IE33988B1 - Benzodiazepine derivatives and the manufacture thereof - Google Patents
Benzodiazepine derivatives and the manufacture thereofInfo
- Publication number
- IE33988B1 IE33988B1 IE156/70A IE15670A IE33988B1 IE 33988 B1 IE33988 B1 IE 33988B1 IE 156/70 A IE156/70 A IE 156/70A IE 15670 A IE15670 A IE 15670A IE 33988 B1 IE33988 B1 IE 33988B1
- Authority
- IE
- Ireland
- Prior art keywords
- compound
- formula
- alkoxyalkoxy
- alkoxy
- alkyl
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 22
- 125000003545 alkoxy group Chemical group 0.000 abstract 12
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000004984 dialkylaminoalkoxy group Chemical group 0.000 abstract 11
- 125000005041 acyloxyalkyl group Chemical group 0.000 abstract 10
- 125000004414 alkyl thio group Chemical group 0.000 abstract 10
- 125000003418 alkyl amino alkoxy group Chemical group 0.000 abstract 9
- 125000000278 alkyl amino alkyl group Chemical group 0.000 abstract 9
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 9
- -1 carbalkoxy Chemical group 0.000 abstract 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 8
- 125000001188 haloalkyl group Chemical group 0.000 abstract 7
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 6
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 5
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 4
- 230000001590 oxidative effect Effects 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000002431 aminoalkoxy group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940005530 anxiolytics Drugs 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 230000003635 deoxygenating effect Effects 0.000 abstract 1
- 125000005265 dialkylamine group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000006682 monohaloalkyl group Chemical group 0.000 abstract 1
- 229940035363 muscle relaxants Drugs 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IE617/73A IE33990B1 (en) | 1969-02-14 | 1970-02-06 | Benzodiazepine derivatives |
IE619/73A IE33992B1 (en) | 1969-02-14 | 1970-02-06 | Benzodiazepine derivatives and manufacture thereof |
IE616/73A IE33989B1 (en) | 1969-02-14 | 1970-02-06 | Phenyl ketones |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH225569A CH562220A5 (enrdf_load_stackoverflow) | 1969-02-14 | 1969-02-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
IE33988L IE33988L (en) | 1970-08-14 |
IE33988B1 true IE33988B1 (en) | 1974-12-30 |
Family
ID=4229492
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE156/70A IE33988B1 (en) | 1969-02-14 | 1970-02-06 | Benzodiazepine derivatives and the manufacture thereof |
IE618/73A IE33991B1 (en) | 1969-02-14 | 1970-02-06 | Benzodiazepine derivatives |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE618/73A IE33991B1 (en) | 1969-02-14 | 1970-02-06 | Benzodiazepine derivatives |
Country Status (23)
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE787117A (fr) * | 1971-08-04 | 1973-02-05 | Hoffmann La Roche | Derives de benzodiazepine |
JPS4867288A (enrdf_load_stackoverflow) * | 1971-12-14 | 1973-09-13 | ||
US3932637A (en) * | 1974-07-22 | 1976-01-13 | Sumitomo Chemical Company, Limited | Methods and compositions for improving the feed intake of meat producing animals |
CA1163266A (en) * | 1980-07-31 | 1984-03-06 | Albert E. Fischli | Benzodiazepine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3136815A (en) * | 1959-12-10 | 1964-06-09 | Hoffmann La Roche | Amino substituted benzophenone oximes and derivatives thereof |
