IE912533A1 - Novel substituted thiazolyl and substituted pyridinyl¹derivatives - Google Patents

Novel substituted thiazolyl and substituted pyridinyl¹derivatives

Info

Publication number
IE912533A1
IE912533A1 IE253391A IE253391A IE912533A1 IE 912533 A1 IE912533 A1 IE 912533A1 IE 253391 A IE253391 A IE 253391A IE 253391 A IE253391 A IE 253391A IE 912533 A1 IE912533 A1 IE 912533A1
Authority
IE
Ireland
Prior art keywords
formula
compound
alkyl
radical
hydrogen
Prior art date
Application number
IE253391A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of IE912533A1 publication Critical patent/IE912533A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IE253391A 1990-07-19 1991-07-18 Novel substituted thiazolyl and substituted pyridinyl¹derivatives IE912533A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55432590A 1990-07-19 1990-07-19

Publications (1)

Publication Number Publication Date
IE912533A1 true IE912533A1 (en) 1992-01-29

Family

ID=24212925

Family Applications (1)

Application Number Title Priority Date Filing Date
IE253391A IE912533A1 (en) 1990-07-19 1991-07-18 Novel substituted thiazolyl and substituted pyridinyl¹derivatives

Country Status (27)

Country Link
EP (1) EP0539420B1 (enrdf_load_stackoverflow)
JP (1) JP3085707B2 (enrdf_load_stackoverflow)
KR (1) KR100206723B1 (enrdf_load_stackoverflow)
CN (1) CN1037770C (enrdf_load_stackoverflow)
AT (1) ATE188477T1 (enrdf_load_stackoverflow)
AU (1) AU646280B2 (enrdf_load_stackoverflow)
CA (1) CA2086546A1 (enrdf_load_stackoverflow)
CZ (1) CZ279903B6 (enrdf_load_stackoverflow)
DE (1) DE69131895T2 (enrdf_load_stackoverflow)
DK (1) DK0539420T3 (enrdf_load_stackoverflow)
ES (1) ES2142802T3 (enrdf_load_stackoverflow)
FI (1) FI102753B (enrdf_load_stackoverflow)
GR (1) GR3032999T3 (enrdf_load_stackoverflow)
HU (1) HU221298B1 (enrdf_load_stackoverflow)
IE (1) IE912533A1 (enrdf_load_stackoverflow)
IL (1) IL98865A (enrdf_load_stackoverflow)
MX (1) MX9100307A (enrdf_load_stackoverflow)
NO (1) NO304791B1 (enrdf_load_stackoverflow)
NZ (1) NZ238863A (enrdf_load_stackoverflow)
PH (1) PH31063A (enrdf_load_stackoverflow)
PL (1) PL170580B1 (enrdf_load_stackoverflow)
PT (1) PT98366B (enrdf_load_stackoverflow)
RU (1) RU2067978C1 (enrdf_load_stackoverflow)
SK (1) SK280690B6 (enrdf_load_stackoverflow)
TW (1) TW209217B (enrdf_load_stackoverflow)
WO (1) WO1992001697A1 (enrdf_load_stackoverflow)
ZA (1) ZA915654B (enrdf_load_stackoverflow)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
DK1196409T3 (da) 1999-06-28 2004-06-07 Janssen Pharmaceutica Nv Respiratoriske syncytilvirusreplikationsinhibitorer
WO2001000615A1 (en) * 1999-06-28 2001-01-04 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
TR200103804T2 (tr) 1999-06-28 2002-05-21 Janssen Pharmaceutica N.V. Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler
CN1257169C (zh) * 1999-10-08 2006-05-24 格吕伦塔尔有限公司 双环咪唑－3－基－胺衍生物
BRPI0406761A (pt) 2003-01-14 2005-12-20 Arena Pharm Inc Derivados de arila e heteroarila 1,2,3-trissubstituìdos como moduladores do metabolismo e a profilaxia e tratamento de distúrbios relacionados a estes tais como diabetes e hiper-glicemia
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
RU2239637C1 (ru) * 2003-07-17 2004-11-10 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Улучшенный способ получения 5-[2-этокси-5-(4-метилпиперазин-1-илсульфонил)фенил]-1 метил-3-н-пропил-1,6-дигидро-7h-пиразол [4,3-d] пиримидин-7-она
RU2264814C2 (ru) * 2003-12-29 2005-11-27 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Антигистаминная фармацевтическая композиция
ATE460402T1 (de) * 2004-05-12 2010-03-15 Bristol Myers Squibb Co Für die behandlung von thrombotischen leiden geeignete harnstoffantagonisten des p2y1- rezeptors
DE102004044884A1 (de) * 2004-09-14 2006-05-24 Grünenthal GmbH Substituierte bizyklische Imidazo-3-yl-amin-Verbindungen
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
PE20131371A1 (es) 2010-09-22 2013-11-25 Arena Pharm Inc Moduladores del receptor gpr119 y el tratamiento de trastornos relacionados con este
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
KR102595163B1 (ko) 2015-01-06 2023-10-30 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 상태의 치료 방법
ES2929526T3 (es) 2015-06-22 2022-11-29 Arena Pharm Inc Sal cristalina de L-arginina del ácido (R)-2-(7-(4-ciclopentil-3-(trifluorometil)benciloxi)-1,2,3,4-tetrahidrociclo-penta[b]indol-3-il)acético para su uso en trastornos asociados al receptor S1P1
MA52778A (fr) 2018-06-06 2021-04-21 Arena Pharm Inc Méthodes de traitement de troubles associés au récepteur s1p1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
DE3701863A1 (de) * 1987-01-23 1988-08-04 Standard Elektrik Lorenz Ag Sender zur kohaerent optischen nachrichtenuebertragung
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives

