IE44433B1 - Substituted n-methylene derivatives of thienamycin - Google Patents

Substituted n-methylene derivatives of thienamycin

Info

Publication number
IE44433B1
IE44433B1 IE2542/76A IE254276A IE44433B1 IE 44433 B1 IE44433 B1 IE 44433B1 IE 2542/76 A IE2542/76 A IE 2542/76A IE 254276 A IE254276 A IE 254276A IE 44433 B1 IE44433 B1 IE 44433B1
Authority
IE
Ireland
Prior art keywords
compound
alkyl
formula
composition
methyl
Prior art date
Application number
IE2542/76A
Other languages
English (en)
Other versions
IE44433L (en
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of IE44433L publication Critical patent/IE44433L/xx
Publication of IE44433B1 publication Critical patent/IE44433B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IE2542/76A 1975-11-21 1976-11-18 Substituted n-methylene derivatives of thienamycin IE44433B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63429675A 1975-11-21 1975-11-21
US67626176A 1976-04-12 1976-04-12
US73365476A 1976-10-18 1976-10-18

Publications (2)

Publication Number Publication Date
IE44433L IE44433L (en) 1977-05-21
IE44433B1 true IE44433B1 (en) 1981-12-02

Family

ID=27417545

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2542/76A IE44433B1 (en) 1975-11-21 1976-11-18 Substituted n-methylene derivatives of thienamycin

Country Status (27)

Country Link
AT (1) AT358168B (cg-RX-API-DMAC7.html)
AU (1) AU512383B2 (cg-RX-API-DMAC7.html)
BG (1) BG34037A3 (cg-RX-API-DMAC7.html)
CA (1) CA1083577A (cg-RX-API-DMAC7.html)
CH (2) CH632510A5 (cg-RX-API-DMAC7.html)
DD (1) DD127742A5 (cg-RX-API-DMAC7.html)
DE (1) DE2652679A1 (cg-RX-API-DMAC7.html)
DK (1) DK157401C (cg-RX-API-DMAC7.html)
EG (1) EG12261A (cg-RX-API-DMAC7.html)
ES (1) ES453501A1 (cg-RX-API-DMAC7.html)
FI (1) FI62306C (cg-RX-API-DMAC7.html)
FR (1) FR2332012A1 (cg-RX-API-DMAC7.html)
GB (1) GB1570990A (cg-RX-API-DMAC7.html)
GR (1) GR62072B (cg-RX-API-DMAC7.html)
HK (1) HK29683A (cg-RX-API-DMAC7.html)
HU (1) HU180865B (cg-RX-API-DMAC7.html)
IE (1) IE44433B1 (cg-RX-API-DMAC7.html)
IL (1) IL50911A (cg-RX-API-DMAC7.html)
KE (1) KE3286A (cg-RX-API-DMAC7.html)
NL (1) NL189297C (cg-RX-API-DMAC7.html)
NO (1) NO153298C (cg-RX-API-DMAC7.html)
NZ (1) NZ182630A (cg-RX-API-DMAC7.html)
PH (1) PH16714A (cg-RX-API-DMAC7.html)
PL (1) PL110937B1 (cg-RX-API-DMAC7.html)
PT (1) PT65865B (cg-RX-API-DMAC7.html)
SE (1) SE427841B (cg-RX-API-DMAC7.html)
SG (1) SG10983G (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
SE436569B (sv) * 1977-05-05 1985-01-07 Merck & Co Inc Analogiforfarande for framstellning av tienamycinderivat
US4232030A (en) * 1977-09-15 1980-11-04 Merck & Co., Inc. Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
DK153486C (da) * 1978-07-03 1988-11-28 Merck & Co Inc Analogifremgangsmaade til fremstilling af krystallinsk n-formimidoyl-thienamycin-monohydrat
EP0044170A1 (en) * 1980-07-11 1982-01-20 Beecham Group Plc Beta-lactam antibiotics, their preparation and use
CA2089261A1 (en) * 1990-08-30 1992-03-01 John F.W. Keana Substituted amidines having high binding to the sigma receptor and the use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1004670A (en) * 1963-04-23 1965-09-15 Beecham Res Lab Penicillins
GB1348984A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Antibiotics and processes for their production
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Also Published As

