HUP9900405A2 - HIV ellenes hatású ciklosporinszármazékok - Google Patents
HIV ellenes hatású ciklosporinszármazékokInfo
- Publication number
- HUP9900405A2 HUP9900405A2 HU9900405A HUP9900405A HUP9900405A2 HU P9900405 A2 HUP9900405 A2 HU P9900405A2 HU 9900405 A HU9900405 A HU 9900405A HU P9900405 A HUP9900405 A HU P9900405A HU P9900405 A2 HUP9900405 A2 HU P9900405A2
- Authority
- HU
- Hungary
- Prior art keywords
- pipe powder
- oxy
- stands
- methyl
- formula
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 230000036436 anti-hiv Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 8
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical group CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Chemical group CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- 239000004474 valine Chemical group 0.000 abstract 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 2
- 239000004473 Threonine Substances 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 hydroxy- Chemical class 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- OKQFBOQZAAASNI-ZETCQYMHSA-N (2s)-4-acetyloxy-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)(C)OC(C)=O OKQFBOQZAAASNI-ZETCQYMHSA-N 0.000 abstract 1
- JRKMRRWEUORVRJ-YFKPBYRVSA-N (2s)-4-hydroxy-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)(C)O JRKMRRWEUORVRJ-YFKPBYRVSA-N 0.000 abstract 1
- QWCKQJZIFLGMSD-UHFFFAOYSA-N 2-Aminobutanoic acid Natural products CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 abstract 1
- 241000251468 Actinopterygii Species 0.000 abstract 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 abstract 1
- 102000001189 Cyclic Peptides Human genes 0.000 abstract 1
- 108010069514 Cyclic Peptides Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 abstract 1
- 229930195711 D-Serine Natural products 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 abstract 1
- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical group CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical group C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 1
- AKCRVYNORCOYQT-YFKPBYRVSA-N N-methyl-L-valine Chemical compound CN[C@@H](C(C)C)C(O)=O AKCRVYNORCOYQT-YFKPBYRVSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004744 butyloxycarbonyl group Chemical group 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- XJODGRWDFZVTKW-ZCFIWIBFSA-N n-methylleucine Chemical compound CN[C@@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-ZCFIWIBFSA-N 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A találmány az B.C.D.E.F / | A \ K.J.I.H.G. (I) általánős képletű, új,ciklűsős peptidekre vőnatkőzik, amelyek a ciklőspőrinők közétartőznak, és imműnszűppresszív hatás nélkül műtatnak HIV elleni erősgátló hatást. A képletben A jelentése R1-CH2CH(CH3)-CH(OH)-CH(NHCH3)-COOH (II) képletű szűbsztitűált hőmőtreőnin, amelyben R1 n-prőpil-vagy prőpenilcsőpőrt, és a kettőskötés előnyösen transz-kőnfigűrációjú, B jelentése alfa-aminő-vajsav, valin, nőrvalin vagytreőnin, C jelentése CH3NH-CH(R)-COOH (III) képletű (D)-aminősav,amelyben R egyenes vagy elágazó alkil-, alkenil-, alkinilcsőpőrt,amely csőpőrtők hidrőxi-, aminő-, alkil-aminő-, dialkil-aminő-,alkőxi- vagy acil-őxi-csőpőrttal szűbsztitűálva lehetnek; tővábbáCOOR2, CONHR2 csőpőrt, ahől R2 egyenes vagy elágazó alkilcsőpőrtlehet; tővábbá X-R3 csőpőrt, ahől X őxigén vagy kén, és R3 egyenesvagy elágazó alkil-, alkenil- vagy alkinilcsőpőrt, és ahől ha Xkénatőm, R3 aril- vagy heterőarilcsőpőrt is lehet; tővábbá halőgén,előnyösen flűőr; tővábbá cianőcsőpőrt; valamint CHR4R5 csőpőrt, ahőlR4 hidrőgén, metil-, etil-, fenilcsőpőrt, és R5 hidrőgén,hidrőxicsőpőrt, halőgén, előnyösen flűőr, valamint aminőcsőpőrt,alkil-aminő-, dialkil-aminő-, acil-őxi-, előnyösen acetil-őxi-csőpőrt,tővábbá (terc-bűtőxi-karbőnil)-aminő-etőxi-etőxi-acetil-őxi-csőpőrt,alkőxi-karbőnil-, előnyösen bűtőxi-karbőnil-csőpőrt, D jelentése N-metil-gamma-hidrőxi-leűcin vagy N-metil-gamma-acetil-őxi-leűcin, E jelentése valin, F, I és J jelentése minden esetben N-metil-leűcin, G jelentése alanin, H jelentése (D)-alanin, (D)-szerin,és K jelentése N-metil-valin. A találmány tárgyát képezik tővábbá azúj vegyületeket tartalmazó gyógyszerek és a vegyületek előállításieljárása. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95111162 | 1995-07-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9900405A2 true HUP9900405A2 (hu) | 1999-06-28 |
| HUP9900405A3 HUP9900405A3 (en) | 2001-04-28 |
Family
ID=8219438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9900405A HUP9900405A3 (en) | 1995-07-17 | 1996-07-17 | Cyclosporin derivatives with anti-hiv effect |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5948884A (hu) |
| EP (1) | EP0842191B1 (hu) |
| JP (1) | JP3920919B2 (hu) |
| KR (1) | KR100441220B1 (hu) |
| CN (1) | CN1141317C (hu) |
| AT (1) | ATE209216T1 (hu) |
| AU (1) | AU722858B2 (hu) |
| BR (1) | BR9609795A (hu) |
| CA (1) | CA2226880C (hu) |
| CZ (1) | CZ290754B6 (hu) |
| DE (1) | DE59608274D1 (hu) |
| HU (1) | HUP9900405A3 (hu) |
| IL (1) | IL122754A (hu) |
| NO (1) | NO980195D0 (hu) |
| NZ (1) | NZ315324A (hu) |
| PL (1) | PL324531A1 (hu) |
| WO (1) | WO1997004005A2 (hu) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2757521B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2757520B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent |
| FR2757522B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2762843B1 (fr) * | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US6270957B1 (en) | 1997-08-26 | 2001-08-07 | Wisconsin Alumni Research Foundation | Non-Imuunosuppressive cyclosporins and their use in the prevention and treatment of HIV infection |
| US6316405B1 (en) * | 1997-08-26 | 2001-11-13 | Wisconsin Alumni Research Foundation | Cyclosporin a conjugates and uses therefor |
| FR2772768B1 (fr) * | 1997-12-19 | 2000-01-14 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
| WO1999065933A1 (en) * | 1998-06-12 | 1999-12-23 | C-Chem Ag | Novel cyclosporins |
| DK1091975T3 (da) | 1998-07-01 | 2006-04-18 | Debiopharm Sa | Ny cyclosporin med forbedret aktivitetsprofil |
| KR100465012B1 (ko) * | 2001-05-11 | 2005-01-13 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
| PT1436321E (pt) | 2001-10-19 | 2006-10-31 | Isotechnika Inc | Sintese de analogos de ciclosporina |
| US7108988B2 (en) | 2001-11-02 | 2006-09-19 | The J. David Gladstone Institutes | Methods of identifying agents for inhibiting lentivirus replication |
| US6987090B2 (en) * | 2002-05-09 | 2006-01-17 | Lg Household & Health Care Ltd. | Use of 3-position cyclosporin derivatives for hair growth |
| AU2004222306A1 (en) * | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| EP1804823A4 (en) * | 2004-09-29 | 2010-06-09 | Amr Technology Inc | NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS |
| US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| KR101309409B1 (ko) * | 2004-10-01 | 2013-09-23 | 싸이넥시스, 인크. | Ｃ형 간염 바이러스 감염의 치료 및 예방을 위한 ３-에테르및 ３-티오에테르 치환된 시클로스포린 유도체 |
| US7361636B2 (en) * | 2004-10-06 | 2008-04-22 | Amr Technology, Inc. | Cyclosporin alkynes and their utility as pharmaceutical agents |
| JP5322647B2 (ja) * | 2005-09-30 | 2013-10-23 | スシネキス インク | ウイルス感染の治療及び予防のためのシクロスポリンａのアリールアルキル及びヘテロアリールアルキル誘導体 |
| AU2006299426B2 (en) * | 2005-09-30 | 2012-07-26 | Scynexis, Inc. | Methods and pharmaceutical compositions for the treatment and prevention of hepatitis C infection |
| US7696166B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) * | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US20070232532A1 (en) * | 2006-03-28 | 2007-10-04 | Amr Technology, Inc. | Use of cyclosporin alkene analogues for preventing or treating viral-induced disorders |
