KR910007927A - 축합 이미다졸 유도체 및 이의 제조방법 - Google Patents
축합 이미다졸 유도체 및 이의 제조방법 Download PDFInfo
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- KR910007927A KR910007927A KR1019900017392A KR900017392A KR910007927A KR 910007927 A KR910007927 A KR 910007927A KR 1019900017392 A KR1019900017392 A KR 1019900017392A KR 900017392 A KR900017392 A KR 900017392A KR 910007927 A KR910007927 A KR 910007927A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (16)
- 일반식 (I)의 화합물 및 이의 약학적으로 허용되는 염.상기식에서 R1은 저급알킬, 할로(저급)알킬, 시클로(저급)알킬 또는 저급알킬티오 이고, R2은 수소 또는 이미노-보호그룹이고, R3는 수소 또는 할로겐이고, A는 저급 알킬렌이며,는 하기 일반식의 그룹이다 :[여기에서 X1, X2, X3및 X4는 각각 N 또는 CR4(R4는 수소, 저급 알킬, 저급알콕시, 할로겐, 할로(저급)알킬, 에스테르화된 카복시, 할로(저급)알콕시 또는 하이드록시이다)이다. 단, X1, X2, X3및 X4중 적어도 하나는 N이다]
- 제1항에 있어서 R2가 수소 또는 아르(저급) 알킬이고,가 하기 일반식의 그룹인 화합물.상기식에서 X1, X2, X3및 X4는 각각 N 또는 CR4(R4는 수소, 저급 알킬, 저급알콕시, 할로겐, 할로(저급)알콕시 또는 하이드록시이다)이다.
- 제2항에 있어서, X1, X2및 X3가 각각 CR4(R4는 제2항에 정의한 바와 같다)이고 X4가 N인 화합물.
- 제3항에 있어서, R1이 프로필, 부틸, 펜틸, 프리플루오로메틸프로필, 시클로프로필, 시클로헥실, 에틸티오 또는 프로필티도이고, R2가 수소이고, R3가 수소 또는 플루오로이고, A가 메틸렌 또는 메틸메틸렌이며, R4가 수소, 메틸, 메톡시, 클로로, 브로모, 트리플루오로에톡시 또는 하이드록시인 화합물.
- 제4항에 있어서, R1이 부틸이고, R3가 수소이고, A가 메틸렌이고, X1이 CR4(R4는 수소 또는 메틸이다)이며, X2및 X3가 각각 CH인 화합물.
- 제5항에 있어서, 2-부틸-3-[[2'-(1H-테트라졸-5-일]비페닐-4-일]메틸]-3H-이미디조 [4.5-b]피리딘 또는 이의 나트륨염.
- 제5항에 있어서, 2-부틸-7-메틸-3-[[2'-(1H-테트라졸-5-일]비페닐-4-일]메틸]-3H-이미디조 [4.5-b]피리딘 또는 이의 나트륨염.
- 제1항에 있어서,가 하기 일반식의 그룹인 화합물.
- 일반식(II)의 화합물을 테트라졸 그룹의 형성 반응에 의해 반응시켜 일반식(I)의 화합물 또는 이의 염을 수득하거나; 일반식(III)의 화합물 또는 이의 염을 일반식(IV)의 화합물 또는 이의 염과 반응시켜 일반식(I)의 화합물 또는 이의 염을 수득하거나; 일반식(Ia)의 화합물을 이미노-보호그룹의 제거 반응에 의해 반응시켜 일반식(Ib)의 화합물 또는 이의 염을 수득하거나; 일반식(V)의 화합물 또는 이의 염을 이미다졸 그룹 및 테트라졸 그룹의 형성반응에 의해 반응시켜 일반식(I)의 화합물 또는 이의 염을 수득하거나; 일반식(VI)의 화합물 또는 이의 염을 이미다졸 그룹의 형성반응에 의해 반응시켜 일반식(I)의 화합물 또는 이의 염을 수득함으로써, 일반식(I)의 화합물 또는 이의 염을 제조하는 방법.상기 식에서, R1은 저급알킬, 할로(저급)알킬, 시클로(저급)알킬 또는 저급알킬티오이고, R2수소 또는 이미노-보호그룹이고, R2는 이미노-보호그룹이고, R3는 수소 또는 할로겐이고, R5는 산 잔기이고, A는 저급 알킬렌이며,는 하기 일반식의 그룹이다 :[여기에서 X1, X2, X3및 X4는 각각 N 또는 CR4(R4는 수소, 저급 알킬, 저급알콕시, 할로겐, 할로(저급)알킬, 에스테르화된 카복시, 할로(저급)알콕시 또는 하이드록시이다)이다. 단, X1, X2, X3및 X4중 적어도 하나는 N이다]
- 약학적으로 허용되는 비-독성 담체 또는 부형제와 함께 제1항의 화합물 또는 이의 약학적으로 허용되는 염으로 이루어진 약학적 조성물.
- 제1항의 화합물 또는 이의 약학적으로 허용되는 염을 사람 또는 동물에게 투여함으로써 안지오덴신 II 매개된 질병을 치료하거나 예방하는 방법.
- 제1항의 화합물 또는 이의 약학적으로 허용되는 염을 사람 또는 동물에게 투여함으로써 고혈압 또는 심부전증을 치료하거나 예방하는 방법.
- 제1항의 화합물 또는 이의 약학적으로 허용되는 염을 약제로서 사용하기 위한 용도.
- 제1항의 화합물 또는 이의 약학적으로 허용되는 염을 안지오덴신 II 길항제로서 사용하기 위한 용도.
- 안지오텐신 II 매개된 질병을 치료하거나 예방하는 약제를 제조하기 위한 제1항의 화합물의 용도.
- 약학적으로 허용되는 비-독성 담체 또는 부형체와 함께 제1항의 화합물을 혼합함으로써 약학적 조성물을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8924458.6 | 1989-10-31 | ||
GB898924458A GB8924458D0 (en) | 1989-10-31 | 1989-10-31 | Condensed imidazole derivatives and a process for preparation thereof |
GB898929069A GB8929069D0 (en) | 1989-12-22 | 1989-12-22 | Condensed imidazole derivatives and process for preparation thereof |
GB8929069.6 | 1989-12-22 | ||
GB9011336.6 | 1990-05-21 | ||
GB909011336A GB9011336D0 (en) | 1990-05-21 | 1990-05-21 | Condensed imidazole derivatives and process for preparation thereof |
Publications (1)
Publication Number | Publication Date |
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KR910007927A true KR910007927A (ko) | 1991-05-30 |
Family
ID=27264770
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019900017392A KR910007927A (ko) | 1989-10-31 | 1990-10-30 | 축합 이미다졸 유도체 및 이의 제조방법 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0426021A1 (ko) |
JP (2) | JPH03188076A (ko) |
KR (1) | KR910007927A (ko) |
CN (1) | CN1051358A (ko) |
AU (1) | AU6560390A (ko) |
CA (1) | CA2028880A1 (ko) |
FI (1) | FI905200A0 (ko) |
HU (1) | HUT55779A (ko) |
IE (1) | IE903815A1 (ko) |
IL (1) | IL96019A0 (ko) |
NO (1) | NO904694L (ko) |
PH (1) | PH27020A (ko) |
PT (1) | PT95745A (ko) |
Families Citing this family (57)
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EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CN104163792B (zh) * | 2013-05-20 | 2017-04-12 | 湖南化工研究院 | N‑吡啶酰胺类化合物及其制备方法与应用 |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
EP0400835A1 (en) * | 1989-05-15 | 1990-12-05 | Merck & Co. Inc. | Substituted benzimidazoles as angiotensin II antagonists |
-
1990
- 1990-10-16 IL IL96019A patent/IL96019A0/xx unknown
- 1990-10-23 FI FI905200A patent/FI905200A0/fi not_active Application Discontinuation
- 1990-10-23 IE IE381590A patent/IE903815A1/en unknown
- 1990-10-23 PH PH41436A patent/PH27020A/en unknown
- 1990-10-26 EP EP90120543A patent/EP0426021A1/en not_active Withdrawn
- 1990-10-29 AU AU65603/90A patent/AU6560390A/en not_active Abandoned
- 1990-10-30 PT PT95745A patent/PT95745A/pt not_active Application Discontinuation
- 1990-10-30 HU HU906947A patent/HUT55779A/hu unknown
- 1990-10-30 CN CN90108723A patent/CN1051358A/zh active Pending
- 1990-10-30 CA CA002028880A patent/CA2028880A1/en not_active Abandoned
- 1990-10-30 JP JP2294869A patent/JPH03188076A/ja active Pending
- 1990-10-30 NO NO90904694A patent/NO904694L/no unknown
- 1990-10-30 KR KR1019900017392A patent/KR910007927A/ko not_active Application Discontinuation
- 1990-10-31 JP JP2296456A patent/JPH03184976A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PH27020A (en) | 1993-02-01 |
JPH03184976A (ja) | 1991-08-12 |
CN1051358A (zh) | 1991-05-15 |
IL96019A0 (en) | 1991-07-18 |
CA2028880A1 (en) | 1991-05-01 |
FI905200A0 (fi) | 1990-10-23 |
HU906947D0 (en) | 1991-05-28 |
NO904694D0 (no) | 1990-10-30 |
EP0426021A1 (en) | 1991-05-08 |
AU6560390A (en) | 1991-05-09 |
JPH03188076A (ja) | 1991-08-16 |
NO904694L (no) | 1991-05-02 |
IE903815A1 (en) | 1991-05-08 |
PT95745A (pt) | 1991-09-13 |
HUT55779A (en) | 1991-06-28 |
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