IE61178B1 - Novel pharmacological compounds - Google Patents

Novel pharmacological compounds

Info

Publication number
IE61178B1
IE61178B1 IE312587A IE312587A IE61178B1 IE 61178 B1 IE61178 B1 IE 61178B1 IE 312587 A IE312587 A IE 312587A IE 312587 A IE312587 A IE 312587A IE 61178 B1 IE61178 B1 IE 61178B1
Authority
IE
Ireland
Prior art keywords
carbon atoms
alkyl
alkoxy
compound
compound according
Prior art date
Application number
IE312587A
Other languages
English (en)
Other versions
IE873125L (en
Inventor
Thomas Borje Alminger
Rolf Axel Bergman
Hans Bungaard
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE8604998A external-priority patent/SE8604998D0/xx
Priority claimed from SE8605551A external-priority patent/SE8605551D0/xx
Priority claimed from SE8704049A external-priority patent/SE8704049D0/xx
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of IE873125L publication Critical patent/IE873125L/xx
Publication of IE61178B1 publication Critical patent/IE61178B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE312587A 1986-11-21 1987-11-19 Novel pharmacological compounds IE61178B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8604998A SE8604998D0 (sv) 1986-11-21 1986-11-21 Novel pharmacological compounds
SE8605551A SE8605551D0 (sv) 1986-12-23 1986-12-23 Novel pharmacological compounds
SE8704049A SE8704049D0 (sv) 1987-10-16 1987-10-16 Novel pharmacological compounds

Publications (2)

Publication Number Publication Date
IE873125L IE873125L (en) 1988-05-21
IE61178B1 true IE61178B1 (en) 1994-10-05

Family

ID=27355365

Family Applications (2)

Application Number Title Priority Date Filing Date
IE312587A IE61178B1 (en) 1986-11-21 1987-11-19 Novel pharmacological compounds
IE940326A IE940326L (en) 1986-11-21 1987-11-19 Benzimidazole derivatives substituted with a radical group¹and their use for inhibiting gastric acid secretion

Family Applications After (1)

Application Number Title Priority Date Filing Date
IE940326A IE940326L (en) 1986-11-21 1987-11-19 Benzimidazole derivatives substituted with a radical group¹and their use for inhibiting gastric acid secretion

Country Status (24)

Country Link
EP (3) EP0279149B1 (en:Method)
JP (1) JPH02500744A (en:Method)
KR (1) KR890700125A (en:Method)
AT (1) ATE84032T1 (en:Method)
AU (1) AU612129B2 (en:Method)
DE (1) DE3783356T2 (en:Method)
DK (1) DK365488A (en:Method)
EG (1) EG18379A (en:Method)
ES (1) ES2052603T3 (en:Method)
FI (1) FI892454A7 (en:Method)
GR (1) GR3007385T3 (en:Method)
HU (1) HU204814B (en:Method)
IE (2) IE61178B1 (en:Method)
IL (1) IL84504A (en:Method)
IS (1) IS1565B (en:Method)
LV (1) LV10954B (en:Method)
MY (1) MY101784A (en:Method)
NO (1) NO173998C (en:Method)
NZ (2) NZ234564A (en:Method)
PL (1) PL157655B1 (en:Method)
PT (1) PT86186B (en:Method)
RU (1) RU2062778C1 (en:Method)
WO (1) WO1988003921A1 (en:Method)
YU (1) YU47116B (en:Method)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801907D0 (sv) * 1988-05-20 1988-05-20 Haessle Ab Novel pharmacological compounds
WO1990003373A1 (en) * 1988-09-20 1990-04-05 Hisamitsu Pharmaceutical Co., Inc. NOVEL DIBENZ[b,e]OXEPIN DERIVATIVES
SE8804629D0 (sv) * 1988-12-22 1988-12-22 Ab Haessle New therapeutically active compounds
EG19302A (en) * 1988-12-22 1994-11-30 Haessle Ab Compound with gastric acid inhibitory effect and process for its preparation
US5049674A (en) * 1989-12-20 1991-09-17 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
US5274099A (en) * 1989-12-20 1993-12-28 Aktiebolaget Hassle Therapeutically active fluoro substituted benzimidazoles
SE9002206D0 (sv) 1990-06-20 1990-06-20 Haessle Ab New compounds
ES2140391T3 (es) * 1990-06-20 2000-03-01 Astra Ab Derivados de dialcoxi-piridinil-bencimidazol, procedimiento para su preparacion y su uso farmaceutico.
US5312824A (en) * 1990-10-17 1994-05-17 Takeda Chemical Industries, Ltd. Certain 2-[(4-difluoromethoxy-2-pyridyl)-methylthio or methylsulfinyl-5-benzimidazoles useful for treating peptic ulcers
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
EP0604657B1 (en) * 1992-05-21 2000-01-12 Otsuka Pharmaceutical Factory, Inc. Phosphonic diester derivative
AU6556894A (en) * 1993-05-18 1994-12-12 Upjohn Company, The Bisphosphonate esters for treating gastric disorders
US6875872B1 (en) 1993-05-28 2005-04-05 Astrazeneca Compounds
SE508669C2 (sv) * 1996-04-26 1998-10-26 Astra Ab Nytt förfarande
JP2002510293A (ja) * 1997-05-30 2002-04-02 ドクター・レディーズ・リサーチ・ファウンデーション 抗潰瘍剤として新規なベンゾイミダゾール誘導体、それらの製造方法、及びそれらを含有する薬学的組成物
NZ505515A (en) * 1997-12-31 2003-03-28 Univ Kansas Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof
ZA9810765B (en) * 1998-05-28 1999-08-06 Ranbaxy Lab Ltd Stable oral pharmaceutical composition containing a substituted pyridylsulfinyl benzimidazole.
US6420384B2 (en) 1999-12-17 2002-07-16 Ariad Pharmaceuticals, Inc. Proton pump inhibitors
WO2002030920A1 (fr) * 2000-10-12 2002-04-18 Takeda Chemical Industries, Ltd. Composes derives de benzimidazole, leur procede de production et leur utilisation
EP1437352A4 (en) * 2001-09-25 2004-12-08 Takeda Chemical Industries Ltd BENZIMIDAZOLE COMPOUND, METHOD FOR THE PRODUCTION AND USE THEREOF
KR100822981B1 (ko) * 2002-07-19 2008-04-16 윈스턴 파마슈티컬즈, 엘엘씨 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용
GB0400781D0 (en) * 2004-01-14 2004-02-18 Novartis Ag Organic compounds
EP1781619B1 (en) * 2004-08-27 2011-08-17 Laboratorios Del Dr. Esteve, S.A. Sigma receptor inhibitors
CA2616512A1 (en) * 2005-07-28 2007-02-08 Intervet International B.V. Novel benzimidazole (thio) carbamates with antiparasitic activity and the synthesis thereof
US10272070B2 (en) 2014-10-14 2019-04-30 The Board of Trustees of the Leland Stanford Junio r University Method for treating neurodegenerative diseases
KR20180094989A (ko) 2015-12-15 2018-08-24 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 주니어 유니버시티 노화 관련 인지장애 및 신경염증의 예방 및/또는 치료 방법
CA3108773A1 (en) 2018-08-06 2020-02-13 The Board Of Trustees Of The Leland Stanford Junior University 2-arylbenzimidazoles as ppargc1a activators for treating neurodegenerative diseases
CA3150303A1 (en) * 2019-08-20 2021-02-25 Ono Pharmaceutical Co., Ltd. Salt and crystal form of compound having agonistic activity to s1p5 receptor

