IE44433B1 - Substituted n-methylene derivatives of thienamycin - Google Patents

Substituted n-methylene derivatives of thienamycin

Info

Publication number
IE44433B1
IE44433B1 IE2542/76A IE254276A IE44433B1 IE 44433 B1 IE44433 B1 IE 44433B1 IE 2542/76 A IE2542/76 A IE 2542/76A IE 254276 A IE254276 A IE 254276A IE 44433 B1 IE44433 B1 IE 44433B1
Authority
IE
Ireland
Prior art keywords
compound
alkyl
formula
composition
methyl
Prior art date
Application number
IE2542/76A
Other languages
English (en)
Other versions
IE44433L (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE44433L publication Critical patent/IE44433L/xx
Publication of IE44433B1 publication Critical patent/IE44433B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE2542/76A 1975-11-21 1976-11-18 Substituted n-methylene derivatives of thienamycin IE44433B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63429675A 1975-11-21 1975-11-21
US67626176A 1976-04-12 1976-04-12
US73365476A 1976-10-18 1976-10-18

Publications (2)

Publication Number Publication Date
IE44433L IE44433L (en) 1977-05-21
IE44433B1 true IE44433B1 (en) 1981-12-02

Family

ID=27417545

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2542/76A IE44433B1 (en) 1975-11-21 1976-11-18 Substituted n-methylene derivatives of thienamycin

Country Status (27)

Country Link
AT (1) AT358168B (enrdf_load_stackoverflow)
AU (1) AU512383B2 (enrdf_load_stackoverflow)
BG (1) BG34037A3 (enrdf_load_stackoverflow)
CA (1) CA1083577A (enrdf_load_stackoverflow)
CH (2) CH632510A5 (enrdf_load_stackoverflow)
DD (1) DD127742A5 (enrdf_load_stackoverflow)
DE (1) DE2652679A1 (enrdf_load_stackoverflow)
DK (1) DK157401C (enrdf_load_stackoverflow)
EG (1) EG12261A (enrdf_load_stackoverflow)
ES (1) ES453501A1 (enrdf_load_stackoverflow)
FI (1) FI62306C (enrdf_load_stackoverflow)
FR (1) FR2332012A1 (enrdf_load_stackoverflow)
GB (1) GB1570990A (enrdf_load_stackoverflow)
GR (1) GR62072B (enrdf_load_stackoverflow)
HK (1) HK29683A (enrdf_load_stackoverflow)
HU (1) HU180865B (enrdf_load_stackoverflow)
IE (1) IE44433B1 (enrdf_load_stackoverflow)
IL (1) IL50911A (enrdf_load_stackoverflow)
KE (1) KE3286A (enrdf_load_stackoverflow)
NL (1) NL189297C (enrdf_load_stackoverflow)
NO (1) NO153298C (enrdf_load_stackoverflow)
NZ (1) NZ182630A (enrdf_load_stackoverflow)
PH (1) PH16714A (enrdf_load_stackoverflow)
PL (1) PL110937B1 (enrdf_load_stackoverflow)
PT (1) PT65865B (enrdf_load_stackoverflow)
SE (1) SE427841B (enrdf_load_stackoverflow)
SG (1) SG10983G (enrdf_load_stackoverflow)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
DK170778A (da) * 1977-05-05 1979-01-15 Merck & Co Inc Fremgangsmaade til fremstilling af n-alkyl-n-iminomethyl-derivater af thienamycin
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
EP0551330A4 (en) * 1990-08-30 1994-07-06 Oregon State Substituted amidines having high binding to the sigma receptor and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348985A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Esters of cephalosporin compounds
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
NZ182630A (en) 1979-07-11
NL189297C (nl) 1993-03-01
AU1964776A (en) 1978-05-25
CH633800A5 (en) 1982-12-31
FR2332012B1 (enrdf_load_stackoverflow) 1978-11-17
PT65865B (en) 1978-10-12
FI763308A7 (enrdf_load_stackoverflow) 1977-05-22
SE7612963L (sv) 1977-05-22
GB1570990A (en) 1980-07-09
DK157401B (da) 1990-01-02
DK157401C (da) 1990-05-21
DE2652679C2 (enrdf_load_stackoverflow) 1990-03-01
EG12261A (en) 1978-12-31
AU512383B2 (en) 1980-10-09
AT358168B (de) 1980-08-25
IE44433L (en) 1977-05-21
DD127742A5 (de) 1977-10-12
PL110937B1 (en) 1980-08-30
NL189297B (nl) 1992-10-01
SE427841B (sv) 1983-05-09
FR2332012A1 (fr) 1977-06-17
GR62072B (en) 1979-02-20
IL50911A0 (en) 1977-01-31
NL7612939A (nl) 1977-05-24
ES453501A1 (es) 1978-03-01
PL193809A1 (pl) 1978-01-16
PT65865A (en) 1976-12-01
DE2652679A1 (de) 1977-06-02
KE3286A (en) 1983-06-17
IL50911A (en) 1981-01-30
CA1083577A (en) 1980-08-12
BG34037A3 (bg) 1983-06-15
DK523576A (da) 1977-05-22
FI62306B (fi) 1982-08-31
CH632510A5 (en) 1982-10-15
FI62306C (fi) 1982-12-10
NO153298B (no) 1985-11-11
NO763958L (enrdf_load_stackoverflow) 1977-05-24
SG10983G (en) 1983-12-16
HU180865B (en) 1983-04-29
PH16714A (en) 1984-01-25
HK29683A (en) 1983-08-26
NO153298C (no) 1986-02-19
ATA863476A (de) 1980-01-15

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Legal Events

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MK9A Patent expired