IE871769L - Fluorooxirane carboxylates - Google Patents

Fluorooxirane carboxylates

Info

Publication number
IE871769L
IE871769L IE871769A IE176987A IE871769L IE 871769 L IE871769 L IE 871769L IE 871769 A IE871769 A IE 871769A IE 176987 A IE176987 A IE 176987A IE 871769 L IE871769 L IE 871769L
Authority
IE
Ireland
Prior art keywords
antibodies
fluorooxirane
carboxylates
monoclonal antibodies
bind
Prior art date
Application number
IE871769A
Other versions
IE60888B1 (en
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/946,554 external-priority patent/US4834976A/en
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of IE871769L publication Critical patent/IE871769L/en
Publication of IE60888B1 publication Critical patent/IE60888B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Cell lines have been produced that secrete monoclonal antibodies which bind to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, can be used singly or in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, to form prophylactic and therapeutic compositions. <IMAGE> [DE3722098A1]
IE176987A 1986-07-03 1987-07-02 Monoclonal antibodies to pseudomonas aeruginosa flagella IE60888B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88198486A 1986-07-03 1986-07-03
US06/946,554 US4834976A (en) 1986-07-03 1986-12-24 Monoclonal antibodies to pseudomonas aeruginosa flagella
US4814387A 1987-05-15 1987-05-15

Publications (2)

Publication Number Publication Date
IE871769L true IE871769L (en) 1988-01-03
IE60888B1 IE60888B1 (en) 1994-08-24

Family

ID=27367280

Family Applications (1)

Application Number Title Priority Date Filing Date
IE176987A IE60888B1 (en) 1986-07-03 1987-07-02 Monoclonal antibodies to pseudomonas aeruginosa flagella

Country Status (19)

Country Link
JP (1) JP2639422B2 (en)
KR (1) KR910002373B1 (en)
AT (1) AT399885B (en)
AU (1) AU615162B2 (en)
BE (1) BE1000743A3 (en)
CH (1) CH677796A5 (en)
DE (1) DE3722098C2 (en)
DK (1) DK172840B1 (en)
ES (1) ES2013321A6 (en)
FR (1) FR2601458B1 (en)
GB (1) GB2192185B (en)
IE (1) IE60888B1 (en)
IL (1) IL83047A (en)
IT (1) IT1221940B (en)
LU (1) LU86938A1 (en)
NL (1) NL194961C (en)
OA (1) OA08629A (en)
PT (1) PT85247B (en)
SE (1) SE506421C2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772464A (en) * 1985-08-01 1988-09-20 Miles Laboratories, Inc. Protective antibodies to serotypic determinants of flagellar antigens
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
GB2192185B (en) * 1986-07-03 1991-01-16 Genetic Systems Corp Monoclonal antibodies to pseudomonas aeruginosa flagella
CA1341375C (en) * 1988-10-12 2002-07-09 Baxter International Inc. Compositions and methods for the treatment and prevention of gram-negative bacterial infections
JPH02299594A (en) * 1989-01-30 1990-12-11 Sumitomo Chem Co Ltd Human monoclonal antibody and production thereof
WO1990013033A1 (en) * 1989-04-14 1990-11-01 Biocontrol Systems, Incorporated Process and device for detecting a particular motile organism
SG50585A1 (en) * 1990-01-18 1998-07-20 Cura Nominees Pty Ltd Glycoalkaloids
US20100272736A1 (en) * 2009-02-04 2010-10-28 Kalobios Pharmaceuticals, Inc. Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection
EP2542577A1 (en) * 2010-03-01 2013-01-09 Lostam Biopharmaceuticals Ltd Improved therapeutic antibodies against flagellated pseudomonas aeruginosa

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422649D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
JP2691708B2 (en) * 1984-09-26 1997-12-17 住友製薬株式会社 Human monoclonal antibody and method for producing the same
HU205630B (en) * 1985-06-06 1992-05-28 Genetic Systems Corp Process for producing monoclonal antibodys inhibiting exotoxine and toxic effect of pseudomonas aeruginosa and specific for them, celle lines producing them and pharmaceutical compositions
DE3689713T2 (en) * 1985-08-01 1994-07-07 Miles Inc Protective antibodies against serotypic determinants of flagellar antigens.
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
ZA868673B (en) * 1985-12-10 1988-07-27 Genetic Systems Corp Monoclonal antibodies cross-reactive and cross-protective against p.aeruginosa serotypes
GB2192185B (en) * 1986-07-03 1991-01-16 Genetic Systems Corp Monoclonal antibodies to pseudomonas aeruginosa flagella

Also Published As

Publication number Publication date
PT85247B (en) 1990-06-29
SE506421C2 (en) 1997-12-15
KR910002373B1 (en) 1991-04-20
DK336687D0 (en) 1987-06-30
AU615162B2 (en) 1991-09-26
GB8715347D0 (en) 1987-08-05
DK172840B1 (en) 1999-08-09
OA08629A (en) 1988-11-30
CH677796A5 (en) 1991-06-28
IL83047A0 (en) 1987-12-31
JP2639422B2 (en) 1997-08-13
LU86938A1 (en) 1988-02-02
GB2192185B (en) 1991-01-16
DE3722098A1 (en) 1988-03-03
NL8701554A (en) 1988-02-01
AU7495887A (en) 1988-01-07
NL194961B (en) 2003-05-01
KR880001815A (en) 1988-04-27
SE8702734D0 (en) 1987-07-02
PT85247A (en) 1987-08-01
FR2601458A1 (en) 1988-01-15
IT8721163A0 (en) 1987-07-02
IT1221940B (en) 1990-08-31
DK336687A (en) 1988-01-04
DE3722098C2 (en) 1998-06-04
IE60888B1 (en) 1994-08-24
IL83047A (en) 1992-12-01
BE1000743A3 (en) 1989-03-28
AT399885B (en) 1995-08-25
SE8702734L (en) 1988-01-04
NL194961C (en) 2003-09-02
ES2013321A6 (en) 1990-05-01
GB2192185A (en) 1988-01-06
FR2601458B1 (en) 1992-08-21
JPS63102697A (en) 1988-05-07
ATA168387A (en) 1994-12-15

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Legal Events

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MK9A Patent expired