DE69105931D1 - Ein Verfahren zur Darstellung von 2(R)-Methyl-4,4,4-trifluorobutylamin, Intermediate und ein Verfahren zur Darstellung eines Derivats. - Google Patents

Ein Verfahren zur Darstellung von 2(R)-Methyl-4,4,4-trifluorobutylamin, Intermediate und ein Verfahren zur Darstellung eines Derivats.

Info

Publication number
DE69105931D1
DE69105931D1 DE69105931T DE69105931T DE69105931D1 DE 69105931 D1 DE69105931 D1 DE 69105931D1 DE 69105931 T DE69105931 T DE 69105931T DE 69105931 T DE69105931 T DE 69105931T DE 69105931 D1 DE69105931 D1 DE 69105931D1
Authority
DE
Germany
Prior art keywords
methyl
preparation
trifluorobutylamine
butyramide
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69105931T
Other languages
English (en)
Other versions
DE69105931T2 (de
Inventor
Robert Toms Jacobs
Ying Kwong Yee
Peter Robert Bernstein
Andrew George Brewster
George Joseph Sependa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69105931D1 publication Critical patent/DE69105931D1/de
Publication of DE69105931T2 publication Critical patent/DE69105931T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/15—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69105931T 1990-12-05 1991-11-29 Ein Verfahren zur Darstellung von 2(R)-Methyl-4,4,4-trifluorobutylamin, Intermediate und ein Verfahren zur Darstellung eines Derivats. Expired - Fee Related DE69105931T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909026425A GB9026425D0 (en) 1990-12-05 1990-12-05 Process

Publications (2)

Publication Number Publication Date
DE69105931D1 true DE69105931D1 (de) 1995-01-26
DE69105931T2 DE69105931T2 (de) 1995-05-04

Family

ID=10686507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69105931T Expired - Fee Related DE69105931T2 (de) 1990-12-05 1991-11-29 Ein Verfahren zur Darstellung von 2(R)-Methyl-4,4,4-trifluorobutylamin, Intermediate und ein Verfahren zur Darstellung eines Derivats.

Country Status (20)

Country Link
US (1) US5274118A (de)
EP (1) EP0489548B1 (de)
JP (1) JP3160041B2 (de)
AT (1) ATE115543T1 (de)
AU (1) AU649498B2 (de)
CA (1) CA2056068C (de)
CZ (1) CZ281659B6 (de)
DE (1) DE69105931T2 (de)
DK (1) DK0489548T3 (de)
ES (1) ES2066373T3 (de)
FI (1) FI109995B (de)
GB (1) GB9026425D0 (de)
HU (1) HU212936B (de)
IE (1) IE65663B1 (de)
IL (1) IL100092A (de)
NO (1) NO176516C (de)
NZ (1) NZ240857A (de)
PT (1) PT99684B (de)
SK (1) SK280473B6 (de)
ZA (1) ZA919572B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
GB9026427D0 (en) * 1990-12-05 1991-01-23 Ici Plc Chemical process
GB9119001D0 (en) * 1991-09-05 1991-10-23 Ici Plc Pharmaceutical agents
JPWO2005005648A1 (ja) * 2003-07-11 2007-09-20 三菱ウェルファーマ株式会社 新規な光学活性カルボン酸の製造法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2243977A (en) * 1938-07-18 1941-06-03 Sandoz Ltd Process for the preparation of amino-alcohols
GB8927981D0 (en) * 1989-12-11 1990-02-14 Ici Plc Carbamoyl derivative
US5105014A (en) * 1991-08-06 1992-04-14 Mallinckrodt Medical, Inc. Synthesis of vicinal diamines

Also Published As

Publication number Publication date
DK0489548T3 (da) 1995-05-08
CS368791A3 (en) 1992-09-16
AU8838591A (en) 1992-06-11
PT99684A (pt) 1992-10-30
NZ240857A (en) 1994-05-26
ES2066373T3 (es) 1995-03-01
FI915721A (fi) 1992-06-06
PT99684B (pt) 1999-05-31
JP3160041B2 (ja) 2001-04-23
EP0489548A1 (de) 1992-06-10
IE914219A1 (en) 1992-06-17
HU212936B (en) 1996-12-30
GB9026425D0 (en) 1991-01-23
IE65663B1 (en) 1995-11-15
FI109995B (fi) 2002-11-15
US5274118A (en) 1993-12-28
CA2056068A1 (en) 1992-06-06
SK280473B6 (sk) 2000-02-14
HU913758D0 (en) 1992-02-28
NO176516B (no) 1995-01-09
HUT61964A (en) 1993-03-29
IL100092A0 (en) 1992-08-18
NO914776D0 (no) 1991-12-04
IL100092A (en) 1996-10-16
NO176516C (no) 1995-04-19
AU649498B2 (en) 1994-05-26
ATE115543T1 (de) 1994-12-15
DE69105931T2 (de) 1995-05-04
CA2056068C (en) 2003-05-06
FI915721A0 (fi) 1991-12-04
JPH04290870A (ja) 1992-10-15
CZ281659B6 (cs) 1996-12-11
ZA919572B (en) 1992-10-28
NO914776L (no) 1992-06-09
EP0489548B1 (de) 1994-12-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee