IE46402B1 - Process for the preparation of d, 1-5-methyltetra-hydrofolic acid - Google Patents

Process for the preparation of d, 1-5-methyltetra-hydrofolic acid

Info

Publication number
IE46402B1
IE46402B1 IE285/78A IE28578A IE46402B1 IE 46402 B1 IE46402 B1 IE 46402B1 IE 285/78 A IE285/78 A IE 285/78A IE 28578 A IE28578 A IE 28578A IE 46402 B1 IE46402 B1 IE 46402B1
Authority
IE
Ireland
Prior art keywords
acid
ratio
sodium
reducing agent
folic acid
Prior art date
Application number
IE285/78A
Other languages
English (en)
Other versions
IE780285L (en
Inventor
Federico Gennari
Original Assignee
Bioresearch Sas
Camozzi Livio Dr And C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Sas, Camozzi Livio Dr And C filed Critical Bioresearch Sas
Publication of IE780285L publication Critical patent/IE780285L/xx
Publication of IE46402B1 publication Critical patent/IE46402B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IE285/78A 1977-02-22 1978-02-09 Process for the preparation of d, 1-5-methyltetra-hydrofolic acid IE46402B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7290/77A GB1572137A (en) 1977-02-22 1977-02-22 Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts

Publications (2)

Publication Number Publication Date
IE780285L IE780285L (en) 1978-08-22
IE46402B1 true IE46402B1 (en) 1983-06-01

Family

ID=9830275

Family Applications (1)

Application Number Title Priority Date Filing Date
IE285/78A IE46402B1 (en) 1977-02-22 1978-02-09 Process for the preparation of d, 1-5-methyltetra-hydrofolic acid

Country Status (32)

Country Link
JP (1) JPS5831353B2 (es)
AR (1) AR215162A1 (es)
AT (1) AT380020B (es)
AU (1) AU520715B2 (es)
BE (1) BE863808A (es)
CA (1) CA1093554A (es)
CH (1) CH635344A5 (es)
CZ (1) CZ279815B6 (es)
DD (1) DD134099A5 (es)
DE (1) DE2807393A1 (es)
DK (1) DK144944C (es)
EG (1) EG13399A (es)
ES (1) ES467153A1 (es)
FI (1) FI67082C (es)
FR (2) FR2381047A1 (es)
GB (1) GB1572137A (es)
GR (1) GR71704B (es)
HU (1) HU179422B (es)
IE (1) IE46402B1 (es)
IL (1) IL54052A (es)
IN (1) IN149574B (es)
LU (1) LU79067A1 (es)
MX (1) MX5288E (es)
NL (1) NL190285C (es)
NO (1) NO147793C (es)
NZ (1) NZ186465A (es)
PL (1) PL118654B1 (es)
PT (1) PT67656B (es)
SE (1) SE437028B (es)
SU (1) SU747427A3 (es)
YU (1) YU40505B (es)
ZA (1) ZA78837B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (ja) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd ５−メチル−（６ｒｓ）−５，６，７，８−テトラヒドロ−ｌ−葉酸のマグネシウム塩またはその遊離酸の製法
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
IT1229517B (it) * 1989-01-31 1991-09-03 Bioresearch Spa Impiego di acido 5-metiltetraidrofolico, di acido 5 formiltetraidrofolico, e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato adatte ad essere impiegate nella terapia dei disordini depressivi e composizioni farmaceutiche relative.
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
NL8901432A (nl) * 1989-06-06 1991-01-02 Pharmachemie Bv Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
CH680731A5 (es) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
CH682665A5 (de) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Verfahren zur Reinigung von rohen Erdalkalimetallsalzen von N(5)-Methyl-5,6,7,8-tetrahydrofolsäure.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN103214487A (zh) * 2013-04-12 2013-07-24 张家港威胜生物医药有限公司 一种重要医药化工原料(6s)-5-甲基四氢叶酸盐的合成
WO2015193778A1 (en) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Crystalline form of levomefolate calcium
US20200071269A1 (en) 2018-08-28 2020-03-05 Pmc Organometallix, Inc. Low free 2-mercaptoethanol ester and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (es) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid

Also Published As

Publication number Publication date
FR2385397B1 (es) 1981-07-17
SU747427A3 (ru) 1980-07-23
IE780285L (en) 1978-08-22
YU37978A (en) 1983-01-21
PT67656A (en) 1978-03-01
PL204747A1 (pl) 1979-03-12
NL190285C (nl) 1994-01-03
AU3343078A (en) 1979-08-30
FR2385397A1 (fr) 1978-10-27
NO147793C (no) 1983-06-15
FR2381047B1 (es) 1981-07-24
NL7801775A (nl) 1978-08-24
FI780565A (fi) 1978-08-23
CZ279815B6 (cs) 1995-07-12
GB1572137A (en) 1980-07-23
DK144944B (da) 1982-07-12
DK144944C (da) 1982-11-29
ZA78837B (en) 1979-09-26
JPS5831353B2 (ja) 1983-07-05
IL54052A0 (en) 1978-04-30
DE2807393A1 (de) 1978-09-07
NZ186465A (en) 1980-10-08
YU40505B (en) 1986-02-28
JPS53124297A (en) 1978-10-30
FI67082B (fi) 1984-09-28
DK76578A (da) 1978-08-23
GR71704B (es) 1983-06-21
HU179422B (en) 1982-10-28
CH635344A5 (en) 1983-03-31
LU79067A1 (fr) 1978-06-27
SE7801973L (sv) 1978-08-23
CZ112978A3 (en) 1995-02-15
NO147793B (no) 1983-03-07
IN149574B (es) 1982-01-30
AR215162A1 (es) 1979-09-14
PT67656B (en) 1979-07-19
ATA90378A (de) 1985-08-15
CA1093554A (en) 1981-01-13
AU520715B2 (en) 1982-02-25
PL118654B1 (en) 1981-10-31
MX5288E (es) 1983-06-06
FI67082C (fi) 1985-01-10
IL54052A (en) 1981-07-31
NO780594L (no) 1978-08-23
AT380020B (de) 1986-03-25
DE2807393C2 (es) 1990-06-13
FR2381047A1 (fr) 1978-09-15
NL190285B (nl) 1993-08-02
ES467153A1 (es) 1978-11-16
BE863808A (fr) 1978-05-29
SE437028B (sv) 1985-02-04
EG13399A (en) 1981-12-31
DD134099A5 (de) 1979-02-07

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