HUP9902412A2 - Új királis biszfoszfinok és eljárás ezek előáálítására - Google Patents

Új királis biszfoszfinok és eljárás ezek előáálítására

Info

Publication number
HUP9902412A2
HUP9902412A2 HU9902412A HUP9902412A HUP9902412A2 HU P9902412 A2 HUP9902412 A2 HU P9902412A2 HU 9902412 A HU9902412 A HU 9902412A HU P9902412 A HUP9902412 A HU P9902412A HU P9902412 A2 HUP9902412 A2 HU P9902412A2
Authority
HU
Hungary
Prior art keywords
producing
compounds
novel chiral
alkyl
chiral bisphosphines
Prior art date
Application number
HU9902412A
Other languages
English (en)
Inventor
Philip Pye
Kai Rossen
Ralph P. Volante
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of HUP9902412A2 publication Critical patent/HUP9902412A2/hu
Publication of HUP9902412A3 publication Critical patent/HUP9902412A3/hu
Publication of HU223052B1 publication Critical patent/HU223052B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5027—Polyphosphines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65525—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring
    • C07F9/65527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655381—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring
    • C07F9/65539—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a seven-(or more) membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

A találmány tárgya (100) vagy (101) általánős képletű vegyületek, ahőlR jelentése 1-4 szénatőmős alkil-, 3-6 szénatőmős ciklőalkil- vagyadőtt esetben szűbsztitűált arilcsőpőrt, a szűbsztitűens jelentéseflűőratőm, -CH3, -CF3 vagy CH3O-csőpőrt; és X1 és X2 a két R2P-velszűbsztitűált benzőlgyűrűt köti össze, és egymástól függetlenül 2-4-tagú összekötő hidat alkőt, amely 2-4 szénatőmból és legfeljebb egyszűbsztitűálatlan vagy szűbsztitűált heterőatőmból áll, amely lehet S,O, SO, SO2 vagy N-R. A vegyületek kűlcsszerepet töltenek be nagyenantiőmertisztaságőt eredményező aszimmetrikűs reakciókhőzhasználható katalizátőrők előállításánál. ŕ
HU9902412A 1996-06-12 1997-06-10 Új királis biszfoszfinok és eljárás előállításukra HU223052B1 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1959096P 1996-06-12 1996-06-12
PCT/US1997/009827 WO1997047632A1 (en) 1996-06-12 1997-06-10 Novel chiral bisphosphines

Publications (3)

Publication Number Publication Date
HUP9902412A2 true HUP9902412A2 (hu) 1999-11-29
HUP9902412A3 HUP9902412A3 (en) 2001-09-28
HU223052B1 HU223052B1 (hu) 2004-03-01

Family

ID=21794005

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9902412A HU223052B1 (hu) 1996-06-12 1997-06-10 Új királis biszfoszfinok és eljárás előállításukra

Country Status (18)

Country Link
US (2) US5874629A (hu)
EP (1) EP0906322B1 (hu)
CN (1) CN1082964C (hu)
AR (1) AR007555A1 (hu)
AT (1) ATE238319T1 (hu)
AU (1) AU3303897A (hu)
BR (1) BR9709677B1 (hu)
CZ (1) CZ295748B6 (hu)
DE (1) DE69721257T2 (hu)
DK (1) DK0906322T3 (hu)
EA (1) EA001377B1 (hu)
ES (1) ES2196343T3 (hu)
HU (1) HU223052B1 (hu)
PT (1) PT906322E (hu)
SK (1) SK284369B6 (hu)
TW (1) TW450971B (hu)
UA (1) UA57742C2 (hu)
WO (1) WO1997047632A1 (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6334219B1 (en) * 1994-09-26 2001-12-25 Adc Telecommunications Inc. Channel selection for a hybrid fiber coax network
US5977364A (en) * 1998-02-02 1999-11-02 Merck & Co., Inc. Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
DE10005794A1 (de) * 2000-02-10 2001-08-16 Basf Ag Verbindungen des Phosphors, Arsens und des Antimons
ATE495183T1 (de) * 2000-03-30 2011-01-15 Chirotech Technology Ltd Ruthenium-diphosphin komplexe und ihre verwendung als katalysatoren
US6482952B2 (en) 2000-06-20 2002-11-19 Merck & Co., Inc. Process for preparing acetonides
WO2002057278A1 (en) * 2001-01-19 2002-07-25 Chirotech Technology Limited Ligands and their use
JP2006527246A (ja) * 2003-06-13 2006-11-30 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー 配位子
GB0313709D0 (en) * 2003-06-13 2003-07-16 Johnson Matthey Plc Ligands
US7449601B2 (en) * 2004-12-16 2008-11-11 E. I. Du Pont De Nemours And Company Catalysts useful for catalyzing the coupling of arylhalides with arylboronic acids
PL1861352T3 (pl) * 2005-03-17 2010-05-31 Basf Se Sposób wytwarzania optycznie czynnych pochodnych kwasu 3-fenylopropionowego i otrzymywane z nich produkty
EP1885688B1 (en) * 2005-05-20 2010-09-22 Dr. Reddy's Laboratories (EU) Limited Asymmetric hydrogenation for the preparation of diphenylalanine derivatives
GB0700622D0 (en) 2007-01-12 2007-02-21 Johnson Matthey Plc Process for preparing cationic rhodium complexes
GB0716714D0 (en) 2007-08-29 2007-10-10 Johnson Matthey Plc Ligands
GB0812290D0 (en) 2008-07-04 2008-08-13 Johnson Matthey Plc Process for preparing cationic rhodium complexes
GB0915946D0 (en) 2009-09-11 2009-10-28 Univ St Andrews Metal-catalysed carbonylation of unsaturated compounds
CZ303113B6 (cs) * 2010-03-16 2012-04-11 Zentiva, K.S. Zpusob prípravy sitagliptinu
GB201104522D0 (en) 2011-03-17 2011-05-04 Johnson Matthey Plc Complexes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2681057B2 (ja) * 1990-10-01 1997-11-19 高砂香料工業株式会社 ２，２’―ビス（ジフェニルホスフィノ）―５，５’，６，６’，７，７’，８，８’―オクタヒドロ―１，１’―ビナフチル及びこれを配位子とする遷移金属錯体
DE4330730A1 (de) * 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
DE59407903D1 (de) * 1993-10-08 1999-04-15 Hoffmann La Roche Optisch aktive phosphorverbindungen
US5399771A (en) * 1994-06-01 1995-03-21 Merck & Co., Inc. Process of synthesizing binaphthyl derivatives

Also Published As

Publication number Publication date
BR9709677B1 (pt) 2010-05-18
EP0906322A1 (en) 1999-04-07
CZ409898A3 (cs) 1999-05-12
CZ295748B6 (cs) 2005-10-12
ES2196343T3 (es) 2003-12-16
SK284369B6 (sk) 2005-02-04
HUP9902412A3 (en) 2001-09-28
ATE238319T1 (de) 2003-05-15
HU223052B1 (hu) 2004-03-01
EA199900016A1 (ru) 1999-06-24
UA57742C2 (uk) 2003-07-15
US6043387A (en) 2000-03-28
TW450971B (en) 2001-08-21
BR9709677A (pt) 2000-05-09
SK169198A3 (en) 1999-08-06
EP0906322B1 (en) 2003-04-23
US5874629A (en) 1999-02-23
EA001377B1 (ru) 2001-02-26
DK0906322T3 (da) 2003-06-02
DE69721257D1 (de) 2003-05-28
AR007555A1 (es) 1999-11-10
AU3303897A (en) 1998-01-07
PT906322E (pt) 2003-08-29
DE69721257T2 (de) 2004-02-05
CN1082964C (zh) 2002-04-17
CN1221422A (zh) 1999-06-30
WO1997047632A1 (en) 1997-12-18

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Legal Events

Date Code Title Description
HFG4 Patent granted, date of granting

Effective date: 20031205

GB9A Succession in title

Owner name: MERCK SHARP & DOHME CORP., US

Free format text: FORMER OWNER(S): MERCK & CO., INC., US

MM4A Lapse of definitive patent protection due to non-payment of fees