ID23495A - Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida - Google Patents

Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida

Info

Publication number
ID23495A
ID23495A IDW991170A ID991170A ID23495A ID 23495 A ID23495 A ID 23495A ID W991170 A IDW991170 A ID W991170A ID 991170 A ID991170 A ID 991170A ID 23495 A ID23495 A ID 23495A
Authority
ID
Indonesia
Prior art keywords
glycosylseramide
active substances
cell active
contain alpha
hcv cell
Prior art date
Application number
IDW991170A
Other languages
English (en)
Indonesian (id)
Inventor
Masaru Taniguchi
Tetsu Kawano
Yasuhiko Koezuka
Original Assignee
Kirin Brewery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery filed Critical Kirin Brewery
Publication of ID23495A publication Critical patent/ID23495A/id

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4613—Natural-killer cells [NK or NK-T]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
IDW991170A 1997-04-10 1998-04-10 Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida ID23495A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9241297 1997-04-10

Publications (1)

Publication Number Publication Date
ID23495A true ID23495A (id) 2000-04-27

Family

ID=14053712

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW991170A ID23495A (id) 1997-04-10 1998-04-10 Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida

Country Status (13)

Country Link
US (2) US6531453B1 (fr)
EP (2) EP1520583B1 (fr)
JP (1) JP3495740B2 (fr)
KR (1) KR100527950B1 (fr)
CN (2) CN1222293C (fr)
AT (2) ATE286735T1 (fr)
CA (1) CA2286482C (fr)
DE (2) DE69828603T2 (fr)
ES (2) ES2235324T3 (fr)
HK (1) HK1029526A1 (fr)
ID (1) ID23495A (fr)
TW (1) TW592703B (fr)
WO (1) WO1998044928A1 (fr)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100527950B1 (ko) * 1997-04-10 2005-11-09 기린 비루 가부시키가이샤 알파-글리코실세라미드를 함유하는 엔케이티 세포활성화제
TW575420B (en) * 1997-09-22 2004-02-11 Kirin Brewery Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides
FR2792205B1 (fr) * 1999-04-19 2001-07-27 Inst Nat Sante Rech Med Composition pharmaceutique comprenant des cellules nkt activees par des pim, et son utilisation en therapie
SE0000258D0 (sv) 2000-01-27 2000-01-27 A & Science Invest Ab Pharmaceutical preparation and method for treatment of diabetes
US20010051156A1 (en) * 2000-04-28 2001-12-13 Defu Zeng Methods for inhibition of polyclonal B cell activation and immunoglobulin class switching to pathogenic autoantibodies by blocking CD1-mediated interactions
KR20030032961A (ko) * 2000-06-06 2003-04-26 기린 비루 가부시키가이샤 내츄럴 킬러 ｔ 세포의 증폭 방법
US20020115624A1 (en) * 2000-06-22 2002-08-22 Behar Samuel M. Alpha gylcosylceramides for treating bacterial and fungal infections
JPWO2002038146A1 (ja) * 2000-11-07 2004-03-11 株式会社林原生物化学研究所 粘膜免疫調節剤並びにその用途
US7419958B2 (en) 2001-03-26 2008-09-02 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
EP1434859A2 (fr) * 2001-07-25 2004-07-07 New York University Utilisation de glycosylceramides comme adjuvants pour des vaccins contre les infections et le cancer
CN100439383C (zh) 2001-08-16 2008-12-03 阿斯比奥制药株式会社 糖脂及其作为有效成分的用于自体免疫疾病的药物
WO2003042377A1 (fr) * 2001-11-07 2003-05-22 Kirin Beer Kabushiki Kaisha Activation de la proliferation des cellules t in vitro et populations de cellules t ayant prolifere
US6911434B2 (en) * 2002-02-04 2005-06-28 Corixa Corporation Prophylactic and therapeutic treatment of infectious and other diseases with immunoeffector compounds
