FI109995B - Menetelmä (2R)-metyyli-4,4,4-trifluoributyyliamiinin ja (R)-4-[5-(N-[4,4,4-trifluori-2-metyylibutyyli]karbamoyyli)-1-metyyli-indol-3-yylimetyyli]-3-metoksi-N-o-tolyylisulfonyylibentsamidin valmistamiseksi - Google Patents

Menetelmä (2R)-metyyli-4,4,4-trifluoributyyliamiinin ja (R)-4-[5-(N-[4,4,4-trifluori-2-metyylibutyyli]karbamoyyli)-1-metyyli-indol-3-yylimetyyli]-3-metoksi-N-o-tolyylisulfonyylibentsamidin valmistamiseksi Download PDF

Info

Publication number
FI109995B
FI109995B FI915721A FI915721A FI109995B FI 109995 B FI109995 B FI 109995B FI 915721 A FI915721 A FI 915721A FI 915721 A FI915721 A FI 915721A FI 109995 B FI109995 B FI 109995B
Authority
FI
Finland
Prior art keywords
methyl
butyramide
trifluorobutylamine
diastereomeric
acid
Prior art date
Application number
FI915721A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI915721A0 (fi
FI915721A (fi
Inventor
Peter Robert Bernstein
Andrew George Brewster
Ying Kwong Yee
Robert Toms Jacobs
George Joseph Sependa
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of FI915721A0 publication Critical patent/FI915721A0/fi
Publication of FI915721A publication Critical patent/FI915721A/fi
Application granted granted Critical
Publication of FI109995B publication Critical patent/FI109995B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI915721A 1990-12-05 1991-12-04 Menetelmä (2R)-metyyli-4,4,4-trifluoributyyliamiinin ja (R)-4-[5-(N-[4,4,4-trifluori-2-metyylibutyyli]karbamoyyli)-1-metyyli-indol-3-yylimetyyli]-3-metoksi-N-o-tolyylisulfonyylibentsamidin valmistamiseksi FI109995B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9026425 1990-12-05
GB909026425A GB9026425D0 (en) 1990-12-05 1990-12-05 Process

Publications (3)

Publication Number Publication Date
FI915721A0 FI915721A0 (fi) 1991-12-04
FI915721A FI915721A (fi) 1992-06-06
FI109995B true FI109995B (fi) 2002-11-15

Family

ID=10686507

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915721A FI109995B (fi) 1990-12-05 1991-12-04 Menetelmä (2R)-metyyli-4,4,4-trifluoributyyliamiinin ja (R)-4-[5-(N-[4,4,4-trifluori-2-metyylibutyyli]karbamoyyli)-1-metyyli-indol-3-yylimetyyli]-3-metoksi-N-o-tolyylisulfonyylibentsamidin valmistamiseksi

Country Status (20)

Country Link
US (1) US5274118A (no)
EP (1) EP0489548B1 (no)
JP (1) JP3160041B2 (no)
AT (1) ATE115543T1 (no)
AU (1) AU649498B2 (no)
CA (1) CA2056068C (no)
CZ (1) CZ281659B6 (no)
DE (1) DE69105931T2 (no)
DK (1) DK0489548T3 (no)
ES (1) ES2066373T3 (no)
FI (1) FI109995B (no)
GB (1) GB9026425D0 (no)
HU (1) HU212936B (no)
IE (1) IE65663B1 (no)
IL (1) IL100092A (no)
NO (1) NO176516C (no)
NZ (1) NZ240857A (no)
PT (1) PT99684B (no)
SK (1) SK280473B6 (no)
ZA (1) ZA919572B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
WO2005005648A1 (ja) * 2003-07-11 2005-01-20 Mitsubishi Pharma Corporation 新規な光学活性カルボン酸の製造法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2243977A (en) * 1938-07-18 1941-06-03 Sandoz Ltd Process for the preparation of amino-alcohols
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
US5105014A (en) * 1991-08-06 1992-04-14 Mallinckrodt Medical, Inc. Synthesis of vicinal diamines

