IE59293B1 - Pharmaceutical 9,10-dihydro ergot alkaloid containing compositions - Google Patents
Pharmaceutical 9,10-dihydro ergot alkaloid containing compositionsInfo
- Publication number
- IE59293B1 IE59293B1 IE29186A IE29186A IE59293B1 IE 59293 B1 IE59293 B1 IE 59293B1 IE 29186 A IE29186 A IE 29186A IE 29186 A IE29186 A IE 29186A IE 59293 B1 IE59293 B1 IE 59293B1
- Authority
- IE
- Ireland
- Prior art keywords
- formulation according
- fatty material
- dergocrine
- dihydroergotamine
- formulation
- Prior art date
Links
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- 229960003133 ergot alkaloid Drugs 0.000 title claims abstract description 25
- 238000009472 formulation Methods 0.000 claims abstract description 39
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- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 claims abstract description 11
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- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims abstract description 11
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- 235000010446 mineral oil Nutrition 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000012735 once-a-day formulation Substances 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 208000030153 prolactin-producing pituitary gland adenoma Diseases 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 230000005062 synaptic transmission Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858502889A GB8502889D0 (en) | 1985-02-05 | 1985-02-05 | Co-dergocrine compositions |
| GB858517604A GB8517604D0 (en) | 1985-07-12 | 1985-07-12 | Dihydroergotamine compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE860291L IE860291L (en) | 1986-08-05 |
| IE59293B1 true IE59293B1 (en) | 1994-02-09 |
Family
ID=26288767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE29186A IE59293B1 (en) | 1985-02-05 | 1986-02-03 | Pharmaceutical 9,10-dihydro ergot alkaloid containing compositions |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS61183225A (pt) |
| KR (1) | KR920010388B1 (pt) |
| AU (1) | AU597570B2 (pt) |
| BE (1) | BE904152A (pt) |
| CA (1) | CA1263087A (pt) |
| CH (1) | CH667592A5 (pt) |
| CY (1) | CY1604A (pt) |
| DE (1) | DE3602577A1 (pt) |
| DK (1) | DK167138B1 (pt) |
| ES (1) | ES8800040A1 (pt) |
| FR (1) | FR2576787B1 (pt) |
| GB (1) | GB2170407B (pt) |
| GR (1) | GR860310B (pt) |
| HK (1) | HK57191A (pt) |
| HU (1) | HU195729B (pt) |
| IE (1) | IE59293B1 (pt) |
| IT (1) | IT1191255B (pt) |
| LU (1) | LU86289A1 (pt) |
| NL (1) | NL8600161A (pt) |
| NZ (1) | NZ215020A (pt) |
| PH (1) | PH23384A (pt) |
| PT (1) | PT81954B (pt) |
| SE (1) | SE8600496L (pt) |
| SG (1) | SG56191G (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2610827B1 (fr) * | 1987-02-18 | 1991-09-13 | Pf Medicament | Comprime de dihydroergotamine (d.h.e.) du type a matrice hydrophile et son procede de fabrication |
| SI8710406B (sl) * | 1987-03-11 | 1998-08-31 | Lek | Tablete s podaljšanim delovanjem na osnovi hidroksipropilmetilceluloze z veliko molsko maso in postopek za njihovo pripravo |
| US7771746B2 (en) | 1999-12-03 | 2010-08-10 | Polichem Sa | Methods for making sustained-release pharmaceutical compositions of ergot alkaloids having improved bioavailability and compositions thereof |
| ES2236017T3 (es) * | 1999-12-03 | 2005-07-16 | Polichem S.A. | Procedimientos para la prepaaraciones farmaceuticas de liberacion sostenida de alcaloides del ergot que tienen biodfisponibilidad mejorada y composiciones de los mismos. |
| NZ504526A (en) * | 2000-05-12 | 2003-05-30 | Meracol Corp Ltd | Treating herpes simplex symptoms using a mixture of cetyl myristate and cetyl palmitate |
| CA2408541C (en) * | 2000-05-12 | 2009-07-28 | Meracol Corporation Limited | Treating eczema and/or psoriasis |
| US20030153620A1 (en) | 2000-05-12 | 2003-08-14 | Meakin Timothy David | Treating eczema and/or psoriasis |
| WO2001085162A1 (en) * | 2000-05-12 | 2001-11-15 | Meracol Corporation Limited | Treating irritable bowel syndrome or disease |
| WO2003026640A1 (en) * | 2001-09-28 | 2003-04-03 | Meracol Corporation Limited | Treating food allergies and/or food intolerances |
