FR23C1050I1 - Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci - Google Patents

Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci

Info

Publication number
FR23C1050I1
FR23C1050I1 FR23C1050C FR23C1050C FR23C1050I1 FR 23C1050 I1 FR23C1050 I1 FR 23C1050I1 FR 23C1050 C FR23C1050 C FR 23C1050C FR 23C1050 C FR23C1050 C FR 23C1050C FR 23C1050 I1 FR23C1050 I1 FR 23C1050I1
Authority
FR
France
Prior art keywords
alkynylbenzene
disubstituted
salt
disubstituted alkynylbenzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR23C1050C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of FR23C1050I1 publication Critical patent/FR23C1050I1/fr
Active legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
FR23C1050C 2012-01-19 2023-12-19 Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci Active FR23C1050I1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012009467 2012-01-19
PCT/JP2013/050740 WO2013108809A1 (fr) 2012-01-19 2013-01-17 Composé d'alkynylbenzène 3,5-disubstitué et un sel de celui-ci

Publications (1)

Publication Number Publication Date
FR23C1050I1 true FR23C1050I1 (fr) 2024-01-26

Family

ID=48799233

Family Applications (1)

Application Number Title Priority Date Filing Date
FR23C1050C Active FR23C1050I1 (fr) 2012-01-19 2023-12-19 Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci

Country Status (24)

