ES2066373T3 - Un proceso para la preparacion de 2(r)-metil-4,4,4-trifluorobutilamina, intermedios, y un proceso para la preparacion de un derivado de la misma. - Google Patents

Un proceso para la preparacion de 2(r)-metil-4,4,4-trifluorobutilamina, intermedios, y un proceso para la preparacion de un derivado de la misma.

Info

Publication number
ES2066373T3
ES2066373T3 ES91311073T ES91311073T ES2066373T3 ES 2066373 T3 ES2066373 T3 ES 2066373T3 ES 91311073 T ES91311073 T ES 91311073T ES 91311073 T ES91311073 T ES 91311073T ES 2066373 T3 ES2066373 T3 ES 2066373T3
Authority
ES
Spain
Prior art keywords
preparation
methyl
butyramide
derivative
trifluorobutilamina
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91311073T
Other languages
English (en)
Inventor
Robert Toms Jacobs
Ying Kwong Yee
Peter Robert Bernstein
Andrew George Brewster
George Joseph Sependa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2066373T3 publication Critical patent/ES2066373T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE (2R)-METIL-4,4,4-TRIFLUOROBUTILIMINA O UNA SAL DE ADICION ACIDA DE LA MISMA QUE CONSISTE EN: A) ACILAR UNA AMINA OPTICAMENTE ACTIVA CON ACIDO 2-METIL-4,4,4 -TRIFLUOROBUTANOICO O CON UN DERIVADO REACTIVO DEL MISMO PARA OBTENER UNA BUTILAMIDA; B) SEPARAR LA BUTIRAMIDA (R)-DISTOMERICA; Y C) CONVERTIR LA BUTIRAMIDA (R)-DIATOMERICA EN LA (2R)-METIL-4,4,4-TRIFLUOROBUTALAMINA DESEADA O EN UNA SAL DE ADICION ACIDA DE LA MISMA. EL PRODUCTO SE PUEDE ACILAR CON UN ACIDO CARBOXILICO QUE TIENE LA FORMULA III EN DONDE U ES CARBOXI O UN DERIVADO REACTIVO DEL MISMO PARA OBTENER (R)-4 [5-(N-[4,4,4-TRIFLUORO-2-METILBUTIL]CARBAMIL)-1-METILINDOL-3-IL-METIL ]-3-METOXI-N-O-COLILSULFONILBENZAMIDA. EL INDOL ES UTIL COMO ANTAGONISTA DE LEUCOTRIENO, EN EL TRATAMIENTO, POR EJEMPLO DEL ASMA O DE LA RINITIS ALERGICA.
ES91311073T 1990-12-05 1991-11-29 Un proceso para la preparacion de 2(r)-metil-4,4,4-trifluorobutilamina, intermedios, y un proceso para la preparacion de un derivado de la misma. Expired - Lifetime ES2066373T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026425A GB9026425D0 (en) 1990-12-05 1990-12-05 Process

Publications (1)

Publication Number Publication Date
ES2066373T3 true ES2066373T3 (es) 1995-03-01

Family

ID=10686507

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91311073T Expired - Lifetime ES2066373T3 (es) 1990-12-05 1991-11-29 Un proceso para la preparacion de 2(r)-metil-4,4,4-trifluorobutilamina, intermedios, y un proceso para la preparacion de un derivado de la misma.

Country Status (20)

Country Link
US (1) US5274118A (es)
EP (1) EP0489548B1 (es)
JP (1) JP3160041B2 (es)
AT (1) ATE115543T1 (es)
AU (1) AU649498B2 (es)
CA (1) CA2056068C (es)
CZ (1) CZ281659B6 (es)
DE (1) DE69105931T2 (es)
DK (1) DK0489548T3 (es)
ES (1) ES2066373T3 (es)
FI (1) FI109995B (es)
GB (1) GB9026425D0 (es)
HU (1) HU212936B (es)
IE (1) IE65663B1 (es)
IL (1) IL100092A (es)
NO (1) NO176516C (es)
NZ (1) NZ240857A (es)
PT (1) PT99684B (es)
SK (1) SK280473B6 (es)
ZA (1) ZA919572B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
WO2005005648A1 (ja) * 2003-07-11 2005-01-20 Mitsubishi Pharma Corporation 新規な光学活性カルボン酸の製造法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2243977A (en) * 1938-07-18 1941-06-03 Sandoz Ltd Process for the preparation of amino-alcohols
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
US5105014A (en) * 1991-08-06 1992-04-14 Mallinckrodt Medical, Inc. Synthesis of vicinal diamines

Also Published As

Publication number Publication date
CA2056068C (en) 2003-05-06
EP0489548B1 (en) 1994-12-14
DK0489548T3 (da) 1995-05-08
NO914776L (no) 1992-06-09
HU212936B (en) 1996-12-30
IE65663B1 (en) 1995-11-15
NO176516C (no) 1995-04-19
CS368791A3 (en) 1992-09-16
HUT61964A (en) 1993-03-29
EP0489548A1 (en) 1992-06-10
PT99684A (pt) 1992-10-30
DE69105931T2 (de) 1995-05-04
NO914776D0 (no) 1991-12-04
FI915721A0 (fi) 1991-12-04
CA2056068A1 (en) 1992-06-06
AU8838591A (en) 1992-06-11
NZ240857A (en) 1994-05-26
AU649498B2 (en) 1994-05-26
FI915721A (fi) 1992-06-06
IL100092A (en) 1996-10-16
CZ281659B6 (cs) 1996-12-11
DE69105931D1 (de) 1995-01-26
GB9026425D0 (en) 1991-01-23
HU913758D0 (en) 1992-02-28
ZA919572B (en) 1992-10-28
IL100092A0 (en) 1992-08-18
ATE115543T1 (de) 1994-12-15
JP3160041B2 (ja) 2001-04-23
FI109995B (fi) 2002-11-15
IE914219A1 (en) 1992-06-17
SK280473B6 (sk) 2000-02-14
US5274118A (en) 1993-12-28
PT99684B (pt) 1999-05-31
JPH04290870A (ja) 1992-10-15
NO176516B (no) 1995-01-09

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