HUT62010A - Process for producing oligonucleotide analogs comprising terminal 3 - 3, or 5 - 5- intermolecular bonds - Google Patents
Process for producing oligonucleotide analogs comprising terminal 3 - 3, or 5 - 5- intermolecular bondsInfo
- Publication number
- HUT62010A HUT62010A HU912215A HU221591A HUT62010A HU T62010 A HUT62010 A HU T62010A HU 912215 A HU912215 A HU 912215A HU 221591 A HU221591 A HU 221591A HU T62010 A HUT62010 A HU T62010A
- Authority
- HU
- Hungary
- Prior art keywords
- terminal
- oligonucleotide analogs
- intermolecular bonds
- producing oligonucleotide
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R15/00—Details of measuring arrangements of the types provided for in groups G01R17/00 - G01R29/00, G01R33/00 - G01R33/26 or G01R35/00
- G01R15/14—Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks
- G01R15/18—Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
- G01R15/186—Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers using current transformers with a core consisting of two or more parts, e.g. clamp-on type
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4021019 | 1990-07-02 |
Publications (3)
Publication Number | Publication Date |
---|---|
HU912215D0 HU912215D0 (en) | 1991-12-30 |
HUT62010A true HUT62010A (en) | 1993-03-29 |
HU215147B HU215147B (hu) | 2000-03-28 |
Family
ID=6409497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU215/91A HU215147B (hu) | 1990-07-02 | 1991-07-01 | Eljárás terminális 3'- 3' - ,illetve 5'- 5' -intermolekuláris kötéseket tartalmazó oligonukleotid analógok előállítására |
Country Status (22)
Country | Link |
---|---|
US (1) | US5750669A (hu) |
EP (1) | EP0464638B1 (hu) |
JP (1) | JP3186795B2 (hu) |
KR (1) | KR100200400B1 (hu) |
AT (1) | ATE151076T1 (hu) |
AU (1) | AU647143B2 (hu) |
CA (1) | CA2045891C (hu) |
CZ (1) | CZ285408B6 (hu) |
DE (1) | DE59108644D1 (hu) |
DK (1) | DK0464638T3 (hu) |
ES (1) | ES2099718T3 (hu) |
FI (1) | FI104177B1 (hu) |
GR (1) | GR3023432T3 (hu) |
HU (1) | HU215147B (hu) |
IE (1) | IE912309A1 (hu) |
IL (1) | IL98672A (hu) |
NO (1) | NO303018B1 (hu) |
NZ (1) | NZ238769A (hu) |
PT (1) | PT98169B (hu) |
SK (1) | SK279544B6 (hu) |
TW (1) | TW206232B (hu) |
ZA (1) | ZA915056B (hu) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223618A (en) * | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
DE59306170D1 (de) * | 1992-09-24 | 1997-05-22 | Hoechst Ag | Oligoribonucleotid- und Ribozym-Analoga mit terminalen 3'-3'-bzw.5'-5'-Verknüpfungen |
AU6412794A (en) * | 1993-03-31 | 1994-10-24 | Sterling Winthrop Inc. | Oligonucleotides with amide linkages replacing phosphodiester linkages |
US6015886A (en) * | 1993-05-24 | 2000-01-18 | Chemgenes Corporation | Oligonucleotide phosphate esters |
US6605708B1 (en) | 1993-07-28 | 2003-08-12 | Hybridon, Inc. | Building blocks with carbamate internucleoside linkages and oligonucleotides derived therefrom |
US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
US7812149B2 (en) | 1996-06-06 | 2010-10-12 | Isis Pharmaceuticals, Inc. | 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations |
US9096636B2 (en) * | 1996-06-06 | 2015-08-04 | Isis Pharmaceuticals, Inc. | Chimeric oligomeric compounds and their use in gene modulation |
US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
US7309692B1 (en) | 1996-07-08 | 2007-12-18 | Board Of Regents, The University Of Texas System | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 |
US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
CN1060177C (zh) * | 1997-06-28 | 2001-01-03 | 中国科学院上海生物化学研究所 | 3′-单磷酸化寡核苷酸 |
US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
US20030180789A1 (en) * | 1998-12-30 | 2003-09-25 | Dale Roderic M.K. | Arrays with modified oligonucleotide and polynucleotide compositions |
US6087112A (en) * | 1998-12-30 | 2000-07-11 | Oligos Etc. Inc. | Arrays with modified oligonucleotide and polynucleotide compositions |
DE19935756A1 (de) * | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
DE19935303A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
US6271360B1 (en) * | 1999-08-27 | 2001-08-07 | Valigen (Us), Inc. | Single-stranded oligodeoxynucleotide mutational vectors |
EP1702983A3 (en) | 2000-04-13 | 2007-01-10 | Medical University of South Carolina | Tissue-specific and pathogen-specific toxic agents, ribozymes, DNAzymes and antisense oligonucleotides and methods of use thereof |
AU2001272714A1 (en) * | 2000-06-13 | 2001-12-24 | Proligo Llc | Universal solid supports for solid phase oligosynthesis and methods for their preparation and use |
DE60132471T2 (de) * | 2000-09-26 | 2009-01-15 | Idera Pharmaceuticals, Inc., Cambridge | Modulation der immunostimulatorischen aktivität von immunostimulierenden oligonukleotidanaloga durch positionelle chemische veränderungen |
GB0114007D0 (en) * | 2001-06-08 | 2001-08-01 | Isis Innovation | Oilgonucleotides |
US7070933B2 (en) * | 2001-09-28 | 2006-07-04 | Gen-Probe Incorporated | Inversion probes |
CA2471967A1 (en) * | 2002-01-03 | 2003-07-31 | Board Of Regents, The University Of Texas System | Wt1 antisense oligos for the inhibition of breast cancer |
CA2474709A1 (en) * | 2002-02-04 | 2003-08-14 | Biomira, Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
EP1560839A4 (en) | 2002-11-05 | 2008-04-23 | Isis Pharmaceuticals Inc | CHIMERIC OLIGOMER COMPOUNDS AND THEIR USE IN GENE MODULATION |
AU2003290598A1 (en) | 2002-11-05 | 2004-06-03 | Isis Pharmaceuticals, Inc. | Modified oligonucleotides for use in rna interference |
US8569474B2 (en) | 2004-03-09 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Double stranded constructs comprising one or more short strands hybridized to a longer strand |
US8394947B2 (en) | 2004-06-03 | 2013-03-12 | Isis Pharmaceuticals, Inc. | Positionally modified siRNA constructs |
JP2008501694A (ja) * | 2004-06-03 | 2008-01-24 | アイシス ファーマシューティカルズ、インク. | 遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物 |
US7884086B2 (en) | 2004-09-08 | 2011-02-08 | Isis Pharmaceuticals, Inc. | Conjugates for use in hepatocyte free uptake assays |
CA2679750A1 (en) | 2008-09-23 | 2010-03-23 | Nexus Dx, Inc. | Methods for detecting nucleic acids in a sample |
EP2781523A1 (en) | 2013-03-18 | 2014-09-24 | Miltenyi Biotec GmbH | Lipophilic oligonucleotide analogs |
KR101323476B1 (ko) * | 2013-06-12 | 2013-10-31 | 조선미 | 건물용 층간소음 방지재와 이를 이용한 층간소음 방지구조 및 그 시공 방법 |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
US10266843B2 (en) * | 2016-04-08 | 2019-04-23 | Translate Bio, Inc. | Multimeric coding nucleic acid and uses thereof |
US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
JP2021521140A (ja) * | 2018-04-12 | 2021-08-26 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | オリゴヌクレオチド組成物及びその使用方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4123610A (en) * | 1977-03-09 | 1978-10-31 | The United States Government | Nucleic acid crosslinking agent and affinity inactivation of nucleic acids therewith |
US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
FR2540122B1 (fr) * | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application |
DE3332068A1 (de) * | 1983-09-06 | 1985-03-21 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten |
US4795700A (en) * | 1985-01-25 | 1989-01-03 | California Institute Of Technology | Nucleic acid probes and methods of using same |
US5276019A (en) * | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
JPH03503894A (ja) * | 1988-03-25 | 1991-08-29 | ユニバーシィティ オブ バージニア アランミ パテンツ ファウンデイション | オリゴヌクレオチド n‐アルキルホスホラミデート |
WO1990012022A1 (en) * | 1989-03-31 | 1990-10-18 | University Patents, Inc. | Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections |
-
1991
- 1991-06-26 AT AT91110570T patent/ATE151076T1/de not_active IP Right Cessation
- 1991-06-26 ES ES91110570T patent/ES2099718T3/es not_active Expired - Lifetime
- 1991-06-26 DE DE59108644T patent/DE59108644D1/de not_active Expired - Lifetime
- 1991-06-26 DK DK91110570.8T patent/DK0464638T3/da active
- 1991-06-26 EP EP91110570A patent/EP0464638B1/de not_active Expired - Lifetime
- 1991-06-28 NZ NZ238769A patent/NZ238769A/en not_active IP Right Cessation
- 1991-06-28 FI FI913169A patent/FI104177B1/fi not_active IP Right Cessation
- 1991-06-28 CA CA002045891A patent/CA2045891C/en not_active Expired - Lifetime
- 1991-06-30 IL IL9867291A patent/IL98672A/en not_active IP Right Cessation
- 1991-07-01 NO NO912585A patent/NO303018B1/no not_active IP Right Cessation
- 1991-07-01 IE IE230991A patent/IE912309A1/en not_active IP Right Cessation
- 1991-07-01 HU HU215/91A patent/HU215147B/hu unknown
- 1991-07-01 PT PT98169A patent/PT98169B/pt not_active IP Right Cessation
- 1991-07-01 AU AU79475/91A patent/AU647143B2/en not_active Expired
- 1991-07-01 SK SK2014-91A patent/SK279544B6/sk not_active IP Right Cessation
- 1991-07-01 CZ CS912014A patent/CZ285408B6/cs not_active IP Right Cessation
- 1991-07-01 KR KR1019910011064A patent/KR100200400B1/ko not_active IP Right Cessation
- 1991-07-01 ZA ZA915056A patent/ZA915056B/xx unknown
- 1991-07-02 JP JP18820291A patent/JP3186795B2/ja not_active Expired - Lifetime
- 1991-07-27 TW TW080105851A patent/TW206232B/zh not_active IP Right Cessation
-
1994
- 1994-08-01 US US08/282,503 patent/US5750669A/en not_active Expired - Lifetime
-
1997
- 1997-05-15 GR GR970401081T patent/GR3023432T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HPC4 | Succession in title of patentee |
Owner name: AVENTIS PHARMA DEUTSCHLAND GMBH, DE |