IE40865B1 - 4-(alkoxy-phenyl)-2-pyrrolidones,their preparation and use - Google Patents
4-(alkoxy-phenyl)-2-pyrrolidones,their preparation and useInfo
- Publication number
- IE40865B1 IE40865B1 IE611/75A IE61175A IE40865B1 IE 40865 B1 IE40865 B1 IE 40865B1 IE 611/75 A IE611/75 A IE 611/75A IE 61175 A IE61175 A IE 61175A IE 40865 B1 IE40865 B1 IE 40865B1
- Authority
- IE
- Ireland
- Prior art keywords
- pyrrolidones
- carbon atoms
- alkoxy
- phenyl
- alkyl
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- -1 R4 is H Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- DAFOCGYVTAOKAJ-UHFFFAOYSA-N phenibut Chemical compound OC(=O)CC(CN)C1=CC=CC=C1 DAFOCGYVTAOKAJ-UHFFFAOYSA-N 0.000 abstract 1
- CYQAYERJWZKYML-UHFFFAOYSA-N phosphorus pentasulfide Chemical compound S1P(S2)(=S)SP3(=S)SP1(=S)SP2(=S)S3 CYQAYERJWZKYML-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000004040 pyrrolidinones Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2413935A DE2413935A1 (de) | 1974-03-20 | 1974-03-20 | 4-(polyalkoxy-phenyl)-2-pyrrolidone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE40865L IE40865L (en) | 1975-09-20 |
| IE40865B1 true IE40865B1 (en) | 1979-08-29 |
Family
ID=5910915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE611/75A IE40865B1 (en) | 1974-03-20 | 1975-03-20 | 4-(alkoxy-phenyl)-2-pyrrolidones,their preparation and use |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4012495A (enExample) |
| JP (1) | JPS6011028B2 (enExample) |
| AT (1) | AT347931B (enExample) |
| BE (1) | BE826923A (enExample) |
| CA (1) | CA1069517A (enExample) |
| CH (1) | CH621338A5 (enExample) |
| CS (1) | CS214738B2 (enExample) |
| DD (1) | DD119229A5 (enExample) |
| DE (1) | DE2413935A1 (enExample) |
| DK (1) | DK139965C (enExample) |
| ES (1) | ES435750A1 (enExample) |
| FR (1) | FR2264531B1 (enExample) |
| GB (1) | GB1498705A (enExample) |
| HU (1) | HU174074B (enExample) |
| IE (1) | IE40865B1 (enExample) |
| IL (1) | IL46883A (enExample) |
| NL (1) | NL7503367A (enExample) |
| SE (1) | SE402010B (enExample) |
| SU (1) | SU649312A3 (enExample) |
| YU (1) | YU40258B (enExample) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4193926A (en) | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
| DE2541855A1 (de) * | 1975-09-18 | 1977-03-31 | Schering Ag | 4-(polyalkoxy-phenyl)-2-pyrrolidone ii |
| CU21107A3 (es) | 1978-02-10 | 1988-02-01 | Hoffmann La Roche | Pyrrolidines derivatives |
| IL57266A (en) | 1978-06-12 | 1982-12-31 | Mundipharma Ag | Production of pyrrolidin-2-ones and of 3-pyrrolin-2-ones |
| NL8004025A (nl) * | 1979-08-09 | 1981-02-11 | Hoffmann La Roche | Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel. |
| GB2123288A (en) * | 1982-07-16 | 1984-02-01 | Wellcome Found | Anti-thrombotic agent |
| US4548947A (en) * | 1984-05-07 | 1985-10-22 | Warner-Lambert Company | 1-(Substituted-aryl)-dihydro-1H-pyrrolizine-3,5-[2H,6H-]diones and use for reversing amnesia |
| US4584313A (en) * | 1984-05-07 | 1986-04-22 | Warner-Lambert Company | (Substituted-phenyl)-5-oxo-2-pyrrolidinepropanoic acids and esters thereof, and use for reversing electroconvulsive shock-induced amnesia |
| US5783591A (en) * | 1984-10-19 | 1998-07-21 | Schering Aktiengesellschaft | Administration of oxazolidinone and pyrolidinone compounds for the treatment of inflammation |
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| DD295358A5 (de) * | 1989-06-28 | 1991-10-31 | �����@������������������k�� | Verfahren zur racemattrennung von 4-aryl-2-oxo-pyrrolidin-3-carbonsaeure-estern |
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| WO2006028618A1 (en) | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
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| US8178509B2 (en) * | 2006-02-10 | 2012-05-15 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US8058259B2 (en) | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
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| HK1218629A1 (zh) | 2013-02-25 | 2017-03-03 | Bausch Health Ireland Limited | 用於结肠清洁的鸟苷酸环化酶受体激动剂 |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
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Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1516776A (fr) | 1966-07-21 | 1968-03-15 | Rhone Poulenc Sa | Nouveaux dérivés du pyrrole et leur préparation |
| GB1350582A (en) * | 1970-07-24 | 1974-04-18 | Ucb Sa | Cerivatives of 2-pyrrolidinone |
-
1974
- 1974-03-20 DE DE2413935A patent/DE2413935A1/de active Granted
-
1975
- 1975-03-10 SU SU752111302A patent/SU649312A3/ru active
- 1975-03-17 YU YU632/75A patent/YU40258B/xx unknown
- 1975-03-18 DD DD184858A patent/DD119229A5/xx unknown
- 1975-03-18 DK DK110675A patent/DK139965C/da not_active IP Right Cessation
- 1975-03-18 CH CH345775A patent/CH621338A5/de not_active IP Right Cessation
- 1975-03-18 ES ES435750A patent/ES435750A1/es not_active Expired
- 1975-03-19 CS CS751860A patent/CS214738B2/cs unknown
- 1975-03-19 AT AT210975A patent/AT347931B/de not_active IP Right Cessation
- 1975-03-19 HU HU75SCHE514A patent/HU174074B/hu unknown
- 1975-03-19 SE SE7503157A patent/SE402010B/xx not_active IP Right Cessation
- 1975-03-20 NL NL7503367A patent/NL7503367A/xx not_active Application Discontinuation
- 1975-03-20 CA CA222,720A patent/CA1069517A/en not_active Expired
- 1975-03-20 US US05/560,193 patent/US4012495A/en not_active Expired - Lifetime
- 1975-03-20 FR FR7508701A patent/FR2264531B1/fr not_active Expired
- 1975-03-20 IL IL46883A patent/IL46883A/xx unknown
- 1975-03-20 IE IE611/75A patent/IE40865B1/xx unknown
- 1975-03-20 JP JP50034220A patent/JPS6011028B2/ja not_active Expired
- 1975-03-20 GB GB11686/75A patent/GB1498705A/en not_active Expired
- 1975-03-20 BE BE154536A patent/BE826923A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE7503157L (sv) | 1975-11-28 |
| DK139965C (da) | 1979-10-29 |
| IL46883A (en) | 1979-09-30 |
| BE826923A (fr) | 1975-09-22 |
| IL46883A0 (en) | 1975-05-22 |
| DE2413935C2 (enExample) | 1988-05-26 |
| SU649312A3 (ru) | 1979-02-25 |
| DD119229A5 (enExample) | 1976-04-12 |
| DK110675A (enExample) | 1975-09-21 |
| DE2413935A1 (de) | 1975-10-16 |
| NL7503367A (nl) | 1975-09-23 |
| US4012495A (en) | 1977-03-15 |
| DK139965B (da) | 1979-05-28 |
| CH621338A5 (enExample) | 1981-01-30 |
| CS214738B2 (en) | 1982-05-28 |
| JPS6011028B2 (ja) | 1985-03-22 |
| AT347931B (de) | 1979-01-25 |
| JPS50157360A (enExample) | 1975-12-19 |
| HU174074B (hu) | 1979-10-28 |
| YU63275A (en) | 1982-06-30 |
| IE40865L (en) | 1975-09-20 |
| ES435750A1 (es) | 1976-12-16 |
| CA1069517A (en) | 1980-01-08 |
| FR2264531A1 (enExample) | 1975-10-17 |
| AU7931075A (en) | 1976-09-23 |
| YU40258B (en) | 1985-10-31 |
| SE402010B (sv) | 1978-06-12 |
| FR2264531B1 (enExample) | 1978-07-28 |
| GB1498705A (en) | 1978-01-25 |
| ATA210975A (de) | 1978-06-15 |
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