FI853255A0 - Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin. - Google Patents

Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin.

Info

Publication number
FI853255A0
FI853255A0 FI853255A FI853255A FI853255A0 FI 853255 A0 FI853255 A0 FI 853255A0 FI 853255 A FI853255 A FI 853255A FI 853255 A FI853255 A FI 853255A FI 853255 A0 FI853255 A0 FI 853255A0
Authority
FI
Finland
Prior art keywords
bensazepine
framstaellning
tetrahydro
chloro
methyl
Prior art date
Application number
FI853255A
Other languages
English (en)
Other versions
FI853255L (fi
Inventor
Stanley John Borowski
Thomas Anthony Post
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of FI853255A0 publication Critical patent/FI853255A0/fi
Publication of FI853255L publication Critical patent/FI853255L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FI853255A 1984-09-05 1985-08-23 Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin. FI853255L (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (2)

Publication Number Publication Date
FI853255A0 true FI853255A0 (fi) 1985-08-23
FI853255L FI853255L (fi) 1986-03-06

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
FI853255A FI853255L (fi) 1984-09-05 1985-08-23 Foerfarande foer framstaellning av 6-klor-n-metyl-2,3,4,5-tetrahydro-1h-3-bensazepin.

Country Status (19)

Country Link
US (1) US4541954A (fi)
EP (1) EP0174118A3 (fi)
JP (1) JPS6168469A (fi)
KR (1) KR860002470A (fi)
AU (1) AU581918B2 (fi)
CA (1) CA1244017A (fi)
DK (1) DK379985A (fi)
EG (1) EG17149A (fi)
ES (1) ES8609266A1 (fi)
FI (1) FI853255L (fi)
GR (1) GR852041B (fi)
HU (1) HU194181B (fi)
IL (1) IL76100A0 (fi)
NO (1) NO853255L (fi)
NZ (1) NZ213141A (fi)
PH (1) PH20796A (fi)
PT (1) PT81018B (fi)
ZA (1) ZA856268B (fi)
ZW (1) ZW13385A1 (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
US5401595A (en) * 1991-12-06 1995-03-28 Yuasa Corporation Film type battery and layer-built film type battery
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
PL2332921T3 (pl) * 2003-06-17 2016-08-31 Arena Pharm Inc Chlorowodorek 8-chloro-1-metylo-2,3,4,5-tetrahydro-1H-3-benzazepiny
EP2332920A3 (en) 2003-06-17 2011-12-21 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
NZ555981A (en) 2004-12-21 2011-01-28 Arena Pharm Inc Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
NZ555482A (en) 2004-12-23 2011-01-28 Arena Pharm Inc Compositions comprising a 5HT2C receptor modulator and 2-methylamphetamine and methods of use
EP2471779A1 (en) 2006-04-03 2012-07-04 Arena Pharmaceuticals, Inc. Process for the resolution of a mixture of (R)- and (S)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
ES2522587T3 (es) * 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
WO2009111004A1 (en) * 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
US8952197B2 (en) 2009-06-18 2015-02-10 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-HT2C receptor agonists
KR20130112848A (ko) 2010-06-02 2013-10-14 아레나 파마슈티칼스, 인크. 5-ｈｔ2ｃ 수용체 아고니스트의 제조 방법
CN103347523A (zh) 2010-09-01 2013-10-09 艾尼纳制药公司 向具有肾损伤的个体给药氯卡色林
WO2012030957A2 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
KR20180118801A (ko) 2010-09-01 2018-10-31 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
CA2808909A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Salts of lorcaserin with optically active acids
BR112015007779A2 (pt) 2012-10-09 2017-07-04 Arena Pharm Inc célula de fluxo de permeabilidade e sistema de condutância hidráulica

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
DE3272044D1 (de) * 1981-11-27 1986-08-21 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists

Also Published As

Publication number Publication date
FI853255L (fi) 1986-03-06
HU194181B (en) 1988-01-28
NO853255L (no) 1986-03-06
ZA856268B (en) 1986-07-30
NZ213141A (en) 1988-07-28
ES8609266A1 (es) 1986-09-01
DK379985A (da) 1986-03-06
EP0174118A3 (en) 1986-12-30
KR860002470A (ko) 1986-04-26
IL76100A0 (en) 1985-12-31
AU4648185A (en) 1986-03-13
ES546285A0 (es) 1986-09-01
GR852041B (fi) 1985-12-19
AU581918B2 (en) 1989-03-09
CA1244017A (en) 1988-11-01
EP0174118A2 (en) 1986-03-12
US4541954A (en) 1985-09-17
PT81018B (en) 1987-06-24
JPS6168469A (ja) 1986-04-08
HUT38617A (en) 1986-06-30
ZW13385A1 (en) 1985-11-20
PH20796A (en) 1987-04-14
EG17149A (en) 1989-06-30
DK379985D0 (da) 1985-08-21
PT81018A (en) 1985-09-01

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: SMITHKLINE BECKMAN CORPORATION