IE921534A1 - Novel composition of angiotensin-ii receptor antagonists and¹calcium channel blockers - Google Patents
Novel composition of angiotensin-ii receptor antagonists and¹calcium channel blockersInfo
- Publication number
- IE921534A1 IE921534A1 IE153492A IE921534A IE921534A1 IE 921534 A1 IE921534 A1 IE 921534A1 IE 153492 A IE153492 A IE 153492A IE 921534 A IE921534 A IE 921534A IE 921534 A1 IE921534 A1 IE 921534A1
- Authority
- IE
- Ireland
- Prior art keywords
- tetrazol
- imidazole
- methyl
- propyl
- carbon atoms
- Prior art date
Links
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 title claims abstract description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 21
- 229940127291 Calcium channel antagonist Drugs 0.000 claims abstract description 13
- 239000000480 calcium channel blocker Substances 0.000 claims abstract description 13
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims abstract description 10
- 206010020772 Hypertension Diseases 0.000 claims abstract description 6
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims abstract description 5
- 229960004166 diltiazem Drugs 0.000 claims abstract description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
- 125000000217 alkyl group Chemical group 0.000 claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 14
- NKWCGTOZTHZDHB-UHFFFAOYSA-N 1h-imidazol-1-ium-4-carboxylate Chemical compound OC(=O)C1=CNC=N1 NKWCGTOZTHZDHB-UHFFFAOYSA-N 0.000 claims description 11
- 229940126317 angiotensin II receptor antagonist Drugs 0.000 claims description 10
- -1 ryosidine Chemical compound 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
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|---|---|---|---|
| US70074091A | 1991-05-15 | 1991-05-15 |
Publications (1)
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| IE921534A1 true IE921534A1 (en) | 1992-11-18 |
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| IE153492A IE921534A1 (en) | 1991-05-15 | 1992-07-01 | Novel composition of angiotensin-ii receptor antagonists and¹calcium channel blockers |
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| AU (1) | AU664375B2 (enExample) |
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| IE (1) | IE921534A1 (enExample) |
| IL (1) | IL101858A (enExample) |
| MX (1) | MX9202243A (enExample) |
| NZ (1) | NZ242724A (enExample) |
| WO (1) | WO1992020342A1 (enExample) |
| ZA (1) | ZA923557B (enExample) |
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| JP3057471B2 (ja) | 1993-06-07 | 2000-06-26 | 武田薬品工業株式会社 | アンジオテンシンｉｉ介在性諸疾患の予防または治療剤 |
| WO1995026188A1 (en) * | 1994-03-29 | 1995-10-05 | Merck & Co., Inc. | Treatment of atherosclerosis with angiotensin ii receptor blocking imidazoles |
| ES2193233T3 (es) | 1995-03-16 | 2003-11-01 | Pfizer | Uso de amiodipina, una sal de la misma o felodipina en combinacion con un inhibidor ace en la fabricacion de un medicamento para el tratamiento de insuficiencia cardiaca conjuntiva no isquemica. |
| TW442301B (en) * | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
| ES2552639T3 (es) | 1998-07-10 | 2015-12-01 | Novartis Pharma Ag | Uso combinado de valsartán y bloqueantes de los canales de calcio para fines terapéuticos |
| US6204281B1 (en) | 1998-07-10 | 2001-03-20 | Novartis Ag | Method of treatment and pharmaceutical composition |
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| US6395728B2 (en) | 1999-07-08 | 2002-05-28 | Novartis Ag | Method of treatment and pharmaceutical composition |
| JP4000505B2 (ja) | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
| GB0008332D0 (en) * | 2000-04-04 | 2000-05-24 | Pfizer Ltd | Treament |
| WO2001082858A2 (de) * | 2000-05-04 | 2001-11-08 | Ipf Pharmaceuticals Gmbh | Neue verbindungen zur behandlung inflammatorischer und kardiovaskulärer erkrankungen |
| JP2004514703A (ja) * | 2000-12-01 | 2004-05-20 | ノバルティス アクチエンゲゼルシャフト | 有機化合物の組合せ剤 |
| EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| MXPA05008142A (es) * | 2003-01-31 | 2005-09-30 | Sankyo Co | Medicamento para la profilaxis y el tratamiento de arteriosclerosis e hipertension. |
| TW200833325A (en) * | 2006-12-26 | 2008-08-16 | Daiichi Sankyo Co Ltd | Pharmaceutical composition comprising ascorbic acid |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| CN101772513B (zh) | 2007-06-04 | 2013-11-13 | 协同医药品公司 | 有效用于胃肠功能紊乱、炎症、癌症和其他疾病治疗的鸟苷酸环化酶激动剂 |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| HK1220611A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 用於治疗胃肠道病症的组成物 |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| HRP20240805T1 (hr) | 2013-06-05 | 2024-09-27 | Bausch Health Ireland Limited | Ultra-pročišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i uporabe |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2607004B1 (fr) * | 1986-11-20 | 1990-06-01 | Synthelabo | Compositions pharmaceutiques contenant du diltiazem et un inhibiteur de l'enzyme de conversion de l'angiotensine |
| US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
| CA2020073A1 (en) * | 1989-07-03 | 1991-01-04 | Eric E. Allen | Substituted quinazolinones as angiotensin ii antagonists |
| DK0565634T3 (da) * | 1990-12-14 | 1999-09-27 | Smithkline Beecham Corp | Angiotensin-II-receptorblokkersammensætninger |
-
1992
- 1992-05-13 NZ NZ242724A patent/NZ242724A/xx not_active IP Right Cessation
- 1992-05-14 EP EP92912707A patent/EP0584250A1/en not_active Withdrawn
- 1992-05-14 CA CA002103276A patent/CA2103276A1/en not_active Abandoned
- 1992-05-14 IL IL10185892A patent/IL101858A/en not_active IP Right Cessation
- 1992-05-14 MX MX9202243A patent/MX9202243A/es unknown
- 1992-05-14 JP JP5500110A patent/JP2930252B2/ja not_active Expired - Lifetime
- 1992-05-14 CZ CS932351A patent/CZ281570B6/cs not_active IP Right Cessation
- 1992-05-14 WO PCT/US1992/003873 patent/WO1992020342A1/en not_active Ceased
- 1992-05-14 AU AU20269/92A patent/AU664375B2/en not_active Expired
- 1992-05-15 ZA ZA923557A patent/ZA923557B/xx unknown
- 1992-07-01 IE IE153492A patent/IE921534A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06508128A (ja) | 1994-09-14 |
| IL101858A (en) | 1996-08-04 |
| WO1992020342A1 (en) | 1992-11-26 |
| AU2026992A (en) | 1992-12-30 |
| JP2930252B2 (ja) | 1999-08-03 |
| CA2103276A1 (en) | 1992-11-16 |
| EP0584250A1 (en) | 1994-03-02 |
| EP0584250A4 (enExample) | 1994-03-30 |
| CZ235193A3 (en) | 1994-03-16 |
| CZ281570B6 (cs) | 1996-11-13 |
| ZA923557B (en) | 1993-11-15 |
| IL101858A0 (en) | 1992-12-30 |
| AU664375B2 (en) | 1995-11-16 |
| MX9202243A (es) | 1992-11-01 |
| NZ242724A (en) | 1994-09-27 |
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| Date | Code | Title | Description |
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| FC9A | Application refused sect. 31(1) |