EG17149A - Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine - Google Patents

Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

Info

Publication number
EG17149A
EG17149A EG545/85A EG54585A EG17149A EG 17149 A EG17149 A EG 17149A EG 545/85 A EG545/85 A EG 545/85A EG 54585 A EG54585 A EG 54585A EG 17149 A EG17149 A EG 17149A
Authority
EG
Egypt
Prior art keywords
benzazepine
tetrahydro
chloro
methyl
preparing
Prior art date
Application number
EG545/85A
Other languages
English (en)
Inventor
John Borowski Stanly
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Application granted granted Critical
Publication of EG17149A publication Critical patent/EG17149A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
EG545/85A 1984-09-05 1985-09-04 Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine EG17149A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/647,552 US4541954A (en) 1984-09-05 1984-09-05 Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Publications (1)

Publication Number Publication Date
EG17149A true EG17149A (en) 1989-06-30

Family

ID=24597406

Family Applications (1)

Application Number Title Priority Date Filing Date
EG545/85A EG17149A (en) 1984-09-05 1985-09-04 Method for preparing 6-chloro-n-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

Country Status (19)

Country Link
US (1) US4541954A (fi)
EP (1) EP0174118A3 (fi)
JP (1) JPS6168469A (fi)
KR (1) KR860002470A (fi)
AU (1) AU581918B2 (fi)
CA (1) CA1244017A (fi)
DK (1) DK379985A (fi)
EG (1) EG17149A (fi)
ES (1) ES8609266A1 (fi)
FI (1) FI853255L (fi)
GR (1) GR852041B (fi)
HU (1) HU194181B (fi)
IL (1) IL76100A0 (fi)
NO (1) NO853255L (fi)
NZ (1) NZ213141A (fi)
PH (1) PH20796A (fi)
PT (1) PT81018B (fi)
ZA (1) ZA856268B (fi)
ZW (1) ZW13385A1 (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993000811A1 (en) * 1991-07-01 1993-01-21 The General Hospital Corporation Invertebrate phenylethanolamine transporter and the use thereof
CA2100678A1 (en) * 1991-12-06 1993-06-07 Hiroshi Kagawa Film type battery and layer-built film type battery
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
HUE028976T2 (en) * 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EA016558B1 (ru) 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
JP5270167B2 (ja) 2004-12-21 2013-08-21 アリーナ ファーマシューティカルズ， インコーポレイテッド （ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンザゼピン塩酸塩の結晶形
CN102631349A (zh) 2004-12-23 2012-08-15 艾尼纳制药公司 5HT2c受体调节剂组合物和使用方法
JP5199997B2 (ja) 2006-04-03 2013-05-15 アリーナ ファーマシューティカルズ， インコーポレイテッド ８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンズアゼピンおよびこれに関連する中間体を調製するためのプロセス
CN101547892B (zh) * 2006-12-05 2014-08-20 艾尼纳制药公司 制备(r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的方法和其中间体
JP5491421B2 (ja) * 2008-03-04 2014-05-14 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス
WO2010148207A2 (en) 2009-06-18 2010-12-23 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
EP2611433A2 (en) 2010-09-01 2013-07-10 Arena Pharmaceuticals, Inc. Non-hygroscopic salts of 5-ht2c agonists
SG10201506870PA (en) 2010-09-01 2015-10-29 Arena Pharm Inc Salts of lorcaserin with optically active acids
SG188362A1 (en) 2010-09-01 2013-04-30 Arena Pharm Inc Modified-release dosage forms of 5-ht2c agonists useful for weight management
US8999970B2 (en) 2010-09-01 2015-04-07 Arena Pharmaceuticals, Inc. Administration of an anti-obesity compound to individuals with renal impairment
KR20150070249A (ko) 2012-10-09 2015-06-24 아레나 파마슈티칼스, 인크. 체중 관리 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1118688A (en) * 1967-02-17 1968-07-03 Scherico Ltd Novel benzazepines and process for making same
CH481110A (de) * 1967-02-17 1969-11-15 Geigy Ag J R Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
US4251660A (en) * 1978-08-10 1981-02-17 Smithkline Corporation Method for preparing tetrahydroisoquinolines
US4200754A (en) * 1979-02-02 1980-04-29 Smithkline Corporation Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
ZA827887B (en) * 1981-11-27 1983-11-30 Smithkline Beckman Corp Pharmaceutical compositions and method of producing alpha2 antagonism
DE3272044D1 (de) * 1981-11-27 1986-08-21 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
IE53962B1 (en) * 1981-11-27 1989-04-26 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists

Also Published As

Publication number Publication date
EP0174118A2 (en) 1986-03-12
PT81018A (en) 1985-09-01
AU581918B2 (en) 1989-03-09
ZA856268B (en) 1986-07-30
ES8609266A1 (es) 1986-09-01
NO853255L (no) 1986-03-06
HU194181B (en) 1988-01-28
ES546285A0 (es) 1986-09-01
IL76100A0 (en) 1985-12-31
ZW13385A1 (en) 1985-11-20
GR852041B (fi) 1985-12-19
PH20796A (en) 1987-04-14
NZ213141A (en) 1988-07-28
DK379985A (da) 1986-03-06
FI853255A0 (fi) 1985-08-23
KR860002470A (ko) 1986-04-26
HUT38617A (en) 1986-06-30
US4541954A (en) 1985-09-17
FI853255L (fi) 1986-03-06
CA1244017A (en) 1988-11-01
PT81018B (en) 1987-06-24
EP0174118A3 (en) 1986-12-30
JPS6168469A (ja) 1986-04-08
DK379985D0 (da) 1985-08-21
AU4648185A (en) 1986-03-13

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