IE861494L - Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a - Google Patents
Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin aInfo
- Publication number
- IE861494L IE861494L IE861494A IE149486A IE861494L IE 861494 L IE861494 L IE 861494L IE 861494 A IE861494 A IE 861494A IE 149486 A IE149486 A IE 149486A IE 861494 L IE861494 L IE 861494L
- Authority
- IE
- Ireland
- Prior art keywords
- exotoxin
- monoclonal antibodies
- human monoclonal
- antibodies
- protective human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
[WO8607382A1]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74217085A | 1985-06-06 | 1985-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
IE861494L true IE861494L (en) | 1986-12-06 |
Family
ID=24983768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE861494A IE861494L (en) | 1985-06-06 | 1986-06-05 | Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0229107A4 (en) |
JP (1) | JPS63500035A (en) |
AU (2) | AU5991786A (en) |
DK (1) | DK59387A (en) |
ES (1) | ES8707296A1 (en) |
FI (1) | FI870482A (en) |
HU (1) | HU205630B (en) |
IE (1) | IE861494L (en) |
IL (1) | IL79010A0 (en) |
NO (1) | NO174003C (en) |
WO (1) | WO1986007382A1 (en) |
ZA (1) | ZA864196B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2192185B (en) * | 1986-07-03 | 1991-01-16 | Genetic Systems Corp | Monoclonal antibodies to pseudomonas aeruginosa flagella |
JPS6463374A (en) * | 1987-09-03 | 1989-03-09 | Agency Ind Science Techn | Human monoclonal antibody, antibody-forming cell, antibody-forming hybridoma and production of antibody |
US5126259A (en) * | 1987-12-24 | 1992-06-30 | Takeda Chemical Industries, Ltd. | Human b. lymphoblastoid cell, hybridoma, antibody and production of antibody |
CA1341375C (en) * | 1988-10-12 | 2002-07-09 | Baxter International Inc. | Compositions and methods for the treatment and prevention of gram-negative bacterial infections |
EP0382031A3 (en) * | 1989-02-10 | 1991-06-26 | Miles Inc. | Monoclonal antibodies in immune serum globulin |
JP2012516897A (en) * | 2009-02-04 | 2012-07-26 | カロバイオス ファーマシューティカルズ インコーポレイティッド | Combination of antibiotics and antibody therapy for the treatment of Pseudomonas aeruginosa infection |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4464465A (en) * | 1982-04-05 | 1984-08-07 | Genetic Systems Corporation | Cell-driven viral transfer in eukaryotes |
AU567693B2 (en) * | 1982-09-30 | 1987-12-03 | University Of Rochester | Human monoclonal antibodies against bacterial toxins |
US5179018A (en) * | 1983-10-14 | 1993-01-12 | Centocor, Inc. | Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria |
GB8422649D0 (en) * | 1984-09-07 | 1984-10-10 | Technology Licence Co Ltd | Monoclonal antibodies |
JP2691708B2 (en) * | 1984-09-26 | 1997-12-17 | 住友製薬株式会社 | Human monoclonal antibody and method for producing the same |
-
1986
- 1986-06-02 JP JP61503371A patent/JPS63500035A/en active Pending
- 1986-06-02 EP EP19860903954 patent/EP0229107A4/en not_active Withdrawn
- 1986-06-02 HU HU863265A patent/HU205630B/en not_active IP Right Cessation
- 1986-06-02 WO PCT/US1986/001204 patent/WO1986007382A1/en not_active Application Discontinuation
- 1986-06-02 AU AU59917/86A patent/AU5991786A/en not_active Abandoned
- 1986-06-03 IL IL79010A patent/IL79010A0/en not_active IP Right Cessation
- 1986-06-05 ES ES555741A patent/ES8707296A1/en not_active Expired
- 1986-06-05 IE IE861494A patent/IE861494L/en unknown
- 1986-06-05 ZA ZA864196A patent/ZA864196B/en unknown
-
1987
- 1987-02-05 DK DK059387A patent/DK59387A/en not_active Application Discontinuation
- 1987-02-05 NO NO870457A patent/NO174003C/en unknown
- 1987-02-05 FI FI870482A patent/FI870482A/en not_active IP Right Cessation
-
1990
- 1990-11-13 AU AU66583/90A patent/AU6658390A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FI870482A0 (en) | 1987-02-05 |
EP0229107A1 (en) | 1987-07-22 |
IL79010A0 (en) | 1986-09-30 |
FI870482A (en) | 1987-02-05 |
ZA864196B (en) | 1987-02-25 |
DK59387D0 (en) | 1987-02-05 |
NO174003B (en) | 1993-11-22 |
HU205630B (en) | 1992-05-28 |
DK59387A (en) | 1987-02-05 |
ES8707296A1 (en) | 1987-07-16 |
NO870457L (en) | 1987-02-05 |
ES555741A0 (en) | 1987-07-16 |
EP0229107A4 (en) | 1987-11-09 |
HUT42135A (en) | 1987-06-29 |
NO174003C (en) | 1994-03-02 |
JPS63500035A (en) | 1988-01-07 |
AU6658390A (en) | 1991-03-14 |
AU5991786A (en) | 1987-01-07 |
WO1986007382A1 (en) | 1986-12-18 |
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