GB1306454A - Benzodiazepine derivatives - Google Patents

Benzodiazepine derivatives

Info

Publication number
GB1306454A
GB1306454A GB6675372A GB6675370A GB1306454A GB 1306454 A GB1306454 A GB 1306454A GB 6675372 A GB6675372 A GB 6675372A GB 6675370 A GB6675370 A GB 6675370A GB 1306454 A GB1306454 A GB 1306454A
Authority
GB
United Kingdom
Prior art keywords
carbalkoxy
dialkylaminoalkoxy
alkyl
alkylaminoalkoxy
acyloxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6675372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1306454A publication Critical patent/GB1306454A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

1306454 Benzodiazepines F HOFFMANNLA ROCHE & CO AG 11 Feb 1970 [14 Feb 1969] 33753/72 Divided out of 1306451 Heading C2C Compounds of the general formula (R 1 = halogen, NO 2 ; R 2 = phenyl, halophenyl, pyridyl; R 6 = H, carbalkoxy; R 3 = H, alkyl, hydroxyalkyl, carbalkoxy, alkylaminoalkyl, dialkylaminoalkyl, acyloxyalkyl, haloalkyl; R 4 = alkoxy, haloalkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, hydroxyalkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl; provided that R 4 is not alkylaminoalkoxy or dialkylaminoalkoxy when R 3 = carbalkoxy) are prepared by (a) reacting a compound of the formula (R 28 = acyl; R 24 = alkoxy, alkylaminoalkoxy, dialkylaminoalkoxy, hydroxyalkoxy, alkoxyalkoxy; R 25 = H, alkyl, hydroxyalkyl, carbalkoxy, alkylaminoalkyl, dialkylaminoalkyl, acyloxyalkyl) or (R 30 = mesyl, tosyl; R 31 = H, alkyl, hydroxyalkyl, carbalkoxy, dialkylaminoalkyl, acyloxyalkyl; R 32 = alkoxy, dialkylaminoalkoxy, hydroxyalkoxy, alkoxyalkoxy, alkylthio, alkyl - sulphinyl, alkylsulphonyl) with a base, or (b) introducing or modifying the 1-substituent.
GB6675372A 1969-02-14 1970-02-11 Benzodiazepine derivatives Expired GB1306454A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH225569A CH562220A5 (en) 1969-02-14 1969-02-14

Publications (1)

Publication Number Publication Date
GB1306454A true GB1306454A (en) 1973-02-14

Family

ID=4229492

Family Applications (5)

Application Number Title Priority Date Filing Date
GB645070A Expired GB1306451A (en) 1969-02-14 1970-02-11 Benzodiazepine derivatives and manufacture thereof
GB3375172A Expired GB1306452A (en) 1969-02-14 1970-02-11 Phenyl ketones
GB6675372A Expired GB1306454A (en) 1969-02-14 1970-02-11 Benzodiazepine derivatives
GB4314272A Expired GB1306455A (en) 1969-02-14 1970-02-11 Benzodiazepine derivatives and manufacture thereof
GB3385272A Expired GB1306453A (en) 1969-02-14 1970-05-12 Benzodiazepine derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB645070A Expired GB1306451A (en) 1969-02-14 1970-02-11 Benzodiazepine derivatives and manufacture thereof
GB3375172A Expired GB1306452A (en) 1969-02-14 1970-02-11 Phenyl ketones

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB4314272A Expired GB1306455A (en) 1969-02-14 1970-02-11 Benzodiazepine derivatives and manufacture thereof
GB3385272A Expired GB1306453A (en) 1969-02-14 1970-05-12 Benzodiazepine derivatives

Country Status (23)

Country Link
AT (10) AT302322B (en)
BE (1) BE745852A (en)
BR (1) BR6915093D0 (en)
CA (1) CA971960A (en)
CH (1) CH562220A5 (en)
CS (1) CS159260B2 (en)
DE (1) DE2005508A1 (en)
DK (1) DK137899B (en)
DO (1) DOP1970001703A (en)
ES (1) ES376528A1 (en)
FI (1) FI49965C (en)
FR (1) FR2034550B1 (en)
GB (5) GB1306451A (en)
IE (2) IE33991B1 (en)
IL (2) IL33821A (en)
IS (1) IS1906A7 (en)
NL (1) NL156401B (en)
NO (2) NO128328B (en)
OA (1) OA03435A (en)
PL (1) PL80826B1 (en)
RO (5) RO57161A (en)
SE (1) SE358393B (en)
SU (11) SU415880A3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787117A (en) * 1971-08-04 1973-02-05 Hoffmann La Roche BENZODIAZEPINE DERIVATIVES
JPS4867288A (en) * 1971-12-14 1973-09-13
US3932637A (en) * 1974-07-22 1976-01-13 Sumitomo Chemical Company, Limited Methods and compositions for improving the feed intake of meat producing animals
CA1163266A (en) * 1980-07-31 1984-03-06 Albert E. Fischli Benzodiazepine derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3136815A (en) * 1959-12-10 1964-06-09 Hoffmann La Roche Amino substituted benzophenone oximes and derivatives thereof

Also Published As

Publication number Publication date
RO57028A (en) 1974-12-11
AT302321B (en) 1972-10-10
SU428603A3 (en) 1974-05-15
IL42330A0 (en) 1973-07-30
AT302319B (en) 1972-10-10
RO58075A (en) 1975-06-15
AT302320B (en) 1972-10-10
IS1906A7 (en) 1970-08-15
AT301555B (en) 1972-09-11
NL7002084A (en) 1970-08-18
NO128110B (en) 1973-10-01
DK137899B (en) 1978-05-29
IL33821A0 (en) 1970-04-20
SU431673A3 (en) 1974-06-05
FI49965C (en) 1975-11-10
CS159260B2 (en) 1974-12-27
CA971960A (en) 1975-07-29
SU406359A3 (en) 1973-11-05
GB1306455A (en) 1973-02-14
SU497774A3 (en) 1975-12-30
BE745852A (en) 1970-08-12
NO128328B (en) 1973-10-29
GB1306452A (en) 1973-02-14
GB1306453A (en) 1973-02-14
SU415880A3 (en) 1974-02-15
SU406360A3 (en) 1973-11-05
DE2005508A1 (en) 1970-08-27
FR2034550A1 (en) 1970-12-11
AT302323B (en) 1972-10-10
IE33988L (en) 1970-08-14
OA03435A (en) 1971-03-30
BR6915093D0 (en) 1973-03-08
NL156401B (en) 1978-04-17
SU430552A3 (en) 1974-05-30
DK137899C (en) 1978-10-30
SU517258A3 (en) 1976-06-05
ES376528A1 (en) 1972-04-16
PL80826B1 (en) 1975-08-30
AT302318B (en) 1972-10-10
FR2034550B1 (en) 1974-02-22
RO57160A (en) 1974-12-11
GB1306451A (en) 1973-02-14
IL33821A (en) 1974-05-16
SU453841A3 (en) 1974-12-15
AT302316B (en) 1972-10-10
IE33988B1 (en) 1974-12-30
RO57161A (en) 1974-12-11
SU402219A3 (en) 1973-10-12
SE358393B (en) 1973-07-30
FI49965B (en) 1975-07-31
AT299208B (en) 1972-06-12
SU404253A3 (en) 1973-10-26
DOP1970001703A (en) 1975-02-14
CH562220A5 (en) 1975-05-30
AT302322B (en) 1972-10-10
SU421195A3 (en) 1974-03-25
RO57030A (en) 1975-01-15
AT302317B (en) 1972-10-10
IE33991B1 (en) 1974-12-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees