IL100092A - Process for preparation) (- methyl-4,4,4-trifluorobutylamine Intermediate product 4,4,4-trifluoro-2-methyl-N -]) S (-1- phenylethyl (butyramide and process for preparation) R (- - Google Patents

Process for preparation) (- methyl-4,4,4-trifluorobutylamine Intermediate product 4,4,4-trifluoro-2-methyl-N -]) S (-1- phenylethyl (butyramide and process for preparation) R (-

Info

Publication number
IL100092A
IL100092A IL10009291A IL10009291A IL100092A IL 100092 A IL100092 A IL 100092A IL 10009291 A IL10009291 A IL 10009291A IL 10009291 A IL10009291 A IL 10009291A IL 100092 A IL100092 A IL 100092A
Authority
IL
Israel
Prior art keywords
methyl
butyramide
trifluorobutylamine
acid
diastereomeric
Prior art date
Application number
IL10009291A
Other languages
English (en)
Hebrew (he)
Other versions
IL100092A0 (en
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of IL100092A0 publication Critical patent/IL100092A0/xx
Publication of IL100092A publication Critical patent/IL100092A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/16Preparation of optical isomers
    • C07C231/18Preparation of optical isomers by stereospecific synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL10009291A 1990-12-05 1991-11-19 Process for preparation) (- methyl-4,4,4-trifluorobutylamine Intermediate product 4,4,4-trifluoro-2-methyl-N -]) S (-1- phenylethyl (butyramide and process for preparation) R (- IL100092A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026425A GB9026425D0 (en) 1990-12-05 1990-12-05 Process

Publications (2)

Publication Number Publication Date
IL100092A0 IL100092A0 (en) 1992-08-18
IL100092A true IL100092A (en) 1996-10-16

Family

ID=10686507

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10009291A IL100092A (en) 1990-12-05 1991-11-19 Process for preparation) (- methyl-4,4,4-trifluorobutylamine Intermediate product 4,4,4-trifluoro-2-methyl-N -]) S (-1- phenylethyl (butyramide and process for preparation) R (-

Country Status (20)

Country Link
US (1) US5274118A (no)
EP (1) EP0489548B1 (no)
JP (1) JP3160041B2 (no)
AT (1) ATE115543T1 (no)
AU (1) AU649498B2 (no)
CA (1) CA2056068C (no)
CZ (1) CZ281659B6 (no)
DE (1) DE69105931T2 (no)
DK (1) DK0489548T3 (no)
ES (1) ES2066373T3 (no)
FI (1) FI109995B (no)
GB (1) GB9026425D0 (no)
HU (1) HU212936B (no)
IE (1) IE65663B1 (no)
IL (1) IL100092A (no)
NO (1) NO176516C (no)
NZ (1) NZ240857A (no)
PT (1) PT99684B (no)
SK (1) SK280473B6 (no)
ZA (1) ZA919572B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
WO2005005648A1 (ja) * 2003-07-11 2005-01-20 Mitsubishi Pharma Corporation 新規な光学活性カルボン酸の製造法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2243977A (en) * 1938-07-18 1941-06-03 Sandoz Ltd Process for the preparation of amino-alcohols
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
US5105014A (en) * 1991-08-06 1992-04-14 Mallinckrodt Medical, Inc. Synthesis of vicinal diamines

Also Published As

Publication number Publication date
CA2056068C (en) 2003-05-06
EP0489548B1 (en) 1994-12-14
DK0489548T3 (da) 1995-05-08
NO914776L (no) 1992-06-09
HU212936B (en) 1996-12-30
IE65663B1 (en) 1995-11-15
NO176516C (no) 1995-04-19
CS368791A3 (en) 1992-09-16
HUT61964A (en) 1993-03-29
EP0489548A1 (en) 1992-06-10
PT99684A (pt) 1992-10-30
DE69105931T2 (de) 1995-05-04
NO914776D0 (no) 1991-12-04
FI915721A0 (fi) 1991-12-04
CA2056068A1 (en) 1992-06-06
AU8838591A (en) 1992-06-11
NZ240857A (en) 1994-05-26
AU649498B2 (en) 1994-05-26
FI915721A (fi) 1992-06-06
CZ281659B6 (cs) 1996-12-11
DE69105931D1 (de) 1995-01-26
ES2066373T3 (es) 1995-03-01
GB9026425D0 (en) 1991-01-23
HU913758D0 (en) 1992-02-28
ZA919572B (en) 1992-10-28
IL100092A0 (en) 1992-08-18
ATE115543T1 (de) 1994-12-15
JP3160041B2 (ja) 2001-04-23
FI109995B (fi) 2002-11-15
IE914219A1 (en) 1992-06-17
SK280473B6 (sk) 2000-02-14
US5274118A (en) 1993-12-28
PT99684B (pt) 1999-05-31
JPH04290870A (ja) 1992-10-15
NO176516B (no) 1995-01-09

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