Also Published As

Publication number Publication date
CA2056068C (en) 2003-05-06
EP0489548B1 (en) 1994-12-14
DK0489548T3 (da) 1995-05-08
NO914776L (no) 1992-06-09
HU212936B (en) 1996-12-30
IE65663B1 (en) 1995-11-15
NO176516C (no) 1995-04-19
CS368791A3 (en) 1992-09-16
HUT61964A (en) 1993-03-29
EP0489548A1 (en) 1992-06-10
PT99684A (pt) 1992-10-30
DE69105931T2 (de) 1995-05-04
NO914776D0 (no) 1991-12-04
FI915721A0 (fi) 1991-12-04
CA2056068A1 (en) 1992-06-06
AU8838591A (en) 1992-06-11
NZ240857A (en) 1994-05-26
AU649498B2 (en) 1994-05-26
FI915721A (fi) 1992-06-06
IL100092A (en) 1996-10-16
CZ281659B6 (cs) 1996-12-11
DE69105931D1 (de) 1995-01-26
ES2066373T3 (es) 1995-03-01
GB9026425D0 (en) 1991-01-23
HU913758D0 (en) 1992-02-28
ZA919572B (en) 1992-10-28
IL100092A0 (en) 1992-08-18
ATE115543T1 (de) 1994-12-15
JP3160041B2 (ja) 2001-04-23
IE914219A1 (en) 1992-06-17
SK280473B6 (sk) 2000-02-14
US5274118A (en) 1993-12-28
PT99684B (pt) 1999-05-31
JPH04290870A (ja) 1992-10-15
NO176516B (no) 1995-01-09

Similar Documents

Publication Publication Date Title
CA2036876C (fr) Derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2692575A1 (fr) Nouveaux dérivés du pyrazole, procédé pour leur préparation et compositions pharmaceutiques les contenant.
FR2568571A1 (fr) Derive d'indole
AU2002358585A1 (en) Acetylene derivatives having mglur 5 antagonistic activity
JPH03246258A (ja) ４―（４―アルコキシフェニル）―２―ブチルアミン誘導体およびその製造法
CH667454A5 (fr) Derives d'indoles.
CA2055326A1 (fr) Derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FI109995B (fi) Menetelmä (2R)-metyyli-4,4,4-trifluoributyyliamiinin ja (R)-4-[5-(N-[4,4,4-trifluori-2-metyylibutyyli]karbamoyyli)-1-metyyli-indol-3-yylimetyyli]-3-metoksi-N-o-tolyylisulfonyylibentsamidin valmistamiseksi
DE69411589T2 (de) Indol, indolin und chinolin derivate mit einer 5ht1d antagonistischen wirkung
JP2000516634A (ja) カッパアゴニストとしてのピロリジニルおよびピロリニルエチルアミン化合物
KR100228328B1 (ko) (2r)-메틸-4,4,4-트리플루오로부틸아민 또는 이것의 산부가염을 제조하는 방법
CH658786A5 (fr) Medicaments qui contiennent d'alpha-(n-pyrrolyl)-acides ou de leurs sels ou esters.
RU2055069C1 (ru) Способ получения (2r)-метил-4,4,4-трифторбутиламина или его кислотно-аддитивной соли, 4,4,4-трифтор-2-метил-n[(s)-1-фенилэтил]-бутирамид и (2r)-метил-4,4,4-трифторбутил[(1s)-фенилэтил]амин или его кислотно-аддитивная соль и способ получения (r)-4-[5-(n-[4,4,4-tpифtop-2-metилбуtил]-kapбamoил)-1-metилиhдoл-3-ил-metил]-3-metokcи-n-ортотолилсульфонилбензамида
US5286740A (en) Carbamoyl derivatives
EP0929525B1 (fr) Heteroaryloxyethylamines comme ligands du recepteur 5-ht1a
KR100228327B1 (ko) 3-알킬화 인돌의 제조방법
BE882223A (fr) Derives d'amine-3 (1h, 3) quinazolinedione-2,4, leur procede de preparation et leurs applications en therapeutique
JPH0450301B2 (no)

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: ZENECA LIMITED

MA Patent expired