ID30129A - Turunan-turunan tioamida - Google Patents

Turunan-turunan tioamida

Info

Publication number
ID30129A
ID30129A IDW00200101770A ID20011770A ID30129A ID 30129 A ID30129 A ID 30129A ID W00200101770 A IDW00200101770 A ID W00200101770A ID 20011770 A ID20011770 A ID 20011770A ID 30129 A ID30129 A ID 30129A
Authority
ID
Indonesia
Prior art keywords
tioamida
decreases
vcam
vla
asthma
Prior art date
Application number
IDW00200101770A
Other languages
English (en)
Indonesian (id)
Inventor
Kenneth Gregory Hull
Achytharao Sidduri
Jefferson Wright Tilley
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ID30129A publication Critical patent/ID30129A/id

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/46Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/48Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56Amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30Oxygen or sulfur atoms
    • C07D233/32One oxygen atom
    • C07D233/38One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Gyroscopes (AREA)
  • Liquid Crystal Substances (AREA)
IDW00200101770A 1999-02-18 2000-02-10 Turunan-turunan tioamida ID30129A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12047599P 1999-02-18 1999-02-18

Publications (1)

Publication Number Publication Date
ID30129A true ID30129A (id) 2001-11-08

Family

ID=22390545

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW00200101770A ID30129A (id) 1999-02-18 2000-02-10 Turunan-turunan tioamida

Country Status (29)

Country Link
US (6) US6288267B1 (ru)
EP (1) EP1154993B1 (ru)
JP (1) JP2002537286A (ru)
KR (1) KR100649819B1 (ru)
CN (1) CN1213025C (ru)
AT (1) ATE278664T1 (ru)
AU (1) AU773388B2 (ru)
BR (1) BR0008280A (ru)
CA (1) CA2362831C (ru)
CZ (1) CZ20012980A3 (ru)
DE (1) DE60014588T2 (ru)
DK (1) DK1154993T3 (ru)
ES (1) ES2228458T3 (ru)
HK (1) HK1044330A1 (ru)
HR (1) HRP20010595B1 (ru)
HU (1) HUP0200155A3 (ru)
ID (1) ID30129A (ru)
IL (2) IL144636A0 (ru)
MA (1) MA26769A1 (ru)
NO (1) NO20014018L (ru)
NZ (1) NZ513254A (ru)
PL (1) PL349461A1 (ru)
PT (1) PT1154993E (ru)
RU (1) RU2245874C2 (ru)
SI (1) SI1154993T1 (ru)
TR (1) TR200102399T2 (ru)
WO (1) WO2000048994A1 (ru)
YU (1) YU58701A (ru)
ZA (1) ZA200106180B (ru)

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US6521626B1 (en) * 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
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US6380387B1 (en) 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
EP2267042B1 (en) * 2000-01-26 2015-06-10 Mitsui Chemicals, Inc. Olefin diblock copolymer of very low polydispersity and process for preparing the same
WO2001070670A1 (fr) 2000-03-23 2001-09-27 Ajinomoto Co., Inc. Nouveau derive de phenylalanine
US6960597B2 (en) * 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
PL361424A1 (en) * 2000-09-14 2004-10-04 Grünenthal GmbH ß-THIO-AMINO ACIDS
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20090297611A1 (en) * 2003-07-31 2009-12-03 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or vcam inhibitor for treatment of asthma or chronic obstructive pulmonary disease
US20050069227A1 (en) * 2003-09-29 2005-03-31 Mark Steele Flexible package having integrated slit member
US20050176755A1 (en) * 2003-10-31 2005-08-11 Dyatkin Alexey B. Aza-bridged-bicyclic amino acid derivatives as alpha4 integrin antagonists
BRPI0506676A (pt) * 2004-02-10 2007-05-15 Janssen Phamaceutica N V piridazinona uréias como antagonistas de integrinas alfa4
CN1938283A (zh) * 2004-02-10 2007-03-28 詹森药业有限公司 作为α4整联蛋白拮抗剂的哒嗪酮
US7514409B2 (en) * 2004-03-10 2009-04-07 Merck & Co., Inc. VLA-4 antagonists
CA2576647C (en) * 2004-08-16 2011-12-13 Merck & Co., Inc. Vla-4 antagonists
US7641325B2 (en) * 2004-10-04 2010-01-05 Kodak Graphic Communications Group Canada Non-conductive fluid droplet characterizing apparatus and method
WO2006081986A1 (en) * 2005-02-07 2006-08-10 F.Hoffmann-La Roche Ag Bambuterol and integrin inhibitor combination
WO2006094640A2 (en) * 2005-03-04 2006-09-14 F.Hoffmann-La Roche Ag Roflumilast and integrin inhibitor combination and method of treatment
CZ2005337A3 (cs) * 2005-05-26 2007-01-10 Universita Karlova v Praze, Farmaceutická fakulta v Hradci Králové Antimykotické a antimykobakteriální thiosalicylanilidy a způsob jejich přípravy
CN103265495B (zh) * 2005-12-29 2016-11-16 莱西肯医药有限公司 多环氨基酸衍生物及其使用方法
AU2008219007A1 (en) 2007-02-20 2008-08-28 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
NZ585556A (en) * 2007-11-07 2012-07-27 Celldex Therapeutics Inc Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
EA022201B1 (ru) 2008-04-11 2015-11-30 Мерримак Фармасьютикалз, Инк. Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение
WO2010059315A1 (en) 2008-11-18 2010-05-27 Merrimack Pharmaceuticals, Inc. Human serum albumin linkers and conjugates thereof
US8343706B2 (en) 2010-01-25 2013-01-01 International Business Machines Corporation Fluorine-free fused ring heteroaromatic photoacid generators and resist compositions containing the same
EP2769223A1 (en) 2011-10-17 2014-08-27 Westfälische Wilhelms-Universität Münster Assessment of pml risk and methods based thereon
WO2014036520A1 (en) 2012-08-30 2014-03-06 Merrimack Pharmaceuticals, Inc. Combination therapies comprising anti-erbb3 agents
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
JP7189369B2 (ja) 2018-10-30 2022-12-13 ギリアード サイエンシーズ, インコーポレイテッド アルファ4β7インテグリンの阻害のための化合物
JP7192139B2 (ja) 2018-10-30 2022-12-19 ギリアード サイエンシーズ, インコーポレイテッド α4β7インテグリン阻害剤としてのキノリン誘導体
WO2020092394A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
EP4013499A1 (en) 2019-08-14 2022-06-22 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
CN113683499B (zh) * 2021-09-10 2024-01-30 上海皓鸿生物医药科技有限公司 一种制备杜韦利西布中间体的方法

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JP2002504534A (ja) 1998-02-26 2002-02-12 セルテック・セラピューティクス・リミテッド α4インテグリンの阻害剤としてのフェニルアラニン誘導体
US6521626B1 (en) 1998-03-24 2003-02-18 Celltech R&D Limited Thiocarboxamide derivatives
GB9811159D0 (en) 1998-05-22 1998-07-22 Celltech Therapeutics Ltd Chemical compounds

Also Published As

Publication number Publication date
NO20014018D0 (no) 2001-08-17
US20010041799A1 (en) 2001-11-15
HRP20010595A2 (en) 2002-08-31
PL349461A1 (en) 2002-07-29
EP1154993A1 (en) 2001-11-21
JP2002537286A (ja) 2002-11-05
HK1044330A1 (en) 2002-10-18
YU58701A (sh) 2004-05-12
CN1213025C (zh) 2005-08-03
NO20014018L (no) 2001-08-17
HUP0200155A3 (en) 2005-04-28
HRP20010595B1 (en) 2006-02-28
RU2245874C2 (ru) 2005-02-10
PT1154993E (pt) 2005-01-31
AU773388B2 (en) 2004-05-27
IL144636A (en) 2007-06-17
TR200102399T2 (tr) 2002-01-21
ATE278664T1 (de) 2004-10-15
WO2000048994A1 (en) 2000-08-24
US20020010338A1 (en) 2002-01-24
AU2547500A (en) 2000-09-04
US6479666B2 (en) 2002-11-12
DK1154993T3 (da) 2005-02-14
US20020040148A1 (en) 2002-04-04
US20020028933A1 (en) 2002-03-07
CA2362831A1 (en) 2000-08-24
SI1154993T1 (en) 2004-12-31
EP1154993B1 (en) 2004-10-06
KR20010102243A (ko) 2001-11-15
DE60014588D1 (en) 2004-11-11
US6288267B1 (en) 2001-09-11
US6423728B1 (en) 2002-07-23
BR0008280A (pt) 2001-11-06
US6426348B1 (en) 2002-07-30
CZ20012980A3 (cs) 2002-04-17
US6458844B2 (en) 2002-10-01
NZ513254A (en) 2003-10-31
HUP0200155A2 (en) 2002-06-29
CN1342140A (zh) 2002-03-27
US20020052508A1 (en) 2002-05-02
ES2228458T3 (es) 2005-04-16
DE60014588T2 (de) 2006-02-23
CA2362831C (en) 2008-10-07
MA26769A1 (fr) 2004-12-20
IL144636A0 (en) 2002-05-23
ZA200106180B (en) 2002-10-28
KR100649819B1 (ko) 2007-02-28

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