HUP9900822A2 - Piperazinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és eljárás tachikinin-mediált betegségek kezelésére - Google Patents

Piperazinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és eljárás tachikinin-mediált betegségek kezelésére

Info

Publication number
HUP9900822A2
HUP9900822A2 HU9900822A HUP9900822A HUP9900822A2 HU P9900822 A2 HUP9900822 A2 HU P9900822A2 HU 9900822 A HU9900822 A HU 9900822A HU P9900822 A HUP9900822 A HU P9900822A HU P9900822 A2 HUP9900822 A2 HU P9900822A2
Authority
HU
Hungary
Prior art keywords
mediated diseases
producing
pharmaceutical compositions
compositions containing
piperazine derivatives
Prior art date
Application number
HU9900822A
Other languages
English (en)
Inventor
Daijiro Hagiwara
Nobukiyo Konishi
Takashi Manabe
Hiroshi Matsuda
Masaaki Matsuo
Hiroshi Miyake
Kenji Murano
Shinji Shigenaga
Original Assignee
Fujisawa Pharmaceutical Co.,Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co.,Ltd. filed Critical Fujisawa Pharmaceutical Co.,Ltd.
Publication of HUP9900822A2 publication Critical patent/HUP9900822A2/hu
Publication of HUP9900822A3 publication Critical patent/HUP9900822A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

A találmány tárgya (I) képletű (2R)-1-[3,5-bisz(triflűőr-metil)-benzőil]-2-(1H-indől-3-il-metil)-4-[N-(4-metil-1-piperazinil)-karbamőil- metil]-piperazin vagy ennek fűmársavas sója. A találmánytárgya tővábá előállítási eljárás a fenti vegyület előállítására,valamint gyógyszerkészítmény, amely a fenti vegyületet tartalmazza,illetve alkalmazási eljárás amelyben ezt gyógyszerként felhasználjáktachikinin-mediált betegségek kezelésére vagy megelőzésére. ŕ
HU9900822A 1995-05-25 1996-05-21 Piperazine derivatives, process for producing them, pharmaceutical compositions containing them and method for treating tachykinin-mediated diseases HUP9900822A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45017695A 1995-05-25 1995-05-25

Publications (2)

Publication Number Publication Date
HUP9900822A2 true HUP9900822A2 (hu) 1999-06-28
HUP9900822A3 HUP9900822A3 (en) 1999-11-29

Family

ID=23787083

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900822A HUP9900822A3 (en) 1995-05-25 1996-05-21 Piperazine derivatives, process for producing them, pharmaceutical compositions containing them and method for treating tachykinin-mediated diseases

Country Status (14)

Country Link
EP (1) EP0846116A1 (hu)
JP (1) JP3071829B2 (hu)
KR (1) KR19990021857A (hu)
CN (1) CN1072220C (hu)
AU (1) AU706021B2 (hu)
CA (1) CA2222041A1 (hu)
EA (1) EA000669B1 (hu)
HU (1) HUP9900822A3 (hu)
IL (1) IL118369A (hu)
NZ (1) NZ307625A (hu)
TR (1) TR199600438A2 (hu)
TW (1) TW391960B (hu)
WO (1) WO1996037489A1 (hu)
ZA (1) ZA964101B (hu)

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DE10036818A1 (de) * 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
UA75425C2 (en) * 2001-07-09 2006-04-17 Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds
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Also Published As

Publication number Publication date
EP0846116A1 (en) 1998-06-10
NZ307625A (en) 1999-02-25
IL118369A (en) 2000-06-01
CN1072220C (zh) 2001-10-03
WO1996037489A1 (en) 1996-11-28
TW391960B (en) 2000-06-01
IL118369A0 (en) 1996-09-12
AU5703196A (en) 1996-12-11
TR199600438A2 (tr) 1996-12-21
CA2222041A1 (en) 1996-11-28
AU706021B2 (en) 1999-06-03
JP3071829B2 (ja) 2000-07-31
ZA964101B (en) 1996-07-29
EA199700425A1 (ru) 1998-12-24
JPH11505830A (ja) 1999-05-25
KR19990021857A (ko) 1999-03-25
HUP9900822A3 (en) 1999-11-29
CN1191533A (zh) 1998-08-26
EA000669B1 (ru) 2000-02-28

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