IE35956B1 - Fused ring indole derivatives - Google Patents
Fused ring indole derivativesInfo
- Publication number
- IE35956B1 IE35956B1 IE14/72A IE1472A IE35956B1 IE 35956 B1 IE35956 B1 IE 35956B1 IE 14/72 A IE14/72 A IE 14/72A IE 1472 A IE1472 A IE 1472A IE 35956 B1 IE35956 B1 IE 35956B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- aryl
- ketones
- prepared
- possibly
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 heterocyclyl ketones Chemical class 0.000 abstract 3
- 150000002576 ketones Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical class CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 abstract 1
- OEDWIKDEEXZWAU-UHFFFAOYSA-N 3-bromo-2,2-dimethylpropanenitrile Chemical compound BrCC(C)(C)C#N OEDWIKDEEXZWAU-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 230000005792 cardiovascular activity Effects 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000002829 reductive effect Effects 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- KCTFEXPTSVGSGH-UHFFFAOYSA-N spiro[1,3-dioxolane-2,2'-1H-indole]-3'-one Chemical compound C1COC2(NC3=CC=CC=C3C2=O)O1 KCTFEXPTSVGSGH-UHFFFAOYSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB125071*[A GB1366133A (en) | 1971-01-11 | 1971-01-11 | Fused ring indole derivatives |
| GB4095971 | 1971-09-02 | ||
| GB5646771 | 1971-12-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE35956L IE35956L (en) | 1972-07-11 |
| IE35956B1 true IE35956B1 (en) | 1976-07-07 |
Family
ID=27253859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE14/72A IE35956B1 (en) | 1971-01-11 | 1972-01-08 | Fused ring indole derivatives |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS5531156B2 (enExample) |
| AR (1) | AR192734A1 (enExample) |
| AT (1) | AT312595B (enExample) |
| AU (1) | AU464388B2 (enExample) |
| BE (1) | BE777911A (enExample) |
| CA (1) | CA1012150A (enExample) |
| CH (1) | CH573938A5 (enExample) |
| CY (1) | CY926A (enExample) |
| DK (1) | DK150143C (enExample) |
| EG (1) | EG10888A (enExample) |
| ES (2) | ES398678A1 (enExample) |
| FI (1) | FI54120C (enExample) |
| FR (1) | FR2121699B1 (enExample) |
| GB (1) | GB1366133A (enExample) |
| HK (1) | HK52877A (enExample) |
| IE (1) | IE35956B1 (enExample) |
| KE (1) | KE2777A (enExample) |
| MY (1) | MY7800048A (enExample) |
| NL (1) | NL174251C (enExample) |
| SE (1) | SE398645B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1476740A (en) | 1974-11-20 | 1977-06-16 | Wyeth John & Brother Ltd | Pyrimido-1,2-b-isoquinoline derivatives their preparation and their pharmaceutical compositions |
| GB1520611A (en) * | 1976-06-11 | 1978-08-09 | Wyeth John & Brother Ltd | Fused ring indole derivatives |
| JPS5845741B2 (ja) * | 1977-06-06 | 1983-10-12 | 株式会社日立製作所 | 情報検索装置 |
| ZA824382B (en) * | 1981-07-07 | 1984-02-29 | Wyeth John & Brother Ltd | Anti-obesity agents |
| JPS60204057A (ja) * | 1984-03-28 | 1985-10-15 | Casio Comput Co Ltd | デ−タ記憶機能付小型電子機器 |
| GB8606253D0 (en) * | 1986-03-13 | 1986-04-16 | Wyeth John & Brother Ltd | Pyrimidoindoles |
| GB8606254D0 (en) * | 1986-03-13 | 1986-04-16 | Wyeth John & Brother Ltd | Substituted pyrimidoindoles |
| GB8614246D0 (en) * | 1986-06-11 | 1986-07-16 | Wyeth John & Brother Ltd | Substituted pyrimidoindoles |
| WO2010090680A1 (en) * | 2008-12-15 | 2010-08-12 | Wyeth Llc | Substituted oxindole cb2 agonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888846A (en) * | 1967-03-30 | 1975-06-10 | Hoffmann La Roche | Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives |
| US3586693A (en) * | 1969-07-07 | 1971-06-22 | American Home Prod | Imidazo(1,2-a)indolin-9-ols |
-
1971
- 1971-01-11 GB GB125071*[A patent/GB1366133A/en not_active Expired
- 1971-12-14 CY CY926A patent/CY926A/xx unknown
-
1972
- 1972-01-04 AU AU37558/72A patent/AU464388B2/en not_active Expired
- 1972-01-05 AT AT7772A patent/AT312595B/de not_active IP Right Cessation
- 1972-01-08 ES ES398678A patent/ES398678A1/es not_active Expired
- 1972-01-08 IE IE14/72A patent/IE35956B1/xx unknown
- 1972-01-09 EG EG12/72A patent/EG10888A/xx active
- 1972-01-10 AR AR240009A patent/AR192734A1/es active
- 1972-01-10 FI FI45/72A patent/FI54120C/fi active
- 1972-01-10 DK DK11672A patent/DK150143C/da not_active IP Right Cessation
- 1972-01-10 FR FR7200619A patent/FR2121699B1/fr not_active Expired
- 1972-01-11 BE BE777911A patent/BE777911A/xx not_active IP Right Cessation
- 1972-01-11 JP JP725481A patent/JPS5531156B2/ja not_active Expired
- 1972-01-11 CH CH36472A patent/CH573938A5/xx not_active IP Right Cessation
- 1972-01-11 SE SE7200278A patent/SE398645B/xx unknown
- 1972-01-11 NL NLAANVRAGE7200415,A patent/NL174251C/xx not_active IP Right Cessation
- 1972-10-26 KE KE2777A patent/KE2777A/xx unknown
- 1972-11-23 CA CA157,326A patent/CA1012150A/en not_active Expired
- 1972-12-05 ES ES409296A patent/ES409296A1/es not_active Expired
-
1977
- 1977-10-13 HK HK528/77A patent/HK52877A/xx unknown
-
1978
- 1978-12-31 MY MY197848A patent/MY7800048A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR192734A1 (es) | 1973-03-14 |
| AT312595B (de) | 1974-01-10 |
| DK150143C (da) | 1987-06-01 |
| NL174251B (nl) | 1983-12-16 |
| FI54120C (fi) | 1978-10-10 |
| CA1012150A (en) | 1977-06-14 |
| NL174251C (nl) | 1984-05-16 |
| FI54120B (fi) | 1978-06-30 |
| NL7200415A (enExample) | 1972-07-13 |
| ES409296A1 (es) | 1976-03-16 |
| ES398678A1 (es) | 1975-05-16 |
| AU3755872A (en) | 1973-07-05 |
| MY7800048A (en) | 1978-12-31 |
| FR2121699A1 (enExample) | 1972-08-25 |
| AU464388B2 (en) | 1975-08-28 |
| FR2121699B1 (enExample) | 1975-08-01 |
| KE2777A (en) | 1977-10-21 |
| IE35956L (en) | 1972-07-11 |
| JPS5531156B2 (enExample) | 1980-08-15 |
| HK52877A (en) | 1977-10-20 |
| GB1366133A (en) | 1974-09-11 |
| SE398645B (sv) | 1978-01-09 |
| EG10888A (en) | 1978-06-30 |
| CY926A (en) | 1977-12-23 |
| DK150143B (da) | 1986-12-15 |
| BE777911A (fr) | 1972-07-11 |
| CH573938A5 (enExample) | 1976-03-31 |
| JPS4839500A (enExample) | 1973-06-09 |
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