PL1716147T3 - Pochodne diazaspiropiperydyny jako inhibitory transportera 1 glicyny i transportera 2 glicyny - Google Patents

Pochodne diazaspiropiperydyny jako inhibitory transportera 1 glicyny i transportera 2 glicyny

Info

Publication number
PL1716147T3
PL1716147T3 PL04804425T PL04804425T PL1716147T3 PL 1716147 T3 PL1716147 T3 PL 1716147T3 PL 04804425 T PL04804425 T PL 04804425T PL 04804425 T PL04804425 T PL 04804425T PL 1716147 T3 PL1716147 T3 PL 1716147T3
Authority
PL
Poland
Prior art keywords
glycine transporter
sup
diaza
inhibitors
spiropiperidine derivatives
Prior art date
Application number
PL04804425T
Other languages
English (en)
Inventor
Synese Jolidon
Emmanuel Pinard
Andrew William Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL1716147T3 publication Critical patent/PL1716147T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL04804425T 2004-01-08 2004-12-30 Pochodne diazaspiropiperydyny jako inhibitory transportera 1 glicyny i transportera 2 glicyny PL1716147T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04100034 2004-01-08
EP04804425A EP1716147B1 (en) 2004-01-08 2004-12-30 Diaza-spiropiperidine derivatives as inhibitors of glycine transporter 1 and glycine transporter 2
PCT/EP2004/014840 WO2005068462A1 (en) 2004-01-08 2004-12-30 Diaza-spiropiperidine derivatives as inhibitors of transporter 1 and glycine transporter 2

Publications (1)

Publication Number Publication Date
PL1716147T3 true PL1716147T3 (pl) 2008-03-31

Family

ID=34717284

Family Applications (1)

Application Number Title Priority Date Filing Date
PL04804425T PL1716147T3 (pl) 2004-01-08 2004-12-30 Pochodne diazaspiropiperydyny jako inhibitory transportera 1 glicyny i transportera 2 glicyny

Country Status (14)

Country Link
US (1) US7265126B2 (pl)
EP (1) EP1716147B1 (pl)
JP (1) JP4527732B2 (pl)
KR (1) KR100783836B1 (pl)
CN (1) CN100422183C (pl)
AT (1) ATE378339T1 (pl)
AU (1) AU2004313692B2 (pl)
BR (1) BRPI0418374A (pl)
CA (1) CA2553938A1 (pl)
DE (1) DE602004010186T2 (pl)
ES (1) ES2295963T3 (pl)
PL (1) PL1716147T3 (pl)
RU (1) RU2351599C2 (pl)
WO (1) WO2005068462A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8552024B2 (en) * 2010-08-13 2013-10-08 Hoffman-La Roche Inc. Azacyclic compounds
AR092031A1 (es) * 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
AU2017290362B2 (en) 2016-07-01 2021-08-05 Pharmacosmos Holding A/S Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
WO2020041770A1 (en) 2018-08-24 2020-02-27 G1 Therapeutics, Inc. Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE897058A (fr) * 1982-06-25 1983-12-16 Sandoz Sa Utilisation d'un derive du spiro-succinimide dans le traitement de la demence du type alzheimer
BE900003A (fr) * 1983-06-27 1984-12-27 Sandoz Sa Derives du spirosuccinimide utilisables comme medicaments.
IL107881A0 (en) * 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
CA2467118A1 (en) * 2001-12-20 2003-07-03 H. Lundbeck A/S Aryloxyphenyl and arylsulfanylphenyl derivatives

Also Published As

Publication number Publication date
WO2005068462A1 (en) 2005-07-28
US7265126B2 (en) 2007-09-04
ES2295963T3 (es) 2008-04-16
KR20060112684A (ko) 2006-11-01
KR100783836B1 (ko) 2007-12-10
CA2553938A1 (en) 2005-07-28
AU2004313692B2 (en) 2011-07-28
US20050154000A1 (en) 2005-07-14
RU2006128612A (ru) 2008-02-20
RU2351599C2 (ru) 2009-04-10
EP1716147A1 (en) 2006-11-02
ATE378339T1 (de) 2007-11-15
DE602004010186T2 (de) 2008-07-03
DE602004010186D1 (de) 2007-12-27
CN1902203A (zh) 2007-01-24
EP1716147B1 (en) 2007-11-14
CN100422183C (zh) 2008-10-01
BRPI0418374A (pt) 2007-05-22
JP2007517815A (ja) 2007-07-05
AU2004313692A1 (en) 2005-07-28
JP4527732B2 (ja) 2010-08-18

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