BRPI0418374A - derivados de diaza-espiropiperidina como inibidores de transportador 1 de glicina e transportador 2 de glicina - Google Patents

derivados de diaza-espiropiperidina como inibidores de transportador 1 de glicina e transportador 2 de glicina

Info

Publication number
BRPI0418374A
BRPI0418374A BRPI0418374-6A BRPI0418374A BRPI0418374A BR PI0418374 A BRPI0418374 A BR PI0418374A BR PI0418374 A BRPI0418374 A BR PI0418374A BR PI0418374 A BRPI0418374 A BR PI0418374A
Authority
BR
Brazil
Prior art keywords
lower alkyl
halogen
optionally substituted
group
glycine transporter
Prior art date
Application number
BRPI0418374-6A
Other languages
English (en)
Inventor
Synese Jolidon
Emmanuel Pinard
Andrew William Thomas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0418374A publication Critical patent/BRPI0418374A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00

Abstract

DERIVADOS DE DIAZA-ESPIROPIREDIDINA COMO INIBIDORES DE TRANSPORTADOR 1 DE GLICINA E TRANSPORTADOR 2 DE GLICINA. A presente invenção refere-se a compostos de fórmula (I) em que A-B é CH~ 2~-CH~ 2~, -CH~ 2~-O-, -O-CH~ 2~-, -CH~ 2~-S-, -S-CH~ 2~-, -CH~ 2~-C(O)-, -C(O)-CH~ 2~-, -N(R¬ 4 ¬)-CH ~2~- ou -CH~ 2 ~-N(R¬ 4 ¬)-; R¬ 1 ¬ é alquila inferior, alquenila inferior, cicloalquila, ou é arila opcionalmente substituída por um ou dois substituintes, selecionados do grupo consistindo em halogênio, ciano, alquila inferior, CF~ 3~, OCF~ 3~ ou alcóxi inferior, ou é heteroalila, opcionalmente substituída por um ou dois substituintes selecionados do grupo consistindo em halogênio, alquila inferior, CF~ 3~ou alcóxi inferior; R¬ 2 ¬ é aquila inferior, cicloalquila, ou é arila, opcionalmente substituída por um ou dois substituintes, selecionado do grupo consistindo em halogênio, alquila inferior, CF~ 3~, alcóxi inferior, ou é heteroalila, opcionalmente substituída por um ou dois substituintes, selecionados do grupo consistindo em halogênio, alquila inferior, CF ~3~ ou alcóxi inferior; ou é heteroarila, opcionalmente substituída por um ou dois substituintes, selecionados do grupo consistindo em halogênio, alquila inferior, CF~ 3~ ou alcóxi inferior; R¬ 3 ¬ é o hidrogênio, alquila inferior ou benzila; R¬ 4 ¬ é hidrogênio ou benzila; n é o 0,1 ou 2; e a sais farmaceuticamente disponíveis destes. Os compostos de formúla I podem se empregados no tratamento de distúrbios neurológicos e neuropsiquiátricos.
BRPI0418374-6A 2004-01-08 2004-12-30 derivados de diaza-espiropiperidina como inibidores de transportador 1 de glicina e transportador 2 de glicina BRPI0418374A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100034 2004-01-08
PCT/EP2004/014840 WO2005068462A1 (en) 2004-01-08 2004-12-30 Diaza-spiropiperidine derivatives as inhibitors of transporter 1 and glycine transporter 2

Publications (1)

Publication Number Publication Date
BRPI0418374A true BRPI0418374A (pt) 2007-05-22

Family

ID=34717284

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418374-6A BRPI0418374A (pt) 2004-01-08 2004-12-30 derivados de diaza-espiropiperidina como inibidores de transportador 1 de glicina e transportador 2 de glicina

Country Status (14)

Country Link
US (1) US7265126B2 (pt)
EP (1) EP1716147B1 (pt)
JP (1) JP4527732B2 (pt)
KR (1) KR100783836B1 (pt)
CN (1) CN100422183C (pt)
AT (1) ATE378339T1 (pt)
AU (1) AU2004313692B2 (pt)
BR (1) BRPI0418374A (pt)
CA (1) CA2553938A1 (pt)
DE (1) DE602004010186T2 (pt)
ES (1) ES2295963T3 (pt)
PL (1) PL1716147T3 (pt)
RU (1) RU2351599C2 (pt)
WO (1) WO2005068462A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8552024B2 (en) * 2010-08-13 2013-10-08 Hoffman-La Roche Inc. Azacyclic compounds
AR092031A1 (es) * 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
CA3028752A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
SG11202101807SA (en) 2018-08-24 2021-03-30 G1 Therapeutics Inc Improved synthesis of 1,4-diazaspiro[5.5]undecan-3-one

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE897058A (fr) * 1982-06-25 1983-12-16 Sandoz Sa Utilisation d'un derive du spiro-succinimide dans le traitement de la demence du type alzheimer
BE900003A (fr) * 1983-06-27 1984-12-27 Sandoz Sa Derives du spirosuccinimide utilisables comme medicaments.
IL107881A0 (en) * 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
WO2003053942A1 (en) * 2001-12-20 2003-07-03 H. Lundbeck A/S Aryloxyphenyl and arylsulfanylphenyl derivatives

Also Published As

Publication number Publication date
CN100422183C (zh) 2008-10-01
US7265126B2 (en) 2007-09-04
RU2006128612A (ru) 2008-02-20
RU2351599C2 (ru) 2009-04-10
EP1716147B1 (en) 2007-11-14
PL1716147T3 (pl) 2008-03-31
AU2004313692B2 (en) 2011-07-28
DE602004010186T2 (de) 2008-07-03
CA2553938A1 (en) 2005-07-28
ATE378339T1 (de) 2007-11-15
AU2004313692A1 (en) 2005-07-28
JP2007517815A (ja) 2007-07-05
KR20060112684A (ko) 2006-11-01
US20050154000A1 (en) 2005-07-14
ES2295963T3 (es) 2008-04-16
JP4527732B2 (ja) 2010-08-18
CN1902203A (zh) 2007-01-24
DE602004010186D1 (de) 2007-12-27
KR100783836B1 (ko) 2007-12-10
WO2005068462A1 (en) 2005-07-28
EP1716147A1 (en) 2006-11-02

Similar Documents

Publication Publication Date Title
BRPI0507903A (pt) derivados de quinazolina e composição farmacêutica compreendendo os mesmos
EA200870358A1 (ru) 2-(циклический амино) пиримидоновые производные в качестве ингибиторов tpk1
EA201000050A1 (ru) Замещенные бициклолактамные соединения
BRPI0519794A2 (pt) derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos
ATE515505T1 (de) Heterocyclische fxr-bindende verbindungen
EA200900066A1 (ru) Кристаллические сольваты и комплексы производных (1s)-1,5-ангидро-1-c-(3-((фенил)метил)фенил) -d-глюцитола с аминокислотами в качестве ингибиторов sglt2 для лечения диабета
DE602005023544D1 (de) Angiogeneseinhibitoren
BRPI0508051A (pt) derivados de heteroarilaminopirazol utilizáveis para o tratamento de diabetes
BRPI0718966B8 (pt) composto, composição farmacêutica, inibidor plk1 e agente antitumoral
DE602006007012D1 (de) Pyridinderivate als dipeptedyl-peptidase-hemmer
ATE307810T1 (de) Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
DE602006010540D1 (de) (3,4-dihydro-chinazolin-2-yl)-(2-aryloxy-ethyl)-amine mit aktivität am 5-ht-rezeptor
MY148988A (en) Terphenyl derivatives for treatment of alzheimer's disease
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
ATE466842T1 (de) 3-substituierte pyridinderivate als h3- antagonisten
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
TNSN07469A1 (en) N-(heteroaryl) -1- heteroarylalkyl -1h-indole-2- carboxamide derivatives, preparation and use thereof
DE502005006955D1 (de) N-(phenyl-oxazol-4-ylmethoxymethyl)-cyclohexyl-bernsteinsäureamid derivate und verwandte verbindungen als ppar-liganden (peroxisomen-proliferatoren-aktivierte rezeptoren) zur behandlung von hyperlipidämie und diabetes
ATE543803T1 (de) 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
ATE396183T1 (de) Chromanderivate und ihre verwendung als liganden des 5-ht-rezeptors
EA200801536A1 (ru) Новые тиенопирсульфоновые производные
ATE466007T1 (de) 5-substituierte indol-2-carbonsäureamidderivate
ATE435223T1 (de) Pyrimidin-, chinazolin-, pteridin- und triazinderivate
ATE380816T1 (de) Substituierte imidazopyrimidine zur prävention und behandlung von krebs
EA200700707A1 (ru) Производные 2-ациламинотиазола

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]