FR2839310A1 (fr) * 2002-05-03 2003-11-07 Pasteur Institut Nouveau procede de preparation d' alpha-glycosylceramides, nouveaux derives alpha-glycosylceramide et leurs applications
WO2003105769A2 (fr) 2002-06-13 2003-12-24 New York University C-glycolipide de synthese et utilisation de celui-ci pour le traitement du cancer, des maladies infectieuses et des maladies auto-immunes
EP1572114A2 (fr) * 2002-09-27 2005-09-14 Biomira, Inc. Analogues du glycosylceramide
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
WO2004064820A2 (fr) 2003-01-20 2004-08-05 Nederlandse Organisatie Voor Toegepast- Natuurwetenschappelijk Onderzoek Tno Utilisation de sphingolipides pour reduire les taux de triacylglycerol et de cholesterol dans le plasma
NL1022443C2 (nl) 2003-01-20 2004-07-22 Tno Sphingolipiden voor verbetering van de samenstelling van de darmflora.
KR20050105215A (ko) * 2003-02-14 2005-11-03 다이이치 아스비오파마 가부시키가이샤 당지질 유도체 및 그 제조 방법 및 그 합성 중간체 및 그제조 방법
US20040171522A1 (en) * 2003-02-27 2004-09-02 Yaron Ilan Regulation of immune responses by manipulation of intermediary metabolite levels
WO2005032462A2 (fr) 2003-02-27 2005-04-14 Enzo Therapeutics, Inc. Traitement au glucocerebroside d'une maladie
US9717754B2 (en) 2003-02-27 2017-08-01 Enzo Therapeutics, Inc. Glucocerebroside treatment of disease
EP1605039B1 (fr) * 2003-03-03 2008-04-23 Kirin Pharma Kabushiki Kaisha Cellule dendritique presentant des derives de alpha-glycosylceramide et un antigene et utilisable dans la suppression de la reponse immunitaire
US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
US7771726B2 (en) * 2003-10-08 2010-08-10 New York University Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases
US20060269524A1 (en) * 2004-02-19 2006-11-30 Kibun Food Chemifa Co., Ltd. Composition for nkt cell activation
EP1576894A1 (fr) * 2004-03-16 2005-09-21 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Utilisation de sphingolipides pour la prevention et le traitement diabete deType 2, la resistance a l'insuline et syndrome metabolique
DE602005026785D1 (de) * 2004-03-16 2011-04-21 Tno Verwendung von sphingolipiden bei der behandlung und vorbeugung von typ-2-diabetes mellitus, insulinresistenz und metabolismussyndrom
AU2005235080A1 (en) * 2004-03-31 2005-11-03 New York University Novel synthetic C-glycolipids, their synthesis and use to treat infections, cancer and autoimmune diseases
CN1997395B (zh) 2004-06-11 2012-08-29 独立行政法人理化学研究所 含有包含在脂质体中的调节性细胞配体的药物
US8022043B2 (en) * 2004-08-27 2011-09-20 Albert Einstein College Of Medicine Of Yeshiva University Ceramide derivatives as modulators of immunity and autoimmunity
AU2005280163B2 (en) * 2004-08-27 2011-11-24 Albert Einstein College Of Medicine, Inc. Ceramide derivatives as modulators of immunity and autoimmunity
DE602005020643D1 (de) 2004-09-03 2010-05-27 Univ Chicago Verfahren zur aktivierung von nkt-zellen
US8513008B2 (en) 2004-10-07 2013-08-20 Argos Therapeutics, Inc. Mature dendritic cell compositions and methods for culturing same
CN101080487B (zh) * 2004-10-07 2012-11-14 阿戈斯治疗公司 成熟树突细胞组合物及其培养方法
WO2006060117A2 (fr) * 2004-11-02 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Methodes d'inhibition des cellules nkt
AU2005310341A1 (en) 2004-11-30 2006-06-08 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Sphingolipids in treatment and prevention of steatosis and of steatosis or of hepatotoxicity and its sequelae
JP5090928B2 (ja) * 2004-12-28 2012-12-05 ザ ロックフェラー ユニバーシティ Ｎｋｔ細胞に対する抗原としての糖脂質及びその類似体
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
DK1848813T3 (da) 2005-01-28 2013-07-15 Univ Brigham Young Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
WO2006093352A1 (fr) 2005-03-04 2006-09-08 Riken Compose a structure cyclique et son utilisation
JP4909264B2 (ja) * 2005-04-01 2012-04-04 独立行政法人理化学研究所 経鼻ワクチン
RU2008103792A (ru) * 2005-07-01 2009-08-10 Джапэн Эз Репризентид Бай Президент Оф Нэшнл Сентер Оф Ньюролоджи Энд Сайкайатри (Jp) Производное гликолипидов и лекарственное средство, содержащее это производное в качестве активного компонента
JP2007070311A (ja) * 2005-09-09 2007-03-22 Gunma Univ α−ガラクトシルセラミドからなる感染症予防剤及び感染症治療剤
US20090117089A1 (en) * 2005-09-19 2009-05-07 The Rockefeller University Glycolipids and analogues thereof as antigens for nk t cells
CA2626997C (fr) 2005-10-25 2014-12-23 Ludwig Institute For Cancer Research Analogues de l'alpha-galactosylceramide et applications
WO2007049819A1 (fr) * 2005-10-28 2007-05-03 Japan As Represented By President Of National Center Of Neurology And Psychiatry Agent therapeutique comprenant un derive de glycolipide capable d’inhiber la fonction de cellules nkt
US20070231344A1 (en) * 2005-10-28 2007-10-04 The Brigham And Women's Hospital, Inc. Conjugate vaccines for non-proteinaceous antigens
WO2007099999A1 (fr) * 2006-02-28 2007-09-07 Riken Nouveau glycolipide et utilisation de celui-ci
US8227581B2 (en) * 2006-04-07 2012-07-24 The Scripps Research Institute Modified α-galactosyl ceramides for staining and stimulating natural killer T cells
IL178821A0 (en) * 2006-05-25 2007-07-04 Ilan Yaron Direct and indirect modulation of composition and structure of cell membrane by ??-glycolipids
WO2008005824A1 (fr) * 2006-06-30 2008-01-10 The Scripps Research Institute Adjuvants et procédés d'utilisation
US8263576B2 (en) * 2006-08-15 2012-09-11 Mayo Foundation For Medical Education And Research Non-natural sphingolipid analogs and uses thereof
KR100868959B1 (ko) * 2006-12-30 2008-11-17 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
CA2678618C (fr) 2007-02-21 2019-03-12 Vaccinex, Inc. Modulation d'activite de cellule nkt avec des molecules cd1d chargees en antigene
US8299223B2 (en) * 2007-02-22 2012-10-30 Riken Pseudoglycolipid and use thereof
US8916164B2 (en) 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (fr) 2007-11-07 2009-05-13 Wittycell Cellule Nkt activant des antigènes et/ou médicaments à liaison gycolipids covalentyl
EP2060252A1 (fr) 2007-11-19 2009-05-20 Wittycell Nouvelle formulation de dérivés de galactosylcéramide
BRPI0820960B8 (pt) 2007-12-05 2021-05-25 Abivax composição, composição farmacêutica, e uso da composição
EP2272854B1 (fr) * 2008-03-25 2015-08-05 Riken Nouveau glycolipide et son utilisation
US9220767B2 (en) 2008-10-08 2015-12-29 Abivax Vaccine composition for use against influenza
AU2010203451B2 (en) * 2009-01-08 2016-06-30 Albert Einstein College Of Medicine, Inc. Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
JP5669215B2 (ja) 2010-02-05 2015-02-12 独立行政法人理化学研究所 新規合成糖脂質およびその用途
US8835613B2 (en) 2010-03-12 2014-09-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services β-mannosylceramide and stimulation of NKT cell anti-tumor immunity
EP2647384B1 (fr) 2010-12-02 2018-05-23 Riken IMMUNOTHÉRAPIE À L'AIDE DE CELLULES ALLO-NKT, CELLULES POUR IMMUNOTHÉRAPIE DANS LESQUELLES alpha CHAÎNE DU GÈNE DE RÉCEPTEUR DES LYMPHOCYTES T (TCR) A ÉTÉ RÉARRANGÉE EN UN V alpha-J alpha UNIFORME ET CONSTITUTION D'UNE BANQUE DE CELLULES NKT ISSUES DESDITES CELLULES
EP2842961B1 (fr) 2012-04-26 2016-12-14 Riken Nouveau glycolipide de carbamate et son utilisation
EP2889039B1 (fr) 2012-08-22 2017-11-08 Regimmune Corporation Préparation pour la prévention ou le traitement du diabète de type 1
US20150224129A1 (en) * 2012-10-03 2015-08-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of bacterial superinfections post-influenza with invariant nkt cell agonists
AU2013339046A1 (en) 2012-11-05 2015-05-21 Regimmune Corporation Immune-tolerance inducer
PL2923208T3 (pl) 2012-11-21 2019-09-30 Institut National De La Santé Et De La Recherche Médicale (Inserm) Sposoby określania ryzyka ostrej choroby przeszczep przeciwko gospodarzowi
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
AU2014214770B2 (en) 2013-02-08 2018-09-06 Albert Einstein College Of Medicine Inc. Modified glycolipids and methods of making and using the same
EP2993182B1 (fr) 2013-05-02 2020-10-14 National Institute of Advanced Industrial Science and Technology Agent d'induction d'immunité pour antigène carbohydrate
EP3049090A1 (fr) * 2013-06-28 2016-08-03 The Scripps Research Institute Ligands de cellules nkt et procédés d'utilisation
EP3111945B1 (fr) * 2014-02-26 2021-07-14 National University Corporation Hokkaido University Cellules dendritiques pour l'utilisation dans le traitement de l'infarctus du myocarde
EP3344276B1 (fr) 2015-09-03 2020-04-22 The Board of Regents of the University of Oklahoma Inhibiteurs peptidiques de toxine tcdb declostridium difficile
US10919926B2 (en) 2016-03-22 2021-02-16 Keio University Compound or salt thereof, natural killer T cell activator, and pharmaceutical composition
WO2017207040A1 (fr) 2016-06-01 2017-12-07 Vib Vzw Thérapie anticancéreuse utilisant un antagoniste de la leptine et un activateur des cellules inkt
CN106983760A (zh) * 2017-05-29 2017-07-28 南京佰泰克生物技术有限公司 一种增强肺腺癌细胞对cik细胞杀伤敏感性的组合物
US10933126B2 (en) 2018-05-03 2021-03-02 The Board Of Regents Of The University Of Oklahoma Clostridium difficile immunogenic compositions and methods of use
WO2022118913A1 (fr) 2020-12-04 2022-06-09 株式会社レグイミューン Préparation de liposomes contenant un composé ligand cd1d présentant une pharmacocinétique améliorée
CN114196629B (zh) * 2021-12-23 2024-02-27 珠海贝索细胞科学技术有限公司 一种高效培养nkt细胞的试剂及其应用和nkt细胞的培养方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK84691D0 (da) * 1991-05-07 1991-05-07 Karsten Buschard Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
TW261533B (fr) * 1992-07-16 1995-11-01 Kirin Brewery
EP0666268B1 (fr) * 1992-10-22 2000-04-19 Kirin Beer Kabushiki Kaisha Nouveau sphingoglycolipide et son utilisation
JPH06199884A (ja) * 1992-12-28 1994-07-19 Nisshin Oil Mills Ltd:The 新規糖脂質誘導体
EP0694558B1 (fr) * 1993-04-15 1999-01-27 Kirin Beer Kabushiki Kaisha Nouveau sphingoglycolipide et son utilisation
JPH1045603A (ja) * 1996-07-30 1998-02-17 Yoshitomi Pharmaceut Ind Ltd スルファチドを有効成分とするＴＮＦ−α産生抑制剤
TW555562B (en) * 1996-12-27 2003-10-01 Kirin Brewery Method for activation of human antigen-presenting cells, activated human antigen-presenting cells and use thereof
KR100527950B1 (ko) * 1997-04-10 2005-11-09 기린 비루 가부시키가이샤 알파-글리코실세라미드를 함유하는 엔케이티 세포활성화제

Also Published As

Publication number Publication date
ES2318236T3 (es) 2009-05-01
CN1222293C (zh) 2005-10-12
CN1259872A (zh) 2000-07-12
DE69840528D1 (de) 2009-03-19
EP0988860B1 (fr) 2005-01-12
EP1520583A3 (fr) 2006-01-25
TW592703B (en) 2004-06-21
WO1998044928A1 (fr) 1998-10-15
US6747010B2 (en) 2004-06-08
CA2286482C (fr) 2008-08-05
ATE286735T1 (de) 2005-01-15
AU742253B2 (en) 2001-12-20
JP3495740B2 (ja) 2004-02-09
DE69828603T2 (de) 2005-12-29
ES2235324T3 (es) 2005-07-01
AU6748598A (en) 1998-10-30
EP1520583A2 (fr) 2005-04-06
EP0988860A1 (fr) 2000-03-29
CA2286482A1 (fr) 1998-10-15
ATE421881T1 (de) 2009-02-15
HK1029526A1 (en) 2001-04-06
EP0988860A4 (fr) 2003-09-03
US6531453B1 (en) 2003-03-11
KR20010006174A (ko) 2001-01-26
US20030139351A1 (en) 2003-07-24
EP1520583B1 (fr) 2009-01-28
DE69828603D1 (de) 2005-02-17
KR100527950B1 (ko) 2005-11-09
CN1768759A (zh) 2006-05-10

Similar Documents

Publication Publication Date Title
ID23495A (id) Zat-zat pengaktif sel nkt yang mengandung alpha-glikosilseramida
NO307461B1 (no) Substituerte bifenyl-isoksazol-sulfonamider, anvendelse derav og farmasøytisk preparat
HUP0002495A1 (hu) VLA-4 Által közvetített leukocita adhéziót gátló dipeptidszármazékok és rokon vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0104495A2 (hu) N-szubsztituált 2-ciano-pirrolidinek és ezeket tartalmazó gyógyászati készítmények
KR0141913B1 (en) Anti-virus agents
DE69110625D1 (de) Oxazolopyridinderivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen.
ES2148254T3 (es) Peptidos antimicrobianos ciclicos y preparacion de los mismos.
JPS5513275A (en) Prodrug of non-steroid anti-inflammatory drug having improved absorption and anti-inflammatory drug composition comprising it
ATE38991T1 (de) In 2-stellung substituierte 1,3propyledendephosphonat-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
HUP0102500A2 (hu) Növekedési hormon szekretagógok alkalmazása szisztémás lupus erythematosus és gyulladásos bélbetegség kezelésére és ezeket tartalmazó gyógyszerkészítmények
AR002909A1 (es) Composicion fungicida y procedimiento para combatir hongos fitopatogenos.
ES2103440T3 (es) Nuevas amidas y sulfonamidas naftalenicas, procedimiento de preparacion y composiciones farmaceuticas que las contienen.
IL96618A0 (en) Pharmaceutical compositions containing fluoroquinolone derivatives
ATE173926T1 (de) Arzneizusammensetzungen enthaltend tandospiron oder seine analoge
AU6250680A (en) Phosphono-hydroxy-acetic acid
IE40942B1 (en) Novel n-sulphenylated oxime-carbamates and their use as insecticides, acaricides and nematicides
ES8500269A1 (es) Procedimiento para la fabricacion de un derivado de azolcarboxamida n,n-subsitutida.
DE69414396D1 (de) Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten
DE69001004D1 (de) Zusammensetzung gegen leberkrankheiten.
EP0666253A4 (fr) ANALOGUE DE N-t-BUTYLANILINE ET REDUCTEUR DU TAUX LIPIDIQUE LE RENFERMANT.
FR2355846A1 (fr) Esters de penicillines utilisables comme medicaments
DE69307414D1 (de) Dipeptidderivate und diese als aktive Bestandteile enthaltendes prophylaktisches oder therapeutisches Mittel gegen Knochenkrankheiten
ES465545A1 (es) Procedimiento para la preparacion de esteres tiolicos del acido amidinofosdorico
FR2412555A1 (fr) Composes polyfluorohydroxyisopropyl carbostyriles tricycliques antihypertensifs, leur preparation et compositions pharmaceutiques les contenant
JPS5683418A (en) Fomentation