| CN111297815B (zh) * | 2020-04-29 | 2022-04-15 | 宝利化（南京）制药有限公司 | 一种甲磺酸二氢麦角碱缓释片及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3147187A (en) * | 1962-09-10 | 1964-09-01 | Don Hall Lab | Sustained release pharmaceutical |
| CH630257A5 (en) * | 1975-03-17 | 1982-06-15 | Hoffmann La Roche | Sustained release formulation |
| DE3124983A1 (de) * | 1981-06-25 | 1983-01-20 | Meditest Inst Fuer Medizinisch | Arzneiformen zur oralen verabreichung |
| CH649300A5 (de) * | 1981-08-07 | 1985-05-15 | Sandoz Ag | Ergopeptinderivate, ihre herstellung und verwendung. |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| DE3303616A1 (de) * | 1982-02-12 | 1983-08-25 | Sandoz-Patent-GmbH, 7850 Lörrach | Mutterkornalkaloide, verfahren zu deren herstellung sowie diese verbindungen enthaltende pharmazeutische zubereitungen |
| US4421736A (en) * | 1982-05-20 | 1983-12-20 | Merrel Dow Pharmaceuticals Inc. | Sustained release diethylpropion compositions |
| JPS604120A (ja) * | 1983-06-22 | 1985-01-10 | Shionogi & Co Ltd | 作用持続型ピナシジル製剤 |
| GB2154874B (en) * | 1984-02-29 | 1987-11-04 | Sandoz Ltd | Bromoscriptine compositions |
| GB8413795D0 (en) * | 1984-05-30 | 1984-07-04 | Sandoz Ltd | Organic compounds |
-
1986
- 1986-01-24 NL NL8600161A patent/NL8600161A/nl not_active Application Discontinuation
- 1986-01-24 HU HU86361A patent/HU195729B/hu not_active IP Right Cessation
- 1986-01-27 CH CH296/86A patent/CH667592A5/de not_active IP Right Cessation
- 1986-01-29 DE DE19863602577 patent/DE3602577A1/de not_active Ceased
- 1986-01-31 FR FR868601477A patent/FR2576787B1/fr not_active Expired - Lifetime
- 1986-02-03 PT PT81954A patent/PT81954B/pt not_active IP Right Cessation
- 1986-02-03 KR KR1019860000698A patent/KR920010388B1/ko not_active IP Right Cessation
- 1986-02-03 GB GB08602602A patent/GB2170407B/en not_active Expired
- 1986-02-03 AU AU52942/86A patent/AU597570B2/en not_active Ceased
- 1986-02-03 GR GR860310A patent/GR860310B/el unknown
- 1986-02-03 BE BE1/011431A patent/BE904152A/fr not_active IP Right Cessation
- 1986-02-03 CA CA000501011A patent/CA1263087A/en not_active Expired
- 1986-02-03 DK DK052086A patent/DK167138B1/da not_active IP Right Cessation
- 1986-02-03 NZ NZ215020A patent/NZ215020A/xx unknown
- 1986-02-03 IE IE29186A patent/IE59293B1/en not_active IP Right Cessation
- 1986-02-04 JP JP61023666A patent/JPS61183225A/ja active Pending
- 1986-02-04 PH PH33379A patent/PH23384A/en unknown
- 1986-02-04 ES ES551635A patent/ES8800040A1/es not_active Expired
- 1986-02-04 SE SE8600496A patent/SE8600496L/ not_active Application Discontinuation
- 1986-02-04 LU LU86289A patent/LU86289A1/fr unknown
- 1986-02-05 IT IT47620/86A patent/IT1191255B/it active
-
1991
- 1991-07-16 SG SG561/91A patent/SG56191G/en unknown
- 1991-07-25 HK HK571/91A patent/HK57191A/xx unknown
-
1992
- 1992-04-03 CY CY1604A patent/CY1604A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IT8647620A0 (it) | 1986-02-05 |
| ES8800040A1 (es) | 1987-10-16 |
| PH23384A (en) | 1989-07-26 |
| CH667592A5 (de) | 1988-10-31 |
| NZ215020A (en) | 1989-07-27 |
| GB8602602D0 (en) | 1986-03-12 |
| CA1263087A (en) | 1989-11-21 |
| FR2576787B1 (fr) | 1990-01-12 |
| DK167138B1 (da) | 1993-09-06 |
| KR920010388B1 (ko) | 1992-11-27 |
| DE3602577A1 (de) | 1986-08-28 |
| IE860291L (en) | 1986-08-05 |
| HUT41984A (en) | 1987-06-29 |
| LU86289A1 (fr) | 1986-09-02 |
| AU597570B2 (en) | 1990-06-07 |
| GR860310B (en) | 1986-05-27 |
| PT81954A (en) | 1986-03-01 |
| HK57191A (en) | 1991-08-02 |
| AU5294286A (en) | 1986-08-14 |
| BE904152A (fr) | 1986-08-04 |
| DK52086D0 (da) | 1986-02-03 |
| CY1604A (en) | 1992-04-03 |
| GB2170407B (en) | 1988-10-26 |
| NL8600161A (nl) | 1986-09-01 |
| SE8600496L (sv) | 1986-08-06 |
| PT81954B (pt) | 1988-07-01 |
| IT1191255B (it) | 1988-02-24 |
| HU195729B (en) | 1988-07-28 |
| KR860006265A (ko) | 1986-09-09 |
| DK52086A (da) | 1986-08-06 |
| ES551635A0 (es) | 1987-10-16 |
| GB2170407A (en) | 1986-08-06 |
| FR2576787A1 (fr) | 1986-08-08 |
| SG56191G (en) | 1991-08-23 |
| SE8600496D0 (sv) | 1986-02-04 |
| JPS61183225A (ja) | 1986-08-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |