phenyl-2-pyridin-2-ylethanamine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
JPH0699423B2 (ja) * 1990-05-10 1994-12-07 フアイザー・インコーポレイテツド 神経保護性インドロン及び関連誘導体

Also Published As

Publication number Publication date
NO940144D0 (no) 1994-01-14
CZ400892A3 (en) 1994-03-16
MX9204190A (es) 1993-01-01
PT100689A (pt) 1993-10-29
WO1993002052A1 (en) 1993-02-04
ZA925306B (en) 1994-01-17
CZ284133B6 (cs) 1998-08-12
EG20048A (en) 1997-03-27
KR0165003B1 (en) 1999-01-15
JPH06504293A (ja) 1994-05-19
NO180445B (no) 1997-01-13
NO180445C (no) 1997-04-23
JP2571904B2 (ja) 1997-01-16
FI981956A7 (fi) 1998-09-11
NZ243580A (en) 1994-10-26
TW201732B (Direct) 1993-03-11
RU2065859C1 (ru) 1996-08-27
CA2113568A1 (en) 1993-02-04
NO940144L (no) 1994-01-14
FI940192L (fi) 1994-01-14
BR9206272A (pt) 1995-04-11
HUT70528A (en) 1995-10-30
CN1043759C (zh) 1999-06-23
FI940192A7 (fi) 1994-01-14
FI981956L (fi) 1998-09-11
HU9400136D0 (en) 1994-05-30
CN1068566A (zh) 1993-02-03
AU655840B2 (en) 1995-01-12
IE922311A1 (en) 1993-01-27
EP0594729A1 (en) 1994-05-04
PT100689B (pt) 1999-06-30
AU2322592A (en) 1993-02-23
FI940192A0 (fi) 1994-01-14
FI981956A0 (fi) 1998-09-11
PL169884B1 (pl) 1996-09-30
IL102473A0 (en) 1993-01-14

Similar Documents

Publication Publication Date Title
IL102473A (en) 2-(4-hydroxypiperidino)-1- alkanol derivatives, pharmaceutical compositions containing them and certain intermediates therefor
CA2230936A1 (en) 5-azabicyclo(3.1.0)hexylalkyl-2-piperidones and -glutarimides as neurokinin receptor antagonists
ES8103020A1 (es) Procedimiento de preparacion de amino-eteres oxidos
FI841181A0 (fi) Nya n-fenyl-n'- cykloalkylalkanoylpiperaziner och foerfarande foer deras framstaellning.
NO990583L (no) Cykliske eterforbindelser som natriumkanalmodulatorer
MY132009A (en) Pharmaceutical compounds.
EP0491659A3 (en) Novel piperidine compounds containing silane groups for use as stabilizers for organic materials
TR199802253T2 (xx) Alkilaminobenzotiazol ve benzoksazol t�revleri
IE841659L (en) Allopurinol prodrugs
AU624951B2 (en) New sulfonamides derived from benzocyclic or benzoheterocyclic acids, their preparation and application in thereapeutics
ES482002A1 (es) Procedimiento para la preparacion de nuevos derivados 5-fe- nilpirazolicos.
MY100115A (en) Nitrogen containing heterocyclic compounds, and their production and use.
SE8903226D0 (sv) Kemiska foereningar
AU4646596A (en) Quinazolinone-containing pharmaceutical compositions and methods for the use thereof
ES8107001A1 (es) Un metodo de preparar nuevas diaminas
GB2183476B (en) Anthihypertensive combination product
EP0379085A3 (de) Phenylalkylamine und diese enthaltende Fungizide
SE7704246L (sv) Desinfektionsmedel
DE69521895D1 (de) Indolderivate als prodrugs von "5-ht1-like" rezeptor agonisten
FI971177A0 (fi) Bisyklisiä karboksiamideja 5-HT1A-antagonisteina
ES8506605A1 (es) Procedimiento de preparacion de eteres oximas basicos y de sus sales de adicion acidas
NO980842L (no) Nye benzensulfonylaminforbindelser, fremgangsmåte ved fremstilling derav, samt farmasöytiske sammensetninger inneholdende slike
JPS5513728A (en) Antistatic polyester composition
DE3362036D1 (en) Ketene-o,o-acetates and process for their preparation
ES381487A1 (es) Un metodo para la preparacion de compuestos 3-(n-alquil- carbamiloximino)-heterociclicos.

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees