HUS2300043I1 - 3,5-diszubsztituált alkilbenzol vegyületek és sóik - Google Patents
3,5-diszubsztituált alkilbenzol vegyületek és sóikInfo
- Publication number
- HUS2300043I1 HUS2300043I1 HUS2300043C HUS2300043C HUS2300043I1 HU S2300043 I1 HUS2300043 I1 HU S2300043I1 HU S2300043 C HUS2300043 C HU S2300043C HU S2300043 C HUS2300043 C HU S2300043C HU S2300043 I1 HUS2300043 I1 HU S2300043I1
- Authority
- HU
- Hungary
- Prior art keywords
- disubstituted
- salt
- alkynylbenzene
- compound
- alkynylbenzene compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012009467 | 2012-01-19 | ||
| EP13728918.7A EP2657233B1 (en) | 2012-01-19 | 2013-01-17 | 3,5-disubstituted alkynylbenzene compound and salt thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUS2300043I1 true HUS2300043I1 (hu) | 2024-01-28 |
Family
ID=48799233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUS2300043C HUS2300043I1 (hu) | 2012-01-19 | 2023-12-21 | 3,5-diszubsztituált alkilbenzol vegyületek és sóik |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9108973B2 (hu) |
| EP (1) | EP2657233B1 (hu) |
| JP (1) | JP5355825B1 (hu) |
| KR (1) | KR101623286B1 (hu) |
| CN (1) | CN103958512B (hu) |
| AU (1) | AU2013210403B2 (hu) |
| BR (1) | BR112014017749B1 (hu) |
| CA (1) | CA2854093C (hu) |
| DK (1) | DK2657233T3 (hu) |
| ES (1) | ES2516392T3 (hu) |
| FI (1) | FIC20230038I1 (hu) |
| FR (1) | FR23C1050I1 (hu) |
| HK (1) | HK1198164A1 (hu) |
| HU (1) | HUS2300043I1 (hu) |
| MX (1) | MX351513B (hu) |
| MY (1) | MY171055A (hu) |
| NL (1) | NL301254I2 (hu) |
| NO (1) | NO2023046I1 (hu) |
| PL (1) | PL2657233T3 (hu) |
| PT (1) | PT2657233E (hu) |
| RU (1) | RU2576384C1 (hu) |
| SG (1) | SG2014009286A (hu) |
| TW (1) | TWI508964B (hu) |
| WO (1) | WO2013108809A1 (hu) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| JP5873656B2 (ja) | 2011-06-13 | 2016-03-01 | 株式会社Ihi | 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤 |
| WO2014007951A2 (en) | 2012-06-13 | 2014-01-09 | Incyte Corporation | Substituted tricyclic compounds as fgfr inhibitors |
| AU2013290074A1 (en) | 2012-07-11 | 2015-01-29 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
| DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| PL3023100T3 (pl) | 2013-07-18 | 2019-07-31 | Taiho Pharmaceutical Co., Ltd. | Lek przeciwnowotworowy do okresowego podawania inhibitora FGFR |
| JP6084292B2 (ja) * | 2013-07-18 | 2017-02-22 | 大鵬薬品工業株式会社 | Ｆｇｆｒ阻害剤耐性癌の治療薬 |
| PL2947086T3 (pl) | 2013-08-12 | 2018-06-29 | Taiho Pharmaceutical Co., Ltd. | Nowy skondensowany związek pirymidynowy lub jego sól |
| RS63405B1 (sr) | 2013-10-25 | 2022-08-31 | Blueprint Medicines Corp | Inhibitori receptora faktora rasta fibroblasta |
| EP3581179A1 (en) * | 2013-12-27 | 2019-12-18 | Chugai Seiyaku Kabushiki Kaisha | Fgfr gatekeeper mutant gene and drug targeting same |
| US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| SG11201608441YA (en) | 2014-06-24 | 2016-11-29 | Taiho Pharmaceutical Co Ltd | Novel pyrrolopyrimidine compound or salt thereof, pharmaceutical composition containing same, especially agent for prevention and/or treatment of tumors etc based on nae inhibitory effect |
| WO2016027781A1 (ja) | 2014-08-18 | 2016-02-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 単環ピリジン誘導体の塩およびその結晶 |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| CN105837575B (zh) * | 2015-01-13 | 2019-01-15 | 四川大学 | 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途 |