Publication number Publication date
NO763958L (cg-RX-API-DMAC7.html) 1977-05-24
DD127742A5 (de) 1977-10-12
NO153298C (no) 1986-02-19
PH16714A (en) 1984-01-25
PL193809A1 (pl) 1978-01-16
IE44433L (en) 1977-05-21
KE3286A (en) 1983-06-17
PT65865B (en) 1978-10-12
DK523576A (da) 1977-05-22
PT65865A (en) 1976-12-01
NL189297B (nl) 1992-10-01
DK157401B (da) 1990-01-02
NL7612939A (nl) 1977-05-24
FI62306B (fi) 1982-08-31
ATA863476A (de) 1980-01-15
DE2652679C2 (cg-RX-API-DMAC7.html) 1990-03-01
AU512383B2 (en) 1980-10-09
SE7612963L (sv) 1977-05-22
NZ182630A (en) 1979-07-11
SE427841B (sv) 1983-05-09
PL110937B1 (en) 1980-08-30
FR2332012A1 (fr) 1977-06-17
GB1570990A (en) 1980-07-09
AT358168B (de) 1980-08-25
BG34037A3 (bg) 1983-06-15
FR2332012B1 (cg-RX-API-DMAC7.html) 1978-11-17
HU180865B (en) 1983-04-29
AU1964776A (en) 1978-05-25
GR62072B (en) 1979-02-20
CA1083577A (en) 1980-08-12
DK157401C (da) 1990-05-21
DE2652679A1 (de) 1977-06-02
EG12261A (en) 1978-12-31
FI763308A7 (cg-RX-API-DMAC7.html) 1977-05-22
FI62306C (fi) 1982-12-10
NL189297C (nl) 1993-03-01
NO153298B (no) 1985-11-11
SG10983G (en) 1983-12-16
IL50911A (en) 1981-01-30
IL50911A0 (en) 1977-01-31
ES453501A1 (es) 1978-03-01
CH632510A5 (en) 1982-10-15
HK29683A (en) 1983-08-26
CH633800A5 (en) 1982-12-31

Similar Documents

Publication Publication Date Title
KR890001426B1 (ko) 카르바페넴 화합물의 제조방법
US4194047A (en) Substituted N-methylene derivatives of thienamycin
US4309438A (en) N-Alkyl-N-iminomethyl derivatives of thienamycin
US4217453A (en) 6-Amido-3-substituted-amino-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid
US4235917A (en) N-Alkyl-N-acyl derivatives of thienamycin
US4235920A (en) N-Alkylated derivatives of thienamycin
US4150145A (en) N-alkylated derivatives of thienamycin sulfoxide and sulfone
US4226870A (en) O-, N- and carboxyl derivatives of thienamycin
CA1283659C (en) Carbapenem antibiotics
US4172144A (en) Schiff's base derivatives of thienamycin
US4424230A (en) 6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo- 3.2.0!hept-2-en-7-one-2-carboxylic acid
GB1570988A (en) Antibiotics of the thienamycin class
US4397861A (en) N- And carboxyl derivatives of thienamycin
GB2128187A (en) Carbapenem antibiotics
US4196211A (en) 6-(α-Hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and derivatives thereof
GB1570990A (en) Derivatives of thienamycin and its isomers
DE69523058T2 (de) Carbapenem-derivate
GB1570987A (en) Thienamycin derivatives
CA2338776C (en) Novel c-2 s/o- and s/n formaldehyde acetal derivatives of carbapenem-3-carboxylic acids and their use as antibiotics and .beta.-lactamase inhibitors
EP0134301A1 (en) 6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid
US4232030A (en) Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone
US4208330A (en) O-Derivatives of thienamycin
GB1570986A (en) Derivatives of thienamycin and its isomers
EP0001265A1 (en) O-, N- and carboxyl derivatives of thienamycin sulfoxide and sulfone, their preparation and pharmaceuticals containing said compounds
KR800001674B1 (ko) 티에나마이신의 치환된 n-메틸렌 유도체 제법

Legal Events

Date Code Title Description
MK9A Patent expired