KR860002470A - 6-클로로-n-메틸-2,3,4,5- 테트라하이드로-1h-3- 벤즈 아제핀의 제조방법 - Google Patents

6-클로로-n-메틸-2,3,4,5- 테트라하이드로-1h-3- 벤즈 아제핀의 제조방법 Download PDF

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Publication number
KR860002470A
KR860002470A KR1019850006061A KR850006061A KR860002470A KR 860002470 A KR860002470 A KR 860002470A KR 1019850006061 A KR1019850006061 A KR 1019850006061A KR 850006061 A KR850006061 A KR 850006061A KR 860002470 A KR860002470 A KR 860002470A
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KR
South Korea
Prior art keywords
methyl
tetrahydro
chloro
preparing
ethyl
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Application number
KR1019850006061A
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English (en)
Inventor
죤 보로우스키(외 1) 스탠리
Original Assignee
리챠드 도미니크 포기오
스미스 클라인 베크만 코포레이션
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Application filed by 리챠드 도미니크 포기오, 스미스 클라인 베크만 코포레이션 filed Critical 리챠드 도미니크 포기오
Publication of KR860002470A publication Critical patent/KR860002470A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

6-클로로-N-메틸-2,3,4,5-테트라하이드로-1H-3-벤즈 아제핀의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 염화알루미늄과 삼염화벤젠용액에 N-메틸-N-[2-(2´-클로로페닐)에틸]-2-클로로에틸아민을 반응시키는 과정으로 구성되는 6-클로로-메틸-2,3,4,5-테트라하이드로-1H-3-벤즈아제핀을 제조하는 방법.
  2. 1,2,4-삼염화벤젠을 사용하는 청구범위 제1항의 방법.
  3. 약 180℃ 내지 약 215℃의 온도에서, 약 3시간 내지 약 8시간동안 반응이 실시되는 청구범위 제1항의 방법.
  4. 염화에틸아민 N-메틸-N-[2-(2´-클로로페닐)에틸]-2-클로로에틸아민과 오산화인의 삼염화벤젠 용액을 반응시켜서 제조하는 청구범위 제1항의 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006061A 1984-09-05 1985-08-22 6-클로로-n-메틸-2,3,4,5- 테트라하이드로-1h-3- 벤즈 아제핀의 제조방법 KR860002470A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US647552 1984-09-05
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (1)

Publication Number Publication Date
KR860002470A true KR860002470A (ko) 1986-04-26

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006061A KR860002470A (ko) 1984-09-05 1985-08-22 6-클로로-n-메틸-2,3,4,5- 테트라하이드로-1h-3- 벤즈 아제핀의 제조방법

Country Status (19)

Country Link
US (1) US4541954A (ko)
EP (1) EP0174118A3 (ko)
JP (1) JPS6168469A (ko)
KR (1) KR860002470A (ko)
AU (1) AU581918B2 (ko)
CA (1) CA1244017A (ko)
DK (1) DK379985A (ko)
EG (1) EG17149A (ko)
ES (1) ES8609266A1 (ko)
FI (1) FI853255L (ko)
GR (1) GR852041B (ko)
HU (1) HU194181B (ko)
IL (1) IL76100A0 (ko)
NO (1) NO853255L (ko)
NZ (1) NZ213141A (ko)
PH (1) PH20796A (ko)
PT (1) PT81018B (ko)
ZA (1) ZA856268B (ko)
ZW (1) ZW13385A1 (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
US5401595A (en) * 1991-12-06 1995-03-28 Yuasa Corporation Film type battery and layer-built film type battery
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
EP2189448B1 (en) * 2003-06-17 2014-01-29 Arena Pharmaceuticals, Inc. Processes for the Separation of 3-Benzazepine Racemates
CN101792417A (zh) 2003-06-17 2010-08-04 艾尼纳制药公司 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物
KR101281919B1 (ko) 2004-12-21 2013-07-03 아레나 파마슈티칼스, 인크. (ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태
PT1833473E (pt) 2004-12-23 2009-12-17 Arena Pharm Inc Composições de modulador de receptor 5ht2c e métodos de utilização
EP2001852A2 (en) 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
CA2670285A1 (en) * 2006-12-05 2008-06-12 Arena Pharmaceuticals, Inc. Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof
JP5491421B2 (ja) * 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US9045431B2 (en) 2010-06-02 2015-06-02 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
EP2939677A1 (en) 2010-09-01 2015-11-04 Arena Pharmaceuticals, Inc. Administration of lorcaserin to indviduals with renal impairment
CN103189360A (zh) 2010-09-01 2013-07-03 艾尼纳制药公司 5-ht2c激动剂的非吸湿性盐
ES2704455T3 (es) 2010-09-01 2019-03-18 Arena Pharm Inc Formas farmacéuticas de liberación modificada de agonistas de 5-HT2C útiles para la gestión del peso
WO2012030938A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
AU2012392187B2 (en) 2012-10-09 2018-07-12 Arena Pharmaceuticals, Inc. Method of weight management

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines

Also Published As

Publication number Publication date
DK379985D0 (da) 1985-08-21
ZW13385A1 (en) 1985-11-20
FI853255A0 (fi) 1985-08-23
DK379985A (da) 1986-03-06
FI853255L (fi) 1986-03-06
PT81018B (en) 1987-06-24
NZ213141A (en) 1988-07-28
EP0174118A2 (en) 1986-03-12
PT81018A (en) 1985-09-01
AU4648185A (en) 1986-03-13
EG17149A (en) 1989-06-30
JPS6168469A (ja) 1986-04-08
ES546285A0 (es) 1986-09-01
IL76100A0 (en) 1985-12-31
HUT38617A (en) 1986-06-30
US4541954A (en) 1985-09-17
ZA856268B (en) 1986-07-30
HU194181B (en) 1988-01-28
CA1244017A (en) 1988-11-01
GR852041B (ko) 1985-12-19
EP0174118A3 (en) 1986-12-30
NO853255L (no) 1986-03-06
AU581918B2 (en) 1989-03-09
PH20796A (en) 1987-04-14
ES8609266A1 (es) 1986-09-01

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