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (en:Method) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS5836312B2 (ja) * 1978-08-21 1983-08-08 日本電信電話株式会社 通信用平衡ケ−ブル線路の障害位置測定方式
JPS5687818A (en) * 1979-12-19 1981-07-16 Ishikawajima Harima Heavy Ind Co Ltd Reflex type position detector
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
JPS57137860A (en) * 1981-02-20 1982-08-25 Sumitomo Electric Ind Ltd Optical tachometer
JPS5999597A (ja) * 1982-11-30 1984-06-08 株式会社東芝 光学測定装置
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
JPS6020051U (ja) * 1983-07-19 1985-02-12 三洋電機株式会社 カセツト収納装置
AU568441B2 (en) 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds

Also Published As

Publication number Publication date
PL268927A1 (en) 1989-01-23
EP0279149A2 (en) 1988-08-24
EP0332647A1 (en) 1989-09-20
WO1988003921A1 (en) 1988-06-02
KR890700125A (ko) 1989-03-02
NO173998B (no) 1993-11-22
JPH02500744A (ja) 1990-03-15
YU47116B (sh) 1994-12-28
EP0279149B1 (en) 1992-12-30
EP0510719A1 (en) 1992-10-28
NZ222495A (en) 1991-04-26
IL84504A (en) 1994-10-07
MY101784A (en) 1992-01-17
IE873125L (en) 1988-05-21
DK365488D0 (da) 1988-07-01
HUT51269A (en) 1990-04-28
DK365488A (da) 1988-07-01
ES2052603T3 (es) 1994-07-16
NO883229D0 (no) 1988-07-20
EG18379A (en) 1992-11-30
IS1565B (is) 1994-12-13
RU2062778C1 (ru) 1996-06-27
IS3284A7 (is) 1988-05-22
AU8330287A (en) 1988-06-16
LV10954B (en) 1996-08-20
PT86186B (pt) 1990-08-31
GR3007385T3 (en:Method) 1993-07-30
HU204814B (en) 1992-02-28
NO883229L (no) 1988-09-16
PL157655B1 (pl) 1992-06-30
FI892454L (fi) 1989-05-19
IE940326L (en) 1988-05-21
AU612129B2 (en) 1991-07-04
FI892454A0 (fi) 1989-05-19
ATE84032T1 (de) 1993-01-15
NZ234564A (en) 1991-04-26
PT86186A (en) 1987-12-01
DE3783356T2 (de) 1993-04-15
FI892454A7 (fi) 1989-05-19
LV10954A (lv) 1995-12-20
NO173998C (no) 1994-03-02
EP0279149A3 (en) 1988-08-31
DE3783356D1 (de) 1993-02-11
YU211087A (en) 1988-12-31

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Legal Events

Date Code Title Description
MM4A Patent lapsed