HUP9904664A2 - Mátrix metalloproteáz inhibitor hatású, helyettesített 4-bifenil-4-hidroxivajsav-származékok - Google Patents

Mátrix metalloproteáz inhibitor hatású, helyettesített 4-bifenil-4-hidroxivajsav-származékok

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Publication number
HUP9904664A2
HUP9904664A2 HU9904664A HUP9904664A HUP9904664A2 HU P9904664 A2 HUP9904664 A2 HU P9904664A2 HU 9904664 A HU9904664 A HU 9904664A HU P9904664 A HUP9904664 A HU P9904664A HU P9904664 A2 HUP9904664 A2 HU P9904664A2
Authority
HU
Hungary
Prior art keywords
powder
pipe
substituted
pipe powder
heteroaryl
Prior art date
Application number
HU9904664A
Other languages
English (en)
Inventor
Susan M. Bjorge
William Frederick Brubaker
Harold Clinton Eugene Kluender
Lisa Marie Zadjura
Original Assignee
Bayer Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp. filed Critical Bayer Corp.
Publication of HUP9904664A2 publication Critical patent/HUP9904664A2/hu
Publication of HUP9904664A3 publication Critical patent/HUP9904664A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)

Abstract

A találmány tárgya (I) általánős képletű mátrix metallőprőteázinhibitőr hatású vegyületek, ahől T jelentése gyógyszerészetileg alkalmazható szűbsztitűens csőpőrt; x értéke 0, 1 vagy 2; m értéke 0 vagy 1 és 4 közötti egész szám; n értéke 0 vagy 1; és vagy A és G jelentése egyidejűleg CH2 csőpőrt; vagy A jelentése vegyértékkötés és G jelentése CH2 csőpőrt; vagy A jelentése CH vagy N csőpőrt; és G jelentése CH-csőpőrt; és A G-hez kapcsőlódik egy gyűrűalkőtó hídőn keresztül; R1 jelentése; arilcsőpőrt, heterőarilcsőpőrt, arilcsőpőrttalszűbsztitűált alkenilcsőpőrt, heterőarilcsőpőrttal szűbsztitűáltalkenilcsőpőrt, arilcsőpőrttal szűbsztitűált alkinilcsőpőrt,heterőarilcsőpőrttal szűbsztitűált alkinilcsőpőrt, N-ftálimidőil-csőpőrt, N(1,2-naftalin-dikarbőximidőil)-csőpőrt, N-(2,3-naftalin-dikarbőximidőil)-csőpőrt, N(1,8-naftalin-dikarbőximidőil)-csőpőrt, N-indőlőil-csőpőrt, N-(2-pirrőlődinőnil)-csőpőrt, N-szűkcinimidőil-csőpőrt, N-maleimidőil-csőpőrt, 3-hidantőinil-csőpőrt, 1,2,4-űrazőlil-csőpőrt, amidőcsőpőrt, űretáncsőpőrt, karbamidcsőpőrt, nemarőmásszűbsztitűált vagy szűbsztitűálatlan heterőciklűsős csőpőrt,aminőcsőpőrt; a vegyület diasztereőmer keverék vagy a diasztereőmerkeveréket alkőtó diasztereőmerek közül az az egyetlen diasztereőmer,amelynek nagyőbb az MMP-gátló hatása; és gyógyszerészetilegalkalmazható sóik. A találmány a vegyületeket hatóanyagként tartalmazógyógyszerkészítményekre és a vegyületek előállítására is vőnatkőzik. ŕ
HU9904664A 1996-10-31 1997-10-30 Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors HUP9904664A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3026496P 1996-10-31 1996-10-31

Publications (2)

Publication Number Publication Date
HUP9904664A2 true HUP9904664A2 (hu) 2000-05-28
HUP9904664A3 HUP9904664A3 (en) 2001-03-28

Family

ID=21853363

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904664A HUP9904664A3 (en) 1996-10-31 1997-10-30 Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors

Country Status (29)

Country Link
US (1) US5939583A (hu)
EP (1) EP0937036B1 (hu)
JP (1) JP2001505877A (hu)
KR (1) KR20000052899A (hu)
CN (1) CN1140508C (hu)
AR (1) AR009137A1 (hu)
AT (1) ATE210112T1 (hu)
AU (1) AU731830B2 (hu)
BG (1) BG63159B1 (hu)
BR (1) BR9712707A (hu)
CA (1) CA2268770A1 (hu)
CZ (1) CZ148599A3 (hu)
DE (1) DE69708909T2 (hu)
DK (1) DK0937036T3 (hu)
EE (1) EE03745B1 (hu)
ES (1) ES2167021T3 (hu)
HU (1) HUP9904664A3 (hu)
ID (1) ID18712A (hu)
IL (1) IL129420A (hu)
MY (1) MY117687A (hu)
NO (1) NO312629B1 (hu)
PL (1) PL333112A1 (hu)
PT (1) PT937036E (hu)
SK (1) SK58399A3 (hu)
TR (1) TR199900945T2 (hu)
TW (1) TW464642B (hu)
UA (1) UA57047C2 (hu)
WO (1) WO1998022436A1 (hu)
ZA (1) ZA979756B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2780402B1 (fr) * 1998-06-30 2001-04-27 Adir Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20010101325A (ko) 1998-12-30 2001-11-14 빌프리더 하이더 치환된 4-비아릴부티르산 유도체 및 5-비아릴펜탄산유도체의 호흡기 질환 치료용 매트릭스 메탈로프로테아제저해제로서의 용도
EP1031349A1 (en) * 1999-02-25 2000-08-30 Bayer Aktiengesellschaft Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases
DE10058163C2 (de) * 2000-11-22 2003-07-10 Bebig Isotopen Und Medizintech Verfahren und Applikator zum Positionieren und/oder Auswerfen von Strahlenquellen über Hohlnadeln in biologisches Gewebe
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US8460243B2 (en) 2003-06-10 2013-06-11 Abbott Diabetes Care Inc. Glucose measuring module and insulin pump combination
US7722536B2 (en) 2003-07-15 2010-05-25 Abbott Diabetes Care Inc. Glucose measuring device integrated into a holster for a personal area network device
US20060010098A1 (en) 2004-06-04 2006-01-12 Goodnow Timothy T Diabetes care host-client architecture and data management system
EP1856063B1 (en) * 2005-02-22 2012-01-25 Ranbaxy Laboratories Limited 5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
US7319152B2 (en) 2005-09-19 2008-01-15 Wyeth 5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
US7414142B2 (en) 2005-09-19 2008-08-19 Wyeth 5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
EP2014647A4 (en) * 2006-04-17 2010-09-08 Sumitomo Chemical Co METHOD FOR THE PRODUCTION OF POLYCYCLIC LACTAM
EA016567B1 (ru) * 2006-08-22 2012-05-30 Ранбакси Лабораториз Лимитед Ингибиторы матриксных металлопротеиназ
US10136845B2 (en) 2011-02-28 2018-11-27 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
JP6804352B2 (ja) * 2017-03-22 2020-12-23 大阪瓦斯株式会社 コラゲナーゼｍｍｐ１及び３の産生抑制剤

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Also Published As

Publication number Publication date
AR009137A1 (es) 2000-03-08
DK0937036T3 (da) 2002-04-02
EP0937036A1 (en) 1999-08-25
TW464642B (en) 2001-11-21
UA57047C2 (uk) 2003-06-16
AU731830B2 (en) 2001-04-05
BR9712707A (pt) 1999-10-26
HUP9904664A3 (en) 2001-03-28
TR199900945T2 (xx) 1999-07-21
CN1140508C (zh) 2004-03-03
DE69708909T2 (de) 2002-04-11
BG63159B1 (bg) 2001-05-31
EE9900180A (et) 1999-12-15
DE69708909D1 (en) 2002-01-17
ID18712A (id) 1998-04-30
NO991994L (no) 1999-06-15
CZ148599A3 (cs) 1999-11-17
SK58399A3 (en) 2000-01-18
AU5102498A (en) 1998-06-10
IL129420A0 (en) 2000-02-17
CN1241177A (zh) 2000-01-12
ATE210112T1 (de) 2001-12-15
NO312629B1 (no) 2002-06-10
NO991994D0 (no) 1999-04-27
ES2167021T3 (es) 2002-05-01
CA2268770A1 (en) 1998-05-28
US5939583A (en) 1999-08-17
KR20000052899A (ko) 2000-08-25
WO1998022436A1 (en) 1998-05-28
MY117687A (en) 2004-07-31
EE03745B1 (et) 2002-06-17
JP2001505877A (ja) 2001-05-08
ZA979756B (en) 1999-11-01
IL129420A (en) 2003-09-17
BG103426A (en) 2000-01-31
PT937036E (pt) 2002-05-31
PL333112A1 (en) 1999-11-08
EP0937036B1 (en) 2001-12-05

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