IE861494L - Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a - Google Patents

Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a

Info

Publication number
IE861494L
IE861494L IE861494A IE149486A IE861494L IE 861494 L IE861494 L IE 861494L IE 861494 A IE861494 A IE 861494A IE 149486 A IE149486 A IE 149486A IE 861494 L IE861494 L IE 861494L
Authority
IE
Ireland
Prior art keywords
exotoxin
monoclonal antibodies
human monoclonal
antibodies
protective human
Prior art date
Application number
IE861494A
Original Assignee
Ti Group Services Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ti Group Services Ltd filed Critical Ti Group Services Ltd
Publication of IE861494L publication Critical patent/IE861494L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included. [WO8607382A1]
IE861494A 1985-06-06 1986-06-05 Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a IE861494L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74217085A 1985-06-06 1985-06-06

Publications (1)

Publication Number Publication Date
IE861494L true IE861494L (en) 1986-12-06

Family

ID=24983768

Family Applications (1)

Application Number Title Priority Date Filing Date
IE861494A IE861494L (en) 1985-06-06 1986-06-05 Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a

Country Status (12)

Country Link
EP (1) EP0229107A4 (en)
JP (1) JPS63500035A (en)
AU (2) AU5991786A (en)
DK (1) DK59387A (en)
ES (1) ES8707296A1 (en)
FI (1) FI870482A (en)
HU (1) HU205630B (en)
IE (1) IE861494L (en)
IL (1) IL79010A0 (en)
NO (1) NO174003C (en)
WO (1) WO1986007382A1 (en)
ZA (1) ZA864196B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2192185B (en) * 1986-07-03 1991-01-16 Genetic Systems Corp Monoclonal antibodies to pseudomonas aeruginosa flagella
JPS6463374A (en) * 1987-09-03 1989-03-09 Agency Ind Science Techn Human monoclonal antibody, antibody-forming cell, antibody-forming hybridoma and production of antibody
US5126259A (en) * 1987-12-24 1992-06-30 Takeda Chemical Industries, Ltd. Human b. lymphoblastoid cell, hybridoma, antibody and production of antibody
CA1341375C (en) * 1988-10-12 2002-07-09 Baxter International Inc. Compositions and methods for the treatment and prevention of gram-negative bacterial infections
EP0382031A3 (en) * 1989-02-10 1991-06-26 Miles Inc. Monoclonal antibodies in immune serum globulin
JP2012516897A (en) * 2009-02-04 2012-07-26 カロバイオス ファーマシューティカルズ インコーポレイティッド Combination of antibiotics and antibody therapy for the treatment of Pseudomonas aeruginosa infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464465A (en) * 1982-04-05 1984-08-07 Genetic Systems Corporation Cell-driven viral transfer in eukaryotes
AU567693B2 (en) * 1982-09-30 1987-12-03 University Of Rochester Human monoclonal antibodies against bacterial toxins
US5179018A (en) * 1983-10-14 1993-01-12 Centocor, Inc. Mamalian monoclonal antibodies against endotoxin of gram-negative bacteria
GB8422649D0 (en) * 1984-09-07 1984-10-10 Technology Licence Co Ltd Monoclonal antibodies
JP2691708B2 (en) * 1984-09-26 1997-12-17 住友製薬株式会社 Human monoclonal antibody and method for producing the same

Also Published As

Publication number Publication date
FI870482A0 (en) 1987-02-05
EP0229107A1 (en) 1987-07-22
IL79010A0 (en) 1986-09-30
FI870482A (en) 1987-02-05
ZA864196B (en) 1987-02-25
DK59387D0 (en) 1987-02-05
NO174003B (en) 1993-11-22
HU205630B (en) 1992-05-28
DK59387A (en) 1987-02-05
ES8707296A1 (en) 1987-07-16
NO870457L (en) 1987-02-05
ES555741A0 (en) 1987-07-16
EP0229107A4 (en) 1987-11-09
HUT42135A (en) 1987-06-29
NO174003C (en) 1994-03-02
JPS63500035A (en) 1988-01-07
AU6658390A (en) 1991-03-14
AU5991786A (en) 1987-01-07
WO1986007382A1 (en) 1986-12-18

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