-
1969
- 1969-02-14 CH CH225569A patent/CH562220A5/xx not_active IP Right Cessation
- 1969-12-15 BR BR215093/69A patent/BR6915093D0/pt unknown
-
1970
- 1970-02-02 IL IL33821A patent/IL33821A/xx unknown
- 1970-02-04 CA CA073,934A patent/CA971960A/en not_active Expired
- 1970-02-05 OA OA53847A patent/OA03435A/xx unknown
- 1970-02-06 DE DE19702005508 patent/DE2005508A1/de not_active Ceased
- 1970-02-06 IE IE156/70A patent/IE33988B1/xx unknown
- 1970-02-06 IE IE618/73A patent/IE33991B1/xx unknown
- 1970-02-10 SU SU1658463A patent/SU406359A3/ru active
- 1970-02-10 SU SU1691948A patent/SU453841A3/ru active
- 1970-02-10 SU SU1691947A patent/SU406360A3/ru active
- 1970-02-10 SU SU1691943A patent/SU404253A3/ru active
- 1970-02-10 SU SU1666627A patent/SU428603A3/ru active
- 1970-02-10 SU SU1670155A patent/SU430552A3/ru active
- 1970-02-10 SU SU1665719A patent/SU431673A3/ru active
- 1970-02-10 SU SU1691526A patent/SU421195A3/ru active
- 1970-02-10 SU SU1691944A patent/SU402219A3/ru active
- 1970-02-10 SU SU1691525A patent/SU415880A3/ru active
- 1970-02-10 SU SU1400104A patent/SU497774A3/ru active
- 1970-02-11 GB GB3375172A patent/GB1306452A/en not_active Expired
- 1970-02-11 CS CS95470*#A patent/CS159260B2/cs unknown
- 1970-02-11 GB GB4314272A patent/GB1306455A/en not_active Expired
- 1970-02-11 GB GB6675372A patent/GB1306454A/en not_active Expired
- 1970-02-11 GB GB645070A patent/GB1306451A/en not_active Expired
- 1970-02-12 IS IS1906A patent/IS1906A7/is unknown
- 1970-02-12 BE BE745852D patent/BE745852A/xx unknown
- 1970-02-12 DO DO1970001703A patent/DOP1970001703A/es unknown
- 1970-02-13 DK DK72870AA patent/DK137899B/da not_active Application Discontinuation
- 1970-02-13 AT AT505171A patent/AT302317B/de not_active IP Right Cessation
- 1970-02-13 ES ES376528A patent/ES376528A1/es not_active Expired
- 1970-02-13 AT AT505371A patent/AT302319B/de not_active IP Right Cessation
- 1970-02-13 NL NL7002084.A patent/NL156401B/xx not_active IP Right Cessation
- 1970-02-13 AT AT504971A patent/AT302316B/de not_active IP Right Cessation
- 1970-02-13 AT AT505271A patent/AT302318B/de not_active IP Right Cessation
- 1970-02-13 AT AT505771A patent/AT302323B/de not_active IP Right Cessation
- 1970-02-13 AT AT505471A patent/AT302320B/de not_active IP Right Cessation
- 1970-02-13 NO NO00510/70A patent/NO128328B/no unknown
- 1970-02-13 FR FR707005175A patent/FR2034550B1/fr not_active Expired
- 1970-02-13 AT AT505571A patent/AT302321B/de not_active IP Right Cessation
- 1970-02-13 PL PL1970138780A patent/PL80826B1/pl unknown
- 1970-02-13 AT AT131770A patent/AT299208B/de not_active IP Right Cessation
- 1970-02-13 FI FI700400A patent/FI49965C/fi active
- 1970-02-13 SE SE01893/70A patent/SE358393B/xx unknown
- 1970-02-13 AT AT505071A patent/AT301555B/de not_active IP Right Cessation
- 1970-02-13 AT AT505671A patent/AT302322B/de not_active IP Right Cessation
- 1970-02-14 RO RO68269A patent/RO57161A/ro unknown
- 1970-02-14 RO RO68267A patent/RO57028A/ro unknown
- 1970-02-14 RO RO68266A patent/RO57160A/ro unknown
- 1970-02-14 RO RO62467A patent/RO58075A/ro unknown
- 1970-02-14 RO RO68268A patent/RO57030A/ro unknown
- 1970-05-12 GB GB3385272A patent/GB1306453A/en not_active Expired
-
1971
- 1971-05-13 SU SU1657960A patent/SU517258A3/ru active
-
1973
- 1973-01-24 NO NO00292/73A patent/NO128110B/no unknown
- 1973-05-22 IL IL7342330A patent/IL42330A0/xx unknown
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