| ATE502633T1 (de) | 2006-05-19 | 2011-04-15 | Scynexis Inc | Cyclosporins zur behandlung und vorbeugung von augenerkrankungen |
| EP2027761A1 (fr) * | 2006-06-02 | 2009-02-25 | Claude Annie Perrichon | Gestion des electrons actifs |
| WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
| US20080255038A1 (en) * | 2007-04-11 | 2008-10-16 | Samuel Earl Hopkins | Pharmaceutical compositions |
| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
| WO2010002428A2 (en) * | 2008-06-06 | 2010-01-07 | Scynexis, Inc. | Novel macrocyclic peptides |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| AU2009334790B2 (en) * | 2008-12-31 | 2016-09-08 | Scynexis, Inc. | Derivatives of cyclosporin A |
| CN101874902B (zh) * | 2009-06-19 | 2013-04-03 | 清华大学 | 一种用于人工椎间盘髓核假体材料的制备方法 |
| CN102834409A (zh) * | 2009-12-30 | 2012-12-19 | 西尼克斯公司 | 环孢菌素类似物 |
| CN103153330B (zh) | 2010-08-12 | 2017-08-18 | 美国科技环球有限公司 | 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用 |
| DK2646043T3 (da) * | 2010-12-03 | 2017-05-22 | S&T Global Inc | Hidtil ukendte cyclosporinderivater til behandling og forebyggelse af en virusinfektion |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| AU2011342284C1 (en) | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| EP2705856A1 (en) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Compounds for the treatment of neurodegenerative disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
| EP0484281B2 (en) * | 1990-11-02 | 2000-11-22 | Novartis AG | Cyclosporins |
-
1996
- 1996-07-17 IL IL12275496A patent/IL122754A/en not_active IP Right Cessation
- 1996-07-17 US US08/009,815 patent/US5948884A/en not_active Expired - Lifetime
- 1996-07-17 BR BR9609795A patent/BR9609795A/pt not_active Application Discontinuation
- 1996-07-17 PL PL96324531A patent/PL324531A1/xx unknown
- 1996-07-17 DE DE59608274T patent/DE59608274D1/de not_active Expired - Lifetime
- 1996-07-17 CN CNB96196264XA patent/CN1141317C/zh not_active Expired - Fee Related
- 1996-07-17 AT AT96927023T patent/ATE209216T1/de not_active IP Right Cessation
- 1996-07-17 NZ NZ315324A patent/NZ315324A/en not_active IP Right Cessation
- 1996-07-17 KR KR10-1998-0700269A patent/KR100441220B1/ko not_active IP Right Cessation
- 1996-07-17 EP EP96927023A patent/EP0842191B1/de not_active Expired - Lifetime
- 1996-07-17 HU HU9900405A patent/HUP9900405A3/hu unknown
- 1996-07-17 WO PCT/EP1996/003129 patent/WO1997004005A2/de active IP Right Grant
- 1996-07-17 AU AU67001/96A patent/AU722858B2/en not_active Ceased
- 1996-07-17 CZ CZ199851A patent/CZ290754B6/cs not_active IP Right Cessation
- 1996-07-17 JP JP50628797A patent/JP3920919B2/ja not_active Expired - Fee Related
- 1996-07-17 CA CA002226880A patent/CA2226880C/en not_active Expired - Fee Related
-
1998
- 1998-01-15 NO NO980195A patent/NO980195D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO980195L (no) | 1998-01-15 |
| AU722858B2 (en) | 2000-08-10 |
| AU6700196A (en) | 1997-02-18 |
| CA2226880A1 (en) | 1997-02-06 |
| EP0842191A2 (de) | 1998-05-20 |
| CN1141317C (zh) | 2004-03-10 |
| JP2000502320A (ja) | 2000-02-29 |
| CN1192750A (zh) | 1998-09-09 |
| NO980195D0 (no) | 1998-01-15 |
| CA2226880C (en) | 2007-04-10 |
| WO1997004005A2 (de) | 1997-02-06 |
| KR100441220B1 (ko) | 2005-02-24 |
| BR9609795A (pt) | 1999-03-16 |
| KR19990028967A (ko) | 1999-04-15 |
| PL324531A1 (en) | 1998-06-08 |
| NZ315324A (en) | 1999-10-28 |
| MX9800477A (es) | 1998-09-30 |
| DE59608274D1 (de) | 2002-01-03 |
| EP0842191B1 (de) | 2001-11-21 |
| CZ5198A3 (cs) | 1998-04-15 |
| US5948884A (en) | 1999-09-07 |
| WO1997004005A3 (de) | 1997-02-27 |
| IL122754A0 (en) | 1998-08-16 |
| CZ290754B6 (cs) | 2002-10-16 |
| JP3920919B2 (ja) | 2007-05-30 |
| HUP9900405A3 (en) | 2001-04-28 |
| ATE209216T1 (de) | 2001-12-15 |
| IL122754A (en) | 2001-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |