MX9800477A - Derivados de ciclosporina con efecto anti-vih. - Google Patents
Derivados de ciclosporina con efecto anti-vih.Info
- Publication number
- MX9800477A MX9800477A MX9800477A MX9800477A MX9800477A MX 9800477 A MX9800477 A MX 9800477A MX 9800477 A MX9800477 A MX 9800477A MX 9800477 A MX9800477 A MX 9800477A MX 9800477 A MX9800477 A MX 9800477A
- Authority
- MX
- Mexico
- Prior art keywords
- chain
- branched
- alkyl
- methyl
- straight
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invencion se refiere a nuevos péptidos cíclicos de la formula general I en la cual las letras A a K significan residuos de los siguientes aminoácidos: A una homotreonina sustituida de la formula general II. R1-CH2CH/CH3)-CH(OH)-CH(NHCH3)-COOH en donde R1 es un n-propilo o propenilo y el doble enlace es preferiblemente una configuracion trans, B es un ácido alfa-aminobutírico, valina, norvalina o treonina, C es un (D)-aminoácido de la formula general CH3NH-CH(R)-COOH III en donde R es alquilo C2-C6, alquenilo, alquinilo de cadena lineal o ramificada, en donde estos grupos pueden además estar sustituidos por hidroxilo, amino, alquilamino de C1-C4, dialquilamino de C1-C4, alcoxi o aciloxi, COOR2, CONHR2, en donde R2 puede ser alquilo C1-C4, de cadena lineal o ramificada, X-R3 en donde X es O o S, y R3, es alquilo de C1-C4, alquenilo o alquinilo de cadena lineal o ramificada, y en donde, cuando X es S, R3, también puede ser arilo o heteroarilo, halogeno, preferiblemente fluor, ciano, o CHR4R5, en donde R4 es hidrogeno, metilo, etilo o fenilo, y R5 es hidrogeno, hidroxilo o halogeno, preferiblemente fluor, y además, amino, alquilamino de C1-C4, dialquilamino C1-C4, aciloxi, preferiblemente acetiloxi, y además, butoxicarbonil-aminoetoxi, y además, terbutoxicarbonil-aminoetoxi, etoxi-acetiloxi, o alcoxicarbonilo, preferiblemente butoxicarbonilo, D es N-metil-gamma-hidroxileucina o N- metilgamma-acetiloxileuicina, E es valina, F, I y J cada uno son N-metil-leucina, G, es alanina, H es (D), alanina o (D)-serina, y K es N-metilvalina. La invencion también se refiere a la preparacion de tales polipéptidos y su uso en la prevencion de infeccion causada por el virus de inmunodeficiencia humana (VIH).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95111162.4 | 1995-07-17 | ||
| EP95111162 | 1995-07-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9800477A true MX9800477A (es) | 1998-09-30 |
| MXPA98000477A MXPA98000477A (es) | 1998-11-16 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9900405A2 (hu) | 1999-06-28 |
| NO980195L (no) | 1998-01-15 |
| AU722858B2 (en) | 2000-08-10 |
| AU6700196A (en) | 1997-02-18 |
| CA2226880A1 (en) | 1997-02-06 |
| EP0842191A2 (de) | 1998-05-20 |
| CN1141317C (zh) | 2004-03-10 |
| JP2000502320A (ja) | 2000-02-29 |
| CN1192750A (zh) | 1998-09-09 |
| NO980195D0 (no) | 1998-01-15 |
| CA2226880C (en) | 2007-04-10 |
| WO1997004005A2 (de) | 1997-02-06 |
| KR100441220B1 (ko) | 2005-02-24 |
| BR9609795A (pt) | 1999-03-16 |
| KR19990028967A (ko) | 1999-04-15 |
| PL324531A1 (en) | 1998-06-08 |
| NZ315324A (en) | 1999-10-28 |
| DE59608274D1 (de) | 2002-01-03 |
| EP0842191B1 (de) | 2001-11-21 |
| CZ5198A3 (cs) | 1998-04-15 |
| US5948884A (en) | 1999-09-07 |
| WO1997004005A3 (de) | 1997-02-27 |
| IL122754A0 (en) | 1998-08-16 |
| CZ290754B6 (cs) | 2002-10-16 |
| JP3920919B2 (ja) | 2007-05-30 |
| HUP9900405A3 (en) | 2001-04-28 |
| ATE209216T1 (de) | 2001-12-15 |
| IL122754A (en) | 2001-10-31 |
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