| MX2017009863A (es) * | 2015-01-30 | 2017-11-15 | Taiho Pharmaceutical Co Ltd | Agente preventivo y/o terapeutico de enfermedad inmune. |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| NZ773116A (en) | 2015-02-20 | 2024-05-31 | Incyte Holdings Corp | Bicyclic heterocycles as fgfr inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MX2017012568A (es) * | 2015-03-31 | 2018-01-25 | Taiho Pharmaceutical Co Ltd | Cristal del compuesto alquinil benceno 3,5-disustituido. |
| US10479780B2 (en) | 2015-06-17 | 2019-11-19 | Chugai Seiyaku Kabushiki Kaisha | Aminopyrazole derivatives |
| JP6141568B1 (ja) * | 2015-09-01 | 2017-06-07 | 大鵬薬品工業株式会社 | 新規なピラゾロ［３，４−ｄ］ピリミジン化合物又はその塩 |
| TWI623316B (zh) * | 2015-12-22 | 2018-05-11 | Taiho Pharmaceutical Co Ltd | Antitumor effect enhancer derived from pyrrolopyrimidine compound |
| EP3269370B1 (en) * | 2016-02-23 | 2020-01-08 | Taiho Pharmaceutical Co., Ltd. | Novel condensed pyrimidine compound or salt thereof |
| US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
| WO2017150725A1 (ja) * | 2016-03-04 | 2017-09-08 | 大鵬薬品工業株式会社 | 悪性腫瘍治療用製剤及び組成物 |
| CN107344940B (zh) * | 2016-05-06 | 2020-04-21 | 广东东阳光药业有限公司 | Btk抑制剂及其用途 |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| AU2018228114B2 (en) * | 2017-02-28 | 2022-04-07 | Taiho Pharmaceutical Co., Ltd. | AGENT ENHANCING ANTITUMOR EFFECT USING PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| JOP20180094A1 (ar) | 2017-10-18 | 2019-04-18 | Hk Inno N Corp | مركب حلقي غير متجانس كمثبط بروتين كيناز |
| CN109776544B (zh) * | 2017-11-15 | 2022-02-01 | 上海医药工业研究院 | 吡唑并[3,4-d]嘧啶类化合物及其制备方法和用途 |
| SG11202008435SA (en) | 2018-03-19 | 2020-10-29 | Taiho Pharmaceutical Co Ltd | Pharmaceutical composition including sodium alkyl sulfate |
| CA3091153A1 (en) | 2018-03-28 | 2019-10-03 | Eisai R&D Management Co., Ltd. | Therapeutic agent for hepatocellular carcinoma |
| SG11202010636VA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Solid forms of an fgfr inhibitor and processes for preparing the same |
| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
| WO2020007234A1 (zh) * | 2018-07-02 | 2020-01-09 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的炔基(杂)芳环类化合物 |
| WO2020095452A1 (ja) * | 2018-11-09 | 2020-05-14 | 大鵬薬品工業株式会社 | ジメトキシベンゼン化合物の製造方法 |
| JP7161546B2 (ja) * | 2018-11-09 | 2022-10-26 | 大鵬薬品工業株式会社 | ジメトキシベンゼン化合物の類縁物質、該化合物の分析方法及び標準品 |
| WO2020110974A1 (ja) | 2018-11-26 | 2020-06-04 | 大鵬薬品工業株式会社 | 線維芽細胞増殖因子受容体阻害剤と内分泌療法との併用による内分泌療法が適用される腫瘍の治療及び予防方法 |
| WO2020170355A1 (ja) * | 2019-02-20 | 2020-08-27 | 大鵬薬品工業株式会社 | Ｆｇｆｒ１変異腫瘍の治療方法 |
| US20220184082A1 (en) * | 2019-02-28 | 2022-06-16 | Taiho Pharmaceutical Co., Ltd. | Cancer therapy using 3,5-disubstituted benzene alkynyl compound and pembrolizumab |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| JP7527309B2 (ja) | 2019-05-13 | 2024-08-02 | リレー セラピューティクス， インコーポレイテッド | Ｆｇｆｒ阻害剤およびそれらの使用 |
| WO2020236524A1 (en) * | 2019-05-17 | 2020-11-26 | Kinnate Biopharma Inc. | Inhibitors of fibroblast growth factor receptor kinases |
| KR20220024821A (ko) | 2019-06-21 | 2022-03-03 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양의 치료 방법 |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| BR112022007163A2 (pt) | 2019-10-14 | 2022-08-23 | Incyte Corp | Heterociclos bicíclicos como inibidores de fgfr |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| CN114641293B (zh) * | 2019-11-08 | 2024-05-31 | 石药集团中奇制药技术（石家庄）有限公司 | 一种fgfr抑制剂的用途 |