Country Link
US (1) US9108973B2 (fr)
EP (1) EP2657233B1 (fr)
JP (1) JP5355825B1 (fr)
KR (1) KR101623286B1 (fr)
CN (1) CN103958512B (fr)
AU (1) AU2013210403B2 (fr)
BR (1) BR112014017749B1 (fr)
CA (1) CA2854093C (fr)
DK (1) DK2657233T3 (fr)
ES (1) ES2516392T3 (fr)
FI (1) FIC20230038I1 (fr)
FR (1) FR23C1050I1 (fr)
HK (1) HK1198164A1 (fr)
HU (1) HUS2300043I1 (fr)
MX (1) MX351513B (fr)
MY (1) MY171055A (fr)
NL (1) NL301254I2 (fr)
NO (1) NO2023046I1 (fr)
PL (1) PL2657233T3 (fr)
PT (1) PT2657233E (fr)
RU (1) RU2576384C1 (fr)
SG (1) SG2014009286A (fr)
TW (1) TWI508964B (fr)
WO (1) WO2013108809A1 (fr)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088266A2 (fr) 2010-12-22 2012-06-28 Incyte Corporation Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3
JP5873656B2 (ja) 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
CN107652289B (zh) 2012-06-13 2020-07-21 因塞特控股公司 作为fgfr抑制剂的取代的三环化合物
SG11201500125QA (en) 2012-07-11 2015-02-27 Blueprint Medicines Corp Inhibitors of the fibroblast growth factor receptor
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
JP6449244B2 (ja) 2013-04-19 2019-01-09 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Fgfr抑制剤としての二環式複素環
US10124003B2 (en) * 2013-07-18 2018-11-13 Taiho Pharmaceutical Co., Ltd. Therapeutic agent for FGFR inhibitor-resistant cancer
PT3023100T (pt) * 2013-07-18 2019-05-29 Taiho Pharmaceutical Co Ltd Fármaco antitumoral para administração intermitente de inibidor de fgfr
JP6035423B2 (ja) 2013-08-12 2016-11-30 大鵬薬品工業株式会社 新規な縮合ピリミジン化合物又はその塩
US9434700B2 (en) 2013-10-25 2016-09-06 Neil Bifulco, JR. Inhibitors of the fibroblast growth factor receptor
ES2756175T3 (es) 2013-12-27 2020-04-27 Chugai Pharmaceutical Co Ltd Genes mutantes guardián de fgfr y fármacos que se dirigen a los mismos
WO2015108992A1 (fr) 2014-01-15 2015-07-23 Blueprint Medicines Corporation Composés hétérobicycliques et leur utilisation en tant qu'inhibiteurs du récepteur fgfr4
US9963456B2 (en) * 2014-06-24 2018-05-08 Taiho Pharmaceutical Co., Ltd Pyrrolopyrimidine compound or salt thereof and compositions containing the pyrrolopyrimidine compound or salt thereof
JP5925978B1 (ja) 2014-08-18 2016-05-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 単環ピリジン誘導体の塩およびその結晶
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CN105837575B (zh) * 2015-01-13 2019-01-15 四川大学 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途
BR112017016278B1 (pt) * 2015-01-30 2022-05-10 Taiho Pharmaceutical Co., Ltd Uso de um composto com atividade inibitória de btk ou um sal deste para produzir um agente preventivo e/ou terapêutico para a prevenção ou tratamento de uma doença imune
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
WO2016134320A1 (fr) 2015-02-20 2016-08-25 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
SG11201707384YA (en) * 2015-03-31 2017-10-30 Taiho Pharmaceutical Co Ltd Crystal of 3,5-disubstituted benzene alkynyl compound
US10479780B2 (en) 2015-06-17 2019-11-19 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivatives
JP6141568B1 (ja) * 2015-09-01 2017-06-07 大鵬薬品工業株式会社 新規なピラゾロ[3,4−d]ピリミジン化合物又はその塩
TWI623316B (zh) * 2015-12-22 2018-05-11 Taiho Pharmaceutical Co Ltd Antitumor effect enhancer derived from pyrrolopyrimidine compound
PT3269370T (pt) * 2016-02-23 2020-03-05 Taiho Pharmaceutical Co Ltd Novo composto de pirimidina condensada ou sal do mesmo
KR20240014585A (ko) 2016-03-04 2024-02-01 다이호야쿠힌고교 가부시키가이샤 악성 종양 치료용 제제 및 조성물
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
CN107344940B (zh) * 2016-05-06 2020-04-21 广东东阳光药业有限公司 Btk抑制剂及其用途
CN107698593A (zh) 2016-08-09 2018-02-16 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
MA47696A (fr) 2017-02-28 2020-01-08 Taiho Pharmaceutical Co Ltd Activateur d'effet antitumoral utilisant un composé pyrazolo[3,4-d]pyrimidine
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
CN109776544B (zh) * 2017-11-15 2022-02-01 上海医药工业研究院 吡唑并[3,4-d]嘧啶类化合物及其制备方法和用途
WO2019181876A1 (fr) 2018-03-19 2019-09-26 大鵬薬品工業株式会社 Composition pharmaceutique comprenant du sulfate d'alkyle de sodium
MX2020008610A (es) 2018-03-28 2020-09-21 Eisai R&D Man Co Ltd Agente terapeutico para carcinoma hepatocelular.
DK3788047T3 (da) 2018-05-04 2024-09-16 Incyte Corp Faste former af en FGFR-inhibitor og fremgangsmåder til fremstilling deraf
SG11202010882XA (en) 2018-05-04 2020-11-27 Incyte Corp Salts of an fgfr inhibitor
WO2020007234A1 (fr) * 2018-07-02 2020-01-09 深圳市塔吉瑞生物医药有限公司 Composé alcynyl(hétéro)aromatique pour l'inhibition de l'activité de protéine kinase
KR20210088651A (ko) 2018-11-09 2021-07-14 다이호야쿠힌고교 가부시키가이샤 디메톡시벤젠 화합물의 제조 방법
EP3882248A4 (fr) * 2018-11-09 2022-07-06 Taiho Pharmaceutical Co., Ltd. Analogues de composés de diméthoxybenzène, procédés d'analyse desdits composés et produits standard desdits composés
US20220023300A1 (en) * 2018-11-26 2022-01-27 Taiho Pharmaceutical Co., Ltd. Therapeutic and prophylactic method for tumor treatable with endocrine therapy by combined use of fibroblast growth factor receptor inhibitor with endocrine therapy
WO2020170355A1 (fr) * 2019-02-20 2020-08-27 大鵬薬品工業株式会社 Procede pour le traitement de tumeurs a variant du fgfr1
WO2020175704A1 (fr) * 2019-02-28 2020-09-03 大鵬薬品工業株式会社 Cancérothérapie utilisant un composé d'alcynyle benzène 3,5-disubstitué et un inhibiteur de point de contrôle immunitaire
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
AU2020274083A1 (en) * 2019-05-13 2021-11-18 D.E. Shaw Research, Llc FGFR inhibitors and methods of use thereof
CA3139161A1 (fr) * 2019-05-17 2020-11-26 Kinnate Biopharma Inc. Inhibiteurs des kinases du recepteur du facteur de croissance des fibroblastes
AU2020297166A1 (en) 2019-06-21 2022-02-17 Taiho Pharmaceutical Co., Ltd. Method for treating malignant tumor
WO2021007269A1 (fr) 2019-07-09 2021-01-14 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
MX2022004513A (es) 2019-10-14 2022-07-19 Incyte Corp Heterociclos biciclicos como inhibidores de los receptores del factor de crecimiento de fibroblastos (fgfr).
WO2021076728A1 (fr) 2019-10-16 2021-04-22 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
WO2021089791A1 (fr) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase
WO2021089005A1 (fr) * 2019-11-08 2021-05-14 石药集团中奇制药技术(石家庄)有限公司 Utilisation d'un inhibiteur de fgfr
BR112022010664A2 (pt) 2019-12-04 2022-08-16 Incyte Corp Derivados de um inibidor de fgfr
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Fgfr阻害剤としての三環式複素環
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
JPWO2021153703A1 (fr) 2020-01-31 2021-08-05
EP4183395A4 (fr) * 2020-07-15 2024-07-24 Taiho Pharmaceutical Co Ltd Combinaison contenant un composé pyrimidine destinée à être utilisée dans le traitement de tumeurs
TWI797711B (zh) * 2020-08-13 2023-04-01 大陸商上海和譽生物醫藥科技有限公司 一種fgfr及其突變抑制劑,其製備方法和應用
WO2022042613A1 (fr) * 2020-08-27 2022-03-03 上海和誉生物医药科技有限公司 Dérivé de 1h-pyrazol-4-amide, son procédé de préparation et son utilisation
CN114805359B (zh) * 2021-01-28 2023-10-27 药雅科技(上海)有限公司 炔代杂环化合物fgfr抑制剂的制备方法和用途
CN115028634B (zh) * 2021-03-08 2023-11-28 药雅科技(上海)有限公司 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途
EP4323405A1 (fr) 2021-04-12 2024-02-21 Incyte Corporation Polythérapie comprenant un inhibiteur de fgfr et un agent de ciblage de nectine-4
CA3220274A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
CN115785103A (zh) * 2022-12-28 2023-03-14 北京康立生医药技术开发有限公司 一种治疗胆管癌药物福巴替尼的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087395A2 (fr) * 2006-01-25 2007-08-02 Osi Pharmaceuticals, Inc. INHIBITEURS DE mTOR INSATURES
EP2954900A1 (fr) * 2007-03-28 2015-12-16 Pharmacyclics, Inc. Inhibiteurs de la tyrosine-kinase de bruton
GB0819105D0 (en) * 2008-10-17 2008-11-26 Chroma Therapeutics Ltd Pyrrolo-pyrimidine compounds
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
CA3113343A1 (fr) * 2010-06-03 2011-12-08 Pharmacyclics Llc Utilisation d'inhibiteurs de la tyrosine-kinase de bruton dans le traitement du lymphome folliculaire

Also Published As

Publication number Publication date
PT2657233E (pt) 2014-10-24
DK2657233T3 (da) 2014-09-22
US9108973B2 (en) 2015-08-18
EP2657233A4 (fr) 2013-12-04
CA2854093A1 (fr) 2013-07-25
NL301254I1 (fr) 2023-12-20
MY171055A (en) 2019-09-23
HK1198164A1 (zh) 2015-03-13
CA2854093C (fr) 2016-07-05
TW201335156A (zh) 2013-09-01
SG2014009286A (en) 2014-04-28
CN103958512B (zh) 2016-01-20
TWI508964B (zh) 2015-11-21
WO2013108809A1 (fr) 2013-07-25
NO2023046I1 (no) 2023-12-20
RU2576384C1 (ru) 2016-03-10
HUS2300043I1 (hu) 2024-01-28
MX2014008605A (es) 2014-08-27
BR112014017749A8 (pt) 2017-07-11
BR112014017749A2 (pt) 2017-06-20
KR101623286B1 (ko) 2016-05-20
FIC20230038I1 (fi) 2023-12-18
PL2657233T3 (pl) 2015-01-30
NL301254I2 (nl) 2024-01-10
BR112014017749B1 (pt) 2021-08-03
JPWO2013108809A1 (ja) 2015-05-11
MX351513B (es) 2017-10-17
JP5355825B1 (ja) 2013-11-27
EP2657233B1 (fr) 2014-08-27
ES2516392T3 (es) 2014-10-30
KR20140080551A (ko) 2014-06-30
US20140343035A1 (en) 2014-11-20
CN103958512A (zh) 2014-07-30
EP2657233A1 (fr) 2013-10-30
AU2013210403B2 (en) 2016-01-14
AU2013210403A1 (en) 2014-06-26

Similar Documents

Publication Publication Date Title
FR23C1050I1 (fr) Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci
NO2022010I1 (no) ripretinib, or a pharmaceutically acceptable salt thereof
BR302012005333S1 (pt) "configuração aplicada em tampa".
FR2985500B1 (fr) Configuration d'helicoptere
FR2994831B1 (fr) Prothese de main.
CL2014003459A1 (es) Compuestos fungicidas heterocíclicos.
FR2984087B1 (fr) Element d'application cosmetique.
CL2014002034A1 (es) Compuestos derivados de isoxazol-fenil-azetidina fenil sustituidos; y compuestos intermediarios.
IT1398747B1 (it) Oscillatore.
PL2817297T3 (pl) Sulfinyloaminobenzamidy skuteczne chwastobójczo
BR112013031570A2 (pt) inalador de pó seco.
CL2015001192A1 (es) Composición herbicida
BR112014027025A2 (pt) composição cosmética.
FR2991704B1 (fr) Coffrage d'ouverture
BR302012006162S1 (pt) "configuração aplicada em cartucho"
FR2990456B1 (fr) Marche d'escalier prefabriquee
FR2987772B1 (fr) Chargeur d'etuis robotise
FR2992202B1 (fr) Emulsion directe cosmetique.
TH1501000684B (th) กระบวยรับสิ่งมีชีวิตแต่ละตัว
BR302012003604S1 (pt) "configuração aplicada em cápsula"
BR302012003605S1 (pt) "configuração aplicada em cápsula"
ITRM20130075A1 (it) "mattone semipieno"
BR302012003277S1 (pt) "configuração aplicada em tampa"
UA25723S (uk) Іграшка м'яконабивна «тигрик»
BR302012005087S1 (pt) "configuração aplicada em recipiente"