GB1399608A - Process for preparing indole derivatives - Google Patents
Process for preparing indole derivativesInfo
- Publication number
- GB1399608A GB1399608A GB5378271A GB5378271A GB1399608A GB 1399608 A GB1399608 A GB 1399608A GB 5378271 A GB5378271 A GB 5378271A GB 5378271 A GB5378271 A GB 5378271A GB 1399608 A GB1399608 A GB 1399608A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- oxo
- aralkyl
- absent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1399608 Derivatives of 3-(piperidinoalkyl)- indoles JOHN WYETH & BRO Ltd 6 Nov 1972 [19 Nov 1971] 53782/71 Addition to 1218570 Heading C2C The invention comprises compounds of formula wherein R<SP>1</SP> is H, C 1-6 alkyl, C 7-10 aralkyl or aroyl; R<SP>2</SP> is H, C 1-6 alkyl or aryl; R<SP>3</SP> is H, halogen, OH or C 1-6 alkyl or alkoxy; R<SP>4</SP> is H, halogen or C 1-6 alkyl; R<SP>5</SP> is aryl (possibly heterocyclic), C 1-6 alkoxy, aryloxy, C 7-10 aralkyl or aralkoxy, diaryl-C 1-6 -alkyl or C 5-7 cycloalkyl; R<SP>6</SP> is an organic quaternizing group removable under mild conditions, e.g. by hydrogenolysis; X is an anion; A is C 1-4 alkylene (possibly substituted by OH or 1-2 oxo groups which may be ketalized); Z is oxo when the bond represented by the broken line is absent, or is oxo or H 2 when that bond is present. These compounds, which are prepared by reacting together the appropriate 3-X-A-indole and 1-R<SP>6</SP>-piperidine, may be hydrogenolysed to give the corresponding unquaternized compounds (in which R<SP>6</SP> and X are absent). Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which act on the cardiovascular system (e.g. hypotensive and/or antihypertensive activity).
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5378271A GB1399608A (en) | 1971-11-19 | 1971-11-19 | Process for preparing indole derivatives |
CA155,563A CA994778A (en) | 1971-11-19 | 1972-10-31 | Process for preparing indole derivatives |
FI317172A FI56170C (en) | 1971-11-19 | 1972-11-13 | NYA SAOSOM MELLANPRODUKTER VID FRAMSTAELLNING AV THERAPEUTISKT VAERDEFULLA 3-INDOLYLPIPERIDINDERIVAT ANVAENDBARA KVATERNAERA ARYLMETYLPIPERIDINIUMSALTER |
NL7215534A NL7215534A (en) | 1971-11-19 | 1972-11-16 | |
SE1502672A SE397529B (en) | 1971-11-19 | 1972-11-17 | NEW INDIVIDUAL DERIVATIVES INTENDED AS INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 3-INDOLYLPIPERIDE INDIVIDUALS WITH THERAPEUTIC EFFECT |
CH1683072A CH572921A5 (en) | 1971-11-19 | 1972-11-17 | |
JP11548272A JPS5545554B2 (en) | 1971-11-19 | 1972-11-17 | |
DK576372A DK140759B (en) | 1971-11-19 | 1972-11-17 | Indole derivatives for use as intermediates in the preparation of other indole derivatives. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5378271A GB1399608A (en) | 1971-11-19 | 1971-11-19 | Process for preparing indole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1399608A true GB1399608A (en) | 1975-07-02 |
Family
ID=10468968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5378271A Expired GB1399608A (en) | 1971-11-19 | 1971-11-19 | Process for preparing indole derivatives |
Country Status (8)
Country | Link |
---|---|
JP (1) | JPS5545554B2 (en) |
CA (1) | CA994778A (en) |
CH (1) | CH572921A5 (en) |
DK (1) | DK140759B (en) |
FI (1) | FI56170C (en) |
GB (1) | GB1399608A (en) |
NL (1) | NL7215534A (en) |
SE (1) | SE397529B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5114949A (en) * | 1989-11-20 | 1992-05-19 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and medicinal products containing them |
-
1971
- 1971-11-19 GB GB5378271A patent/GB1399608A/en not_active Expired
-
1972
- 1972-10-31 CA CA155,563A patent/CA994778A/en not_active Expired
- 1972-11-13 FI FI317172A patent/FI56170C/en active
- 1972-11-16 NL NL7215534A patent/NL7215534A/xx active Search and Examination
- 1972-11-17 JP JP11548272A patent/JPS5545554B2/ja not_active Expired
- 1972-11-17 CH CH1683072A patent/CH572921A5/xx not_active IP Right Cessation
- 1972-11-17 SE SE1502672A patent/SE397529B/en unknown
- 1972-11-17 DK DK576372A patent/DK140759B/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5114949A (en) * | 1989-11-20 | 1992-05-19 | Rhone-Poulenc Sante | Heterocyclic derivatives, their preparation and medicinal products containing them |
Also Published As
Publication number | Publication date |
---|---|
DK140759B (en) | 1979-11-12 |
DK140759C (en) | 1980-05-05 |
FI56170B (en) | 1979-08-31 |
JPS4861470A (en) | 1973-08-28 |
NL7215534A (en) | 1973-05-22 |
CA994778A (en) | 1976-08-10 |
FI56170C (en) | 1979-12-10 |
JPS5545554B2 (en) | 1980-11-18 |
CH572921A5 (en) | 1976-02-27 |
SE397529B (en) | 1977-11-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PE20 | Patent expired after termination of 20 years |