SE8702734L - MONOCLONAL ANTIBODIES AGAINST PSEUDOMONAS AERUGINOSA FLAGELS - Google Patents

MONOCLONAL ANTIBODIES AGAINST PSEUDOMONAS AERUGINOSA FLAGELS

Info

Publication number
SE8702734L
SE8702734L SE8702734A SE8702734A SE8702734L SE 8702734 L SE8702734 L SE 8702734L SE 8702734 A SE8702734 A SE 8702734A SE 8702734 A SE8702734 A SE 8702734A SE 8702734 L SE8702734 L SE 8702734L
Authority
SE
Sweden
Prior art keywords
monoclonal antibodies
pseudomonas aeruginosa
flagels
antibodies against
antibodies
Prior art date
Application number
SE8702734A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE506421C2 (en
SE8702734D0 (en
Inventor
M E Lostrom
A W Siadak
M J Rosok
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/946,554 external-priority patent/US4834976A/en
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of SE8702734D0 publication Critical patent/SE8702734D0/en
Publication of SE8702734L publication Critical patent/SE8702734L/en
Publication of SE506421C2 publication Critical patent/SE506421C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cell lines have been produced that secrete monoclonal antibodies which bind to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, can be used singly or in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, to form prophylactic and therapeutic compositions. <IMAGE>
SE8702734A 1986-07-03 1987-07-02 Monoclonal antibodies to Pseudomonas aeruginosa and preparations containing them, test kit containing the preparation, and cell lines expressing the antibodies SE506421C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88198486A 1986-07-03 1986-07-03
US06/946,554 US4834976A (en) 1986-07-03 1986-12-24 Monoclonal antibodies to pseudomonas aeruginosa flagella
US4814387A 1987-05-15 1987-05-15

Publications (3)

Publication Number Publication Date
SE8702734D0 SE8702734D0 (en) 1987-07-02
SE8702734L true SE8702734L (en) 1988-01-04
SE506421C2 SE506421C2 (en) 1997-12-15

Family

ID=27367280

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8702734A SE506421C2 (en) 1986-07-03 1987-07-02 Monoclonal antibodies to Pseudomonas aeruginosa and preparations containing them, test kit containing the preparation, and cell lines expressing the antibodies

Country Status (19)

Country Link
JP (1) JP2639422B2 (en)
KR (1) KR910002373B1 (en)
AT (1) AT399885B (en)
AU (1) AU615162B2 (en)
BE (1) BE1000743A3 (en)
CH (1) CH677796A5 (en)
DE (1) DE3722098C2 (en)
DK (1) DK172840B1 (en)
ES (1) ES2013321A6 (en)
FR (1) FR2601458B1 (en)
GB (1) GB2192185B (en)
IE (1) IE60888B1 (en)
IL (1) IL83047A (en)
IT (1) IT1221940B (en)
LU (1) LU86938A1 (en)
NL (1) NL194961C (en)
OA (1) OA08629A (en)
PT (1) PT85247B (en)
SE (1) SE506421C2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772464A (en) * 1985-08-01 1988-09-20 Miles Laboratories, Inc. Protective antibodies to serotypic determinants of flagellar antigens
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
AU615162B2 (en) * 1986-07-03 1991-09-26 Genetic Systems Corporation Monoclonal antibodies to pseudomonas aeruginosa flagella
CA1341375C (en) * 1988-10-12 2002-07-09 Baxter International Inc. Compositions and methods for the treatment and prevention of gram-negative bacterial infections
JPH02299594A (en) * 1989-01-30 1990-12-11 Sumitomo Chem Co Ltd Human monoclonal antibody and production thereof
WO1990013033A1 (en) * 1989-04-14 1990-11-01 Biocontrol Systems, Incorporated Process and device for detecting a particular motile organism
AU654474B2 (en) * 1990-01-18 1994-11-10 Cura Nominees Pty Ltd Glycoalkaloids
JP2012516897A (en) * 2009-02-04 2012-07-26 カロバイオス ファーマシューティカルズ インコーポレイティッド Combination of antibiotics and antibody therapy for the treatment of Pseudomonas aeruginosa infection
US8653242B2 (en) 2010-03-01 2014-02-18 Lostam Pharmaceuticals Ltd. Therapeutic antibodies against flagellated Pseudomonas aeruginosa

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8422649D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
JP2691708B2 (en) * 1984-09-26 1997-12-17 住友製薬株式会社 Human monoclonal antibody and method for producing the same
HU205630B (en) * 1985-06-06 1992-05-28 Genetic Systems Corp Process for producing monoclonal antibodys inhibiting exotoxine and toxic effect of pseudomonas aeruginosa and specific for them, celle lines producing them and pharmaceutical compositions
DE3689713T2 (en) * 1985-08-01 1994-07-07 Miles Inc Protective antibodies against serotypic determinants of flagellar antigens.
US4918163A (en) * 1985-09-27 1990-04-17 Pfizer Inc. Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria
ZA868673B (en) * 1985-12-10 1988-07-27 Genetic Systems Corp Monoclonal antibodies cross-reactive and cross-protective against p.aeruginosa serotypes
NZ218499A (en) * 1985-12-10 1990-04-26 Genetic Systems Corp Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods
AU615162B2 (en) * 1986-07-03 1991-09-26 Genetic Systems Corporation Monoclonal antibodies to pseudomonas aeruginosa flagella

Also Published As

Publication number Publication date
SE506421C2 (en) 1997-12-15
NL8701554A (en) 1988-02-01
KR880001815A (en) 1988-04-27
ES2013321A6 (en) 1990-05-01
IE60888B1 (en) 1994-08-24
ATA168387A (en) 1994-12-15
IL83047A0 (en) 1987-12-31
PT85247A (en) 1987-08-01
NL194961C (en) 2003-09-02
DK336687D0 (en) 1987-06-30
GB8715347D0 (en) 1987-08-05
NL194961B (en) 2003-05-01
GB2192185A (en) 1988-01-06
BE1000743A3 (en) 1989-03-28
CH677796A5 (en) 1991-06-28
DK172840B1 (en) 1999-08-09
FR2601458A1 (en) 1988-01-15
GB2192185B (en) 1991-01-16
OA08629A (en) 1988-11-30
AT399885B (en) 1995-08-25
LU86938A1 (en) 1988-02-02
AU7495887A (en) 1988-01-07
JPS63102697A (en) 1988-05-07
FR2601458B1 (en) 1992-08-21
AU615162B2 (en) 1991-09-26
DE3722098A1 (en) 1988-03-03
JP2639422B2 (en) 1997-08-13
PT85247B (en) 1990-06-29
KR910002373B1 (en) 1991-04-20
DE3722098C2 (en) 1998-06-04
IE871769L (en) 1988-01-03
IT8721163A0 (en) 1987-07-02
SE8702734D0 (en) 1987-07-02
DK336687A (en) 1988-01-04
IT1221940B (en) 1990-08-31
IL83047A (en) 1992-12-01

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