Also Published As

Publication number Publication date
EP0539420A1 (en) 1993-05-05
CS223991A3 (en) 1992-02-19
CA2086546A1 (en) 1992-01-20
HU221298B1 (en) 2002-09-28
GR3032999T3 (en) 2000-07-31
FI930199A7 (fi) 1993-01-18
NO930139D0 (no) 1993-01-15
CZ279903B6 (cs) 1995-08-16
AU646280B2 (en) 1994-02-17
AU8209391A (en) 1992-02-18
PT98366A (pt) 1992-05-29
ZA915654B (en) 1993-03-31
NZ238863A (en) 1993-03-26
FI930199A0 (fi) 1993-01-18
WO1992001697A1 (en) 1992-02-06
DE69131895D1 (de) 2000-02-10
CN1058216A (zh) 1992-01-29
PL297612A1 (enrdf_load_stackoverflow) 1992-07-13
PL170580B1 (pl) 1997-01-31
TW209217B (enrdf_load_stackoverflow) 1993-07-11
IL98865A (en) 1995-11-27
ATE188477T1 (de) 2000-01-15
KR100206723B1 (ko) 1999-07-01
JPH05508638A (ja) 1993-12-02
NO304791B1 (no) 1999-02-15
MX9100307A (es) 1992-02-28
DE69131895T2 (de) 2000-07-20
FI102753B1 (fi) 1999-02-15
IL98865A0 (en) 1992-07-15
CN1037770C (zh) 1998-03-18
FI102753B (fi) 1999-02-15
NO930139L (no) 1993-01-15
HUT64066A (en) 1993-11-29
JP3085707B2 (ja) 2000-09-11
DK0539420T3 (da) 2000-05-29
HU9300096D0 (en) 1993-04-28
PT98366B (pt) 1999-01-29
SK280690B6 (sk) 2000-06-12
ES2142802T3 (es) 2000-05-01
RU2067978C1 (ru) 1996-10-20
EP0539420B1 (en) 2000-01-05
PH31063A (en) 1998-02-05

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Legal Events

Date Code Title Description
FJ9A Application deemed to be withdrawn section 31(3)