DE602005020643D1 - Verfahren zur aktivierung von nkt-zellen - Google Patents
Verfahren zur aktivierung von nkt-zellenInfo
- Publication number
- DE602005020643D1 DE602005020643D1 DE602005020643T DE602005020643T DE602005020643D1 DE 602005020643 D1 DE602005020643 D1 DE 602005020643D1 DE 602005020643 T DE602005020643 T DE 602005020643T DE 602005020643 T DE602005020643 T DE 602005020643T DE 602005020643 D1 DE602005020643 D1 DE 602005020643D1
- Authority
- DE
- Germany
- Prior art keywords
- nkt cell
- activating
- nkt cells
- activating nkt
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003213 activating effect Effects 0.000 title abstract 3
- 210000000581 natural killer T-cell Anatomy 0.000 abstract 6
- JMENXJYBCQFIRK-KRJDXUSZSA-N N-hexacosanoylisoglobotriaosyl ceramide Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@@H](CO)O1 JMENXJYBCQFIRK-KRJDXUSZSA-N 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000002458 cell surface marker Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60694104P | 2004-09-03 | 2004-09-03 | |
| PCT/US2005/031407 WO2006029010A2 (en) | 2004-09-03 | 2005-09-02 | Methods of activating nkt cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602005020643D1 true DE602005020643D1 (de) | 2010-05-27 |
Family
ID=35945148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005020643T Active DE602005020643D1 (de) | 2004-09-03 | 2005-09-02 | Verfahren zur aktivierung von nkt-zellen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7998739B2 (de) |
| EP (1) | EP1786439B1 (de) |
| JP (1) | JP5005541B2 (de) |
| AT (1) | ATE464056T1 (de) |
| AU (1) | AU2005282684B9 (de) |
| CA (1) | CA2578052C (de) |
| DE (1) | DE602005020643D1 (de) |
| DK (1) | DK1786439T3 (de) |
| ES (1) | ES2344740T3 (de) |
| WO (1) | WO2006029010A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
| DE602005020643D1 (de) * | 2004-09-03 | 2010-05-27 | Univ Chicago | Verfahren zur aktivierung von nkt-zellen |
| WO2006083671A2 (en) | 2005-01-28 | 2006-08-10 | Brigham Young University | Bacterial glycolipid activation of cd1d-restricted nkt cells |
| SI2056842T1 (sl) | 2006-04-07 | 2013-02-28 | The Scripps Research Institute | Modificiran galaktosil-ceramid za zdravljenje kancerogenih obolenj |
| CA2655947C (en) * | 2006-06-30 | 2016-08-02 | The Scripps Research Institute | Compositions comprising nkt cell agonist compounds and methods of use |
| CN101730546B (zh) * | 2007-04-25 | 2013-04-24 | Immurx公司 | 包含nkt活化剂、cd40激动剂和任选的抗原的佐剂组合,及其诱导细胞免疫协同增强的用途 |
| US8916164B2 (en) | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
| EP2058011A1 (de) | 2007-11-07 | 2009-05-13 | Wittycell | NKT-Zellen aktivierende, kovalent gebundene Glykolipid-Antigene und/oder Arzneimittel |
| EP2060252A1 (de) | 2007-11-19 | 2009-05-20 | Wittycell | Neue Formulierung von Galactosylceramid-Derivaten |
| US8211861B2 (en) * | 2007-12-05 | 2012-07-03 | Wittycell | Compositions for and methods of enhancing the immune response to antigens |
| CN102215864A (zh) | 2008-10-08 | 2011-10-12 | 威蒂赛尔公司 | 用于抗流感的疫苗组合物 |
| WO2013033283A1 (en) * | 2011-08-30 | 2013-03-07 | Cornell University | Improving systemic glucose tolerance in type-2 diabetes |
| GB201617716D0 (en) | 2016-10-19 | 2016-11-30 | Ucl Business Plc | Cell |
| GB201617714D0 (en) | 2016-10-19 | 2016-11-30 | Ucl Business Plc | T Cell receptor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0988860B1 (de) | 1997-04-10 | 2005-01-12 | Kirin Beer Kabushiki Kaisha | Verwendung von a-Glycosylceramiden zur Herstellung eines therapeutischen Mittelszur Behandlung von Autoimmunkrankheiten |
| JP2005500336A (ja) * | 2001-07-25 | 2005-01-06 | ニューヨーク・ユニバーシティ | 感染および癌に対するワクチンのためのアジュバントとしてのグリコシルセラミドの使用 |
| AU2003251518B2 (en) * | 2002-06-13 | 2009-07-02 | New York University | Synthetic C-glycolipid and its use for treating cancer infectious diseases and autoimmune diseases |
| DE602005020643D1 (de) * | 2004-09-03 | 2010-05-27 | Univ Chicago | Verfahren zur aktivierung von nkt-zellen |
-
2005
- 2005-09-02 DE DE602005020643T patent/DE602005020643D1/de active Active
- 2005-09-02 AU AU2005282684A patent/AU2005282684B9/en not_active Ceased
- 2005-09-02 WO PCT/US2005/031407 patent/WO2006029010A2/en active Application Filing
- 2005-09-02 US US11/218,906 patent/US7998739B2/en not_active Expired - Fee Related
- 2005-09-02 ES ES05810863T patent/ES2344740T3/es active Active
- 2005-09-02 AT AT05810863T patent/ATE464056T1/de not_active IP Right Cessation
- 2005-09-02 EP EP05810863A patent/EP1786439B1/de not_active Not-in-force
- 2005-09-02 JP JP2007530414A patent/JP5005541B2/ja not_active Expired - Fee Related
- 2005-09-02 DK DK05810863.0T patent/DK1786439T3/da active
- 2005-09-02 CA CA2578052A patent/CA2578052C/en not_active Expired - Fee Related
-
2010
- 2010-10-11 US US12/901,971 patent/US20110082106A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2344740T3 (es) | 2010-09-06 |
| AU2005282684A1 (en) | 2006-03-16 |
| JP2008512093A (ja) | 2008-04-24 |
| JP5005541B2 (ja) | 2012-08-22 |
| ATE464056T1 (de) | 2010-04-15 |
| US7998739B2 (en) | 2011-08-16 |
| EP1786439B1 (de) | 2010-04-14 |
| WO2006029010A3 (en) | 2006-09-08 |
| DK1786439T3 (da) | 2010-07-12 |
| CA2578052A1 (en) | 2006-03-16 |
| AU2005282684B2 (en) | 2011-03-10 |
| CA2578052C (en) | 2013-08-13 |
| US20060073118A1 (en) | 2006-04-06 |
| AU2005282684B9 (en) | 2011-07-07 |
| EP1786439A2 (de) | 2007-05-23 |
| WO2006029010A2 (en) | 2006-03-16 |
| US20110082106A1 (en) | 2011-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |