FR23C1050I1 - Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci - Google Patents

Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci

Info

Publication number
FR23C1050I1
FR23C1050I1 FR23C1050C FR23C1050C FR23C1050I1 FR 23C1050 I1 FR23C1050 I1 FR 23C1050I1 FR 23C1050 C FR23C1050 C FR 23C1050C FR 23C1050 C FR23C1050 C FR 23C1050C FR 23C1050 I1 FR23C1050 I1 FR 23C1050I1
Authority
FR
France
Prior art keywords
alkynylbenzene
disubstituted
salt
disubstituted alkynylbenzene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR23C1050C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of FR23C1050I1 publication Critical patent/FR23C1050I1/fr
Active legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
FR23C1050C 2012-01-19 2023-12-19 Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci Active FR23C1050I1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012009467 2012-01-19
PCT/JP2013/050740 WO2013108809A1 (fr) 2012-01-19 2013-01-17 Composé d'alkynylbenzène 3,5-disubstitué et un sel de celui-ci

Publications (1)

Publication Number Publication Date
FR23C1050I1 true FR23C1050I1 (fr) 2024-01-26

Family

ID=48799233

Family Applications (1)

Application Number Title Priority Date Filing Date
FR23C1050C Active FR23C1050I1 (fr) 2012-01-19 2023-12-19 Compose d'alkynylbenzene 3,5-disubstitue et un sel de celui-ci

Country Status (24)

Country Link
US (1) US9108973B2 (fr)
EP (1) EP2657233B1 (fr)
JP (1) JP5355825B1 (fr)
KR (1) KR101623286B1 (fr)
CN (1) CN103958512B (fr)
AU (1) AU2013210403B2 (fr)
BR (1) BR112014017749B1 (fr)
CA (1) CA2854093C (fr)
DK (1) DK2657233T3 (fr)
ES (1) ES2516392T3 (fr)
FI (1) FIC20230038I1 (fr)
FR (1) FR23C1050I1 (fr)
HK (1) HK1198164A1 (fr)
HU (1) HUS2300043I1 (fr)
MX (1) MX351513B (fr)
MY (1) MY171055A (fr)
NL (1) NL301254I2 (fr)
NO (1) NO2023046I1 (fr)
PL (1) PL2657233T3 (fr)
PT (1) PT2657233E (fr)
RU (1) RU2576384C1 (fr)
SG (1) SG2014009286A (fr)
TW (1) TWI508964B (fr)
WO (1) WO2013108809A1 (fr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088266A2 (fr) 2010-12-22 2012-06-28 Incyte Corporation Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3
JP5873656B2 (ja) 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
WO2014007951A2 (fr) 2012-06-13 2014-01-09 Incyte Corporation Composés tricycliques substitués utilisés comme inhibiteurs de fgfr
AU2013290074A1 (en) 2012-07-11 2015-01-29 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
PL3023100T3 (pl) 2013-07-18 2019-07-31 Taiho Pharmaceutical Co., Ltd. Lek przeciwnowotworowy do okresowego podawania inhibitora FGFR
JP6084292B2 (ja) * 2013-07-18 2017-02-22 大鵬薬品工業株式会社 Fgfr阻害剤耐性癌の治療薬
PL2947086T3 (pl) 2013-08-12 2018-06-29 Taiho Pharmaceutical Co., Ltd. Nowy skondensowany związek pirymidynowy lub jego sól
RS63405B1 (sr) 2013-10-25 2022-08-31 Blueprint Medicines Corp Inhibitori receptora faktora rasta fibroblasta
EP3581179A1 (fr) * 2013-12-27 2019-12-18 Chugai Seiyaku Kabushiki Kaisha Gène mutant gardien du récepteur du facteur de croissance fibroblastique et médicament de ciblage associé
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
SG11201608441YA (en) 2014-06-24 2016-11-29 Taiho Pharmaceutical Co Ltd Novel pyrrolopyrimidine compound or salt thereof, pharmaceutical composition containing same, especially agent for prevention and/or treatment of tumors etc based on nae inhibitory effect
WO2016027781A1 (fr) 2014-08-18 2016-02-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 Sel de dérivé de pyridine monocyclique et son cristal
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CN105837575B (zh) * 2015-01-13 2019-01-15 四川大学 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途
MX2017009863A (es) * 2015-01-30 2017-11-15 Taiho Pharmaceutical Co Ltd Agente preventivo y/o terapeutico de enfermedad inmune.
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
NZ773116A (en) 2015-02-20 2024-05-31 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
MX2017012568A (es) * 2015-03-31 2018-01-25 Taiho Pharmaceutical Co Ltd Cristal del compuesto alquinil benceno 3,5-disustituido.
US10479780B2 (en) 2015-06-17 2019-11-19 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivatives
JP6141568B1 (ja) * 2015-09-01 2017-06-07 大鵬薬品工業株式会社 新規なピラゾロ[3,4−d]ピリミジン化合物又はその塩
TWI623316B (zh) * 2015-12-22 2018-05-11 Taiho Pharmaceutical Co Ltd Antitumor effect enhancer derived from pyrrolopyrimidine compound
EP3269370B1 (fr) * 2016-02-23 2020-01-08 Taiho Pharmaceutical Co., Ltd. Nouveau composé pyrimidine condensé ou sel de celui-ci
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
WO2017150725A1 (fr) * 2016-03-04 2017-09-08 大鵬薬品工業株式会社 Préparation et composition de traitement de tumeurs malignes
CN107344940B (zh) * 2016-05-06 2020-04-21 广东东阳光药业有限公司 Btk抑制剂及其用途
CN107698593A (zh) * 2016-08-09 2018-02-16 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
AU2018228114B2 (en) * 2017-02-28 2022-04-07 Taiho Pharmaceutical Co., Ltd. AGENT ENHANCING ANTITUMOR EFFECT USING PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
CN109776544B (zh) * 2017-11-15 2022-02-01 上海医药工业研究院 吡唑并[3,4-d]嘧啶类化合物及其制备方法和用途
SG11202008435SA (en) 2018-03-19 2020-10-29 Taiho Pharmaceutical Co Ltd Pharmaceutical composition including sodium alkyl sulfate
CA3091153A1 (fr) 2018-03-28 2019-10-03 Eisai R&D Management Co., Ltd. Agent therapeutique pour le carcinome hepatocellulaire
SG11202010636VA (en) 2018-05-04 2020-11-27 Incyte Corp Solid forms of an fgfr inhibitor and processes for preparing the same
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
WO2020007234A1 (fr) * 2018-07-02 2020-01-09 深圳市塔吉瑞生物医药有限公司 Composé alcynyl(hétéro)aromatique pour l'inhibition de l'activité de protéine kinase
WO2020095452A1 (fr) * 2018-11-09 2020-05-14 大鵬薬品工業株式会社 Procédé de fabrication de composé diméthoxybenzène
JP7161546B2 (ja) * 2018-11-09 2022-10-26 大鵬薬品工業株式会社 ジメトキシベンゼン化合物の類縁物質、該化合物の分析方法及び標準品
WO2020110974A1 (fr) 2018-11-26 2020-06-04 大鵬薬品工業株式会社 Procédé thérapeutique et prophylactique contre une tumeur pouvant être traitée par endocrinothérapie faisant appel à une utilisation combinée d'un inhibiteur des récepteurs du facteur de croissance des fibroblastes et d'une endocrinothérapie
WO2020170355A1 (fr) * 2019-02-20 2020-08-27 大鵬薬品工業株式会社 Procede pour le traitement de tumeurs a variant du fgfr1
US20220184082A1 (en) * 2019-02-28 2022-06-16 Taiho Pharmaceutical Co., Ltd. Cancer therapy using 3,5-disubstituted benzene alkynyl compound and pembrolizumab
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
JP7527309B2 (ja) 2019-05-13 2024-08-02 リレー セラピューティクス, インコーポレイテッド Fgfr阻害剤およびそれらの使用
WO2020236524A1 (fr) * 2019-05-17 2020-11-26 Kinnate Biopharma Inc. Inhibiteurs des kinases du récepteur du facteur de croissance des fibroblastes
KR20220024821A (ko) 2019-06-21 2022-03-03 다이호야쿠힌고교 가부시키가이샤 악성 종양의 치료 방법
WO2021007269A1 (fr) 2019-07-09 2021-01-14 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
WO2021067374A1 (fr) 2019-10-01 2021-04-08 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
BR112022007163A2 (pt) 2019-10-14 2022-08-23 Incyte Corp Heterociclos bicíclicos como inibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
CN114641293B (zh) * 2019-11-08 2024-05-31 石药集团中奇制药技术(石家庄)有限公司 一种fgfr抑制剂的用途
US11407750B2 (en) 2019-12-04 2022-08-09 Incyte Corporation Derivatives of an FGFR inhibitor
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Fgfr阻害剤としての三環式複素環
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
CN115023231A (zh) 2020-01-31 2022-09-06 国立大学法人京都大学 软骨营养不良的治疗
KR20230031926A (ko) * 2020-07-15 2023-03-07 다이호야쿠힌고교 가부시키가이샤 종양의 치료에 사용되는 피리미딘 화합물을 포함하는 조합
TWI797711B (zh) * 2020-08-13 2023-04-01 大陸商上海和譽生物醫藥科技有限公司 一種fgfr及其突變抑制劑,其製備方法和應用
WO2022042613A1 (fr) * 2020-08-27 2022-03-03 上海和誉生物医药科技有限公司 Dérivé de 1h-pyrazol-4-amide, son procédé de préparation et son utilisation
CN114805359B (zh) * 2021-01-28 2023-10-27 药雅科技(上海)有限公司 炔代杂环化合物fgfr抑制剂的制备方法和用途
CN115028634B (zh) * 2021-03-08 2023-11-28 药雅科技(上海)有限公司 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途
WO2022221170A1 (fr) 2021-04-12 2022-10-20 Incyte Corporation Polythérapie comprenant un inhibiteur de fgfr et un agent de ciblage de nectine-4
EP4352059A1 (fr) 2021-06-09 2024-04-17 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
CN115785103A (zh) * 2022-12-28 2023-03-14 北京康立生医药技术开发有限公司 一种治疗胆管癌药物福巴替尼的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007087395A2 (fr) 2006-01-25 2007-08-02 Osi Pharmaceuticals, Inc. INHIBITEURS DE mTOR INSATURES
JP5347202B2 (ja) * 2007-03-28 2013-11-20 ファーマサイクリックス,インク. ブルトンチロシンキナーゼインヒビター
GB0819105D0 (en) * 2008-10-17 2008-11-26 Chroma Therapeutics Ltd Pyrrolo-pyrimidine compounds
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
AU2011261185A1 (en) 2010-06-03 2013-01-10 Pharmacyclics, Inc. The use of inhibitors of Bruton's tyrosine kinase (Btk)

Also Published As

Publication number Publication date
ES2516392T3 (es) 2014-10-30
BR112014017749B1 (pt) 2021-08-03
WO2013108809A1 (fr) 2013-07-25
CN103958512A (zh) 2014-07-30
CN103958512B (zh) 2016-01-20
JPWO2013108809A1 (ja) 2015-05-11
KR20140080551A (ko) 2014-06-30
FIC20230038I1 (fi) 2023-12-18
MX2014008605A (es) 2014-08-27
NL301254I2 (nl) 2024-01-10
NL301254I1 (fr) 2023-12-20
MX351513B (es) 2017-10-17
TW201335156A (zh) 2013-09-01
PL2657233T3 (pl) 2015-01-30
NO2023046I1 (no) 2023-12-20
US20140343035A1 (en) 2014-11-20
CA2854093C (fr) 2016-07-05
US9108973B2 (en) 2015-08-18
EP2657233A1 (fr) 2013-10-30
EP2657233B1 (fr) 2014-08-27
BR112014017749A2 (pt) 2017-06-20
AU2013210403A1 (en) 2014-06-26
BR112014017749A8 (pt) 2017-07-11
MY171055A (en) 2019-09-23
SG2014009286A (en) 2014-04-28
TWI508964B (zh) 2015-11-21
HK1198164A1 (zh) 2015-03-13
CA2854093A1 (fr) 2013-07-25
JP5355825B1 (ja) 2013-11-27
DK2657233T3 (da) 2014-09-22
RU2576384C1 (ru) 2016-03-10
EP2657233A4 (fr) 2013-12-04
AU2013210403B2 (en) 2016-01-14
KR101623286B1 (ko) 2016-05-20
HUS2300043I1 (hu) 2024-01-28
PT2657233E (pt) 2014-10-24

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