ES2013321A6 - Monoclonal antibodies to Pseudomonas aeruginosaflagella - Google Patents
Monoclonal antibodies to Pseudomonas aeruginosaflagellaInfo
- Publication number
- ES2013321A6 ES2013321A6 ES878701936A ES8701936A ES2013321A6 ES 2013321 A6 ES2013321 A6 ES 2013321A6 ES 878701936 A ES878701936 A ES 878701936A ES 8701936 A ES8701936 A ES 8701936A ES 2013321 A6 ES2013321 A6 ES 2013321A6
- Authority
- ES
- Spain
- Prior art keywords
- monoclonal antibodies
- antibodies
- aeruginosaflagella
- pseudomonas
- bind
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Cell lines have been produced that secrete monoclonal antibodies which bind to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, can be used singly or in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, to form prophylactic and therapeutic compositions.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88198486A | 1986-07-03 | 1986-07-03 | |
US06/946,554 US4834976A (en) | 1986-07-03 | 1986-12-24 | Monoclonal antibodies to pseudomonas aeruginosa flagella |
US4814387A | 1987-05-15 | 1987-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2013321A6 true ES2013321A6 (en) | 1990-05-01 |
Family
ID=27367280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES878701936A Expired - Fee Related ES2013321A6 (en) | 1986-07-03 | 1987-07-02 | Monoclonal antibodies to Pseudomonas aeruginosaflagella |
Country Status (19)
Country | Link |
---|---|
JP (1) | JP2639422B2 (en) |
KR (1) | KR910002373B1 (en) |
AT (1) | AT399885B (en) |
AU (1) | AU615162B2 (en) |
BE (1) | BE1000743A3 (en) |
CH (1) | CH677796A5 (en) |
DE (1) | DE3722098C2 (en) |
DK (1) | DK172840B1 (en) |
ES (1) | ES2013321A6 (en) |
FR (1) | FR2601458B1 (en) |
GB (1) | GB2192185B (en) |
IE (1) | IE60888B1 (en) |
IL (1) | IL83047A (en) |
IT (1) | IT1221940B (en) |
LU (1) | LU86938A1 (en) |
NL (1) | NL194961C (en) |
OA (1) | OA08629A (en) |
PT (1) | PT85247B (en) |
SE (1) | SE506421C2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4772464A (en) * | 1985-08-01 | 1988-09-20 | Miles Laboratories, Inc. | Protective antibodies to serotypic determinants of flagellar antigens |
NZ218499A (en) * | 1985-12-10 | 1990-04-26 | Genetic Systems Corp | Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods |
GB2192185B (en) * | 1986-07-03 | 1991-01-16 | Genetic Systems Corp | Monoclonal antibodies to pseudomonas aeruginosa flagella |
CA1341375C (en) * | 1988-10-12 | 2002-07-09 | Baxter International Inc. | Compositions and methods for the treatment and prevention of gram-negative bacterial infections |
JPH02299594A (en) * | 1989-01-30 | 1990-12-11 | Sumitomo Chem Co Ltd | Human monoclonal antibody and production thereof |
WO1990013033A1 (en) * | 1989-04-14 | 1990-11-01 | Biocontrol Systems, Incorporated | Process and device for detecting a particular motile organism |
DE69131861T2 (en) * | 1990-01-18 | 2000-05-18 | Cura Nominees Pty Ltd | GLYCOAL CALALID |
EP2393515A1 (en) * | 2009-02-04 | 2011-12-14 | Kalobios Pharmaceuticals, Inc. | Combination antibiotic and antibody therapy for the treatment of pseudomonas aeruginosa infection |
EP2542577A1 (en) * | 2010-03-01 | 2013-01-09 | Lostam Biopharmaceuticals Ltd | Improved therapeutic antibodies against flagellated pseudomonas aeruginosa |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8422649D0 (en) * | 1984-09-07 | 1984-10-10 | Technology Licence Co Ltd | Monoclonal antibodies |
JP2691708B2 (en) * | 1984-09-26 | 1997-12-17 | 住友製薬株式会社 | Human monoclonal antibody and method for producing the same |
AU5991786A (en) * | 1985-06-06 | 1987-01-07 | Genetic Systems Corporation | Protective human monoclonal antibodies to pseudomonas aeruginosa exotoxin a |
EP0211352B1 (en) * | 1985-08-01 | 1994-03-16 | Miles Inc. | Protective antibodies to serotypic determinants of flagellar antigens |
US4918163A (en) * | 1985-09-27 | 1990-04-17 | Pfizer Inc. | Monoclonal antibodies specific for lipid-A determinants of gram negative bacteria |
ZA868673B (en) * | 1985-12-10 | 1988-07-27 | Genetic Systems Corp | Monoclonal antibodies cross-reactive and cross-protective against p.aeruginosa serotypes |
NZ218499A (en) * | 1985-12-10 | 1990-04-26 | Genetic Systems Corp | Monoclonal antibodies against pseudomonas aeruginosa, pharmaceutical compositions and detection methods |
GB2192185B (en) * | 1986-07-03 | 1991-01-16 | Genetic Systems Corp | Monoclonal antibodies to pseudomonas aeruginosa flagella |
-
1987
- 1987-06-30 GB GB8715347A patent/GB2192185B/en not_active Expired - Lifetime
- 1987-06-30 DK DK198703366A patent/DK172840B1/en not_active IP Right Cessation
- 1987-06-30 AU AU74958/87A patent/AU615162B2/en not_active Expired
- 1987-07-01 IL IL83047A patent/IL83047A/en not_active IP Right Cessation
- 1987-07-02 JP JP62166234A patent/JP2639422B2/en not_active Expired - Lifetime
- 1987-07-02 IE IE176987A patent/IE60888B1/en not_active IP Right Cessation
- 1987-07-02 SE SE8702734A patent/SE506421C2/en not_active IP Right Cessation
- 1987-07-02 NL NL8701554A patent/NL194961C/en not_active IP Right Cessation
- 1987-07-02 ES ES878701936A patent/ES2013321A6/en not_active Expired - Fee Related
- 1987-07-02 IT IT21163/87A patent/IT1221940B/en active
- 1987-07-02 FR FR878709370A patent/FR2601458B1/en not_active Expired - Lifetime
- 1987-07-03 AT AT0168387A patent/AT399885B/en not_active IP Right Cessation
- 1987-07-03 KR KR1019870007069A patent/KR910002373B1/en not_active IP Right Cessation
- 1987-07-03 CH CH2545/87A patent/CH677796A5/de not_active IP Right Cessation
- 1987-07-03 PT PT85247A patent/PT85247B/en unknown
- 1987-07-03 OA OA59157A patent/OA08629A/en unknown
- 1987-07-03 LU LU86938A patent/LU86938A1/en unknown
- 1987-07-03 BE BE8700743A patent/BE1000743A3/en not_active IP Right Cessation
- 1987-07-03 DE DE3722098A patent/DE3722098C2/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20070703 |