IE57996B1 - A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process - Google Patents
A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this processInfo
- Publication number
- IE57996B1 IE57996B1 IE1319/85A IE131985A IE57996B1 IE 57996 B1 IE57996 B1 IE 57996B1 IE 1319/85 A IE1319/85 A IE 1319/85A IE 131985 A IE131985 A IE 131985A IE 57996 B1 IE57996 B1 IE 57996B1
- Authority
- IE
- Ireland
- Prior art keywords
- dna sequence
- dna
- cleavage site
- plasmid
- sequence
- Prior art date
Links
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- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 125000001302 tertiary amino group Chemical group 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 108010087967 type I signal peptidase Proteins 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- VNDYJBBGRKZCSX-UHFFFAOYSA-L zinc bromide Chemical class Br[Zn]Br VNDYJBBGRKZCSX-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843419995 DE3419995A1 (de) | 1984-05-29 | 1984-05-29 | Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE851319L IE851319L (en) | 1985-11-29 |
| IE57996B1 true IE57996B1 (en) | 1993-06-02 |
Family
ID=6237111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1319/85A IE57996B1 (en) | 1984-05-29 | 1985-05-28 | A genetic engineering process for the preparation of human interleukin-2 and means for carrying out this process |
Country Status (11)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK174501B1 (da) * | 1983-12-23 | 2003-04-28 | Hoffmann La Roche | Fremgangsmåde til fremstilling af interleukin-2 |
| CA1340265C (en) * | 1985-01-18 | 1998-12-15 | Kirston E. Koths | Oxidation resistant muteins |
| DE3537461A1 (de) * | 1985-10-22 | 1987-04-23 | Hoechst Ag | Derivat des interleukin-2, seine herstellung und verwendung |
| US5496924A (en) * | 1985-11-27 | 1996-03-05 | Hoechst Aktiengesellschaft | Fusion protein comprising an interleukin-2 fragment ballast portion |
| DE3712985A1 (de) * | 1987-04-16 | 1988-11-03 | Hoechst Ag | Bifunktionelle proteine |
| JPS62185098A (ja) * | 1986-02-10 | 1987-08-13 | Otsuka Pharmaceut Co Ltd | インタ−ロイキン−２活性を有するポリペプチド |
| US5831022A (en) * | 1986-02-18 | 1998-11-03 | Hoffmann-La Roche Inc. | Purification of recombinant human IL-1α |
| US4992367A (en) * | 1986-05-12 | 1991-02-12 | Hoffmann-La Roche Inc. | Enhanced expression of human interleukin-2 in mammalian cells |
| US5017692A (en) * | 1986-09-04 | 1991-05-21 | Schering Corporation | Truncated human interleukin-a alpha |
| CA1339757C (en) * | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| US5162507A (en) * | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
| FR2643646B1 (fr) * | 1989-02-27 | 1993-09-17 | Pasteur Institut | Expression de sequences de nucleotides codant pour des vesicules a gaz |
| US6008319A (en) | 1996-12-23 | 1999-12-28 | University Of Southern California | Vasopermeability enhancing peptide of human interleukin-2 and immunoconjugates thereof |
| US6955807B1 (en) | 1998-05-15 | 2005-10-18 | Bayer Pharmaceuticals Corporation | IL-2 selective agonists and antagonists |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2483592A1 (fr) * | 1980-06-02 | 1981-12-04 | Stein Industrie | Dispositif de reduction des contraintes thermiques sur un echangeur de chaleur |
| CA1341562C (en) * | 1982-03-31 | 2007-11-27 | Tadatsugu Taniguchi | Gene coded for interleukin-2 polypeptide, recombinant dna carrying the said gene, a living cell line possessing the recombinant dna, and method for producing interleukin-2 using the said cell |
| EP0091539B2 (en) * | 1982-03-31 | 1996-11-27 | Ajinomoto Co., Inc. | Gene coding for interleukin-2 polypeptide, recombinant DNA carrying said gene, cell lines possessing the recombinant DNA,and method for producing interleukin-2 using said cells |
| AU579089B2 (en) * | 1983-02-08 | 1988-11-17 | Biogen, Inc. | Human interleukin-2-like polypeptides |
| EP0119621A1 (en) * | 1983-03-21 | 1984-09-26 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Interleukin-2 |
| WO1985000817A1 (en) * | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of interleukin ii |
| FR2559782B1 (fr) * | 1984-02-16 | 1986-07-18 | Transgene Sa | Vecteur d'expression dans les levures de l'interleukine-2, levures transformees et procede de preparation de l'interleukine-2 |
| DE3574731D1 (de) * | 1984-05-08 | 1990-01-18 | Genetics Inst | Ein menschlicher t-zellwachstumsfaktor. |
-
1984
- 1984-05-29 DE DE19843419995 patent/DE3419995A1/de not_active Withdrawn
-
1985
- 1985-05-22 AT AT85106279T patent/ATE65797T1/de not_active IP Right Cessation
- 1985-05-22 DE DE8585106279T patent/DE3583634D1/de not_active Expired - Fee Related
- 1985-05-22 EP EP85106279A patent/EP0163249B1/de not_active Expired - Lifetime
- 1985-05-27 ES ES543508A patent/ES8605813A1/es not_active Expired
- 1985-05-27 GR GR851291A patent/GR851291B/el unknown
- 1985-05-28 ZA ZA854031A patent/ZA854031B/xx unknown
- 1985-05-28 DK DK237985A patent/DK166681B1/da not_active IP Right Cessation
- 1985-05-28 IE IE1319/85A patent/IE57996B1/en not_active IP Right Cessation
- 1985-05-28 JP JP60113324A patent/JPS6199A/ja active Pending
- 1985-05-28 AU AU43070/85A patent/AU589896B2/en not_active Ceased
- 1985-05-29 PT PT80542A patent/PT80542B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT80542A (de) | 1985-06-01 |
| PT80542B (pt) | 1987-09-30 |
| EP0163249A3 (en) | 1988-05-11 |
| DK166681B1 (da) | 1993-06-28 |
| AU4307085A (en) | 1985-12-05 |
| EP0163249A2 (de) | 1985-12-04 |
| JPS6199A (ja) | 1986-01-06 |
| DE3583634D1 (de) | 1991-09-05 |
| GR851291B (enrdf_load_stackoverflow) | 1985-11-25 |
| ATE65797T1 (de) | 1991-08-15 |
| EP0163249B1 (de) | 1991-07-31 |
| ZA854031B (en) | 1986-01-29 |
| DK237985A (da) | 1985-11-30 |
| DE3419995A1 (de) | 1985-12-05 |
| ES543508A0 (es) | 1986-01-16 |
| DK237985D0 (da) | 1985-05-28 |
| ES8605813A1 (es) | 1986-01-16 |
| AU589896B2 (en) | 1989-10-26 |
| IE851319L (en) | 1985-11-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Patent lapsed |