| US11407750B2 (en) | 2019-12-04 | 2022-08-09 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN115023231A (zh) | 2020-01-31 | 2022-09-06 | 国立大学法人京都大学 | 软骨营养不良的治疗 |
| KR20230031926A (ko) * | 2020-07-15 | 2023-03-07 | 다이호야쿠힌고교 가부시키가이샤 | 종양의 치료에 사용되는 피리미딘 화합물을 포함하는 조합 |
| TWI797711B (zh) * | 2020-08-13 | 2023-04-01 | 大陸商上海和譽生物醫藥科技有限公司 | 一種fgfr及其突變抑制劑，其製備方法和應用 |
| WO2022042613A1 (zh) * | 2020-08-27 | 2022-03-03 | 上海和誉生物医药科技有限公司 | 一种1h-吡唑-4-酰胺衍生物，其制备方法和应用 |
| CN114805359B (zh) * | 2021-01-28 | 2023-10-27 | 药雅科技(上海)有限公司 | 炔代杂环化合物fgfr抑制剂的制备方法和用途 |
| CN115028634B (zh) * | 2021-03-08 | 2023-11-28 | 药雅科技(上海)有限公司 | 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途 |
| WO2022221170A1 (en) | 2021-04-12 | 2022-10-20 | Incyte Corporation | Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent |
| EP4352059A1 (en) | 2021-06-09 | 2024-04-17 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
| CN115785103A (zh) * | 2022-12-28 | 2023-03-14 | 北京康立生医药技术开发有限公司 | 一种治疗胆管癌药物福巴替尼的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007087395A2 (en) | 2006-01-25 | 2007-08-02 | Osi Pharmaceuticals, Inc. | UNSATURATED mTOR INHIBITORS |
| JP5347202B2 (ja) * | 2007-03-28 | 2013-11-20 | ファーマサイクリックス，インク． | ブルトンチロシンキナーゼインヒビター |
| GB0819105D0 (en) * | 2008-10-17 | 2008-11-26 | Chroma Therapeutics Ltd | Pyrrolo-pyrimidine compounds |
| KR101483215B1 (ko) | 2010-01-29 | 2015-01-16 | 한미약품 주식회사 | 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체 |
| AU2011261185A1 (en) | 2010-06-03 | 2013-01-10 | Pharmacyclics, Inc. | The use of inhibitors of Bruton's tyrosine kinase (Btk) |
-
2013
- 2013-01-17 SG SG2014009286A patent/SG2014009286A/en unknown
- 2013-01-17 KR KR1020147013608A patent/KR101623286B1/ko active IP Right Grant
- 2013-01-17 ES ES13728918.7T patent/ES2516392T3/es active Active
- 2013-01-17 MY MYPI2014700531A patent/MY171055A/en unknown
- 2013-01-17 JP JP2013523428A patent/JP5355825B1/ja active Active
- 2013-01-17 DK DK13728918.7T patent/DK2657233T3/da active
- 2013-01-17 CN CN201380003870.8A patent/CN103958512B/zh active Active
- 2013-01-17 RU RU2014133907/04A patent/RU2576384C1/ru active
- 2013-01-17 US US14/344,935 patent/US9108973B2/en active Active
- 2013-01-17 WO PCT/JP2013/050740 patent/WO2013108809A1/ja active Application Filing
- 2013-01-17 PT PT137289187T patent/PT2657233E/pt unknown
- 2013-01-17 PL PL13728918T patent/PL2657233T3/pl unknown
- 2013-01-17 MX MX2014008605A patent/MX351513B/es active IP Right Grant
- 2013-01-17 EP EP13728918.7A patent/EP2657233B1/en active Active
- 2013-01-17 AU AU2013210403A patent/AU2013210403B2/en active Active
- 2013-01-17 BR BR112014017749-0A patent/BR112014017749B1/pt active IP Right Grant
- 2013-01-17 CA CA2854093A patent/CA2854093C/en active Active
- 2013-01-18 TW TW102102005A patent/TWI508964B/zh active
-
2014
- 2014-11-18 HK HK14111639.8A patent/HK1198164A1/zh unknown
-
2023
- 2023-12-18 FI FIC20230038C patent/FIC20230038I1/fi unknown
- 2023-12-18 NL NL301254C patent/NL301254I2/nl unknown
- 2023-12-19 FR FR23C1050C patent/FR23C1050I1/fr active Active
- 2023-12-20 NO NO2023046C patent/NO2023046I1/no unknown
- 2023-12-21 HU HUS2300043C patent/HUS2300043I1/hu unknown
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